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Volume 38(3); July 2021
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Review articles
Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL)
Jun-Ho Lee
Yeungnam Univ J Med. 2021;38(3):175-182.   Published online January 19, 2021
DOI: https://doi.org/10.12701/yujm.2020.00801
  • 7,038 View
  • 176 Download
  • 8 Crossref
AbstractAbstract PDF
Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare T-cell non-Hodgkin lymphoma characterized as CD30 positive and anaplastic lymphoma kinase (ALK) negative. In 2016, the World Health Organization declared BIA-ALCL as a new disease entity. The first case of BIA-ALCL was reported in 1997, and as of July 2019, the United States Food and Drug Administration had cited a total of 573 United States and global medical device reports of BIA-ALCL, including 33 deaths. In all clinical case reports, except for those with unknown clinical history, the patient had received at least one textured surface breast implant. Although the etiology is not yet clear, chronic inflammation has been proposed as a potential precursor to tumorigenesis. The most common presentation of BIA-ALCL is peri-implant fluid collection following aesthetic or reconstructive implantation with textured surface breast implants. It can be accompanied by breast swelling, asymmetry, pain, skin lesions, lymphadenopathy, and B-type symptoms. Most cases are detected on average 7 to 10 years after implantation. Diagnostic specimens can be obtained with fine-needle aspiration or biopsy. BIA-ALCL is CD30 positive, epithelial membrane antigen positive, and ALK negative. It can be cured with complete surgical excision at the T1–T3 stage.

Citations

Citations to this article as recorded by  
  • Smooth vs Textured Expanders: Patient Factors and Anatomic Plane Are Greater Factors in Determining First-Stage Breast Reconstruction Outcomes
    Emma S Dahmus, Amanda E Ruffino, Joshua D Madera, Alexandra Long, Shengxuan Wang, Christian A Kauffman, Sean Devitt, Christopher Sanders, Joseph DeSantis
    Aesthetic Surgery Journal.2024; 44(2): NP159.     CrossRef
  • Complication Profiles of Smooth vs Textured Tissue Expanders in Breast Reconstruction: A Systematic Review and Meta-Analysis
    Arman J Fijany, Sara C Chaker, Ya-Ching Hung, Ilana Zago, Nicole Friedlich, Sofia E Olsson, Cole A Holan, Lisandro Montorfano, Ronnie N Mubang, Kevin B Givechian, Michael J Boctor, Maxim Pekarev, Jorys Martinez-Jorge, Elizabeth D Slater
    Aesthetic Surgery Journal.2024; 44(4): 383.     CrossRef
  • The Polyvalent Role of CD30 for Cancer Diagnosis and Treatment
    Adrian Vasile Dumitru, Dana Antonia Țăpoi, Georgian Halcu, Octavian Munteanu, David-Ioan Dumitrascu, Mihail Constantin Ceaușu, Ancuța-Augustina Gheorghișan-Gălățeanu
    Cells.2023; 12(13): 1783.     CrossRef
  • Practice Trends in the Management of Asymptomatic Breast Reconstruction Patients with Textured Implants: A Survey Analysis
    Laura A. Roider, David C. Nguyen, Shreya Pusapadi Ramkumar, Cody V. Tyson, Herluf G. Lund, Christina M. Plikaitis
    Plastic and Reconstructive Surgery - Global Open.2023; 11(7): e5139.     CrossRef
  • Place and objectives of ultrasound examination of the mammary glands after augmentation mammoplasty with silicone endoprostheses in the instrumental algorithm of patients with suspected BIA-ALCL (literature review)
    E. P. Fisenko
    Medical Visualization.2023; 27(4): 68.     CrossRef
  • Evaluation of Different Breast Implant Shapes in the Same Patient: Is There Really a Difference between Round and Anatomical Implants?
    Paolo Montemurro, Patrick Mallucci, Maurizio B. Nava, Per Hedén, William P. Adams, Johannes M. Wagner
    Plastic and Reconstructive Surgery - Global Open.2023; 11(9): e5294.     CrossRef
  • Implantes mamarios en tiempos de linfoma y COVID-19. ¿Han aumentado las complicaciones?
    Estela Vélez-Benítez, Jesús Cuenca-Pardo, Bertha Torres-Gómez, Arturo Ramírez-Montañana, Raúl Alfonso Vallarta-Rodríguez, Rufino Iribarren-Moreno, Guillermo Ramos-Gallardo, Martín de la Cruz Lira-Álvarez
    Cirugía Plástica.2023; 33(3): 100.     CrossRef
  • Comprehensive Evaluation of the Current Knowledge on Breast Implant Associated-Anaplastic Large Cell Lymphoma
    Hyokyung Yoo, Ji-Ung Park, Hak Chang
    Archives of Plastic Surgery.2022; 49(02): 141.     CrossRef
Lactate: a multifunctional signaling molecule
Tae-Yoon Lee
Yeungnam Univ J Med. 2021;38(3):183-193.   Published online February 18, 2021
DOI: https://doi.org/10.12701/yujm.2020.00892
  • 19,117 View
  • 513 Download
  • 34 Crossref
AbstractAbstract PDF
Since its discovery in 1780, lactate has long been misunderstood as a waste by-product of anaerobic glycolysis with multiple deleterious effects. Owing to the lactate shuttle concept introduced in the early 1980s, a paradigm shift began to occur. Increasing evidence indicates that lactate is a coordinator of whole-body metabolism. Lactate is not only a readily accessible fuel that is shuttled throughout the body but also a metabolic buffer that bridges glycolysis and oxidative phosphorylation between cells and intracellular compartments. Lactate also acts as a multifunctional signaling molecule through receptors expressed in various cells and tissues, resulting in diverse biological consequences including decreased lipolysis, immune regulation, anti-inflammation, wound healing, and enhanced exercise performance in association with the gut microbiome. Furthermore, lactate contributes to epigenetic gene regulation by lactylating lysine residues of histones, accounting for its key role in immune modulation and maintenance of homeostasis.

