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Volume 35(2); December 2018
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Review Articles
Functional recovery after radical prostatectomy for prostate cancer
Young Hwii Ko
Yeungnam Univ J Med. 2018;35(2):141-149.   Published online December 31, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.2.141
  • 6,510 View
  • 153 Download
  • 2 Crossref
AbstractAbstract PDF
With the enthusiasm regarding robotic application in radical prostatectomy in accordance with the widespread use of serum prostate-specific antigen as a screening test, the number of surgeries performed for complete removal of the gland is increasing continuously. However, owing to the adjacent anatomical location of the prostate to the nerve and urethral sphincter complex, functional recovery, namely improvement from post-prostatectomy incontinence (PPI) and post-prostatectomy erectile dysfunction, still remains a main problem for patients who are reluctant to undergo surgery and tend to choose alternative ways instead. Since the late 1980s, the introduction of radical prostatectomy by open surgical modalities, the depth of the anatomical understanding of the structure surrounding the prostate is getting tremendous, which leads to the development of new surgical modalities and techniques that are consequently aimed at reducing the incidences of PPI and erectile dysfunction. Briefly, recent data from robotic radical prostatectomy, particularly on PPI, are quite acceptable, but by contrast, the reported potency regain rate still remains <20%, which indicates the need for advanced surgical modification to overcome it. In this review, the authors summarized the recent findings on the anatomy and surgical techniques reported up to now.

Citations

Citations to this article as recorded by  
  • The assessment of erectile dysfunction after radical prostatectomy using pudendal somatosensory evoked potential
    Se Yun Kwon, Jin-Mo Park, Appuwawadu Mestri Nipun Lakshitha de Silva
    PLOS ONE.2023; 18(11): e0292847.     CrossRef
  • Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration
    Lisa Baker, Moses Tar, Adam H. Kramer, Guillermo A. Villegas, Rabab A. Charafeddine, Olga Vafaeva, Parimala Nacharaju, Joel Friedman, Kelvin P. Davies, David J. Sharp
    JCI Insight.2021;[Epub]     CrossRef
Recent advances in minimally invasive surgery for gynecologic indications
Yu-Jin Koo
Yeungnam Univ J Med. 2018;35(2):150-155.   Published online December 31, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.2.150
  • 5,393 View
  • 107 Download
  • 11 Crossref
AbstractAbstract PDF
Recently, an increasing interest in less invasive surgery has led to the advent of laparoendoscopic singlesite surgery (LESS) and natural orifice transluminal endoscopic surgery (NOTES). LESS and NOTES could be technically challenging, but available literature has demonstrated the feasibility and safety of LESS for benign gynecologic diseases. However, the evidence is not strong enough to recommend the use of LESS over that of conventional multiport laparoscopic surgery (MLS). As per the results of the most recently published meta-analysis, the majority of surgical outcomes are equivalent between LESS and MLS, except for the longer operative time in LESS for both adnexal surgery and hysterectomy. Although an increasing number of studies have reported on robotic LESS, NOTES, and LESS for gynecologic malignancy, definite conclusions have not been drawn owing to the lack of sufficient information.

