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Original article
- Surgery
- Diagnostic performance of F-18 FDG PET or PET/CT for detection of recurrent gastric cancer: a systematic review and meta-analysis
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Chang In Choi
, Jae Kyun Park, Tae Yong Jeon, Dae-Hwan Kim - J Yeungnam Med Sci. 2023;40(Suppl):S37-S46. Published online August 17, 2023
- DOI: https://doi.org/10.12701/jyms.2023.00220
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Abstract
PDF - Background
This systematic review and meta-analysis investigated the diagnostic performance of F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) or PET/computed tomography (PET/CT) for the detection of disease recurrence after curative resection of gastric cancer.
Methods
The PubMed and Embase databases, from the earliest available date of indexing through November 30, 2019, were searched for studies evaluating the diagnostic performance of F-18 FDG PET or PET/CT to detect recurrent disease after gastric cancer surgery.
Results
Across 17 studies (1,732 patients), the pooled sensitivity for F-18 FDG PET or PET/CT was 0.82 (95% confidence interval [CI], 0.74–0.88) with heterogeneity of I2=76.5 (p<0.001), and the specificity was 0.86 (95% CI, 0.78–0.91) with heterogeneity of I2=94.2 (p<0.001). Likelihood ratio (LR) tests gave an overall positive LR of 6.0 (95% CI, 3.6–9.7) and negative LR of 0.2 (95% CI, 0.14–0.31). The pooled diagnostic odds ratio was 29 (95% CI, 13–63). The summary receiver operating characteristic curve indicates that the area under the curve was 0.91 (95% CI, 0.88–0.93).
Conclusion
The current meta-analysis showed good sensitivity and specificity of F-18 FDG PET or PET/CT for detecting recurrent disease after curative resection of gastric cancer despite heterogeneity in ethnicity, recurrence rate, histology, and interpretation method. -
Citations
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- Personalized PET Imaging in Gastric Cancer: An Umbrella Review of Meta‐Analyses to Guide Radiopharmaceutical Selection and Clinical Indication
Aiganym Amrenova, Alma Shukirbekova, Sholpan Akhelova, Jamilya Assilbayeva, Andrey Gurin, Maira Ualieva, Bibigul Kaliyaskarova, Asset Sarsekeyev, Nadiar M. Mussin, Amin Tamadon, Swarbhanu Sarkar
International Journal of Biomedical Imaging.2026;[Epub] CrossRef - Follow-Up and Strategies After Curative Surgical Resection for Gastric Cancer
Seokin Kang
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2025; 25(4): 336. CrossRef
- Personalized PET Imaging in Gastric Cancer: An Umbrella Review of Meta‐Analyses to Guide Radiopharmaceutical Selection and Clinical Indication
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