Journal of Yeungnam Medical Science

Volume 14(2); December 1997

Reviews

Diabetew and Exercise.: S K Lee; Yeungnam Univ J Med. 1997;14(2):269-273. Published online December 31, 1997; DOI: https://doi.org/10.12701/yujm.1997.14.2.269

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Radiation Therapy for Patiens with Early-Stage Breast Carcinoma Treated with Breast-Conserving Surgery.: S O Shin; Yeungnam Univ J Med. 1997;14(2):274-284. Published online December 31, 1997; DOI: https://doi.org/10.12701/yujm.1997.14.2.274

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The Effect of Tai-Chi Exercise on the Function of Shoulder Joint, Heart Rate in Breast Cancer Patients
Cheol-Woo Kim, Yi-Sub Kwak, Yi-Soon Kim, Kyung-Chul Kim, Hee-Eun Kim
Journal of Life Science.2010; 20(3): 345. CrossRef

Chemical Pleurodesis of Malignant Pleural Effusion.: K H Lee, H W Lee; Yeungnam Univ J Med. 1997;14(2):285-292. Published online December 31, 1997; DOI: https://doi.org/10.12701/yujm.1997.14.2.285

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Screening Tests for Epithelial Cancer of the Ovary.: D J Lee; Yeungnam Univ J Med. 1997;14(2):293-313. Published online December 31, 1997; DOI: https://doi.org/10.12701/yujm.1997.14.2.293

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Original Articles

Neurobehavioral Performance Test of Workers Exposed to Mixed Organic Solvents.: Chang Yoon Kim, Joon Sakong, Jong Hak Chung, Ree Joo, Man Joong Jeon, Nag Jung Sung, Sang Kyu Kim; Yeungnam Univ J Med. 1997;14(2):314-328. Published online December 31, 1997; DOI: https://doi.org/10.12701/yujm.1997.14.2.314

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Abstract PDF

A cross-sectional study was performed to evaluate the effects of chronic exposure to low-dose solvent on neurobehavioral performance of 48 male workers exposed to organic solvents. A control group of 50 workers was selected from same factories. Each worker completed a medical and occupational questionnaire and four tests of Neurobehavioral Core Test Battery. These included Benton visual retention test, digit symbol, digit span, and pursuit aiming. Comparison of mean performance showed a significantly poorer performance on digit symbol, digit span, and pursuit aiming. In univariate analysis, age contributed to poor performance on Benton visual retention test and educational level was found to reduce the performance on symbol digit in both groups. Amount of alcohol intake was found to reduce the performance on digit symbol and smoking appeared to slow pursuit aiming in the exposure group. In multiple regression analysis, controlling for age, educational level, alcohol, and smoking, solvent exposure was found to be associated with performance of digit span, and number of correct dot of pursuit aiming. Age on Benton visual retention, educational level on digit symbol, and smoking on pursuit aiming were found to be a significant factors on each test items. This study suggest that short-term memory, and perception can be affected easily by chronic exposure of organic solvents which air concentration level were under the Threshold Limit Value.

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An aggravated return-to-work case of organic solvent induced chronic toxic encephalopathy
Sangyun Seo, Jungwon Kim
Annals of Occupational and Environmental Medicine.2018;[Epub] CrossRef
Occupational Psychiatric Disorders in Korea
Kyeong-Sook Choi, Seong-Kyu Kang
Journal of Korean Medical Science.2010; 25(Suppl): S87. CrossRef

Acute Exacerbation with Severe Jaundice in Chronic Hepatitis B Patients.: Heon Ju Lee; Yeungnam Univ J Med. 1997;14(2):329-336. Published online December 31, 1997; DOI: https://doi.org/10.12701/yujm.1997.14.2.329

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Abstract PDF: No abstract available.