Citations

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  • Optimizing Hysterectomy: A Prospective Comparative Analysis of Surgical Techniques and Their Impact on Women’s Lives
    Aslihan Yurtkal, Mujde Canday
    Journal of Personalized Medicine.2024; 14(3): 265.     CrossRef
  • Comparative study to determine the proper sequence of simulation training, pelvic trainer versus virtual reality simulator: a pilot study
    Ngima Yangji Sherpa, Ahmed El Minawi, Ahmed N Askalany, Marwa Abdalla
    Middle East Fertility Society Journal.2024;[Epub]     CrossRef
  • Magnetic Catheter Placement in Neonates: A Handheld Solution to Radiation Exposure and Operational Delays
    Liam Swanepoel, Alexander Przybysz, Pieter Fourie, Jurgen Kosel
    Advanced Sensor Research.2023;[Epub]     CrossRef
  • Surgical Microgrippers: A Survey and Analysis
    Liseth V. Pasaguayo, Zeina Al Masry, Sergio Lescano, Noureddine Zerhouni
    Journal of Medical Devices.2023;[Epub]     CrossRef
  • Teres lift-up technique: a retrospective comparative study for an alternative route for laparoscopic entry in gynecologic and oncologic surgery
    Selim Afsar, Ceyda Sancaklı Usta, Akın Usta, Duygu Lafcı, Izel Gunay, Can Berk Karabudak
    Archives of Gynecology and Obstetrics.2023; 308(5): 1549.     CrossRef
  • Serosal injury to a distended stomach during open entry for laparoendoscopic single-site surgery
    Pei-Chen Chen, Pei-Chen Li, Hsuan Chen, Dah-Ching Ding
    Gynecology and Minimally Invasive Therapy.2022; 11(2): 121.     CrossRef
  • Laparoscopic single site versus conventional laparoscopic surgery for benign ovarian masses
    Xiaoping Jia, Jing Zhou, Yanyan Fu, Hui Wang, Cailing Ma
    Journal of Radiation Research and Applied Sciences.2022; 15(3): 255.     CrossRef
  • A Facile Magnetic System for Tracking of Medical Devices
    Liam Swanepoel, Nouf Alsharif, Alexander Przybysz, Pieter Fourie, Pierre Goussard, Mohammad Asadullah Khan, Abdullah Almansouri, Jurgen Kosel
    Advanced Materials Technologies.2021;[Epub]     CrossRef
  • Laparoendoscopic Single Site Hysterectomy: Literature Review and Procedure Description
    Liliana Mereu, Francesca Dalprà, Saverio Tateo
    Journal of Clinical Medicine.2021; 10(10): 2073.     CrossRef
  • Cervicovaginal reconstruction with small intestinal submucosa graft in congenital cervicovaginal atresia: A report of 38 cases
    Yan Ding, Xuyin Zhang, Ying Zhang, Fang Shen, Jingxin Ding, Keqin Hua
    European Journal of Obstetrics & Gynecology and Reproductive Biology.2021; 267: 49.     CrossRef
  • Benefícios relacionados à cirurgia minimamente invasiva na ginecologia
    Isys Holanda Albuquerque de Vasconcelos, Renata Nogueira Andrade, Beatriz Amâncio Rodrigues, Beatriz Leite Assis, Lorenna da Silva Santos, Luana Lemos Alves, Marlon José dos Santos Rosa, Monica Aparecida Miranda Carvalho, Renata Correia Freire, Scanagatt
    Revista Científica Multidisciplinar Núcleo do Conhecimento.2020; : 28.     CrossRef
Potential health effects of emerging environmental contaminants perfluoroalkyl compounds
Youn Ju Lee
Yeungnam Univ J Med. 2018;35(2):156-164.   Published online December 31, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.2.156
  • 8,121 View
  • 106 Download
  • 8 Crossref
AbstractAbstract PDF
Environmental contaminants are one of the important causal factors for development of various human diseases. In particular, the perinatal period is highly vulnerable to environmental toxicants and resultant dysregulation of fetal development can cause detrimental health outcomes potentially affecting life-long health. Perfluoroalkyl compounds (PFCs), emerging environmental pollutants, are man-made organic molecules, which are widely used in diverse industries and consumer products. PFCs are non-degradable and bioaccumulate in the environment. Importantly, PFCs can be found in cord blood and breast milk as well as in the general population. Due to their physicochemical properties and potential toxicity, many studies have evaluated the health effects of PFCs. This review summarizes the epidemiological and experimental studies addressing the association of PFCs with neurotoxicity and immunotoxicity. While the relationships between PFC levels and changes in neural and immune health are not yet conclusive, accumulative studies provide evidence for positive associations between PFC levels and the incidence of attention deficit hyperactivity disorder and reduced immune response to vaccination both in children and adults. In conclusion, PFCs have the potential to affect human health linked with neurological disorders and immunosuppressive responses. However, our understanding of the molecular mechanism of the effects of PFCs on human health is still in its infancy. Therefore, along with efforts to develop methods to reduce exposure to PFCs, studies on the mode of action of these chemicals are required in the near future.

