Journal of Yeungnam Medical Science

Case report

Metachronous extranodal natural killer/T-cell lymphoma of nasal type and primary testicular lymphoma: Young-In Maeng, Sun-Jae Lee; Yeungnam Univ J Med. 2021;38(3):231-234. Published online September 11, 2020; DOI: https://doi.org/10.12701/yujm.2020.00675

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We report a rare case of metachronous lymphoma with two distinct cell lineages in a 75-year-old man. The patient complained about having nasal obstruction for 2 years and extranodal natural killer (NK)/T-cell lymphoma of the nasal type was diagnosed from a biopsy. The immunohistochemical staining for CD56 and in situ hybridization for Epstein-Barr virus (EBV)–encoded small RNA (EBER-ISH) were positive and the tumor cells were negative for CD20. After 13 months of concurrent chemoradiotherapy, the patient presented with swelling of the left testis. Positron emission tomography scan detected an abnormal uptake in the testis. A diffuse large B-cell lymphoma, not otherwise specified, was diagnosed from subsequent radical orchiectomy. The immunohistochemical staining revealed to be positive for CD20, BCL2, BCL6, and MYC and negative for CD10 and EBER-ISH.

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Extranodal natural killer/T cell lymphoma nasal type simulating osteoradionecrosis with metachronic B lymphoma in the pelvis: Case report
Frida S. Colín-Guadarrama, Violeta E. Flores-Solano, Argelia Berenice-Rodríguez, Víctor H. Toral-Rizo
Indian Journal of Pathology and Microbiology.2024; 67(1): 162. CrossRef
What Effect Does Epstein-Barr Virus Have on Extranodal Natural Killer/T-Cell Lymphoma Prognosis? A Review of 153 Reported Cases
Erika Tvedten, Jordan Richardson, Kiran Motaparthi
Cureus.2021;[Epub] CrossRef

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