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JYMS : Journal of Yeungnam Medical Science

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Wajd Alhadi 1 Article
Cerebral fat embolism syndrome: diagnostic challenges and catastrophic outcomes: a case series
Hussein A. Algahtani, Bader H. Shirah, Nawal Abdelghaffar, Fawziah Alahmari, Wajd Alhadi, Saeed A. Alqahtani
J Yeungnam Med Sci. 2023;40(2):207-211.   Published online September 7, 2022
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AbstractAbstract PDF
Fat embolism syndrome is a rare but alarming, life-threatening clinical condition attributed to fat emboli entering the circulation. It usually occurs as a complication of long-bone fractures and joint reconstruction surgery. Neurological manifestations usually occur 12 to 72 hours after the initial insult. These neurological complications include cerebral infarction, spinal cord ischemia, hemorrhagic stroke, seizures, and coma. Other features include an acute confusional state, autonomic dysfunction, and retinal ischemia. In this case series, we describe three patients with fat embolism syndrome who presented with atypical symptoms and signs and with unusual neuroimaging findings. Cerebral fat embolism may occur without any respiratory or dermatological signs. In these cases, diagnosis is established after excluding other differential diagnoses. Neuroimaging using brain magnetic resonance imaging is of paramount importance in establishing a diagnosis. Aggressive hemodynamic and respiratory support from the beginning and consideration of orthopedic surgical intervention within the first 24 hours after trauma are critical to decreased morbidity and mortality.


Citations to this article as recorded by  
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    Neurología Argentina.2024; 16(2): 87.     CrossRef
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    Xiaowen Qiu, Baohui Zhou, Xiaoyu Qiu
    Brain Injury.2024; : 1.     CrossRef
  • Occurrence of Numerous Cerebral White Matter Hyperintensities in Trauma Patients With Cerebral Fat Embolism: A Systematic Review and Report of Two Cases
    Gregory S Huang, C. Michael Dunham, Elisha A Chance
    Cureus.2023;[Epub]     CrossRef

JYMS : Journal of Yeungnam Medical Science