Citations

Citations to this article as recorded by  
  • Emerging contaminants: A One Health perspective
    Fang Wang, Leilei Xiang, Kelvin Sze-Yin Leung, Martin Elsner, Ying Zhang, Yuming Guo, Bo Pan, Hongwen Sun, Taicheng An, Guangguo Ying, Bryan W. Brooks, Deyi Hou, Damian E. Helbling, Jianqiang Sun, Hao Qiu, Timothy M. Vogel, Wei Zhang, Yanzheng Gao, Myrna
    The Innovation.2024; 5(4): 100612.     CrossRef
  • Modifiable contributing factors to COVID-19: A comprehensive review
    Ronald Neil Kostoff, Michael Brandon Briggs, Darja Kanduc, Saikat Dewanjee, Ramesh Kandimalla, Yehuda Shoenfeld, Alan L. Porter, Aristidis Tsatsakis
    Food and Chemical Toxicology.2023; 171: 113511.     CrossRef
  • Effect of prenatal perfluoroheptanoic acid exposure on spermatogenesis in offspring mice
    Yijie Zhou, Weilian Sun, Qiuqin Tang, Yiwen Lu, Mei Li, Jing Wang, Xiumei Han, Di Wu, Wei Wu
    Ecotoxicology and Environmental Safety.2023; 260: 115072.     CrossRef
  • A Systematic Review of Contaminants of Concern in Uganda: Occurrence, Sources, Potential Risks, and Removal Strategies
    Gabson Baguma, Gadson Bamanya, Allan Gonzaga, Wycliffe Ampaire, Patrick Onen
    Pollutants.2023; 3(4): 544.     CrossRef
  • Association between maternal serum concentration of perfluoroalkyl substances (PFASs) at delivery and acute infectious diseases in infancy
    Zixia Wang, Rong Shi, Guodong Ding, Qian Yao, Chengyu Pan, Yu Gao, Ying Tian
    Chemosphere.2022; 289: 133235.     CrossRef
  • The Association between ADHD and Environmental Chemicals—A Scoping Review
    Sonja Moore, Laura Paalanen, Lisa Melymuk, Andromachi Katsonouri, Marike Kolossa-Gehring, Hanna Tolonen
    International Journal of Environmental Research and Public Health.2022; 19(5): 2849.     CrossRef
  • The Occurrence and Distributions of Per- and polyfluoroalkyl substances (PFAS) in groundwater after a PFAS leakage incident in 2018
    Zhi Yuan Yong, Ki Yong Kim, Jeong-Eun Oh
    Environmental Pollution.2020; : 115395.     CrossRef
  • Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults
    Zhanghua Chen, Tingyu Yang, Douglas I. Walker, Duncan C. Thomas, Chenyu Qiu, Leda Chatzi, Tanya L. Alderete, Jeniffer S. Kim, David V. Conti, Carrie V. Breton, Donghai Liang, Elizabeth R. Hauser, Dean P. Jones, Frank D. Gilliland
    Environment International.2020; 145: 106091.     CrossRef
Original Articles
Effects of small tidal volume and positive end-expiratory pressure on oxygenation in pressure-controlled ventilation-volume guaranteed mode during one-lung ventilation
Sung Hye Byun, So Young Lee, Jin Yong Jung
Yeungnam Univ J Med. 2018;35(2):165-170.   Published online December 20, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.2.165
  • 5,721 View
  • 88 Download
  • 1 Crossref
AbstractAbstract PDF
Background
The purpose of this study was to investigate whether tidal volume (TV) of 8 mL/kg without positive end-expiratory pressure (PEEP) and TV of 6 mL/kg with or without PEEP in pressure-controlled ventilation-volume guaranteed (PCV-VG) mode can maintain arterial oxygenation and decrease inspiratory airway pressure effectively during one-lung ventilation (OLV).
Methods
The study enrolled 27 patients undergoing thoracic surgery. All patients were ventilated with PCVVG mode. During OLV, patients were initially ventilated with TV 8 mL/kg (group TV8) without PEEP. Ventilation was subsequently changed to TV 6 mL/kg with PEEP (5 cmH2O; group TV6+PEEP) or without (group TV6) in random sequence. Peak inspiratory pressure (Ppeak), mean airway pressure (Pmean), and arterial blood gas analysis were measured 30 min after changing ventilator settings. Ventilation was then changed once more to add or eliminate PEEP (5 cmH2O), while maintaining TV 6 mL/kg. Thirty min after changing ventilator settings, the same parameters were measured once more.
Results
The Ppeak was significantly lower in group TV6 (19.3±3.3 cmH2O) than in group TV8 (21.8±3.1 cmH2O) and group TV6+PEEP (20.1±3.4 cmH2O). PaO2 was significantly higher in group TV8 (242.5±111.4 mmHg) than in group TV6 (202.1±101.3 mmHg) (p=0.044). There was no significant difference in PaO2 between group TV8 and group TV6+PEEP (226.8±121.1 mmHg). However, three patients in group TV6 were dropped from the study because PaO2 was lower than 80 mmHg after ventilation.
Conclusion
It is postulated that TV 8 mL/kg without PEEP or TV 6 mL/kg with 5 cmH2O PEEP in PCV-VG mode during OLV can safely maintain adequate oxygenation.