Citations

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  • The synergism of cytosolic acidosis and reduced NAD+/NADH ratio is responsible for lactic acidosis-induced vascular smooth muscle cell impairment in sepsis
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    Journal of Biomedical Science.2024;[Epub]     CrossRef
  • Lactoylglutathione promotes inflammatory signaling in macrophages through histone lactoylation
    Marissa N. Trujillo, Erin Q. Jennings, Emely A. Hoffman, Hao Zhang, Aiden M. Phoebe, Grace E. Mastin, Naoya Kitamura, Julie A. Reisz, Emily Megill, Daniel Kantner, Mariola M. Marcinkiewicz, Shannon M. Twardy, Felicidad Lebario, Eli Chapman, Rebecca L. McC
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  • Association of prehospital lactate levels with base excess in various emergencies – a retrospective study
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    Clinical Chemistry and Laboratory Medicine (CCLM).2024;[Epub]     CrossRef
  • Material matters: Degradation products affect regenerating Schwann cells
    Kendell M. Pawelec, Jeremy M.L. Hix, Erik M. Shapiro
    Biomaterials Advances.2024; 159: 213825.     CrossRef
  • B cells from old mice induce the generation of inflammatory T cells through metabolic pathways
    Kevin Li, Maria Romero, Macarena Cañardo, Denisse Garcia, Alain Diaz, Bonnie B. Blomberg, Daniela Frasca
    Mechanisms of Ageing and Development.2023; 209: 111742.     CrossRef
  • The function and mechanism of lactate and lactylation in tumor metabolism and microenvironment
    Yan Zhang, Qiu Peng, Jinhua Zheng, Yuzhong Yang, Xuemei Zhang, Aiyu Ma, Yuxia Qin, Zailong Qin, Xiang Zheng
    Genes & Diseases.2023; 10(5): 2029.     CrossRef
  • Lactate: a pearl dropped in the ocean—an overlooked signal molecule in physiology and pathology
    Yue Wu, Wanqi Ma, Wei Liu, Shuping Zhang
    Cell Biology International.2023; 47(2): 295.     CrossRef
  • Insights on the role of l-lactate as a signaling molecule in skin aging
    Salvatore Chirumbolo, Dario Bertossi, Pierre Magistretti
    Biogerontology.2023; 24(5): 709.     CrossRef
  • Role of L-lactate as an energy substrate in primary rat podocytes under physiological and glucose deprivation conditions
    Maria Szrejder, Marlena Typiak, Piotr Pikul, Irena Audzeyenka, Patrycja Rachubik, Dorota Rogacka, Magdalena Narajczyk, Agnieszka Piwkowska
    European Journal of Cell Biology.2023; 102(2): 151298.     CrossRef
  • Utilization of delactosed whey permeate for the synthesis of ethyl acetate with Kluyveromyces marxianus
    Andreas Hoffmann, Alexander Franz, Thomas Walther, Christian Löser
    Applied Microbiology and Biotechnology.2023; 107(5-6): 1635.     CrossRef
  • Lactate, histone lactylation and cancer hallmarks
    Xinyu Lv, Yingying Lv, Xiaofeng Dai
    Expert Reviews in Molecular Medicine.2023;[Epub]     CrossRef
  • Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies
    Ariel K. Frame, J. Wesley Robinson, Nader H. Mahmoudzadeh, Jason M. Tennessen, Anne F. Simon, Robert C. Cumming
    Aging.2023;[Epub]     CrossRef
  • Human beta defensin-2 loaded PLGA nanoparticles impregnated in collagen-chitosan composite scaffold for the management of diabetic wounds
    Bharat Kumar Reddy Sanapalli, Vidyasrilekha Yele, Mantosh Kumar Singh, Shilpa.N. Thumbooru, Madhukiran Parvathaneni, Veera Venkata Satyanarayana Reddy Karri
    Biomedicine & Pharmacotherapy.2023; 161: 114540.     CrossRef
  • Immunomodulatory Properties of Probiotics and Their Derived Bioactive Compounds
    Christina Thoda, Maria Touraki
    Applied Sciences.2023; 13(8): 4726.     CrossRef
  • Lactate‐induced protein lactylation: A bridge between epigenetics and metabolic reprogramming in cancer
    Ting Wang, Zeng Ye, Zheng Li, De‐sheng Jing, Gui‐xiong Fan, Meng‐qi Liu, Qi‐feng Zhuo, Shun‐rong Ji, Xian‐jun Yu, Xiao‐wu Xu, Yi Qin
    Cell Proliferation.2023;[Epub]     CrossRef
  • Recent Developments in Protein Lactylation in PTSD and CVD: Novel Strategies and Targets
    Zisis Kozlakidis, Patricia Shi, Ganna Abarbanel, Carolina Klein, Adonis Sfera
    BioTech.2023; 12(2): 38.     CrossRef
  • High-concentrate diet elevates histone lactylation mediated by p300/CBP through the upregulation of lactic acid and induces an inflammatory response in mammary gland of dairy cows
    Lairong Wang, Yan Wang, Meijuan Meng, Nana Ma, Guozhen Wei, Ran Huo, Guangjun Chang, Xiangzhen Shen
    Microbial Pathogenesis.2023; 180: 106135.     CrossRef
  • ANT2 Accelerates Cutaneous Wound Healing in Aged Skin by Regulating Energy Homeostasis and Inflammation
    Seung-Hwa Woo, Yun Jeong Mo, Yun-Il Lee, Ji Hwan Park, Daehee Hwang, Tae Jun Park, Hee Young Kang, Sang Chul Park, Young-Sam Lee
    Journal of Investigative Dermatology.2023; 143(11): 2295.     CrossRef
  • Exogenous lactate administration: A potential novel therapeutic approach for neonatal hypoxia-ischemia
    Qianting Deng, Chongyun Wu, Timon Cheng-Yi Liu, Rui Duan, Luodan Yang
    Experimental Neurology.2023; 367: 114450.     CrossRef
  • An adult Drosophila glioma model to highlight metabolic dysfunctions and evaluate the role of the serotonin 5‐HT7 receptor as a potential therapeutic target
