Journal of Yeungnam Medical Science

Review article

Optogenetic neuromodulation with gamma oscillation as a new strategy for Alzheimer disease: a narrative review: Haneol Ko, Sang-Pil Yoon; J Yeungnam Med Sci. 2022;39(4):269-277. Published online February 14, 2022; DOI: https://doi.org/10.12701/jyms.2021.01683

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The amyloid hypothesis has been considered a major explanation of the pathogenesis of Alzheimer disease. However, failure of phase III clinical trials with anti-amyloid-beta monoclonal antibodies reveals the need for other therapeutic approaches to treat Alzheimer disease. Compared to its relatively short history, optogenetics has developed considerably. The expression of microbial opsins in cells using genetic engineering allows specific control of cell signals or molecules. The application of optogenetics to Alzheimer disease research or clinical approaches is increasing. When applied with gamma entrainment, optogenetic neuromodulation can improve Alzheimer disease symptoms. Although safety problems exist with optogenetics such as the use of viral vectors, this technique has great potential for use in Alzheimer disease. In this paper, we review the historical applications of optogenetic neuromodulation with gamma entrainment to investigate the mechanisms involved in Alzheimer disease and potential therapeutic strategies.

Citations

Citations to this article as recorded by

Modulating Proteasome Function with Polyphenol Metabolites: A Promising Therapeutic Avenue for Alzheimer's Disease
Nyerovwo Charity Okei
European Journal of Medical and Health Research.2024; 2(2): 16. CrossRef
A comprehensive review of optical fiber technologies in optogenetics and their prospective developments in future clinical therapies
Siyu Chen, Zhuo Wang, Kun Xiao, Benzhao He, Jing Zhao, Xin Yang, Qingqing Liu, Anuj K. Sharma, Arnaldo Leal Junior, Rui Min
Optics & Laser Technology.2024; 179: 111332. CrossRef
Non-Invasive Brain Sensing Technologies for Modulation of Neurological Disorders
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Daily Dynamics of Resting-State Electroencephalographic Theta and Gamma Fluctuations Are Associated With Cognitive Performance in Healthy Aging
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The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences.2024;[Epub] CrossRef
Exogenous AMPA downregulates gamma-frequency network oscillation in CA3 of rat hippocampal slices
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Scientific Reports.2023;[Epub] CrossRef
Light-Controlled Modulation and Analysis of Neuronal Functions
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International Journal of Molecular Sciences.2022; 23(21): 12921. CrossRef

Case report

Incidentally found cystic lymphangioma of the adrenal gland in an elderly male cadaver: Hee Cheol Kim, Yunji Kang, Young Hee Maeng, Jinu Kim, Sang-Pil Yoon; Yeungnam Univ J Med. 2019;36(3):265-268. Published online July 16, 2019; DOI: https://doi.org/10.12701/yujm.2019.00262

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Abstract PDF: Adrenal cystic lymphangiomas are extremely rare entities that are often identified incidentally, with less than 60 cases reported to date. We found a protruding ovoid mass consisting of a multiloculated cystic lesion within right adrenal gland in the cadaver of a 75-year-old Korean man. The epithelial cells lining the adrenal cyst were diffusely positive for cluster of differentiation 31 and podoplanin, and negative for pan-cytokeratin. The histopathological diagnosis confirmed a cystic lymphangioma arising from the adrenal gland. Post-mortem findings of the present case are discussed based on the clinicopathological features of adrenal cystic lymphangiomas.

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