Citations

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  • Pressure-Controlled Ventilation-Volume Guaranteed Mode Combined with an Open-Lung Approach Improves Lung Mechanics, Oxygenation Parameters, and the Inflammatory Response during One-Lung Ventilation: A Randomized Controlled Trial
    Jianli Li, Baogui Cai, Dongdong Yu, Meinv Liu, Xiaoqian Wu, Junfang Rong
    BioMed Research International.2020; 2020: 1.     CrossRef
Oncological and functional outcomes following robot-assisted laparoscopic radical prostatectomy at a single institution: a minimum 5-year follow-up
Jun-Koo Kang, Jae-Wook Chung, So Young Chun, Yun-Sok Ha, Seock Hwan Choi, Jun Nyung Lee, Bum Soo Kim, Ghil Suk Yoon, Hyun Tae Kim, Tae-Hwan Kim, Tae Gyun Kwon
Yeungnam Univ J Med. 2018;35(2):171-178.   Published online December 31, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.2.171
  • 6,227 View
  • 56 Download
  • 1 Crossref
AbstractAbstract PDF
Background
To evaluate mid-term oncological and functional outcomes in patients with prostate cancer treated by robot-assisted laparoscopic radical prostatectomy (RALP) at our institution.
Methods
We retrospectively reviewed the medical records of 128 patients with prostate cancer who underwent RALP at our institution between February 2008 and April 2010. All patients enrolled in this study were followed up for at least 5 years. We analyzed biochemical recurrence (BCR)-free survival using a Kaplan-Meier survival curve analysis and predictive factors for BCR using multivariate Cox regression analysis. Continence recovery rate, defined as no use of urinary pads, was also evaluated.
Results
Based on the D’Amico risk classification, there were 30 low-risk patients (23.4%), 47 intermediaterisk patients (38.8%), and 51 high-risk patients (39.8%), preoperatively. Based on pathological findings, 50.0% of patients (64/128) showed non-organ confined disease (≥T3a) and 26.6% (34/128) had high grade disease (Gleason score ≥8). During a median follow-up period of 71 months (range, 66-78 months), the frequency of BCR was 33.6% (43/128) and the median BCR-free survival was 65.9 (0.4-88.0) months. Multivariate Cox regression analysis revealed that high grade disease (Gleason score ≥8) was an independent predictor for BCR (hazard ratio=4.180, 95% confidence interval=1.02-17.12, p=0.047). In addition, a majority of patients remained continent following the RALP procedure, without the need for additional intervention for post-prostatectomy incontinence.
Conclusion
Our study demonstrated acceptable outcomes following an initial RALP procedure, despite 50% of the patients investigated demonstrating high-risk features associated with non-organ confined disease.

Citations

Citations to this article as recorded by  
  • Prediction of a positive surgical margin and biochemical recurrence after robot-assisted radical prostatectomy
    Ching-Wei Yang, Hsiao-Hsien Wang, Mohamed Fayez Hassouna, Manish Chand, William J. S. Huang, Hsiao-Jen Chung
    Scientific Reports.2021;[Epub]     CrossRef
Retrograde balloon dilation as a therapeutic option for post-gynecologic surgery ureteral stricture followed by ureteroureterostomy: a comparative study regarding stricture length
Geon Woo Lim, Young Dong Yu, Kyung Hwa Choi, Seung Ryeol Rhee, Dong Soo Park, Young Kwon Hong
Yeungnam Univ J Med. 2018;35(2):179-186.   Published online December 31, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.2.179
  • 5,681 View
  • 72 Download
  • 3 Crossref
AbstractAbstract PDF
Background
To evaluate the success rate of balloon dilation and the factors possibly influencing the outcomes of balloon dilation for the ureteric strictured portion of ureteroureterostomy (UUS) site in patients with post-gynecologic surgeries.
Methods
A single institution data base was screened for the patients who received balloon dilation for a treatment of ureteral stricture diagnosed after gynecologic surgery. Overall 114 patients underwent primary intra-operative UUS due to ureteral injury during gynecologic surgery. Among them, 102 patients received balloon dilation, and their medical records were retrospectively reviewed. Success of balloon dilation was defined as the condition that requires no further clinical interventions after 6 months from balloon dilation.
Results
The ureter injury rate of women treated with open radical abdominal hysterectomy was highest (32 cases, 31.4%). 60 patients (60.8%) showed successful outcomes regarding dilation. All patients underwent technically successful dilation with a full expansion of balloon during the procedure, but 40 patients (39.2%) were clinically unsuccessful as they showed a recurrence of ureteral stricture on the previous balloon dilation site after the first dilation procedure. Univariate logistic regression analyses showed that stricture length >2 cm was a significant predictor of successful dilation (odds ratio, 0.751; 95% confidence interval, 0.634-0.901; p-value, 0.030), but it failed to achieve independent predictor status in multivariate analysis.
Conclusion
Balloon dilation can an effective alternative treatment option for strictured portion of the primary UUS in post-gynecologic surgery patients when its length is <2 cm.