    Marylène Bertrand, Frédéric Szeremeta, Nadège Hervouet‐Coste, Vincent Sarou‐Kanian, Céline Landon, Séverine Morisset‐Lopez, Martine Decoville
    The FASEB Journal.2023;[Epub]     CrossRef
  • Reply to Lund et al.
    Dalia Barayan, Fadi Khalaf, Carly M. Knuth, Abdikarim Abdullahi, Sarah Rehou, Robert A. Screaton, Marc G. Jeschke
    American Journal of Physiology-Endocrinology and Metabolism.2023; 325(4): E423.     CrossRef
  • Crosstalk between lactic acid and immune regulation and its value in the diagnosis and treatment of liver failure
    Yong Lin, Gengjie Yan, Minggang Wang, Kan Zhang, Faming Shu, Meiyan Liu, Fuli Long, Dewen Mao
    Open Life Sciences.2023;[Epub]     CrossRef
  • Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models
    Nataliya A. Kolotyeva, Frida N. Gilmiyarova, Anton S. Averchuk, Tatiana I. Baranich, Nataliya A. Rozanova, Maria V. Kukla, Pavel P. Tregub, Alla B. Salmina
    International Journal of Molecular Sciences.2023; 24(19): 14709.     CrossRef
  • Phytochemicals Target Multiple Metabolic Pathways in Cancer
    Oleg Shuvalov, Yulia Kirdeeva, Alexandra Daks, Olga Fedorova, Sergey Parfenyev, Hans-Uwe Simon, Nickolai A. Barlev
    Antioxidants.2023; 12(11): 2012.     CrossRef
  • Lactylation driven by lactate metabolism in the disc accelerates intervertebral disc degeneration: A hypothesis
    Chuan Cheng, Zhiqiang Xu, Cao Yang, Xinghuo Wu
    Medical Hypotheses.2022; 159: 110758.     CrossRef
  • A bioorthogonal chemical reporter for the detection and identification of protein lactylation
    Yanan Sun, Yanchi Chen, Tao Peng
    Chemical Science.2022; 13(20): 6019.     CrossRef
  • Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells
    Lianhong Pan, Fan Feng, Jiaqin Wu, Shibing Fan, Juanjuan Han, Shunxi Wang, Li Yang, Wanqian Liu, Chunli Wang, Kang Xu
    Pharmacological Research.2022; 181: 106270.     CrossRef
  • Understanding lactate sensing and signalling
    Michelangelo Certo, Alba Llibre, Wheeseong Lee, Claudio Mauro
    Trends in Endocrinology & Metabolism.2022; 33(10): 722.     CrossRef
  • Venous Wall of Patients with Chronic Venous Disease Exhibits a Glycolytic Phenotype
    Oscar Fraile-Martinez, Cielo García-Montero, Miguel Ángel Alvarez-Mon, Ana M. Gomez-Lahoz, Jorge Monserrat, Maria Llavero-Valero, Fernando Ruiz-Grande, Santiago Coca, Melchor Alvarez-Mon, Julia Buján, Natalio García-Honduvilla, Jose V. Saz, Miguel A. Orte
    Journal of Personalized Medicine.2022; 12(10): 1642.     CrossRef
  • Lactate induces metabolic and epigenetic reprogramming of pro‐inflammatory Th17 cells
    Aleksandra Lopez Krol, Hannah P Nehring, Felix F Krause, Anne Wempe, Hartmann Raifer, Andrea Nist, Thorsten Stiewe, Wilhelm Bertrams, Bernd Schmeck, Maik Luu, Hanna Leister, Ho‐Ryun Chung, Uta‐Maria Bauer, Till Adhikary, Alexander Visekruna
    EMBO reports.2022;[Epub]     CrossRef
  • Crosstalk between glucose metabolism, lactate production and immune response modulation
    Lei Ye, Yi Jiang, Mingming Zhang
    Cytokine & Growth Factor Reviews.2022; 68: 81.     CrossRef
  • Metabolic orchestration of the wound healing response
    Sabine A. Eming, Peter J. Murray, Edward J. Pearce
    Cell Metabolism.2021; 33(9): 1726.     CrossRef
  • Epigenetic Regulation of Immunotherapy Response in Triple-Negative Breast Cancer
    Pere Llinàs-Arias, Sandra Íñiguez-Muñoz, Kelly McCann, Leonie Voorwerk, Javier I. J. Orozco, Miquel Ensenyat-Mendez, Borja Sesé, Maggie L. DiNome, Diego M. Marzese
    Cancers.2021; 13(16): 4139.     CrossRef
Psychiatric understanding and treatment of patients with amputations
So-Hye Jo, Suk-Hun Kang, Wan-Seok Seo, Bon-Hoon Koo, Hye-Geum Kim, Seok-Ho Yun
Yeungnam Univ J Med. 2021;38(3):194-201.   Published online May 11, 2021
DOI: https://doi.org/10.12701/yujm.2021.00990
  • 10,346 View
  • 308 Download
  • 11 Crossref
AbstractAbstract PDF
Amputation changes the lives of patients and their families. Consequently, the patient must adapt to altered body function and image. During this adaptation process, psychological problems, such as depression, anxiety, and posttraumatic stress disorder, can occur. The psychological difficulties of patients with amputation are often accepted as normal responses that are often poorly recognized by patients, family members, and their primary physicians. Psychological problems can interfere with rehabilitation and cause additional psychosocial problems. Therefore, their early detection and treatment are important. A multidisciplinary team approach, including mental health professionals, is ideal for comprehensive and biopsychosocial management. Mental health professionals could help patients set realistic goals and use adaptive coping styles. Psychiatric approaches should consider the physical, cognitive, psychological, social, and spiritual functions and social support systems before and after amputation. The abilities and limitations of physical, cognitive, psychological, and social functions should also be considered. To improve the patient’s adaptation, psychological interventions such as short-term psychotherapy, cognitive behavioral therapy, mindfulness meditation, biofeedback, and group psychotherapy can be helpful.

