Journal of Yeungnam Medical Science

Da Jung Jung

3 Articles

Association between cadmium exposure and hearing impairment: a population-based study in Korean adults: Da Jung Jung; Yeungnam Univ J Med. 2019;36(2):141-147. Published online April 15, 2019; DOI: https://doi.org/10.12701/yujm.2019.00178

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Background
The present study aimed to evaluate the clinical association between cadmium exposure and hearing impairment among the Korean population.
Methods
This retrospective cross-sectional study used the data obtained from the Korean National Health and Nutrition Examination Survey were used for our study. Finally, 3,228 participants were included in our study, which were then divided into quartiles based on their blood cadmium levels: first quartile (1Q), second quartile (2Q), third quartile (3Q), and fourth quartile (4Q) groups. The hearing thresholds were measured using an automatic audiometer at 0.5, 1, 2, 3, 4, and 6 kHz. Hearing loss (HL) was defined as >25 dB AHT.
Results
All the groups had 807 participants each. The area under the receiver operating characteristic curves of cadmium level for HL were 0.634 (95% confidence interval [CI], 0.621–0.646). The participants in the 4Q group had higher Low/Mid-Freq, High-Freq, and AHT values than those in the other groups in the multivariate analysis after adjusting for confounding factors. The logistic regression showed that the OR for HL per 1 µg/L increase in cadmium was 1.25 (95% CI, 1.09–1.44; p=0.002) on the multivariate analysis. Moreover, the multivariate logistic regression analyses revealed that the participants in the 4Q group exhibited a 1.59-, 1.38-, and 1.41-fold higher odds for HL than those in the 1Q, 2Q, and 3Q groups, respectively.
Conclusion
High cadmium level quartile was associated with increased hearing thresholds and HL among the Korean adult population.

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The role of calcium, Akt and ERK signaling in cadmium-induced hair cell death
Jennifer Galdieri, Chloe Adams, María Padilla, Tamara M. Stawicki
Molecular and Cellular Neuroscience.2023; 124: 103815. CrossRef

Spontaneous migration of a congenital intratympanic membrane cholesteatoma: Tae Hoon Kim, Kyu-Yup Lee, Da Jung Jung; Yeungnam Univ J Med. 2018;35(2):244-247. Published online December 31, 2018; DOI: https://doi.org/10.12701/yujm.2018.35.2.244

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Abstract PDF

Congenital intratympanic membrane cholesteatoma (ITMC) is a rare type of congenital cholesteatoma located within the tympanic membrane. This lesion tends to increase in size over time. The development of ITMC can cause several complications such as hearing impairment, dizziness, facial palsy, and intracranial complications, similar to any other cholesteatoma. The treatment of congenital cholesteatoma requires the removal of the lesion through surgery, because disease progression induces bony destruction of the nearby tissue. Most patients presenting with this cholesteatoma type are also treated with primary surgical removal. However, we recently experienced a case of an ITMC that showed a natural transition to an external auditory canal cholesteatoma.

Citations

Citations to this article as recorded by

Intratympanic membrane cholesteatoma after traumatic tympanic membrane perforation: a case report
Junhui Jeong, Hyun Seung Choi
Journal of Medical Case Reports.2023;[Epub] CrossRef
A Case of Intratympanic Membrane Cholesteatoma Moving to the External Auditory Canal
Shinya Hirahara, Yutaka Hanamure, Minoru Takaki, Mizuo Umakoshi, Tamon Hayashi
Practica Oto-Rhino-Laryngologica.2021; 114(10): 759. CrossRef

Effect of prehydration solution on hearing threshold after chemotherapy in patients with head and neck cancers: a retrospective study: Dongbin Ahn, Kyu-Yup Lee, Eunjung Oh, Minji Oh, Boseung Jung, Da Jung Jung; Received April 20, 2022 Accepted July 19, 2022 Published online August 24, 2022; DOI: https://doi.org/10.12701/jyms.2022.00276 [Epub ahead of print]

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Abstract PDF: Background
The study aimed to evaluate the effect of prehydration solution on hearing thresholds after cisplatin chemotherapy.
Methods
In this retrospective cohort study, we reviewed the data of patients who underwent ≥3 courses of cisplatin-based chemotherapy for locally advanced head and neck cancers at a tertiary referral center (n=64). The dextrose solution (DW) group (n=26) received 2 L of normal saline and 1 L of 5% dextrose. The Hartmann solution (HS) group (n=38) received 2 L of normal saline and 1 L of HS. Hearing data were measured 1 day before starting the first course of chemotherapy, and again 20 days after the first, second, and third courses of chemotherapy. The severity of hearing loss was evaluated using the Common Terminology Criteria for Adverse Events (CTCAE).
Results
Thresholds at all frequencies after chemotherapy were greater in the DW group than in the HS group. The increase in thresholds in 1 to 4 kHz after the third course of chemotherapy was greater in the DW group than in the HS group. CTCAE grades after the second and third courses of chemotherapy were greater in the DW group than in the HS group. Logistic regression showed that the odds ratio for CTCAE grade 3 or 4 after the third course of chemotherapy in the DW group was 4.84 on univariate analysis.
Conclusion
Prehydration using a solution with salt was associated with a decrease in change in hearing thresholds after cisplatin chemotherapy in patients with head and neck cancers.

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