Citations

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  • Mechanical characteristics of the ureter and clinical implications
    Sorcha O’Meara, Eoghan M. Cunnane, Stefanie M. Croghan, Connor V. Cunnane, Michael T. Walsh, Fergal J. O’Brien, Niall F. Davis
    Nature Reviews Urology.2024; 21(4): 197.     CrossRef
  • Analysis of the Efficacy and Risk Factors for Failure of Balloon Dilation for Benign Ureteral Stricture
    Bing Wang, Wenzhi Gao, Kunlin Yang, Honglei Liu, Yangjun Han, Mingxin Diao, Chao Zuo, Minghua Zhang, Yingzhi Diao, Zhihua Li, Xinfei Li, Gang Wang, Peng Zhang, Chunji Wang, Chunjuan Xiao, Chen Huang, Yaming Gu, Xuesong Li
    Journal of Clinical Medicine.2023; 12(4): 1655.     CrossRef
  • Left-sided flap transposition of the appendix for urethroplasty in oncourology
    A. K. Nosov, D. I. Rumyantseva, E. M. Mamizhev, P. A. Lushina, N. A. Shchekuteev, M. V. Berkut
    Cancer Urology.2022; 18(1): 127.     CrossRef
Risk factors for respiratory distress syndrome in full-term neonates
Jin Hyeon Kim, Sang Min Lee, Young Hwan Lee
Yeungnam Univ J Med. 2018;35(2):187-191.   Published online December 31, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.2.187
  • 9,728 View
  • 288 Download
  • 7 Crossref
AbstractAbstract PDF
Background
Respiratory distress syndrome (RDS) is a one of the most common cause of respiratory morbidity and mortality in neonates. This study was conducted to investigate the risk factors for RDS in full-term neonates.
Methods
We conducted this retrospective study using medical records. The study group included 80 full-term neonates diagnosed with RDS and hospitalized in the neonatal intensive care unit between January 2012 and December 2016, at Yeungnam University Hospital. We analyzed sex, gestational age, birth weight, delivery method, maternal age, number of pregnancy, history of abortion, and complication of pregnancy. The control group included 116 full-time neonates who were hospitalized with jaundice during the same period.
Results
The incidence of full-term RDS was more common in males (odds ratio [OR], 3.288; 95% confidence interval [CI], 1.446-7.479), cesarean section (OR, 15.03; 95% CI, 6.381-35.423), multiparity (OR, 4.216; 95% CI, 1.568-11.335). The other factors rendered no significant results.
Conclusion
The risk factors for RDS in full-tern neonates were identified as male sex, cesarean section, and multiparity. Further studies involving more institutions are needed to clarify the risk factors for RDS in fullterm infants.

Citations

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  • The association between sex and neonatal respiratory distress syndrome
    Keren Fang, Shaojie Yue, Shuo Wang, Mingjie Wang, Xiaohe Yu, Ying Ding, Mei Lv, Yang Liu, Chuanding Cao, Zhengchang Liao
    BMC Pediatrics.2024;[Epub]     CrossRef
  • Identification of Inflammatory Mediators in Saliva Samples From Hospitalized Newborns: Potential Biomarkers?
    Vanderlei Amadeu da Rocha, Sanseray da Silveira Cruz-Machado, Isília Aparecida Silva, Pedro Augusto Carlos Magno Fernandes, Regina Pekelmann Markus, Mariana Bueno
    Clinical Nursing Research.2024; 33(4): 207.     CrossRef
  • Global, Regional and National Trends in the Burden of Neonatal Respiratory Failure and essentials of its diagnosis and management from 1992 to 2022: a scoping review
    Joel Noutakdie Tochie, Aurelie T. Sibetcheu, Pascal Ebot Arrey-Ebot, Simeon-Pierre Choukem
    European Journal of Pediatrics.2023; 183(1): 9.     CrossRef
  • Incidence and predictors of respiratory distress syndrome among low birth weight neonates in the first seven days in Northwest Ethiopia Comprehensive Specialized Hospitals, 2023: A retrospective follow-up study
    Wubet Tazeb Wondie, Bruck Tesfaye Legesse, Gebrehiwot Berie Mekonnen, Gosa Tesfaye Degaga, Alemu Birara Zemariam, Gezahagn Demsu Gedefaw, Dereje Esubalew Abebe, Yohannes Tesfahun Kassie, Almaz Tefera Gonete, Alamirew Enyew Belay, Chalachew Adugna Wubneh
    BMJ Open.2023; 13(11): e079063.     CrossRef
  • Determinants for perinatal adverse outcomes among pregnant women with preterm premature rupture of membrane: A prospective cohort study
    Tariku Abewa Abebe, Dawit Desalegn Nima, Yitbarek Fantahun Mariye, Abebaye Aragaw Leminie
    Frontiers in Reproductive Health.2022;[Epub]     CrossRef
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    Mohamed Shawky Elfarargy, Ghada M Al-Ashmawy, Sally Abu-Risha, Haidy Khattab
    International Journal of Immunopathology and Pharmacology.2021; 35: 205873842110005.     CrossRef
  • The Underlying Causes of Respiratory Distress in Late-Preterm and Full-Term Infants Are Different From Those of Early-Preterm Infants
    Li Wang, Shuqing Tang, Hui Liu, Juan Ma, Bingyi Li, Li Wu, Zhichun Feng, Yuan Shi
    Iranian Journal of Pediatrics.2020;[Epub]     CrossRef
Antiepileptic and anti-neuroinflammatory effects of red ginseng in an intrahippocampal kainic acid model of temporal lobe epilepsy demonstrated by electroencephalography
Ju Young Kim, Jin Hyeon Kim, Hee Jin Lee, Sang Hoon Kim, Young Jin Jung, Hee-Young Lee, Hee Jaung Kim, Sae Yoon Kim
Yeungnam Univ J Med. 2018;35(2):192-198.   Published online December 31, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.2.192
  • 6,344 View
  • 108 Download
  • 3 Crossref
AbstractAbstract PDF
Background
Chronic inflammation can lower the seizure threshold and have influence on epileptogenesis. The components of red ginseng (RG) have anti-inflammatory effects. The abundance of peripherally derived immune cells in resected epileptic tissue suggests that the immune system is a potential target for anti-epileptogenic therapies. The present study used continuous electroencephalography (EEG) to evaluate the therapeutic efficacy of RG in intrahippocampal kainic acid (IHKA) animal model of temporal lobe epilepsy.
Methods
Prolonged status epilepticus (SE) was induced in 7-week-old C57BL/6J mice via stereotaxic injection of kainic acid (KA, 150 nL; 1 mg/mL) into the right CA3/dorsal hippocampus. The animals were implanted electrodes and monitored for spontaneous seizures. Following the IHKA injections, one group received treatments of RG (250 mg/kg/day) for 4 weeks (RG group, n=7) while another group received valproic acid (VPA, 30 mg/kg/day) (VPA group, n=7). Laboratory findings and pathological results were assessed at D29 and continuous (24 h/week) EEG monitoring was used to evaluate high-voltage sharp waves on D7, D14, D21, and D28.
Results
At D29, there were no differences between the groups in liver function test but RG group had higher blood urea nitrogen levels. Immunohistochemistry analyses revealed that RG reduced the infiltration of immune cells into the brain and EEG analyses showed that it had anticonvulsant effects.
Conclusion
Repeated treatments with RG after IHKA-induced SE decreased immune cell infiltration into the brain and resulted in a marked decrease in electrographic seizures. RG had anticonvulsant effects that were similar to those of VPA without serious side effects.

