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JYMS : Journal of Yeungnam Medical Science

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Jin Won Huh 1 Article
Ceftizoxime-induced immune hemolytic anemia associated with multi-organ failure
Jin Young Huh, Ari Ahn, Hyungsuk Kim, Seog Woon Kwon, Sujong An, Jae Yong Lee, Byoung Soo Kwon, Eun Hye Oh, Do Hyun Park, Jin Won Huh
Yeungnam Univ J Med. 2017;34(1):123-127.   Published online June 30, 2017
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AbstractAbstract PDF
Drug-induced immune hemolytic anemia (DIIHA) is a rare side effect of drugs. DIIHA may cause a systemic inflammatory response that results in acute multi-organ failure and death. Ceftizoxime belongs to the class of third generation cephalosporins, which are the most common drugs associated with DIIHA. Herein, we present a case of a 66-year-old man who developed fatal DIIHA after receiving a second dose of ceftizoxime. He was admitted to receive photodynamic therapy. He had a history of a single parenteral dose of ceftizoxime 3 months prior to admission. On the day of the procedure — shortly after the infusion of ceftizoxime — the patient's mental status was altered. The blood test results revealed hemolysis. Oliguric acute kidney injury developed, and continuous renal replacement therapy had to be applied. On the suspicion of DIIHA, the patient underwent plasmapheresis. Diagnosis was confirmed by a detection of drug-dependent antibody with immune complex formation. Although his hemolysis improved, his liver failure did not improve. He was eventually discharged to palliative care, and subsequently died.


Citations to this article as recorded by  
  • Case report: Decreased hemoglobin and multiple organ failure caused by ceftizoxime-induced immune hemolytic anemia in a Chinese patient with malignant rectal cancer
    Can Lou, Meng Liu, Ting Ma, Liu Yang, Dan Long, Jiaming Li, Hang Lei, Dong Xiang, Xuefeng Wang, Lei Li, Xiaohong Cai
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Laboratory Workup of Drug-Induced Immune Hemolytic Anemia
    Hyunjin Nah, Hyun Ok Kim
    The Korean Journal of Blood Transfusion.2018; 29(1): 18.     CrossRef

JYMS : Journal of Yeungnam Medical Science