The global obesity epidemic and the growing elderly population largely contribute to the increasing incidence of type 2 diabetes. Insulin resistance acts as a critical link between the present obesity pandemic and type 2 diabetes. Naturally occurring reactive oxygen species (ROS) regulate intracellular signaling and are kept in balance by the antioxidant system. However, the imbalance between ROS production and antioxidant capacity causes ROS accumulation and induces oxidative stress. Oxidative stress interrupts insulin-mediated intracellular signaling pathways, as supported by studies involving genetic modification of antioxidant enzymes in experimental rodents. In addition, a close association between oxidative stress and insulin resistance has been reported in numerous human studies. However, the controversial results with the use of antioxidants in type 2 diabetes raise the question of whether oxidative stress plays a critical role in insulin resistance. In this review article, we discuss the relevance of oxidative stress to insulin resistance based on genetically modified animal models and human trials.
Citations
Citations to this article as recorded by
Effect of substitution of wheat flour with chickpea flour on their physico-chemical characteristics Jiwan S. Sidhu, Tasleem Zafar, Abdulwahab Almusallam, Muslim Ali, Amani Al-Othman Arab Gulf Journal of Scientific Research.2024; 42(2): 290. CrossRef
Mulberry polyphenols restored both small and large intestinal microflora indb/dbmice, potentially alleviating type 2 diabetes Fuhua Li, Jian Ming Food & Function.2024; 15(16): 8521. CrossRef
Effects of Purified Vitexin and Iso-Vitexin from Mung Bean Seed Coat on Antihyperglycemic Activity and Gut Microbiota in Overweight Individuals’ Modulation Pornlada Yutharaksanukul, Preuk Tangpromphan, Paiboon Tunsagool, Sudathip Sae-tan, Sunee Nitisinprasert, Surasawadee Somnuk, Massalin Nakphaichit, Nut Pusuntisumpun, Bandhita Wanikorn Nutrients.2024; 16(17): 3017. CrossRef
The positive implication of natural antioxidants on oxidative stress-mediated diabetes mellitus complications Shouvik Mallik, Bijoy Paria, Sayed Mohammad Firdous, Hesham S. Ghazzawy, Nashi K. Alqahtani, Yong He, Xiaoli Li, Mostafa M. Gouda Journal of Genetic Engineering and Biotechnology.2024; 22(4): 100424. CrossRef
Maternal dietary antioxidant supplementation regulates weaned piglets’ adipose tissue transcriptome and morphology Hernán D. Laviano, Gerardo Gómez, Yolanda Núñez, Juan M. García-Casco, Rita M. Benítez, Ana de las Heras-Molina, Fernando Gómez, Fernando Sánchez-Esquiliche, Beatriz Martínez-Fernández, Antonio González-Bulnes, Ana I. Rey, Clemente J. López-Bote, María Mu PLOS ONE.2024; 19(9): e0310399. CrossRef
Oxidised phosphatidylcholine induces sarcolemmal ceramide accumulation and insulin resistance in skeletal muscle Karin A. Zemski Berry, Amanda Garfield, Purevsuren Jambal, Simona Zarini, Leigh Perreault, Bryan C. Bergman Diabetologia.2024; 67(12): 2819. CrossRef
Mitochondrial Dysfunction as a Factor of Energy Metabolism Disorders in Type 2 Diabetes Mellitus Alexander Blagov, Ludmila Nedosugova, Tatiana Kirichenko, Vasily Sukhorukov, Alexandra Melnichenko, Alexander Orekhov Frontiers in Bioscience-Scholar.2024;[Epub] CrossRef
The consumption of date palm fruits as a source of bioactive compounds in patients with type 2 diabetes: a cross sectional study M.Q. Al-Mssallem Acta Horticulturae.2023; (1371): 381. CrossRef
Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies Mani Raj Chaudhary, Sakshi Chaudhary, Yogita Sharma, Thokchom Arjun Singh, Alok Kumar Mishra, Shweta Sharma, Mohammad Murtaza Mehdi Biogerontology.2023; 24(5): 609. CrossRef
Development and Characterization of Oxidatively Responsive Thiol–Ene Networks for Bone Graft Applications Tyler Touchet, Samuel Briggs, Lance Graul, Duncan J. Maitland ACS Applied Bio Materials.2022; 5(6): 2633. CrossRef
Prevalence of Sarcopenia and Its Association With Diabetes: A Meta-Analysis of Community-Dwelling Asian Population Seung Min Chung, Jun Sung Moon, Min Cheol Chang Frontiers in Medicine.2021;[Epub] CrossRef
Association of Prx4, Total Oxidant Status, and Inflammatory Factors with Insulin Resistance in Polycystic Ovary Syndrome Sahar Mazloomi, Nasrin Sheikh, Marzieh Sanoee Farimani, Shamim Pilehvari, Raffaele Pezzani International Journal of Endocrinology.2021; 2021: 1. CrossRef
Plants Secondary Metabolites as Blood Glucose-Lowering Molecules Mayadah Bashir Shehadeh, Ghadeer A. R. Y. Suaifan, Ala’ Mustafa Abu-Odeh Molecules.2021; 26(14): 4333. CrossRef
An Epidemiological Study Report on the Antioxidant and Phenolic Content of Selected Mediterranean Functional Foods, Their Consumption Association with the Body Mass Index, and Consumers Purchasing Behavior in a Sample of Healthy Greek Adults Aikaterini Kandyliari, Ioannis-Nektarios Elmaliklis, Olga Kontopoulou, Marianna Tsafkopoulou, Georgios Komninos, Christina Ntzatha, Andreas Petsas, Haralabos C. Karantonis, Antonios E. Koutelidakis Applied Sciences.2021; 11(17): 7818. CrossRef
Sterculia tragacantha Lindl Leaf Extract Ameliorates STZ-Induced Diabetes, Oxidative Stress, Inflammation and Neuronal Impairment Amos Sunday Onikanni, Bashir Lawal, Augustine O Olusola, Janet O Olugbodi, Saidu Sani, Basiru Olaitan Ajiboye, Omotayo B Ilesanmi, Mohammed Alqarni, Gomaa Mostafa-Hedeab, Ahmad J Obaidullah, Gaber El-Saber Batiha, Alexander TH Wu Journal of Inflammation Research.2021; Volume 14: 6749. CrossRef
Methionine sulfoxide reductase B3 deficiency inhibits the development of diet-induced insulin resistance in mice Hye-Na Cha, Chang-Hoon Woo, Hwa-Young Kim, So-Young Park Redox Biology.2020; : 101823. CrossRef
Secondary systemic (AA) amyloidosis is a severe complication of progressed Crohn disease (CD) characterized by the deposition of amyloid A in body organs and tissues. Various therapeutic approaches have been recommended, however there is still no effective treatment. Recently, several case reports have demonstrated the effects of anti-tumor necrosis factor-alpha therapy in patients with AA amyloidosis associated with CD. We report on a 35-year-old female patient with CD complicated by AA amyloidosis in the gastrointestinal tract and renal involvement, who was treated with infliximab. The infliximab therapy improved the gastrointestinal symptoms and decreased the serum creatinine.