Citations

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  • Comparative analysis of physicochemical properties, ginsenosides content and α-amylase inhibitory effects in white ginseng and red ginseng
    Huairui Wang, Yao Cheng, Xue Zhang, Yingping Wang, Hui Zhao
    Food Science and Human Wellness.2023; 12(1): 14.     CrossRef
  • Robust chronic convulsive seizures, high frequency oscillations, and human seizure onset patterns in an intrahippocampal kainic acid model in mice
    Christos Panagiotis Lisgaras, Helen E. Scharfman
    Neurobiology of Disease.2022; 166: 105637.     CrossRef
  • The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches
    Siva Prasad Panda, Yogita Dhurandhar, Mehak Agrawal
    Mitochondrion.2022; 66: 27.     CrossRef
Comparison of ultrasound-guided stellate ganglion block at 6th and 7th cervical vertebrae using the lateral paracarotid out-of-plane approach for sympathetic blockade in the upper extremity
Jongyoon Baek, Bum Soo Kim, Hwarim Yu, Hyuckgoo Kim, Chaeseok Lim, Sun Ok Song
Yeungnam Univ J Med. 2018;35(2):199-204.   Published online December 31, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.2.199
  • 6,367 View
  • 107 Download
  • 5 Crossref
AbstractAbstract PDF
Background
The authors have performed ultrasound-guided stellate ganglion block (SGB) in our clinic using a lateral paracarotid approach at the level of the 6th cervical vertebra (C6). Although SGB at C6 is a convenient and safe method, there are ongoing concerns about the weak effect of sympathetic blockade in the ipsilateral upper extremity. Therefore, ultrasound-guided SGB was attempted using a lateral paracarotid approach at the level of the 7th cervical vertebra (C7). This prospective study aimed to compare changes in skin temperature after SGB was performed at C6 and C7, and to introduce a lateral paracarotid approach for SGB.
Methods
Thirty patients underwent SGB twice: once at C6 and once at C7. For every SGB, the skin temperature of the patient’s hypothenar area was measured for 15 min at 1-min intervals. Skin temperatures before and after SGB and side effects were compared between C6 and C7 groups.
Results
The temperature of the upper extremity increased after SGB was performed at C6 and C7. There were significant differences between mean pre-SGB and the largest increases in post-SGB temperatures (0.50±0.38℃ and 1.41±0.68℃ at C6 and C7, respectively; p<0.05). Significantly increased post-SGB temperatures (difference >1℃) were found in 5/30 (16.7%) and 24/30 (80%) cases for C6 and C7, respectively (p<0.05). There were no significant differences in side effects between SGB performed at C6 or C7 (p>0.05).
Conclusion
The lateral paracarotid approach using out-of-plane needle insertion for ultrasound-guided SGB performed at C7 was feasible and more effective at elevating skin temperature in the upper extremity than SGB at C6.

