- Pulmonary and Respiratory Medicine
- Diagnosis and treatment of multidrug-resistant tuberculosis
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Jong Geol Jang
 , Jin Hong Chung
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Yeungnam Univ J Med. 2020;37(4):277-285. Published online September 4, 2020
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DOI: https://doi.org/10.12701/yujm.2020.00626
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- Tuberculosis (TB) is still a major health problem worldwide. Especially, multidrug-resistant TB (MDR-TB), which is defined as TB that shows resistance to both isoniazid and rifampicin, is a barrier in the treatment of TB. Globally, approximately 3.4% of new TB patients and 20% of the patients with a history of previous treatment for TB were diagnosed with MDR-TB. The treatment of MDR-TB requires medications for a long duration (up to 20–24 months) with less effective and toxic second-line drugs and has unfavorable outcomes. However, treatment outcomes are expected to improve due to the introduction of a new agent (bedaquiline), repurposed drugs (linezolid, clofazimine, and cycloserine), and technological advancement in rapid drug sensitivity testing. The World Health Organization (WHO) released a rapid communication in 2018, followed by consolidated guidelines for the treatment of MDR-TB in 2019 based on clinical trials and an individual patient data meta-analysis. In these guidelines, the WHO suggested reclassification of second-line anti-TB drugs and recommended oral treatment regimens that included the new and repurposed agents. The aims of this article are to review the treatment strategies of MDR-TB based on the 2019 WHO guidelines regarding the management of MDR-TB and the diagnostic techniques for detecting resistance, including phenotypic and molecular drug sensitivity tests.
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Citations
Citations to this article as recorded by  - A Case of Multidrug-Resistant Tuberculosis in an Active Duty Military Health Care Worker
Amanda E Saunders, Kevin M Shanahan, John W Downs
Military Medicine.2025; 190(1-2): e448. CrossRef - Latest Progress on Tuberculosis and HIV Co‐Infection: A Closer Look at People of Different Ages
Anna Yusuf Aliyu, Oluwatoyin A. Adeleke
Advanced Therapeutics.2025;[Epub] CrossRef - Advancing against drug-resistant tuberculosis: an extensive review, novel strategies and patent landscape
Meghana N. Patel, Archita J. Patel, Manish N. Nandpal, Manan A. Raval, Ravish J. Patel, Amit A. Patel, Keshav Raj Paudel, Philip M. Hansbro, Sachin Kumar Singh, Gaurav Gupta, Kamal Dua, Samir G. Patel
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Ivaan Pitua, Marvin Kirya, Denis Kiberu, Shivan Nabaasa, Amelia Margaret Namiiro, Michael Collins Segawa, Patrick Semakula, Sarah Maria Najjuka, Joseph Baruch Baluku, Ronald Olum
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Pharmacy & Pharmacology International Journal.2025; 13(1): 21. CrossRef - Dual Burden of MDR‐TB and COVID‐19 in a Previously Treated Tuberculosis Case: Diagnostic and Therapeutic Dilemmas
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Clinical Case Reports.2025;[Epub] CrossRef - Truenat MTB assays for pulmonary tuberculosis and rifampicin resistance in adults and adolescents
Leeberk Raja Inbaraj, Jefferson Daniel, Mukesh Kumar Sathya Narayanan, Vignes Anand Srinivasalu, Adhin Bhaskar, Katie Scandrett, Priya Rajendran, Richard Kirubakaran, Hemant D Shewade, Muniyandi Malaisamy, Chandrasekaran Padmapriyadarsini, Yemisi Takwoing
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Consilium Medicum.2024; 26(03): 199. CrossRef - Prevalence and patterns of drug-resistant Mycobacterium tuberculosis in newly diagnosed patients in China: A systematic review and meta-analysis
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Journal of Global Antimicrobial Resistance.2024; 38: 292. CrossRef - Enhanced detection of rifampicin and isoniazid resistance in mycobacterium tuberculosis using AuNP-qPCR: a rapid and accurate method
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American Journal of Translational Research.2024; 16(6): 2310. CrossRef - Identification of tuberculosis inhibitors through QSAR-based virtual screening and molecular dynamics simulation of novel pyrimidine derivatives
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Pharmacological Research - Modern Chinese Medicine.2024; 13: 100521. CrossRef - Multidrug-resistant tuberculosis treatment outcomes and associated factors at Yirgalem General Hospital, Sidama Region, South Ethiopia: a retrospective cohort study
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Kholis Amalia Nofianti, Luqmanul Hakim, Suzana, Farida Ifadotunikamah
Berkala Ilmiah Kimia Farmasi.2024; 11(1): 26. CrossRef - Comparison of Anxiety Levels in MDR-TB Patients with Individual and Short-term Regimens at Dr. Soebandi Regional General Hospital, Jember, Indonesia
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European Journal of Theoretical and Applied Sciences.2023; 1(4): 36. CrossRef - Machine Learning of the Whole Genome Sequence of Mycobacterium tuberculosis: A Scoping PRISMA-Based Review