Citations

Citations to this article as recorded by  
  • Depression and Anxiety Symptoms Among Lebanese Lower Limb Traumatic Amputees: Association with Education, Employment, Adjustment to Amputation and Prosthesis Satisfaction
    Nour El Hoda Saleh, Fatima Hamiye, Marwa Summaka, Hiba Zein, Rami El Mazbouh, Ibrahim Naim
    Psychiatry.2024; 87(1): 51.     CrossRef
  • Building a Multidisciplinary Clinic Dedicated to Upper-Extremity Limb Loss
    Anirudh Kulkarni, Margaret Luthringer, Alta Fried, Matt Mikosz, Jamie Mauro, Gina Radice Vella, Tara Lally, Ajul Shah
    The Journal of Hand Surgery.2024; 49(3): 267.     CrossRef
  • Effect of Increasing Assistance From a Powered Prosthesis on Weight-Bearing Symmetry, Effort, and Speed During Stand-Up in Individuals With Above-Knee Amputation
    Grace R. Hunt, Sarah Hood, Lukas Gabert, Tommaso Lenzi
    IEEE Transactions on Neural Systems and Rehabilitation Engineering.2023; 31: 11.     CrossRef
  • The Effect of Motivational Interview-Based Counseling in Individuals With Amputation: A Randomized Controlled Trial in Turkey
    Gülhan Küçük Öztürk, Nuray Şimşek
    Rehabilitation Nursing.2023; 48(5): 160.     CrossRef
  • Psychosocial patient perspectives following major lower-limb amputation due to vascular aetiology: a protocol for a systematic meta-aggregation study
    Sisse Heiden Laursen, Helle Lund Rasmussen, Dinnie Seidelin, Peter Hørslev Pedersen, Tanja Mortensen Chræmmer
    BMJ Open.2023; 13(9): e076794.     CrossRef
  • Quality of life following non-dysvascular lower limb amputation is contextualized through occupations: a qualitative study
    Stephanie R. Cimino, Sander L. Hitzig, Vera Fung, Katie N. Dainty, Crystal MacKay, Joanna E. M. Sale, Amanda L. Mayo, Sara J. T. Guilcher
    Disability and Rehabilitation.2023; : 1.     CrossRef
  • Finger prosthesis: A novel way to restore the form, function, and esthetics
    Nagaveni S. Somayaji, Pallawi Sinha, Jitendra Sharan, Jagadish Prasad Rajaguru, Anand Marya
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    Patrick Fangping Yao, Yi David Diao, Eric P. McMullen, Marlin Manka, Jessica Murphy, Celina Lin, Noman Naseer
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Original articles
Personal experience with microvascular decompression and partial sensory rhizotomy for trigeminal neuralgia
Jung Hwan Lee, Jae Meen Lee, Chang Hwa Choi
Yeungnam Univ J Med. 2021;38(3):202-207.   Published online November 23, 2020
DOI: https://doi.org/10.12701/yujm.2020.00745
  • 7,314 View
  • 119 Download
  • 5 Crossref
AbstractAbstract PDF
Background
Trigeminal neuralgia (TN) is a severe, paroxysmal pain in the distribution of the fifth cranial nerve. Microvascular decompression (MVD) is the most widely used surgical treatment for TN. We undertook this study to analyze the effects of and complications of MVD and to refine the surgical procedure for treating TN.
Methods
A total of 88 patients underwent for TN underwent surgery at our hospital. Among them, 77 patients underwent MVD alone, and 11 underwent partial sensory rhizotomy (PSR) with or without MVD. The medical records of these patients were retrospectively analyzed for patient characteristics, clinical results, offending vessels, and complications if any.
Results
The mean follow-up duration was 43.2 months (range, 3–216 months). The most common site of pain was V2+V3 territory (n=27), followed by V2 (n=25) and V3 (n=23). The most common offending vessels were the superior cerebellar artery and anterior inferior cerebellar artery in that order. The overall rate of postoperative complications was 46.1%; however, most complications were transient. There were two cases of permanent partial hearing disturbance. In the MVD alone group, the cure rate was 67.5%, and the improvement rate was 26.0%. Among 11 patients who underwent PSR with or without MVD, the cure rate was 50.0%, and the improvement rate was 30.0%.
Conclusion
The clinical results of MVD were satisfactory. Although the outcomes of PSR were not as favorable as those of pure MVD in this study, PSR can be considered in cases where there is no significant vascular compressive lesion or uncertainty of the causative vessel at the surgery.