Citations

Citations to this article as recorded by  
  • The usefulness of stellate ganglion block with ultrasound-guided lateral paracarotid approach in ventricular arrhythmias: A case series
    Hansung Ryu, Hyuckgoo Kim
    Saudi Journal of Anaesthesia.2024; 18(2): 276.     CrossRef
  • Establishment of ultrasound-guided stellate ganglion block in rats
    Shi-zhu Lin, Lu Chen, Yi-jie Tang, Cheng-jie Zheng, Peng Ke, Meng-nan Chen, Hai-xing Wu, Yu Chen, Liang-cheng Qiu, Xiao-dan Wu, Kai Zeng
    Frontiers in Neuroscience.2023;[Epub]     CrossRef
  • Magnetic resonance imaging validation of medial transthyroid ultrasound‐guided stellate ganglion block: A pilot study
    Boo Young Chung, Christian Holfelder, Robert E. Feldmann, Dieter Kleinboehl, Raoul C. Raum, Justus Benrath
    Pain Practice.2022; 22(3): 329.     CrossRef
  • Prolonged blockade of the cervical sympathetic nerve by stellate ganglion block accelerates therapeutic efficacy in trigeminal neuropathy
    Kazune Kawabata, Teppei Sago, Tsuneto Oowatari, Shunji Shiiba
    Journal of Oral Science.2022; 64(1): 6.     CrossRef
  • Comment on an Article by Aleanakian et al. Titled “Effectiveness, Safety, and Predictive Potential in Ultrasound‐Guided Stellate Ganglion Blockades (SGB) for the Treatment of Sympathetically Maintained Pain”
    Pratibha Singh, Anil Agarwal, Chetna Shamshery
    Pain Practice.2021; 21(5): 602.     CrossRef
Association of head circumference with cognitive decline and symptoms of depression in elderly: a 3-year prospective study
Oh Dae Kwon, So-Young Choi, Jisuk Bae
Yeungnam Univ J Med. 2018;35(2):205-212.   Published online December 31, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.2.205
  • 6,347 View
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AbstractAbstract PDF
Background
Brain volume is associated with dementia and depression in the elderly. An easy way to predict relative brain volume is to measure head circumference. In this study, we investigated the relationship between head circumference and cognition as well as depression in a non-demented elderly community.
Methods
Baseline and follow-up surveys were conducted in 2007 and 2010. At baseline, community residents aged 65 years or over (n=382) within a rural area of South Korea were screened for dementia and symptoms of depression and were followed using the same screening battery after 3 years (n=279). Data from anthropometric measurements (head circumference, height, and body weight), demographics, and blood tests were gathered. Neuropsychological tests, including the Korean version of mini-mental state examination (K-MMSE), clinical dementia rating (CDR) including the CDR-sum of boxes, the Korean version of instrumental activities of daily living, and geriatric depression scale (GDS), were performed. None of the 279 subjects followed were demented.
Results
Baseline performance on the K-MMSE and GDS was poorer for participants with smaller head circumferences. Follow-up performance on the MMSE was also poorer for participants with smaller head circumferences. Interestingly, participants with smaller head circumference showed worse GDS scores at baseline but on follow-up examination, participants with larger head circumference showed rapid worsening than those with smaller head circumference with marginal significance by ANOVA test. In regression coefficient analysis, GDS decline showed significant difference.
Conclusion
Head circumference was not associated with cognitive change but was associated with symptoms of depression in non-demented community residents.
The effect of thalidomide on visceral fat pad mass and triglyceride concentration of the skeletal muscles in rats
Ki-Hoon Kim, Chang-Bon Choi, Jong-Yeon Kim
Yeungnam Univ J Med. 2018;35(2):213-218.   Published online December 31, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.2.213
  • 5,513 View
  • 52 Download
  • 1 Crossref
AbstractAbstract PDF
Background
Body fats, especially both of abdominal fat pad mass and skeletal muscle fat content, are inversely related to insulin action. Therefore, methods for decreasing visceral fat mass and muscle triglyceride content may be helpful for the prevention of insulin resistance.
Methods
Thalidomide, used for its anti-angiogenic and anti-inflammatory properties, was administered to rats for 4 weeks. A 10% solution of thalidomide in dimethyl sulfoxide was injected daily into the peritoneal cavity as much as 100 mg/kg of body weight.
Results
The total visceral fat pad mass in the thalidomide-treated group was 11% lower than in the control group. The size of adipocytes of the epididymal fat pad mass in the thalidomide-treated group was smaller than in the control group. The intraperitoneal thalidomide treatment increased triglyceride concentrations by 16% in the red muscle, but not in the white muscle.
Conclusion
The results suggested that intraperitoneal thalidomide treatment inhibited abdominal fat accumulation, and that the free fatty acids in the blood were preferentially accumulated in the red muscle rather than in the white muscle.