Ricardo Perea-Jacobo, Guillermo René Paredes-Gutiérrez, Miguel Ángel Guerrero-Chevannier, Dora-Luz Flores, Raquel Muñiz-Salazar
Microorganisms.2023; 11(8): 1872. CrossRef - Cotreatment With Clofazimine and Rapamycin Eliminates Drug-Resistant Tuberculosis by Inducing Polyfunctional Central Memory T-Cell Responses
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The Journal of Infectious Diseases.2023; 228(9): 1166. CrossRef - Treatment of drug-resistant tuberculosis in children and young adolescents in Brazil
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Journal of Clinical Tuberculosis and Other Mycobacterial Diseases.2023; 33: 100388. CrossRef - Tackling Drug-Resistant Tuberculosis: New Challenges from the Old Pathogen Mycobacterium tuberculosis
Giuseppe Mancuso, Angelina Midiri, Silvia De Gaetano, Elena Ponzo, Carmelo Biondo
Microorganisms.2023; 11(9): 2277. CrossRef - Drug-resistant Monoarticular Wrist Joint Tuberculosis in Renal Transplant Recipient with Literature Review
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Gabriel Rosenfeld, Andrei Gabrielian, Darrell Hurt, Alex Rosenthal
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Mahesh Kumar, Tarun Virmani, Girish Kumar, Rohitas Deshmukh, Ashwani Sharma, Sofia Duarte, Pedro Brandão, Pedro Fonte
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Yulong Song, Qian Jin, Jihai Qiu, Dan Ye
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Sofiati Dian, Ahmad Rizal Ganiem, Lindsey HM te Brake, Arjan van Laarhoven
CNS Drugs.2023; 37(11): 957. CrossRef - Economic burden of multidrug-resistant tuberculosis on patients and households: a global systematic review and meta-analysis
Temesgen Yihunie Akalu, Archie C. A. Clements, Haileab Fekadu Wolde, Kefyalew Addis Alene
Scientific Reports.2023;[Epub] CrossRef - Nano vs Resistant Tuberculosis: Taking the Lung Route
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AAPS PharmSciTech.2023;[Epub] CrossRef - Multi-Drug Resistance Tuberculosis (MDR-TB) Challenges in India: A Review
Deepak Vishwakarma, Abhay Gaidhane, Sweta Sahu, Ashwini S Rathod
Cureus.2023;[Epub] CrossRef - Multidrug-resistant Tuberculosis and its Implication with COVID-19
Jasmine Arya, Sweety Dahiya, Anil Kumar Chhillar
Coronaviruses.2023;[Epub] CrossRef - Tuberculosis drug discovery: Progression and future interventions in the wake of emerging resistance
Summaya Perveen, Diksha Kumari, Kuljit Singh, Rashmi Sharma
European Journal of Medicinal Chemistry.2022; 229: 114066. CrossRef - Abdominal Tuberculosis Mimicking Ovarian Cancer: A Case Report and Review of the Literature
Ikhwan Rinaldi, Abdul Muthalib, Djaja Gosal, Teguh Wijayadi, Barlian Sutedja, Tjondro Setiawan, Andika Gunawan, Nelly Susanto, Lingga Magdalena, Diah Rini Handjari, Fetisari Kurniawan, Aisyah Rifani, Kevin Winston
International Medical Case Reports Journal.2022; Volume 15: 169. CrossRef - Pediatric Tuberculosis Management: A Global Challenge or Breakthrough?
Lehlogonolo N. F. Maphalle, Bozena B. Michniak-Kohn, Modupe O. Ogunrombi, Oluwatoyin A. Adeleke
Children.2022; 9(8): 1120. CrossRef - Various approaches to improving adherence of patients with tuberculosis. Prospects for the use of additive technologies in TB practice
A. G. Naumov, A. S. Shprykov
PULMONOLOGIYA.2022; 34(1): 80. CrossRef - Antimicrobial Peptides as Potential Anti-Tubercular Leads: A Concise Review
Gabriel S. Oliveira, Raquel P. Costa, Paula Gomes, Maria Salomé Gomes, Tânia Silva, Cátia Teixeira
Pharmaceuticals.2021; 14(4): 323. CrossRef - Treatment of Human Babesiosis: Then and Now
Isaline Renard, Choukri Ben Mamoun
Pathogens.2021; 10(9): 1120. CrossRef - Novel mutations detected from drug resistant Mycobacterium tuberculosis isolated from North East of Thailand
Ei Phoo Thwe, Wises Namwat, Porntip Pinlaor, Kulrattana Rueangsak, Arunnee Sangka
World Journal of Microbiology and Biotechnology.2021;[Epub] CrossRef - On the Mechanism of Development of Autoimmune Diseases Following Exposure to Inactivated Mycobacterium tuberculosis
SV Skupnevskiy, GM Trukhina, EG Pukhaeva, AK Badtiev, FK Rurua, FE Batagova, ZhG Farnieva
ЗДОРОВЬЕ НАСЕЛЕНИЯ И СРЕДА ОБИТАНИЯ - ЗНиСО / PUBLIC HEALTH AND LIFE ENVIRONMENT.2021; : 76. CrossRef - Oral regimen for multi-drug-resistant TB can promote patient-centred and community-based treatment
Suman Saurabh, Pankaj Bhardwaj
Journal of Family Medicine and Primary Care.2021; 10(12): 4607. CrossRef - Adverse effects induced by second-line antituberculosis drugs: an update based on last WHO treatment recommendations for drug-resistant tuberculosis
Ionela-Alina Grosu-Creangă, Antigona Carmen Trofor, Radu Adrian Crișan-Dabija, Daniela Robu-Popa, Cristina Mihaela Ghiciuc, Elena Cătălina Lupușoru
Pneumologia.2021; 70(3): 117. CrossRef - Advances in the science and treatment of respiratory diseases
Jin Hong Chung
Yeungnam University Journal of Medicine.2020; 37(4): 251. CrossRef
- Pulmonary and Respiratory Medicine
- Microbiologic distribution and clinical features of nontuberculous mycobacteria in the tertiary hospital in Daegu.
