Journal of Yeungnam Medical Science

Case Reports

Pulmonary and Respiratory Medicine
Lymphocytic interstitial pneumonia in a patient with Sjögren's syndrome.: Eun Hye Lee, Ji Eun Park, Eun Kyong Goag, Young Joo Kim, In Young Jung, Chi Young Kim, Young Mok Park, Jung Mo Lee, Moo Suk Park; Yeungnam Univ J Med. 2016;33(2):112-115. Published online December 31, 2016; DOI: https://doi.org/10.12701/yujm.2016.33.2.112

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Abstract PDF: Lymphocytic interstitial pneumonia (LIP) is a rare benign lymphoproliferative disorder characterized by diffuse infiltration of the pulmonary parenchymal interstitium by polyclonal lymphocytes and plasma cells. LIP has been associated with a variety of clinical conditions; such as connective tissue disorders and other immune system abnormalities. Treatment usually involves administration of corticosteroids and other immunosuppressants. We report on a 38-year-old female patient who complained of shortness of breath, dry mouth, and dry eyes for more than 1 month, and was positive for Raynaud's phenomenon. Based on surgical biopsy, she was diagnosed as having LIP accompanied by Sjögren's syndrome. The patient was treated with high-dose steroids followed by maintenance therapy for approximately 2 years, and her condition improved.

Pulmonary and Respiratory Medicine
A late onset solitary mediastinal cystic lymphangioma in a 66-year-old woman who underwent kidney transplantation.: Jung Mo Lee, Sang Hoon Lee, Youngmok Park, Chi Young Kim, Eun Kyoung Goag, Eun Hye Lee, Ji Eun Park, Chang Young Lee, Se Kyu Kim; Yeungnam Univ J Med. 2015;32(2):155-158. Published online December 31, 2015; DOI: https://doi.org/10.12701/yujm.2015.32.2.155

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Lymphangioma is a congenital abnormality of the lymphatic system detected primarily in early childhood. There are rare reports of mediastinal lymphangioma in older adults. We hereby report on a 66-year-old female patient who underwent kidney transplantation 20 years previously and who developed pathologically confirmed solitary mediastinal lymphangioma 1 year ago. Chest radiography showed a mediastinal nodule, which was not observed 2 year previously, therefore she was referred to the pulmonary division. She had no symptoms, and chest computed tomography demonstrated a 25-mm, well-defined, low-density nodule located at the anterior mediastinum. The size of the nodule had increased from 25 mm to 34 mm 1 year later, and it was completely resected via video-assisted thoracic surgery. The histological diagnosis was cystic lymphangioma. Therefore, we recommend that clinicians consider cystic lymphangioma as a possible diagnosis even in older patients with a mediastinal cystic mass that shows progressive enlargement.

Citations

Citations to this article as recorded by

Mediastinal Lymphangioma of the Adult: Case Report and Literature Review
Mihaela-Beatrice Tivadar, Amir-Andrei Sabha, Vasile Grigorie, Raluca Bobocea, Andrei-Cristian Bobocea
Clinics and Practice.2026; 16(8): 144. CrossRef

Original Article

Pharmacology, Drug Therapy, and Toxicology
Effect of Progesterone on COX-2 Expression and Proliferation of Prostate Stromal Cell.: Soo Ryun Jung, Sung Han Kim, E Hwa Choi, Ji Eun Park, Eun Mi Jeon, Young Jin Kang, Kwang Youn Lee, Hyoung Chul Choi; Yeungnam Univ J Med. 2006;23(1):62-70. Published online June 30, 2006; DOI: https://doi.org/10.12701/yujm.2006.23.1.62

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Abstract PDF: BACKGROUND
Benign prostatic hyperplasia (BPH) is the most common benign tumor in older men; the etiology of this disease remains poorly understood. Testosterone and dihydrotestosterone (DHT) both act as androgen via a single androgen receptor. Testosterone is converted to DHT by 5alpha-reductase in prostatic stromal cells. Progesterone has been reported to inhibit DHT conversion; howevwe, its effect on prostatic stromal cells remains to be elucidated. MATERILAS AND METHODS: In this experiment, we investigated the effect of progesterone on androgen receptor expression induced by DHT. We also tested the effect of progesterone on cyclooxygenase-2 (COX-2) expression, as well as prostate stromal cell proliferation using the cell count kit-8. RESULTS: Progesterone did not cause an increase of prostate stromal cell proliferation. The mRNA expression of the androgen receptor and COX-2 were not changed by progesterone; the expressions of androgen receptor and COX-2 proteins were decreased by progesterone in prostate stromal cells. CONCLUSION: These results suggest that in prostate stromal cells, progesterone decreases androgen receptor protein expression, which results in decrement of COX-2 protein expression. This effect might be mediated by post-transcriptional regulation.

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