Effect of NG-nitro-L-arginine methyl ester and Methylene Blue on the Endotoxin-induced Vascular Hyporesponsiveness.: Hyoung Chul Choi, Jeoung Hee Ha, Kwang Youn Lee, Won Joon Kim, Uy Dong Sohn; Yeungnam Univ J Med. 1997;14(2):337-349. Published online December 31, 1997; DOI: https://doi.org/10.12701/yujm.1997.14.2.337

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Abstract PDF: The study was undertaken to examine the intensity of involvement of inducible nitric oxide synthase(iNOS) and cyclic GMP signal transduction pathway as one of the mechanisms of vaso-relaxative action of bacterial lipopolysaccharide (LPS) on the canine femoral artery strips. Canine femoral arteries were isolated and spiral strips of 10 mm long and 2 mm wide were made in the Tyroad solution of 0-4degrees C. The strips were prepared for isometric myography in Biancani's isolated muscle chamber contaning 1 ml of Tyrode solution, which was maintained with pH 7.4 by areation with 95% O2/5% CO2 at 37degrees C and nitric oxide (NO) production was measured simulltaneously with isolated nitric oxide mrter. LPS induced NO production, suppressed the phenylephrine (PE) induced contraction and enhanced the acetylcholine (ACh) induced relaxation. NG-nitro-L-arginine methyl ester (L-NAME), an NOS inhibitor, methylene blue, a guanylyl cyclase inhibitor, potentiated PE induced contraction and suppressed ACh induced relaxation on the LPS treated strips. The inhibitory potency of methylene blue for LPS induced vascular hyporeponsiveness was stronger than that of L-NAME. These result suggest that in canine femoral artery, both iNOS and cyclic GMP signal transduction pathway are related with LPS indused vascular hyporeponsiveness, but in minor with iNOS and in major with cyclic GMP signal transduction pathway.

Thiopental Prevents A Beta-Endorphin Response to Cardiopulmonary Bypass.: Sun Ok Song, Daniel B Carr, Dae Pal Park, Dae Lim Jee, Sae Yeon Kim; Yeungnam Univ J Med. 1997;14(2):350-358. Published online December 31, 1997; DOI: https://doi.org/10.12701/yujm.1997.14.2.350

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Surface Marker Analysis in Acute Leukemias.: Jin Young Moon, Chae Hoon Lee, Kyung Dong Kim, Chung Sook Kim; Yeungnam Univ J Med. 1997;14(2):359-369. Published online December 31, 1997; DOI: https://doi.org/10.12701/yujm.1997.14.2.359

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Abstract PDF: We studied the expression of the cell surface antigen associated with myeloid and lymphoid leukemias on bone marrow or peripheral blood blast cells from 153 leukemic patients including 61 cases of acute myelogenous leukemias(AML), 46 of acute lymphocytic leukemias(ALL) and 12 of acute leukemias. They were analyzed by direct or indirect immunofluorescence method for reactivity with the monoclonal antibodies to B cells(CD10, CD19, SmIg), T cells(CD2, CD5, CD7, CD3, CD4, CD8), myeloid antigen(CD13, CD14, CD33, CD61) and a nonspecific antigen, HLA-DR. Lymphoid associated markers detected on AML is CD7 32.8%, CD10 14.8%, CD5 13.1%, CD2 6.6% and CD19 1.6%. TdT was positive in 4.9% of AMLs. Hybrid leukemias were 8 cases out 61 AML cases and were mainly composed of monocytic lineage, M4 and M5a. Myeloid markers detected in ALL were CD13 2.2% and CD33 2.2%. In this study, immunologically classified ALLs were composed of 65.2% of CALLA (+) B precursor type, 10.9% of CALLA (-) B precursor pattern, 8.7% of T cell type, 2.2% of B cell type, 4.5% of mixed lymphoid lineage(B&T), 2.2% of undifferentiated leukemia, and 6.5% of hybrid leukemia. Twelve cases of acute leukemias ware finally diagnosed to be 5 cases of hybrid leukemia, 3 cases of B lineage, 3 case of T lineage and 1 case of mixed lymphoid(B&T) leukemia. In summary, we think the best method for typing acute leukemias is by using a combination of FAB classification and immunophenotying.