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Kyung Soo Hong, June Hong Ahn, Eun Young Choi, Hyun Jung Jin, Kyeong Cheol Shin, Jin Hong Chung, Kwan Ho Lee
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Yeungnam Univ J Med. 2015;32(2):71-79. Published online December 31, 2015
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DOI: https://doi.org/10.12701/yujm.2015.32.2.71
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Abstract
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- BACKGROUND
Recent studies have shown that the nontuberculosis mycobacterium (NTM) recovery rate in clinical cultures has increased within Korea. However, another study conducted by a secondary hospital within Daegu reported different results. Therefore, the purpose of this study is to understand and evaluate the microbiological distribution and clinical features of NTM in Daegu. METHODS: A retrospective study was conducted on 11,672 respiratory specimens undergoing acid fast bacilli (AFB) culture from 6,685 subjects who visited Yeungnam University Respiratory Center from January 2012 to December 2013. RESULTS: Of the 11,672 specimens undergoing AFB culture, 1,310 specimens (11.2%) showed positive results. Of these specimens, NTM was recovered from 587 specimens, showing a recovery rate of 44.8%. Identification test for NTM was performed on 191 subjects; the results were as follows: M. avium-intracellulare complex (MAC) 123 (64.4%), M. abscessus 20 (10.5%), M. kansasii 12 (6.3%), and 33 other NTM germ strains. Of the 382 subjects with NTM, 167 were diagnosed with pulmonary NTM disease (43.7%), however virulence differed depending on NTM strain. Multivariate analysis showed that nodular bronchiectasis, the nodules, and finding consistent with cavity under imaging study were statistically significant for triggering pulmonary NTM disease. AFB culture showing MAC and M. abscessus was statistically significant as well. Positive predictive value for NTM polymerase chain reaction (NTM-PCR) was 88.6%. CONCLUSION: Results for NTM recovery rate within the Daegu area were similar to those for the Seoul metropolitan area. We can assume that NTM infection is increasing in our community, therefore AFB-positive subjects (1) should undergo NTM-PCR, (2) should have their culture results checked for differentiation of mycobacterium tuberculosis complex (MTB) from NTM, and (3) undergo NTM identification test to confirm its type. Administration of treatment with the above results should be helpful in improving the patients' prognosis.
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Citations
Citations to this article as recorded by - Epidemiological Characteristics of Nontuberculous Mycobacterial Pulmonary Disease in South Korea: A Meta-analysis of Individual Participant Data
Geunin Lee, Sol Kim, Shihwan Chang, Hojoon Sohn, Young Ae Kang, Youngmok Park
Tuberculosis and Respiratory Diseases.2024; 87(3): 386. CrossRef - Distribution and Antimicrobial Resistance of Non-Tuberculous Mycobacteria during 2015∼2020: A Single-Center Study in Incheon, South Korea
Jiwoo Kim, Hyo-Jin Ju, Jehyun Koo, Hyeyoung Lee, Hyeonhwan Park, Kyungcheol Song, Jayoung Kim
The Korean Journal of Clinical Laboratory Science.2021; 53(3): 225. CrossRef - Study on the Prevalence of Lung Disease of Non-Tuberculosis Mycobacterium Isolated from Respiratory Specimens in Gwangju Second Hospital over the Last 10 Years
Hae-Gyeong Baek
The Korean Journal of Clinical Laboratory Science.2020; 52(4): 349. CrossRef - Recovery Rates of Non-Tuberculous Mycobacteria from Clinical Specimens Are Increasing in Korean Tertiary-Care Hospitals
Namhee Kim, Jongyoun Yi, Chulhun L. Chang
Journal of Korean Medical Science.2017; 32(8): 1263. CrossRef
- Oncology and Cancer Research
- Early or Late Gefitinib, Which is Better for Survival?: Retrospective Analysis of 228 Korean Patients with Advanced or Metastatic NSCLC.
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Dong Gun Kim, Min Kyoung Kim, Sung Hwa Bae, Sung Ae Koh, Sung Woo Park, Hyun Je Kim, Myung Jin Kim, Hyo Jin Jang, Kyung Hee Lee, Kwan Ho Lee, Jin Hong Chung, Kyung Chul Shin, Hun Mo Ryoo, Myung Soo Hyun
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Yeungnam Univ J Med. 2011;28(1):31-44. Published online June 30, 2011
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DOI: https://doi.org/10.12701/yujm.2011.28.1.31
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Abstract
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- BACKGROUND
The optimal timing of treatment with EGFR-tyrosine kinase inhibitors (EGFR-TKI) in NSCLC patients has not yet been determined. METHODS: We separated 228 patients with advanced/metastatic NSCLC treated with gefitinib into an early gefitinib group (patients who received gefitinib as first- or second-line treatment) and a delayed gefitinib group (patients who received gefitinib as third or fourth-line treatment) and attempted to determine whether the timing of gefitinib treatment affected clinical outcomes. RESULTS: Median overall survival (OS), progression free survival (PFS), and median OS from first-line treatment of advanced/metastatic disease (OSt) for 111 patients in the early gefitinib group were 6.2 months, 3.3 months, and 11.6 months. However, median OS, PFS, and OSt for 84 patients in the delayed gefitinib group were 7.8 months, 2.3 months, and 22.7 months. No differences in OS and PFS were observed between the 2 groups. However, OSt was significantly longer in the delayed gefitnib group. Timing of gefitinib therapy was one of the independent predictors of OSt. Hb > or = 10 g/dl, and having never smoked, and ECOG performance status < or =1 were independent predictors of better PFS. CONCLUSION: Deferral of gefitinib therapy in patients with advanced or metastatic NSCLC may be preferable if they are able to tolerate chemotherapy.