Citations

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  • Revisiting the Efficacy of Redo Microvascular Decompression for Trigeminal Neuralgia
    Zhongding Zhang, Hua Zhao, Yinda Tang, Baimiao Wang, Qing Yuan, Ying Zhang, Yihua Li, Jun Zhong, Shiting Li
    World Neurosurgery.2024;[Epub]     CrossRef
  • Progress in Surgical Treatment of Trigeminal Neuralgia
    滨 何
    Advances in Clinical Medicine.2023; 13(02): 2313.     CrossRef
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    Stephen D Howard, Varun Soti
    Cureus.2023;[Epub]     CrossRef
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    A. N. Zhurkin, A. V. Semenov, V. A. Sorokovikov, N. V. Bartul
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    Risheng Xu, Michael E Xie, Christopher M Jackson
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A retrospective analysis of etiology and outcomes of hemophagocytic lymphohistiocytosis in children and adults
Abraham Kwak, Nani Jung, Ye Jee Shim, Heung Sik Kim, Hyun Ji Lim, Jae Min Lee, Mi Hwa Heo, Young Rok Do
Yeungnam Univ J Med. 2021;38(3):208-218.   Published online November 27, 2020
DOI: https://doi.org/10.12701/yujm.2020.00591
  • 6,349 View
  • 145 Download
  • 4 Crossref
AbstractAbstract PDF
Background
Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe, life-threatening inflammatory condition if untreated. We aimed to investigate the etiologies, outcomes, and risk factors for death in children and adults with HLH.
Methods
The medical records of patients who met the HLH criteria of two regional university hospitals in Korea between January 2001 and December 2019 were retrospectively investigated.
Results
Sixty patients with HLH (35 children and 25 adults) were included. The median age at diagnosis was 7.0 years (range, 0.1–83 years), and the median follow-up duration was 8.5 months (range, 0–204 months). Four patients had primary HLH, 48 patients had secondary HLH (20 infection-associated, 18 neoplasm-associated, and 10 autoimmune-associated HLH), and eight patients had HLH of unknown cause. Infection was the most common cause in children (14/35, 40.0%), whereas neoplasia was the most common cause in adults (13/25, 52.0%). Twenty-eight patients were treated with HLH-2004/94 immunochemotherapy. The 5-year overall survival (OS) rate for all HLH patients was 59.9%. The 5-year OS rates for patients with primary, infection-associated, neoplasm-associated, autoimmune-associated, and unknown cause HLH were 25.0%, 85.0%, 26.7%, 87.5%, and 62.5%, respectively. Using multivariate analysis, neoplasm-induced HLH (p=0.001) and a platelet count <50×109/L (p=0.008) were identified as independent risk factors for poor prognosis in patients with HLH.
Conclusion
Infection was the most common cause of HLH in children, while it was neoplasia in adults. The 5-year OS rate for all HLH patients was 59.9%. HLH caused by an underlying neoplasm or a low platelet count at the time of diagnosis were risk factors for poor prognosis.