A Survey on the Knowledge and Attitudes of Women in Taegu toward Weaning Diet for Infants.: Kyung Ah Kim, Eun Sil Lee, Young Hwan Lee, Son Moon Shin, Kwang Hae Choi; Yeungnam Univ J Med. 1997;14(2):370-382. Published online December 31, 1997; DOI: https://doi.org/10.12701/yujm.1997.14.2.370

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Abstract PDF

Successful Weaning is very important to provide adequate nutrients for nomal growth and to induce a good diet habit. We conducted a survey on the Knowledge and attitudes of women who live in Taegu toward weaning in infants, to figure out how much they know about weaning diet for the infants, which source they prefer to get the information about weaning diet, whether their knowledge affect their practice about weaning in infants, and the most effective way to educate them. A survey was conducted with the prepared questionnaire on women who responded all the residential area and market place, and those who visited Department of Pediatrics, Yeungnam University hospital from July 25 to September 15, 1997. Statistical analysis was done with student t-test and ANOVA using SPSS program. Among total 303 responders, those who aged between 30 and 39 year were 37.2%. Scores for the six questions about weaning policy showed highest in the age group between30 and 39 years. Higher score was recorded in the more educated group, in those who get informations about weaning diet from books, magazines and pediatricians. The majority of the responders had wrong concepts, such as feeding weaning diet using bottle(69.1%), feeding mixed with formula in the same bottle(64.5%), addition of salt(68.4%), Those who had higher educational level preferred books, magazines rather than neighbors or mother to get informations about weaning diet. Those who preferred books or magazines started weaning, stopped bottle feeding, and used spoon earlier, and their children had unbalanced diet habits less frequently. Home-made food was most frequently, and commercial products were used less frequntly. Those who ewre employed preferred home-made good rather than commercial products, it may be caused by the difference of the educational backgrounds from those of the unemployed. In conclusion, most responders ask neighbors and mother to get informations about weaning, and the incorrect knowledge from them colud cause inadquate weaning practice and induced bad diet habit in their children. We have to find the reasons why they did not refer books or magazines frequently, and the way to resolve the problem.

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Market Segmentation for Commercial Baby Food by Food-Related Lifestyle of Korean Housewives
Bang-jin Bark, Wan-Soo Hong
Korean Journal of Food & Cookery Science.2017; 33(4): 452. CrossRef

A Study on the Bone Density in Newborn Infants: Difference of the Bone Mineral Density according to the Gestational Age and the Birth Weight.: Eun Sil Lee, Son Moon Shin, Han Ku Moon, Yong Hoon Park, Kwang Hae Choi; Yeungnam Univ J Med. 1997;14(2):383-392. Published online December 31, 1997; DOI: https://doi.org/10.12701/yujm.1997.14.2.383

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Abstract PDF: To study the differenced of bone mineral density according to the gestational ages and the birth weight and get a reference data for the diagnosis of metabolic bone diseases in the newborn infants, bone mineral densities of the lumbar vertebrae were measured in fifty-three newborn infants bone at Yeungnam University Hospital from March 1, 1995 to February 28, 1997, whose gestational ages were between 28+3 and 41+3 weeks and who had no intrauterine growth retardation, using dual energy X-ray absorptiometry (X-R 26, Norland, USA) within seven days of life. 1. There was no sexual difference in bone mineral density. The bone density increased significantly as gestational age increased from 0.149+/-0.009 g/cm2 at 28-30wks to 0.229+/-0.034 g/cm2 at 39-41wks of gestational age (p<0.05), but there was no significant difference between bone mineral density at 33-34wks and 35-36wks. There was positive linear correlation netween gestational age and bone mineral density (Y=7.5?10-3X-0.082, r=0.7018, p<0.001). 2. The bone mineral density increased significantly as the birth weight increased from 0.158+/-0.020 g/cm2 in 1,000-1,499 g to 0.251+/-0.021 g/cm2 in 3,500-4,000 g of the birth weight (p<0.05), but there was no significant difference between bone mineral densities in 1,000-1,499 g and 1,500-1,999 g of the birth weight. There was positive linear correlation between the birth weight and the bone mineral density (Y=3.9?10-5X+0.093, r=0.7296, p<0.001). There were positive correlations between the bone mineral density and gestational age, and between the bone mineral density and the birth weight. It can be used as a reference data for the further study on the bone mineral metabolism in the newborn infants including preterm babies.