- Pulmonary and Respiratory Medicine
- A Case of Paragonimiasis Suspected Lung Cancer.
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Yeong Ha Ryu, Dae Hyung Woo, Jung Eun Park, Hyun Jung Kim, Kyeong Cheol Shin, Jin Hong Chung, Kwan Ho Lee
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Yeungnam Univ J Med. 2010;27(1):69-73. Published online June 30, 2010
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DOI: https://doi.org/10.12701/yujm.2010.27.1.69
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Abstract
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- A paragonimiasis infestation is caused by the paragonimus species. Paragonimiasis mainly occurs by ingestion of raw or undercooked freshwater crabs or crayfish. In our country, the prevalence of paragonimiasis was high until late 1960s due to eating habits, but after the 1970s the prevalence of the disease has markedly decreased and now the disease is rarely seen. The diagnosis of tuberculosis by Chest X-ray is often confused with pulmonary carcinoma, bacillary and parasitic infections, and chronic mycosis. Pulmonary paragonimiasis must be considered in the differential diagnosis of lung cancer especially in the appropriate clinical setting because effective treatment with praziquantel can be rewarding. We report a case of a 58-year-old woman with pulmonary paragonimiasis that was suspicious for lung cancer, as detected by biopsy.
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Citations
Citations to this article as recorded by - A Case of Delayed Diagnosis of Pulmonary Paragonimiasis due to Improvement after Anti-tuberculosis Therapy
Suhyeon Lee, Yeonsil Yu, Jinyoung An, Jeongmin Lee, Jin-Sung Son, Young Kyung Lee, Sookhee Song, Hyeok Kim, Suhyun Kim
Tuberculosis and Respiratory Diseases.2014; 77(4): 178. CrossRef
- Pulmonary and Respiratory Medicine
- A Case of Lymphangioleiomyomatosis in Lung.
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Jung Eun Park, Hyun Jung Kim, Dae Hyung Woo, Yung Ha Ryu, Kwan Ho Lee, Jin Hong Chung, Kyeong Cheol Shin
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Yeungnam Univ J Med. 2010;27(1):63-68. Published online June 30, 2010
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DOI: https://doi.org/10.12701/yujm.2010.27.1.63
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- Lymphangioleiomyomatosis (LAM) is a rare, cystic lung disease that is associated with mutation in the tuberous sclerosis genes, renal angiomyolipomas, lymphatic spread and a remarkable female gender predilection. The pathology of LAM is represented by the proliferation of immature smooth muscle cells in the walls of airways, and venules and lymphatic vessels in the lung. The clinical course of LAM is characterized by progressive dyspnea on exertion, recurrent pneumothorax and collections of chylous fluid. The diagnosis of pulmonary LAM can be made on chest X-ray, a high-resolution CT scan and lung biopsy. We experienced a case of pulmonary lymphangioleiomyomatosis in a 28-years-old female patient who had suffered from progressive dyspnea on exertion, so we report on it along with a brief review of the relevant literature.
- Pulmonary and Respiratory Medicine
- A Case of Pulmonary Alveolar Proteinosis.
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Dae Hyung Woo, Jung Eun Park, Yung Ha Ryu, Hyun Jung Kim, Kyeong Cheol Shin, Jin Hong Chung, Kwan Ho Lee
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Yeungnam Univ J Med. 2010;27(1):57-62. Published online June 30, 2010
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DOI: https://doi.org/10.12701/yujm.2010.27.1.57
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2,416
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- Pulmonary alveolar proteinosis (PAP) is a rare disorder that's characterized by accumulation of surfactant components in the alveolar space. Idiopathic PAP is recognized as an autoimmune disease that's due to impaired alveolar macrophage function and this caused by autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF). We report here a case of pulmonary alveolar proteinosis that was deemed interstitial lung disease at the initial diagnosis. A 61-year-old man presented with intermittent blood tinged sputum and dyspnea on exertion. The man was a painter for 30 years and he had a 10 pack-years smoking history. Chest computerized tomography (CT) revealed multifocal ground-glass opacity with interstitial thickening at both lungs. His pulmonary function tests and methacholine test revealed non specific results. He was diagnosed with interstitial lung disease on the basis of the chest CT finding and occupational history. However, seven months later, his symptoms progressed. Follow-up chest CT was performed. Wedge resection via video-assisted thoracoscopic surgery (the anterior basal segment of the left lower lobe) was done. Microscopic examination showed large groups of alveoli with excessive amounts of surfactant and a complex mixture of protein and lipid (fat) molecules. Finally, he was diagnosed as having pulmonary alveolar proteinosis.
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Citations
Citations to this article as recorded by - Pulmonary alveolar proteinosis in a 15-year-old girl
Yechan Kyung, Jihyun Kim, Hong Kwan Kim, Joungho Han, Kangmo Ahn
Allergy, Asthma & Respiratory Disease.2015; 3(1): 86. CrossRef
- Pulmonary and Respiratory Medicine
- Eosinophilic Myositis Induced by Anti-tuberculosis Medication.