Citations

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  • Spontaneous resolution of hemophagocytic lymphohistiocytosis in a child infected with epstein–Barr virus
    Rita Alfattal, Hussain Sadeq, Abdullah Ali
    Journal of Applied Hematology.2023; 14(1): 57.     CrossRef
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    María Soledad Caldirola, Andrea Gómez Raccio, Daniela Di Giovanni, María Isabel Gaillard, María Victoria Preciado
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    Bruno Fattizzo, Marta Ferraresi, Juri Giannotta, Wilma Barcellini
    Journal of Clinical Medicine.2021; 10(4): 870.     CrossRef
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    Lauren T. Maloney, Bronwyn Baz, Dia Hazra
    Pediatrics.2021;[Epub]     CrossRef
Clinical effectiveness of omental transposition in facilitating perineal wound healing after abdominoperineal resection: a systematic review
Sungjin Kim, Sung Il Kang, Sohyun Kim, Jae Hwang Kim
Yeungnam Univ J Med. 2021;38(3):219-224.   Published online February 9, 2021
DOI: https://doi.org/10.12701/yujm.2020.00871
  • 4,572 View
  • 57 Download
AbstractAbstract PDF
Background
Omental transposition has been used to facilitate perineal wound healing in patients undergoing abdominoperineal resection (APR). However, there is no high-level evidence supporting the effectiveness of omental transposition in this regard. This study aimed to investigate the clinical efficacy of omental transposition in facilitating perineal wound healing after APR.
Methods
In this systematic review, we systematically searched the PubMed/MEDLINE, Embase, Scopus, Cochrane Library, and Web of Science databases for literature regarding the topic of our study. Studies published since the inception of each database were considered for review. The outcomes of interest were the perineal wound healing rate at 1 and 3 months postoperatively, perineal wound infection rate, and perineal wound healing period.
Results
Of the 1,923 studies identified, four articles representing 819 patients (omental transposition patients, n=295) were included in the final analysis. The wound healing rates at 1 and 3 months postoperatively in the omental transposition group (68.5% and 79.7%, respectively) did not significantly differ from those in the control group (57.4% and 78.7%, respectively) (p=0.759 and p=0.731, respectively). Perineal wound infection and chronic wound complication rates, including sinus, dehiscence, and fistula rates, also did not significantly differ between the omental transposition (8% and 7%, respectively) and control (11% and 7%, respectively) groups (p=0.221 and p=0.790, respectively).
Conclusion
Our results suggest that omental transposition does not affect perineal wound healing in patients who undergo APR.
Significance of albumin to globulin ratio as a predictor of febrile urinary tract infection after ureteroscopic lithotripsy
Seung Yun Yi, Dong Jin Park, Kyungchan Min, Jae-Wook Chung, Yun-Sok Ha, Bum Soo Kim, Hyun Tae Kim, Tae-Hwan Kim, Eun Sang Yoo
Yeungnam Univ J Med. 2021;38(3):225-230.   Published online April 20, 2021
DOI: https://doi.org/10.12701/yujm.2021.00955
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AbstractAbstract PDF
Background
We aimed to analyze the effectiveness of albumin to globulin ratio (AGR) in predicting postoperative febrile urinary tract infection (fUTI) after ureteroscopic lithotripsy (URS) and retrograde intrarenal surgery (RIRS).
Methods
From January 2013 to May 2018, 332 patients underwent URS and RIRS. The rate of postoperative fUTI and risk factors for postoperative fUTI were analyzed using logistic regression. Patients were divided into postoperative fUTI and non-postoperative fUTI (non-fUTI) groups. AGR with other demographic and perioperative data were compared between the two groups to predict the development of fUTI after URS.
Results
Of the 332 patients, postoperative fUTI occurred in 41 (12.3%). Preoperative pyuria, microscopic hematuria, diabetes mellitus, hypoalbuminemia, and hyperglobulinemia were more prevalent in the fUTI group. Patients in the fUTI group had larger stone size, lower preoperative AGR, longer operation time, and longer preoperative antibiotic coverage period. In a multivariable logistic analysis, preoperative pyuria, AGR, and stone size were independently correlated with postoperative fUTI (p<0.001, p=0.008, and p=0.041, respectively). Receiver operating curve analysis showed that the cutoff value of AGR that could predict a high risk of fUTI after URS was 1.437 (sensitivity, 77.3%; specificity, 76.9%), while the cutoff value of stone size was 8.5 mm (sensitivity, 55.3%; specificity, 44.7%).
Conclusion
This study demonstrated that preoperative pyuria, AGR, and stone size can serve as prognostic factors for predicting fUTI after URS.

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    Tal Frenkel Rutenberg, Rana Gabarin, Vitali Kilimnik, Efrat Daglan, Moti Iflah, Shani Zach, Shai Shemesh
    Surgical Infections.2023; 24(7): 645.     CrossRef
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    Heliyon.2022; 8(5): e09457.     CrossRef
Case reports
Metachronous extranodal natural killer/T-cell lymphoma of nasal type and primary testicular lymphoma
Young-In Maeng, Sun-Jae Lee
Yeungnam Univ J Med. 2021;38(3):231-234.   Published online September 11, 2020
DOI: https://doi.org/10.12701/yujm.2020.00675
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AbstractAbstract PDF
We report a rare case of metachronous lymphoma with two distinct cell lineages in a 75-year-old man. The patient complained about having nasal obstruction for 2 years and extranodal natural killer (NK)/T-cell lymphoma of the nasal type was diagnosed from a biopsy. The immunohistochemical staining for CD56 and in situ hybridization for Epstein-Barr virus (EBV)–encoded small RNA (EBER-ISH) were positive and the tumor cells were negative for CD20. After 13 months of concurrent chemoradiotherapy, the patient presented with swelling of the left testis. Positron emission tomography scan detected an abnormal uptake in the testis. A diffuse large B-cell lymphoma, not otherwise specified, was diagnosed from subsequent radical orchiectomy. The immunohistochemical staining revealed to be positive for CD20, BCL2, BCL6, and MYC and negative for CD10 and EBER-ISH.

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  • Extranodal natural killer/T cell lymphoma nasal type simulating osteoradionecrosis with metachronic B lymphoma in the pelvis: Case report
    Frida S. Colín-Guadarrama, Violeta E. Flores-Solano, Argelia Berenice-Rodríguez, Víctor H. Toral-Rizo
    Indian Journal of Pathology and Microbiology.2024; 67(1): 162.     CrossRef
  • What Effect Does Epstein-Barr Virus Have on Extranodal Natural Killer/T-Cell Lymphoma Prognosis? A Review of 153 Reported Cases
    Erika Tvedten, Jordan Richardson, Kiran Motaparthi
    Cureus.2021;[Epub]     CrossRef
Successful laparoscopic surgery of accessory cavitated uterine mass in young women with severe dysmenorrhea
Joon Cheol Park, Dong Ja Kim
Yeungnam Univ J Med. 2021;38(3):235-239.   Published online September 18, 2020
DOI: https://doi.org/10.12701/yujm.2020.00696
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AbstractAbstract PDF
Accessory cavitated uterine mass (ACUM) is a rare and unique condition seen in young women. We report cases of ACUMs in two patients, a 14-year-old girl and a 25-year-old woman, both with complaints of severe dysmenorrhea that had started at menarche and had progressively worsened since. A large cystic lesion was localized in the anterolateral wall of the myometrium separate from the endometrium, which was difficult to distinguish from congenital uterine anomalies. Laparoscopic excision of the ACUMs was successful and completely resolved the dysmenorrhea. Early investigation of severe dysmenorrhea in young women can provide appropriate management and relieve symptoms.

