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Case report
- Hematology
- Estrogen-secreting adrenocortical carcinoma
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You Jeong
, Sung Chul Cho, Hee Joon Cho, Ji Soo Song, Joon Seog Kong, Jong Wook Park, Yun Hyi Ku - Yeungnam Univ J Med. 2019;36(1):54-58. Published online December 20, 2018
- DOI: https://doi.org/10.12701/yujm.2019.00017
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Abstract
PDF - Adrenocortical carcinoma is a rare type of endocrine malignancy with an annual incidence of approximately 1–2 cases per million. The majority of these tumors secrete cortisol, and a few secrete aldosterone or androgen. Estrogen-secreting adrenocortical carcinomas are extremely rare, irrespective of the secretion status of other adrenocortical hormones. Here, we report the case of a 53-year-old man with a cortisol and estrogen-secreting adrenocortical carcinoma. The patient presented with gynecomastia and abdominal discomfort. Radiological assessment revealed a tumor measuring 21×15.3×12 cm localized to the retroperitoneum. A hormonal evaluation revealed increased levels of estradiol, dehydroepiandrosterone sulfate, and cortisol. The patient underwent a right adrenalectomy, and the pathological examination revealed an adrenocortical carcinoma with a Weiss’ score of 6. After surgery, he was treated with adjuvant radiotherapy. Twenty-one months after treatment, the patient remains alive with no evidence of recurrence.
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Citations
Citations to this article as recorded by
- Feminizing Adrenocortical Carcinoma in Men: A Rare Cause of Persistent Gynecomastia and a Contemporary Literature Review
Ana Maria Arnautu, Diana Loreta Paun, Corina Neamtu, Costin Gingu, Victor Nimigean, Dana-Mihaela Tilici, Ruxandra Costinescu, Mirona Costea, Adina Onofrei, Beatrice Grecu, Claudia Nacea-Radu, Sorin Paun
Epidemiologia.2025; 6(4): 64. CrossRef - Gynecomastia in a Man With Adrenal Mass
Jasmine Saini, Patrick Navin, Michael Rivera, Irina Bancos
JCEM Case Reports.2023;[Epub] CrossRef - Adrenocortical Carcinoma: Updates of Clinical and Pathological Features after Renewed World Health Organisation Classification and Pathology Staging
Alfred King-yin Lam
Biomedicines.2021; 9(2): 175. CrossRef
- Feminizing Adrenocortical Carcinoma in Men: A Rare Cause of Persistent Gynecomastia and a Contemporary Literature Review
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