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Hyun Jung Kim, Jung Eun Park, Yeong Ha Ryu, Dae Hyung Woo, Kyeong Cheol Shin, Jin Hong Chung, Kwan Ho Lee
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Yeungnam Univ J Med. 2010;27(1):42-46. Published online June 30, 2010
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DOI: https://doi.org/10.12701/yujm.2010.27.1.42
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- Eosinophilic myositis is a rare idiopathic inflammatory muscle disease, and the patients with this malady present with diverse signs and symptoms such as muscle swelling, tenderness, pain, weakness, cutaneous lesions and eosinophilia. The etiology and pathogenesis of eosinophilic myositis remain elusive. Several drugs may occasionally initiate an immune mediated inflammatory myopathy, including eosinophilic myositis. We report here on a case a 17-year-old female patient who had taken anti-tuberculosis medicine for tuberculosis pleurisy. She presented with many clinical manifestations, including fever, skin rash, proximal muscle weakness, dyspnea, dysphagia and hypereosinophilia. She was diagnosed with eosinophilic myositis by the pathologic study. The muscle weakness progressed despite of stopping the anti-tuberculosis medicine, but the myositis promptly improved following the administration of glucocorticoid. Although drug induced myopathies may be uncommon, if a patient presents with muscular symptoms, then physicians have to consider the possibility of drug induced myopathies.
- Pulmonary and Respiratory Medicine
- A Case of Polyarteritis Nodosa Associated with Pulmonary Tuberculosis.
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Chang Woo Son, Jeong Hwan Cho, In Wook Song, Jung Eun Park, Kyeong Cheol Shin, Jin Hong Chung, Kwan Ho Lee
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Yeungnam Univ J Med. 2009;26(2):130-136. Published online December 31, 2009
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DOI: https://doi.org/10.12701/yujm.2009.26.2.130
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- Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis that typically affects the medium-sized muscular arteries, with occasional involvement of the small muscular arteries. As with other vasculitides, PAN can affect any organ system, including the cardiovascular, gastrointestinal and central nervous systems. The prognosis for patients with untreated PAN is relatively poor, with five-year survival rates of approximately 13 percent. The outcome has improved with proper therapy to approximately 80 percent survival at five years. We report here on a case of a 46 year old man with polyarteritis nodosa and who suffered from pulmonary tuberculosis.
- Pulmonary and Respiratory Medicine
- The Role of Dynamic CT for the Differential Diagnosis of Solitary Pulmonary Nodule.
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Jin Hong Chung, Won Jong Park, Ihn Ho Cho
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Yeungnam Univ J Med. 2008;25(2):102-107. Published online December 31, 2008
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DOI: https://doi.org/10.12701/yujm.2008.25.2.102
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Abstract
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- BACKGROUND
Malignant pulmonary nodules account for 30 to 40 percent of all solitary pulmonary nodules (SPNs). Therefore, characterization of SPNs is very important for treatment. Recently, dynamic CT has been widely used for tissue characterization and formation of differential diagnoses. The purpose of this study was to evaluate the ability of dynamic CT to formulate the differential diagnosis of SPNs. MATERIALS AND METHODS: Nineteen patients with SPNs underwent dynamic CT (unenhanced scans, followed by a series of images at 20, 40, 60, 80, 100, 120, 140, 160, and 180 sec after intravenous injection of contrast medium). Diagnosis of SPN was performed based on pathologic findings in needle biopsy samples. Peak enhancement, net enhancement, slope of enhancement, and maximum relative enhancement ratio of the SPN were measured on dynamic CT, and Levene's test was performed to assess benignancy and malignancy. RESULTS: Twelve SPNs were confirmed to have malignant pathology. There were no significant differences between benign and malignant nodules with respect to peak enhancement (p=0.787), net enhancement (p=0.135), or slope of enhancement (p=0.698). The maximal enhancement ratio was increased in malignancy compared to benignancy, but the difference was not statistically significant (p=0.094). CONCLUSION: In our study, the hemodynamic characteristics of dynamic CT were not significantly different between benign and malignant nodules. Therefore, long-term studies of larger patient samples are required to confirm our findings.
- Pulmonary and Respiratory Medicine
- Chronic Obstructive Pulmonary Disease with Severe Pulmonary Hypertension: A Case Report.
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Chan Soh Park, Hyun Jung Chin, Seok Min Kim, Chang Woo Son, Sung Ken Yu, Jin Hong Chung, Kwan Ho Lee
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Yeungnam Univ J Med. 2008;25(1):50-57. Published online June 30, 2008
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DOI: https://doi.org/10.12701/yujm.2008.25.1.50
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Abstract
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- Pulmonary hypertension is an increase in blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries. Depending on the cause, pulmonary hypertension can be a severe disease with markedly decreased exercise tolerance and right-sided heart failure. Pulmonary hypertension can present as one of five different types: arterial, venous, hypoxic, thromboembolic, or miscellaneous. Chronic obstructive pulmonary disease with severe pulmonary hypertension is a rare disease. A 52-year-old man presented with a complaint of aggravating dyspnea. The mean pulmonary arterial pressure was 61.5 mmHg by Doppler echocardiogram. The patient was prescribed diuretics, digoxin, bronchodilator, sildenafil, bosentan and an oxygen supply. However, he ultimately died of cor pulmonale. Thus, diagnosis and early combination therapy are important.
- Pulmonary and Respiratory Medicine
- Effect of on Aerosolized Vitamin E Pretreatment on Interleukin-1 Induced Acute Lung Injury in Rats
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Jin Hong Chung, Kyeong-Cheol Shin
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Yeungnam Univ J Med. 2007;24(2 Suppl):S365-372. Published online December 31, 2007
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DOI: https://doi.org/10.12701/yujm.2007.24.2S.S365
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Abstract
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- Background
：Interleukin-1 (IL-1) and neutrophil appear to contribute to the pathogenesis of acute respiratory distress syndrome (ARDS). Reactive oxygen species, as well as elastase released from activated neutrophil, are thought to play pivotal roles in the experimental models of acute lung leak. This study investigated whether aerosolized vitamin E can attenuate acute lung injury induced by IL-1 in rats.