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  • Accessory and cavitated uterine masses: a case series and review of the literature
    S. Dekkiche, E. Dubruc, M. Kanbar, A. Feki, M. Mueller, J-Y. Meuwly, P. Mathevet
    Frontiers in Reproductive Health.2023;[Epub]     CrossRef
  • Accessory cavitated uterine malformation: Enhancing awareness about this unexplored perpetrator of dysmenorrhea
    Rana Mondal, Priya Bhave
    International Journal of Gynecology & Obstetrics.2023; 162(2): 409.     CrossRef
  • Large uterine juvenile cystic adenomyoma in an adolescent
    Zlatan Zvizdic, Irmina Sefic-Pasic, Nermina Ibisevic, Senad Murtezic, Semir Vranic
    Journal of Pediatric Surgery Case Reports.2022; 81: 102258.     CrossRef
  • Laparoscopic Approach to Accessory and Cavitatory Uterine Mass(ACUM): A Report of Four Patients in a Year
    Kavitha Yogini Duraisamy, S. Saidarshini, Devi Balasubramaniam, Pradeepa, Divya Gnanasekaran
    The Journal of Obstetrics and Gynecology of India.2022; 72(S2): 466.     CrossRef
The diagnosis of an imperforate anus in female fetuses
Hyun Mi Kim, Hyun-Hwa Cha, Jong In Kim, Won Joon Seong, Sook-Hyun Park, Mi Ju Kim
Yeungnam Univ J Med. 2021;38(3):240-244.   Published online October 7, 2020
DOI: https://doi.org/10.12701/yujm.2020.00507
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AbstractAbstract PDF
Imperforate anus is an anomaly caused by a defect in the development of the hindgut during early pregnancy. It is a relatively common congenital malformation and is more common in males. Although there are cases of a solitary imperforate anus, the condition is more commonly found as a part of a wider spectrum of other congenital anomalies. Although urgent reconstructive anorectal surgery is not necessary, immediate evaluation is important and urgent decompressive surgery may be required. Moreover, as there are often other anomalies that can affect management, prenatal diagnosis can help in optimizing perinatal care and prepare parents through prenatal counseling. In the past, imperforate anus was diagnosed by prenatal ultrasonography based on indirect signs such as bowel dilatation or intraluminal calcified meconium. Currently, it is diagnosed by directly checking the perineum with prenatal ultrasonography. Despite advances in ultrasound technology, accurate prenatal diagnosis is impossible in most cases and imperforate anus is detected after birth. Here, we present two cases of imperforate anus in female fetuses that were not diagnosed prenatally.

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    Cunera M.C. de Beaufort, Joep P.M. Derikx, Simon G.F. Robben, Rick R. van Rijn, Ramon R. Gorter, L.W. Ernest van Heurn
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    Jacobus Jeno Wibisono, Carissa Faustina, Maria Georgina Wibisono, Jeanne Leman, Ratna Sutanto
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  • Аноректальні аномалії розвитку
    Ольга Антонюк, Василь Пикалюк, Олександр Слободян, Альона Романюк, Людмила Шварц
    Notes in Current Biology.2023;[Epub]     CrossRef
  • Anorectoplasty and external sphincteroplasty via inverted V-shaped incision on the perineum for the treatment of imperforate anus with rectal fistula to navicular fossa: Report of 26 cases
    Da Ma, Yi Wang, Ying-Song Liu
    Asian Journal of Surgery.2022; 45(6): 1313.     CrossRef
  • Challenges in prenatal diagnosis of foetal anorectal malformation and hydrocolpos – Case report
    Muhammad Alamsyah Aziz, Fatima Zahra, Cut ZB Razianti, Nuniek Kharismawati, Tjut Sutjighassani, Nadia Larastri Almira, Kevin Dominique Tjandraprawira
    Annals of Medicine & Surgery.2022;[Epub]     CrossRef
Hemophagocytic lymphohistiocytosis with recurrent Kikuchi-Fujimoto disease
Sang Min Lee, Young Tae Lim, Kyung Mi Jang, Mi Jin Gu, Jong Ho Lee, Jae Min Lee
Yeungnam Univ J Med. 2021;38(3):245-250.   Published online November 11, 2020
DOI: https://doi.org/10.12701/yujm.2020.00654
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AbstractAbstract PDF
Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a self-limiting lymphadenitis. It is a benign disease mainly characterized by high fever, lymph node swelling, and leukopenia. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease with clinical symptoms similar to those of KFD, but it requires a significantly more aggressive treatment. A 19-year-old Korean male patient was hospitalized for fever and cervical lymphadenopathy. Variable-sized lymph node enlargements with slightly necrotic lesions were detected on computed tomography. Biopsy specimen from a cervical lymph node showed necrotizing lymphadenitis with HLH. Bone marrow aspiration showed hemophagocytic histiocytosis. The clinical symptoms and the results of the laboratory test and bone marrow aspiration met the diagnostic criteria for HLH. The patient was diagnosed with macrophage activation syndrome—HLH, a secondary HLH associated with KFD. He was treated with dexamethasone (10 mg/m2/day) without immunosuppressive therapy or etoposide-based chemotherapy. The fever disappeared within a day, and other symptoms such as lymphadenopathy, ascites, and pleural effusion improved. Dexamethasone was reduced from day 2 of hospitalization and was tapered over 8 weeks. The patient was discharged on day 6 with continuation of dexamethasone. The patient had no recurrence at the 18-month follow-up.