Congenital Midgut Malrotation : Radiological Findings.: Jae Hong An, Mi Soo Hwang, Bok Hwan Park, Jung Kon Koh; Yeungnam Univ J Med. 1997;14(2):393-398. Published online December 31, 1997; DOI: https://doi.org/10.12701/yujm.1997.14.2.393

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Abstract PDF: An accurate early diagnosis of congenital midgut malrotation is essential to prevention of catastrophic effects of volvulus. To evaluate the usefulness of radiologic examinations in diagnosing intestinal malrotation, we retrospectively analyzed radiologic findings and operation records of 17 intestinal malrotation patients, who were radiologically diagnosed. The age range of the patients studied were from 1day to 12years. The presenting symptoms were vomiting, vomiting with abdominal pain, abdominal distention, diarrhea and failure to thrive. The viewpoints of this analysis were the location of duodeno-jejunal flexure on barium meal and cecal location on barium enema. Sixteen of 17 patients, who were radiologically diagnosed, were surgically proven, but one patient with annular pancreas was false positive. In the case of 3 surgically proved patients, malrotation was suspected on barium meal prior to the barium enema, but final diagnosis was determined on barium enema examination. We concluded that a barium enema should be performed on all children with suspected malrotation where the initial upper gastro-intestinal study was normal or suspicious on account of the small incidence of false positive and false negative barium meals.

Long-term Effect of Desferrioxamine to rHuEPO Regident Anemia in Hemodialysis Patients.: Sang Woo Lim, Hang Jae Jung, Sung Wha Bae, Jun Young Do, Kyung Woo Yoon; Yeungnam Univ J Med. 1997;14(2):399-414. Published online December 31, 1997; DOI: https://doi.org/10.12701/yujm.1997.14.2.399

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Abstract PDF: There are several factors concerning to anemia in chronic renal failure patients. But when rHuEPO is used, most of these factors can be overcome, and the levels of hemoglobin are increased, However, about 10% of the renal failure patients represent rHuEPO-resistant anemia eventhough high dosage of rHuEPO. For these cases, desferrioxamine can be applied to correct rHuEPO resistnacy, and many mechanism og DFO are arguing. So we are going to know whether DFO can applied to correct anemia of the such patients, how long its effect can continued. The seven patients as experimental group(DFO+EPO) who represent refractoriness to rHuEPO and the other seven patients as control group(EPO) were included. Experimental group has lower than 9 g/dL of hemoglobin levels despite high rHuEPO dosage (more than 4000U/Wk) and showed normochromic anemia. There were no definitive causes of anemia such as hemorrhage or iron deficiency. Control group patients has similar characteristics in age, mean dialysis duration but showed adequate response to rHuEPO. DFO was administered to experimental group for 8 weeks along with rHuEPO(the rHuEPO individual mean dosage had been determined by mean dosage of the previous 6 months. Total mean dosage; 123.5 U/Kg/Wk). After 8 weeks of DFO administration, the hemoglobin and rHuEPO dosage levels were checked for 15 consecutive months. It should be noted that the patients determined their own rHuEPO dosage levels according to hemoglobin levels and economic status. In control group, rHuEPO was administered by the same method used in experimental group without DFO through the same period. Fifteen months of ovservation period after DFO trial were divided as Time I(7 months after DFO trial) and Times II(8 months after Time I). The results are as follows: Before DFO trial, mean hemoglobin level of experimental group was 7.8 g/dL, which is similar level(p>0.05) to control group(mean Hb; 8.2 g/dL). But in experimental group, significantly(p<0.05) higher dosages of rHuEPO(mean; 123.5 U/Kg/Wk) than control group (mean;41.6 U/Kg/Wk) had been used. It means resistancy to rHuEPO of experimental group. But after DFO trial, the hemoglobin levels of the experimental group were increased significantly(p<0.05), and these effect were continued to II.(Time I; mean 8.6g/dL, Time II; mean 8.6g/dL) The effects of DFO to hemoglobin were continued for 15 months after DFO trial with simiral degree through Time I, Time II. Also, rHuEPO dosage used in the experimental group were decreased to simiral levels of the control group after DFO trial and these effect were also continued for 15 months(Time I; mean 48.1 U/Kg/Wk. Time II; mean 51.8 U/Kg/Wk). In the same period, hemoglobin levels and rHuEPO dosages used in the control group were not changed significantly. Notibly, hemoglobin increment and rHuEPO usage decrement in experimental group were showed maxilly in the 1st month after DFO trial. That is, after the use of DFO, erythropoiesis was enhanced with a reduced rHuEPO dosage. So we think rHuEPO reisistancy can be overcome by DFO therapy. In conclusion, the DFO can improve the anemia caused by chronic renal failure at least over 1 year, and hence, can reduce the dosage of rHuEPO for anemia correction. Additional studies in order to determined the mechanism of DFO on erythropoiesis and careful attention to potential side effects DFO will be needed.