Materials and Methods：We intratracheally instilled either saline or IL-1 with and without pretreatment with aerosolized vitamin E in rats. After 5 hours of intratracheal instillation, lung lavage neutrophils, lung lavage protein concentration, lung myeloperoxidase(MPO) activity and lung wet weight to dry weight ratio(WW/DW) were measured in rat.
Results
：In rats given IL-1 intratracheally, lung lavage neutrophils, lung lavage protein concentration, lung MPO activity and WW/DW were higher. Pretreatment with aerosolized vitamin E decreased lung lavage neutrophils, lung MPO activity and WW/DW in rats given IL-1 intratracheally.
Conclusion
：These results suggest that direct pulmonary supplement of vitamin E decreases lung inflammation and leak in rats given IL-1 intratracheally.
- Pulmonary and Respiratory Medicine
- A Case of Varicella Pneumonia Associated with Chickenpox in Immunocompetent Patient.
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Won Jong Park, Sung Ken Yu, Kyeong Cheol Shin, Jin Hong Chung, Kwan Ho Lee
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Yeungnam Univ J Med. 2007;24(2):339-343. Published online December 31, 2007
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DOI: https://doi.org/10.12701/yujm.2007.24.2.339
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- Varicella is a contagious infection in childhood disease typically affecting children aged 2-8 years and usually follows benign outcome. In the adult, clinical presentation is more severe and more commonly associated with complications. Varicella pneumonia, although rare, is a potentially life-threatening complication that should be suspected in any adult with varicella and respiratory symptoms. We report a case of varicella pneumonia in immunocompetent patient. The characteristic radiographic findings consisted of diffuse scattered coarse nodular infiltrations, less than 1cm sized, with ground glass opacity and consolidation in both lung fields. The patients was started on intravenous acyclovir. The chest radiograph performed 2 weeks later showed complete resolution of the pulmonary lesions.
- Pulmonary and Respiratory Medicine
- A Case of Gefitinib (Iressa(R))-associated Tumor Lysis Syndrome in Adenocarcinoma of the Lung.
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Kyu Jin Kim, Won Jong Park, Sung Ken Yu, Kyeong Cheol Shin, Jin Hong Chung, Myung Soo Hyun, Kwan Ho Lee
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Yeungnam Univ J Med. 2006;23(2):221-226. Published online December 31, 2006
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DOI: https://doi.org/10.12701/yujm.2006.23.2.221
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- The tumor lysis syndrome has been described as biochemical disturbances associated with rapid destruction of tumor cells and subsequent synchronized massive release of cellular breakdown products sufficient to overwhelm excretory mechanisms and the body's normal reutilization capacity. The cardinal signs of the tumor lysis syndrome are hyperkalemia, hyperphosphatemia, hypocalcemia and hyperuricemia. Gefitinib (Iressa) is an oral, selective epidermal growth factor receptor (EGFR) inhibitor that has activity in female, non-smoker and non-small cell lung cancer with an EGFR mutation. Gefitinib is a well tolerated drug with few side effects. It has been associated with skin rash, diarrhea, nausea, a decrease in liver function and interstitial lung disease. However, there is no prior report of the tumor lysis syndrome associated with gefitinib. We report a case of a 54 year-old woman who developed tumor lysis syndrome that might have been induced by gefitinib after the treatment of adenocarcinoma of lung with an EGFR mutation.
- Pulmonary and Respiratory Medicine
- The Usefulness of Integrated PET/CT to Distinguish between Benignancy and Malignancy in Solitary Pulmonary Nodule.
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Won Jong Park, Dong Hee Kim, Sung Ken Yu, Kyeong Cheol Shin, Jin Hong Chung, Kwan Ho Lee, Kyung Ah Chun, Ihn Ho Cho
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Yeungnam Univ J Med. 2006;23(2):205-212. Published online December 31, 2006
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DOI: https://doi.org/10.12701/yujm.2006.23.2.205
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Abstract
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- BACKGROUND
Malignant pulmonary nodules account for about 30 to 40 percent of solitary pulmonary nodules (SPN). Therefore, tissue characterization of SPNs is very important. Recently, PET/CT has been widely used for tissue characterization, and has become of importance. The purpose of this study was to compare and to assess multiple factors in PET/CT comparing benign and malignant nodules. MATERIALS AND METHOD: Nineteen patients with SPN underwent PET/CT and biopsy. The difference of standardized uptake value 1 (SUV1), standardized uptake value 2 (SUV2) and retention index in PET/CT between malignancy and benignancy were compared by Levene's test. RESULT: There were twelve malignant and seven benign nodules. SUV1 and SUV2 were significantly different between malignant nodule and benign nodule (p=0.006 and 0.022), but retention index was not significantly different between malignant nodule and benign nodule (p=0.526). By receiver-operating-characteristic (ROC) analysis, the sensitivity was 66.7% and the specificity was 71.4% at a cut off value of 5.40 in SUV1. The sensitivity was 75% and the specificity was 71.4% at cut off value of 7.45 in SUV2. CONCLUSION: There was a statistically significant difference in SUV1 and SUV2 between benign and malignant nodules. However, the cut off value of SUV1 and SUV2 by receiver-operating-characteristic (ROC) analysis was 5.40 and 7.45 which is different from previous studies. Therefore, studies on a larger sample of patients are required for confirmation.