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  • Histiocytic necrotizing lymphadenitis with hemophagocytic lymphohistiocytosis in adults: A single‐center analysis of 5 cases
    Qingqing Chen, Jing Zhang, Huijun Huang, Tonglu Qiu, Ze Jin, Yu Shi, Huayuan Zhu, Lei Fan, Jianyong Li, Wenyu Shi, Yi Miao
    Immunity, Inflammation and Disease.2024;[Epub]     CrossRef
  • A young Saudi female with combined hemophagocytic lympho-histiocytosis and Kikuchi’s disease: A case report
    Kamal Al-Zahrani, Batol Gasmelseed, Hesham Waaer Shadi, Rehab Y AL-Ansari
    SAGE Open Medical Case Reports.2023; 11: 2050313X2311543.     CrossRef
  • Cefalea y fiebre: no todo es lo que parece
    María Pilar Iranzo-Alcolea, Carmen Ariño-Palao, Grisell Starita-Fajardo, Andrés González-García, Cecilia Suárez-Carantoña
    Revista Española de Casos Clínicos en Medicina Interna.2023; 8(2): 105.     CrossRef
  • Kikuchi–Fujimoto disease: literature review and report of four cases
    V. G. Potapenko, V. V. Baykov, А. Yu. Markova, N. B. Mikhailova, A. S. Ter‑Grigoryan, Yu. А. Krivolapov
    Oncohematology.2022; 17(4): 48.     CrossRef
Successful treatment with vedolizumab in an adolescent with Crohn disease who had developed active pulmonary tuberculosis while receiving infliximab
Sujin Choi, Bong Seok Choi, Byung-Ho Choe, Ben Kang
Yeungnam Univ J Med. 2021;38(3):251-257.   Published online February 19, 2021
DOI: https://doi.org/10.12701/yujm.2020.00878
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AbstractAbstract PDF
Vedolizumab (VDZ) has been approved for the treatment of inflammatory bowel diseases (IBDs) in patients aged ≥18 years. We report a case of a pediatric patient with Crohn disease (CD) who was successfully treated with VDZ. A 16-year-old female developed severe active pulmonary tuberculosis (TB) during treatment with infliximab (IFX). IFX was stopped, and TB treatment was started. After a 6-month regimen of standard TB medication, her pulmonary TB was cured; however, gastrointestinal symptoms developed. Due to the concern of the patient and parents regarding TB reactivation on restarting treatment with IFX, VDZ was started off-label. After the second dose of VDZ, the patient was in clinical remission and her remission was continuously sustained. Ileocolonoscopy at 1-year after VDZ initiation revealed endoscopic healing. Therapeutic drug monitoring conducted during VDZ treatment showed negative antibodies to VDZ. No serious adverse events occurred during the VDZ treatment. This is the first case report in Korea demonstrating the safe and effective use of VDZ treatment in a pediatric CD patient. In cases that require recommencement of treatment with biologics after recovery of active pulmonary TB caused by anti-tumor necrosis factor agents, VDZ may be a good option even in pediatric IBD.

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  • The safety of vedolizumab in a patient with Crohn’s disease who developed anti-TNF-alpha agent associated latent tuberculosis infection reactivation: A case report
    Yuya Sugiyama, Nobuhiro Ueno, Shion Tachibana, Yu Kobayashi, Yuki Murakami, Takahiro Sasaki, Aki Sakatani, Keitaro Takahashi, Katsuyoshi Ando, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Toshikatsu Okumura, Mikihiro Fujiya
    Medicine.2023; 102(28): e34331.     CrossRef
  • Vedolizumab Is Safe and Efficacious for the Treatment of Pediatric-Onset Inflammatory Bowel Disease Patients Who Fail a Primary Biologic Agent
    Sujin Choi, Eun Sil Kim, Yiyoung Kwon, Mi Jin Kim, Yon Ho Choe, Byung-Ho Choe, Ben Kang
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
Sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large B-cell lymphoma: a rare cause of leg weakness
Kyoung Tae Kim, Se Il Kim, Young Rok Do, Hye Ra Jung, Jang Hyuk Cho
Yeungnam Univ J Med. 2021;38(3):258-263.   Published online April 15, 2021
DOI: https://doi.org/10.12701/yujm.2021.00983
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AbstractAbstract PDF
Neurolymphomatosis (NL) is defined as the involvement of the peripheral nervous system in lymphocytic invasion. It is a very rare form of lymphoma that may occur as an initial presentation or recurrence. It affects various peripheral nervous structures and can therefore mimic disc-related nerve root pathology or compressive mononeuropathy. NL often occurs in malignant B-cell non-Hodgkin lymphomas. Notwithstanding its aggressiveness or intractability, NL should be discriminated from other neurologic complications of lymphoma. Herein, we present a case of primary NL as the initial presentation of diffuse large B-cell lymphoma (DLBCL) of the sciatic nerve. The patient presented with weakness and pain in his left leg but had no obvious lesion explaining the neurologic deficit on initial lumbosacral and knee magnetic resonance imaging (MRI). NL of the left sciatic nerve at the greater sciatic foramen was diagnosed based on subsequent hip MRI, electrodiagnostic test, positron emission tomography/computed tomography, and nerve biopsy findings. Leg weakness slightly improved after chemotherapy and radiotherapy. We report a case wherein NL, a rare cause of leg weakness, manifested as the initial presentation of primary DLBCL involving the sciatic nerve at the greater sciatic foramen.

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JYMS : Journal of Yeungnam Medical Science