Citations

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  • Thalidomide suppresses migration and invasion of colorectal cancer cells by inhibiting HOXB7‐mediated activation of the Wnt/β‐catenin signaling pathway
    Liyang Liu, Wusong Xue
    Chemical Biology & Drug Design.2024;[Epub]     CrossRef
Case Reports
Successful difficult airway management using GlideScope video laryngoscope in a child with Cornelia de Lange Syndrome
Sang-Jin Park, Eun Kyung Choi, Suyong Park, Kunjin Bae, Deokhee Lee
Yeungnam Univ J Med. 2018;35(2):219-221.   Published online December 31, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.2.219
  • 5,005 View
  • 47 Download
AbstractAbstract PDF
Management of airway in a child with Cornelia de Lange Syndrome (CdLS) should be given due consideration because most of them have the problems related to difficult airway. The GlideScope video laryngoscope can be attempted during routine intubation, however it is mostly used in case of difficulty. With adequate preoperative airway assessment, we used the pediatric video laryngoscope as useful alternative airway device in a child with CdLS and orotracheal intubation proceeded uneventfully.
Colchicine for steroid-resistant recurrent pericarditis in a child
Ju Hee Shin, Dong Hyun Lee, Hee Joung Choi
Yeungnam Univ J Med. 2018;35(2):222-226.   Published online December 31, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.2.222
  • 5,335 View
  • 83 Download
  • 3 Crossref
AbstractAbstract PDF
Recurrent pericarditis is rare in children and is considered idiopathic in most cases. Its course is chronic, and preventing recurrences is important for the patient’s quality of life. Although a treatment strategy in pediatric recurrent pericarditis has not yet been established, non-steroidal anti-inflammatory drugs (NSAIDs) are the most common treatment for management of this condition, followed by corticosteroids, colchicine, immunosuppressive agents, immunoglobulins, and interleukin-1β receptor antagonists (e.g. anakinra). Herein, we report a case of recurrent pericarditis with pericardial effusion in a 5-year-old child who presented with fever and epigastric pain. He responded poorly to NSAIDs and corticosteroid therapy, but was successfully treated with colchicine.

Citations

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  • Anakinra in idiopathic recurrent pericarditis: a comprehensive case series and literature review
    Zeynep Toker Dincer, Sejla Karup, Erkin Yilmaz, Osman Corbali, Feyza Nur Azman, Melike Melikoglu, Serdal Ugurlu
    Zeitschrift für Rheumatologie.2024;[Epub]     CrossRef
  • Pediatric Pericarditis: Update
    Rida Shahid, Justin Jin, Kyle Hope, Hari Tunuguntla, Shahnawaz Amdani
    Current Cardiology Reports.2023;[Epub]     CrossRef
  • Effects of Systemic Steroid Administration on Recurrence of Pericardial Effusion in Pediatric Patients After Hematopoietic Stem Cell Transplantation
    Kieran Leong, Martha E. Heal, John L. Bass, Varun Aggarwal, Shanti Narasimhan, Ashish Gupta, Gurumurthy Hiremath
    Journal of Pediatric Hematology/Oncology.2020; 42(4): 256.     CrossRef
Acute left main coronary artery thrombosis as an initial presentation of systemic lupus erythematosus
Kang Un Choi, Ung Kim
Yeungnam Univ J Med. 2018;35(2):227-231.   Published online December 31, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.2.227
  • 4,803 View
  • 47 Download
AbstractAbstract PDF
Left main coronary artery (LMCA) thrombosis is rare and the cause should be determined. A previously healthy young man presented with severe chest pain and dyspnea. The electrocardiogram showed typical ST-segment elevation myocardial infarction with clinical instability. Emergency coronary angiography revealed complete LMCA occlusion by thrombosis. After reperfusion, the patient was admitted to the cardiac care unit. He was diagnosed with hemolytic anemia and tested positive for antinuclear antibodies. Systemic lupus erythematosus (SLE) and LMCA disease due to systemic thrombosis were diagnosed. Steroids were started and the patient was discharged without complications. We report this rare case of LMCA thrombosis as an initial presentation of SLE.
Ocular manifestations in a patient with de novo Fabry disease
You Hyun Lee, Kyu Young Shim, Sung Bae Park, Yu Cheol Kim
Yeungnam Univ J Med. 2018;35(2):232-235.   Published online December 31, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.2.232
  • 5,155 View
  • 85 Download
  • 1 Crossref
AbstractAbstract PDF
Fabry disease (FD) is an X-linked, recessively inherited, rare, progressive, disorder of glycosphingolipid metabolism affecting multiple organs resulting in organ dysfunction. It is rare to find only one FD affected subject with a de novo mutation. Here we report a case of a 41-year-old Asian male diagnosed with de novo FD. Comprehensive ophthalmological evaluation was performed using slit lamp, color fundus photography, optical coherence tomography, fluorescein angiography, and indocyanine green angiography. On slit lamp examination, cornea verticillata and slightly tortuous, and aneurysmal dilatation of inferior bulbar conjunctival vessels were observed. Other imaging modalities showed unremarkable findings. Cornea verticillata and inferior bulbar conjunctival vascular abnormalities may be detected earlier than other ocular abnormalities in de novo FDs like hereditary FDs.

Citations

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  • Implications of Corneal Refractive Surgery in Patients with Fabry Disease
    Majid Moshirfar, Nour Bundogji, Alyson N. Tukan, Yasmyne C. Ronquillo
    Ophthalmology and Therapy.2022; 11(3): 925.     CrossRef

JYMS : Journal of Yeungnam Medical Science