- Pulmonary and Respiratory Medicine
- A Case of Microscopic Polyangiitis with Diffuse Alveolar Hemorrhage.
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Sang Jin Lee, Jae Woung Lee, Hye Jin Kim, Kyeong Cheol Shin, Jin Hong Chung, Kwan Ho Lee, Hye Jung Park
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Yeungnam Univ J Med. 2004;21(1):101-107. Published online June 30, 2004
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DOI: https://doi.org/10.12701/yujm.2004.21.1.101
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- Diffuse alveolar hemorrhage is a rare but serious and frequently life-threatening complication of a variety of conditions. The first goal in the management of patients with diffuse alveolar hemorrhage is to achieve or preserve stability of the respiratory status. Subsequently, the differential diagnosis is aimed at the identification of a remediable cause of the alveolar hemorrhage. The most common causes of diffuse alveolar hemorrhage with glomerulonephritis are microscopic polyangiitis and Wegener's granulomatosis, followed by Goodpasture syndrome and systemic lupus erythematosus. Microscopic polyangiitis (MPA) is a distinct systemic small vessle vasculitis affecting small sized vessels with few or no immune deposits and with no granulomatosus inflammation. The disease may involve multiple organs such as kidney, lung, skin, joint, muscle, gastrointestinal tract, eye, and nervous system. MPA is strongly associated with antineutrophil cytoplasmic autoantibody (ANCA) that is a useful serological diagnostic marker for the most common form of necrotizing vasculitis. Our report concerns a case of microscopic polyangiitis with diffuse alveolar hemorrhage in a 54-year-old man. He was admitted to our hospital due to dyspnea upon exertion and recurrent hemoptysis. Laboratory findings showed hematuria, proteinuria and deterioration of renal function. In the chest CT scan, diffuse ground glass appearance was seen in both lower lungs. A lung biopsy revealed small vessel vasculitis with intraalveolar hemorrhage and showed a positive reaction to against perinuclear ANCA. The patient was treated with prednisolone and cyclophosphamide. Chest infiltration decreased and hemoptysis and hypoxia improved. He is still being followed up in our hospital with a low dose of prednisolone.
- Pulmonary and Respiratory Medicine
- A Case of Unilateral Absence of Left Pulmonary Artery Presenting Hemoptysis.
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Hye Jin Yoon, Tae Mook No, Seon Woong Kim, Dong Hi Park, In Seek Kim, Yeon Jae Kim, Byung Ki Lee, Ji Young Park, Jin Hong Chung
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Yeungnam Univ J Med. 2003;20(1):71-78. Published online June 30, 2003
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DOI: https://doi.org/10.12701/yujm.2003.20.1.71
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- Unilateral absence of a pulmonary artery (UAPA) is a rare congenital anomaly that is frequently associated with other cardiovascular anomalies first reported by Fraentzel in 1968. Most patients who have no associated cardiac anomalies have only minor or absent symptoms. We experienced a case of isolated UAPA in a young female presenting hemoptysis. The chest radiograph showed a small left lung volume and high resolutional CT of chest showed multiple subpleural nodules and centrilobular nodules in parenchyma. The video-assisted thoracoscopic biopsy revealed diffuse dilated vessels in visceral pleura. The pulmonary angiogram confirmed the absence of the left main pulmonary artery.
- Pulmonary and Respiratory Medicine
- Effect of Neutrophil Elastase inhibitor, ICI 200,355, on Interleukin-1 Induced acute lung injury in rats.
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Jin Hong Chung, Yeung Chul Mun, Hye Jung Park, Kyeong Cheol Shin, Kwan Ho Lee
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Yeungnam Univ J Med. 2002;19(1):55-62. Published online June 30, 2002
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DOI: https://doi.org/10.12701/yujm.2002.19.1.55
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Abstract
PDF
- BACKGROUND
Interleukin-1 (IL-1) and neutrophil appear to contribute to the pathogenesis of acute respiratory distress syndrome (ARDS). Elastase, as well as reactive oxygen species released from activated neutrophil, are thought to play pivotal roles in the experimental models of acute lung leak. This study investigated whether ICI 200,355, a synthetic elastase inhibitor, can attenuate acute lung injury induced by IL-1 in rats. MATERIALS AND METHODS: We intratracheally instilled either saline or IL-1 with and without treatment of ICI 200,355 in rats. Lung lavage neutrophils, lung lavage cytokine-induced neutrophil chemoattractant(CINC) concentration, lung lavage protein concentration, lung myeloperoxidase(MPO) activity and lung leak index were measured at 5 hours of intratracheal treatment. RESULTS: In rats given IL-1 intratracheally, lung lavage neutrophils, lung lavage CINC concentration, lung lavage protein concentration, lung MPO activity and lung leak index were higher. Intratracheal ICI 200,355 administration decreased lung lavage neutrophils, lung MPO activity and lung leak index, respectively, but did not decreased lung lavage CINC concentration. CONCLUSION: These results suggest that ICI 200,355 decreases lung inflammation and leak without decreasing lung lavage CINC concentration in rats given IL-1 intratracheally.
- Pulmonary and Respiratory Medicine
- A Case of Nonfunctioning Paraganglioma of the Posterior Mediastinum.
