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Original article
- Thoracic and Cardiovascular Surgery
- Surgical results of only antegrade del Nido cardioplegia infusion in conventional coronary artery bypass grafting: a retrospective study
- Sang-Uk Park, Yo Han Bae, Yun Seok Kim, Kyungsub Song, Woo Sung Jang
- J Yeungnam Med Sci. 2023;40(Suppl):S23-S28. Published online June 28, 2023
- DOI: https://doi.org/10.12701/jyms.2023.00283
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- 1 Web of Science
- 2 Crossref
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Abstract
PDF - Background
Additional retrograde cardioplegia infusion in conventional coronary artery bypass grafting (CABG) was introduced to address the concern of inappropriate cardioplegia delivery through the stenotic coronary artery. However, this method is complex and requires repeated infusions. Therefore, we investigated the surgical outcomes of only antegrade cardioplegia infusion in conventional CABG.
Methods
We included 224 patients who underwent isolated CABG between 2017 and 2019. The patients were divided into two groups according to the cardioplegia infusion method: antegrade cardioplegia infusion with del Nido solution (n=111, group I) and antegrade+retrograde cardioplegia infusion with blood cardioplegia solution (n=113, group II).
Results
The sinus recovery time after release of the aorta cross-clamp was shorter in group I (3.8±7.1 minutes, n=98) than in group II (5.8±4.1 minutes, n=73) (p=0.033). The total cardioplegia infusion volume was lower in group I (1,998.6±668.6 mL) than in group II (7,321.0±2,865.3 mL) (p<0.001). Creatine kinase-MB levels were significantly lower in group I than in group II (p=0.039). Newly developed regional wall motion abnormalities on follow-up echocardiography were detected in two patients (1.8%) in group I and five patients (4.4%) in group II (p=0.233). There was no significant difference in ejection fraction improvement between the two groups (3.3%±9.3% in group I and 3.3%±8.7% in group II, p=0.990).
Conclusion
The only antegrade cardioplegia infusion strategy in conventional CABG is safe and has no harmful effects. -
Citations
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- Effect of del Nido Cardioplegia on Isolated Coronary Artery Bypass Grafting: A Study-level Meta-analysis
Yoshiyuki Yamashita, Massimo Baudo, Dimitrios E. Magouliotis, Serge Sicouri, Marry Ann C. Wertan, Danielle D. Spragan, Gianluca Torregrossa, Basel Ramlawi, Francis P. Sutter
Journal of Cardiothoracic and Vascular Anesthesia.2025;[Epub] CrossRef - Del Nido versus conventional blood cardioplegia in patients with combined aortic root surgery: A retrospective study
Yingshan Huang, Xiangni Zhu, Jichang Kong, Ling Zhang, Wenting Gui, Jiao Wang, Yunling Yang, Yan Xie, Dongmei Wang, Xinyue Li, Long Zhou, Yi Song, Xiaoqi Wang
Perfusion.2024;[Epub] CrossRef
- Effect of del Nido Cardioplegia on Isolated Coronary Artery Bypass Grafting: A Study-level Meta-analysis
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