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JYMS : Journal of Yeungnam Medical Science

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1 "Shin-Woo Kim"
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Does oral doxycycline treatment affect eradication of urine vancomycin-resistant Enterococcus? A tertiary hospital study
Yoonjung Kim, Sohyun Bae, Soyoon Hwang, Ki Tae Kwon, Hyun-Ha Chang, Su-Jeong Kim, Han-Ki Park, Jong-Myung Lee, Shin-Woo Kim
Yeungnam Univ J Med. 2020;37(2):112-121.   Published online February 18, 2020
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  • 3 Crossref
AbstractAbstract PDFSupplementary Material
Vancomycin-resistant Enterococcus (VRE) has become more common in nosocomial infections, especially in urine samples. However, until now, no treatment regimen has been proven to effectively eradicate urine VRE colonization. Therefore, to evaluate the efficacy of doxycycline in eradicating urine VRE and shortening VRE isolation period, we compared VRE colony detection period between doxycycline-treated and untreated patients.
A retrospective cohort study of 83 patients with VRE colonization in urine cultures was conducted at a tertiary academic hospital from January 2011 to February 2018. Kaplan-Meier survival analysis was used to evaluate eradication rates in the treatment and non-treatment groups. Factors affecting urine VRE colonization persistence were analyzed by multiple logistic regression analysis.
The overall rate of VRE eradication during the entire hospital stay was higher in the doxycycline treatment group (90.5%) than in the non-treatment group (58.1%, p=0.014). Survival analysis showed that the 5-, 10-, and 20-day cumulative eradication rates were 78.3%, 100%, and 100% in the doxycycline treatment group, and 18.5%, 45.7%, and 67.8% in the non-treatment group, respectively, thereby indicating that eradication rates were higher in the doxycycline treatment group than in the non-treatment group (p<0.001). Only doxycycline treatment was shown to affect urine VRE colonization persistence in multivariate logistic regression analysis
Doxycycline treatment enhanced the eradication rate of urine VRE colonization and appeared to be useful in shortening VRE isolation period.


Citations to this article as recorded by  
  • Therapeutics for Vancomycin-Resistant Enterococcal Bloodstream Infections
    Kelly A. Cairns, Andrew A. Udy, Trisha N. Peel, Iain J. Abbott, Michael J. Dooley, Anton Y. Peleg
    Clinical Microbiology Reviews.2023;[Epub]     CrossRef
  • Aminopenicillins for treatment of ampicillin-resistant enterococcal urinary tract infections
    Kristen Bunnell, Amy Duong, Thomas Ringsred, Asia Mian, Sanaya Bhathena
    American Journal of Health-System Pharmacy.2022; 79(13): 1056.     CrossRef
  • Doxycycline for ESBL-E Cystitis
    Tomasz Jodlowski, Charles R Ashby, Sarath G Nath
    Clinical Infectious Diseases.2021; 73(1): e274.     CrossRef

JYMS : Journal of Yeungnam Medical Science