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Young Chul Mun, Sung Keun Yu, Hye Jung Park, Kyeong Cheol Shin, Choong Ki Lee, Jin Hong Chung, Kwan Ho Lee, Mee Jin Kim, Jung Cheul Lee
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Yeungnam Univ J Med. 2000;17(2):155-160. Published online December 31, 2000
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DOI: https://doi.org/10.12701/yujm.2000.17.2.155
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- Paraganglioma is a tumor from the extra adrenal paraganglion system and is rarely observed in the mediastinum. The authors experienced a case of nonfunctioning paraganglioma of the posterior mediastinum. The patient was 34-years-old male in whom abnormal mass lesion was nites in chest radiograph with hemoptysis. His blood pressure and serologic examination were within normal range upon admission to our hospital. Chest CT revealed a tumor in the left lower lobe. Diagnostic thoracoscopy was performed and diagnosed a posterior mediastinal mass. Surgical resection was them performed. Posterior mediastinal mass was removed successfully and histological examination of the surgical specimen diagnosed paraganglioma. He received radiotherapy after surgery and was followed up. Related literature are reviewed.
- Infectious Disease
- The Clinical Effects of Cefpirome for the Treatment of Acute Lower Respiratory Infection.
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Kyeong Cheol Shin, Young Hoon Hong, Eun Young Lee, Ki Do Park, Sung Dong Kim, Jin Hong Chung, Choong Ki Lee, Kwan Ho Lee, Cha Kyung Sung, Hyun Woo Lee
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Yeungnam Univ J Med. 1999;16(2):219-227. Published online December 31, 1999
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DOI: https://doi.org/10.12701/yujm.1999.16.2.219
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Abstract
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- BACKGROUND
In contrast to a healthy person, patients who have acute lower pespiratory tract infection with underlying pulmonary diseases have various pathogens, a rapidly progressie downhill course, and a poor response to prior antimicrobial therapy. Broad spectrum antivacterial therapy is needed for full evaluation. MATERIALS AND METHODS: To evaluate the efficacy and safety of cefpirome, we administered 1gm cefpirome, twice a day to 30 patients who had signs and symptoms of acute lower repiratory infection regardless of their underlying disease, except to those who had an allergic history to antibiotics or severe systemic diseases. RESULTS: The results were as follows : 1) Among 30 cases, 21 cases(70.0%) showed excellent improvement, and 7 cases(23.3%) showed good improvement in their symptoms and signs of acute lower respiratory infection. 2) In 14 cases with isolated pathogens, we observed bacteriologic eradication in 11 cases(78.6%). 3) Significant side effects were not found CONCLUSION: Above results suggest that cefpirome was effective as a monotherapy in patients with acute lower respriatory infection, especially on those with as underlying chronic obstructive pulmonary disease(COPD).
- Oncology and Cancer Research
- A Clinical study on the Hypercalcemia in Primary Bronchogenic Carcinoma.
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Hye Jung Park, Kyeong Cheol Shin, Young Chul Moon, Jin Hong Chung, Kwan Ho Lee, Cha Kyung Sung, Hyun Woo Lee
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Yeungnam Univ J Med. 1999;16(2):208-218. Published online December 31, 1999
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DOI: https://doi.org/10.12701/yujm.1999.16.2.208
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Abstract
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- BACKGROUND
Lung cancer-associated hypercalcemia is one of the most disabling and life-threatening paraneoplastic desorders. Humoral hypercalcemia is responsible for most lung cancer-associated hypercalcemia. Patients with hypercalcemia are usually in the advenced atage with obvious bulky tumor and carry a poor prognosis. MATERIALS AND METHODS: Total 29 patients satisfied the following criteria: histologically proven primary lung cancer, corrected calcium level> or =10.5 mg/dL, and symptons which could possibly be attributed to hypercalcemia. In this retrospective study, we evalluated the various clinical aspects of hypercalcemia, in relation to cancer stage, histologic cell type, mass size, bone metastasis, performance status, and other possible characteristics RESULTS: Total 29 lung cancer patients with hypercalcemia were studied, and most of them had squamous cell carcinoma in their histologic finding. The incidence of hypercalcemia was significantly higher between 50 and 69 years of age, and in the advancement of cancer stage. Although serum calcium level showed positive correlation with mass size, performance statusm and bone ore frequent in the patients with higher serum calcium level. There were no differences in effectiveness among therapeutic regimens. Hypercalcemia was more frequently in the later stage of disease than during the initial diagnosis of lung cancer. Most of the patients died within 1 month after development of hypercalcemia. CONCLUSION: We concluded that hypercalcemia in lung cancer is related to extremely poor prognosis, and may be one of the causes of drath and should be treated aggressively to prevent sudden deterioration or death.
- Pulmonary and Respiratory Medicine
- The Role of the Epithelial Cell in Bronchial Asthma.
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Jin Hong Chung
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Yeungnam Univ J Med. 1999;16(1):15-24. Published online June 30, 1999
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DOI: https://doi.org/10.12701/yujm.1999.16.1.15
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Abstract
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- Although traditionally viewed as a physical barrier between the host and a variety of inhaled irritants and pathogens, it has become clear that the epithelium has a much broader functional scope. Epithelial cells are metabolically active and can play an important role in the regulation of the allergic inflammatory response. This review preview provides a consideration of the role of the epithelial cell as both a "target" for exogenous and endogenous stimuli and as an "effector" cell that is capable of producing a variety of products that can influence the inflammatory response in the airways.
- Pulmonary and Respiratory Medicine
- The Clinical Effect of Sparfloxacin for the Treatment of Acute Respiratory Infection.
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Hak Jun Lee, Hye Jung Park, Chang Jin Shin, Kyeong Cheol Shin, Jin Hong Chung, Kwan Ho Lee, Hyun Woo Lee
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