The Study of Reliability and Validity of Attention Deficit Disorder Evaluation Scale-School Version(ADDES-SV).: Jin Woo Bae, Seung Douk Cheung, Jong Bum Lee, Hyung Bae Park, Jin Seung Kim, Chang Jin Song; Yeungnam Univ J Med. 1997;14(2):415-429. Published online December 31, 1997; DOI: https://doi.org/10.12701/yujm.1997.14.2.415

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Abstract PDF: The purpose of this study was to examine the reliability and validity of attention deficit disorder evaluation scale-school version(ADDES-SV). Between October 1996 and November 1996, ADDES-SV was administered to 263 elementary school students in the second grade and between Jun 1996 and October 1996, 28 attention deficit hyperactivity disorder patients. In the reliability test, the test-retest reliability coefficient was significantly high and that of inattention was 0.88, that of impulsivity was 0.80, that of hyperactivity was 0.83 and total score was 0.83. In the reliability test by internal consistancy, the Cronbach alpha coefficient was significantly high and that of inattention was 0.98, that of impulsivity was 0.87, that of hyperactivity was 0.87(p<0.05). The half-sprit reliability coefficient by first-second half method showed high correlation and that of inattention was part 1: 0.96, part 2: 0.96 impulsivity was part 1: 0.95, part 2: 0.93, hyperactivity was part 1: 0.92, part 2: 0.94(p<0.05). Inter-rater reliability by pearson correlation coefficient was significantly high and that of inattention was 0.92, that of impulsivity was 0.87, that of hyperactivity was 0.89 and total score was 0.89. The concurrent validity between ADDES-SV and CAP scale was 0.85 in attention deficit hyperactivity disorder patient group and 0.79 in normal control group(p<0.05). In discriminant validity test between attention deficit hyperactivity disorder patient group and normal control group, the patient group showed higher score(p<0.05). The total discriminant capacity of the patient group in ADDES-SV was 94.6%. In this point of view, ADDES-SV scale showed high reliability and validity in applying to Korean subjects and was proved to be the useful screening test tool for attention deficit hyperactivity disorder research.

Differences in Clinical Laboratory Data between the Elderly and the Young Adults.: Kun A Lee, Keun Mi Lee, Seung Pil Jung, Seong Wook Bae; Yeungnam Univ J Med. 1997;14(2):430-442. Published online December 31, 1997; DOI: https://doi.org/10.12701/yujm.1997.14.2.430

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Abstract PDF: Due to the lowering of biological functions resulted from old age, the elderly is known to have many different clinical laboratory data compared with the young adults. But, in korea, such study is lacking. This research is to find the differences between the elderly and the young adults, and also to know the sexual differences, by comparing the outcomes of the clinical laboratory data. Along with that, it is to help clinical usage of the data in the future. The age of the elderly was between 60 and 83(average age 63.8), and that of the young controls was between 20 and 35. In both sexes, MCV, MCH, ESR, CRP,AST, ALT, gamma GTP, ALP, BUN, total cholesterol were significantly higher in the elderly than in the controls. And lymphocyte count(%), total bilirubin, direct bilirubin, total protein, albumin, T3 were significantly lower in the elderly than in the controls(P<0.05). Hemoglobin, Hct, platelet count, T4 were significantly lower only in the male elderly, and eosinophil count(%), creatinine were significantly higher only in the female elderly(P<0.05). HDLcholesterol was significantly higher only in the male elderly(P<0.01). There were no significant difference between two groups regarding WBCcount, segment neutrophil count(%), monocyte count(%), TSH. Many clinical laboratory data are different between the elderly and the young adults, and some clinical laboratory data also have sexual differences.

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