Journal of Yeungnam Medical Science

Case Reports

Pathology and Forensic Medicine
Glandular papilloma of the lung with malignant transformation: Woo Jung Sung; Yeungnam Univ J Med. 2017;34(2):298-302. Published online December 31, 2017; DOI: https://doi.org/10.12701/yujm.2017.34.2.298

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Glandular papilloma of the lung is one of three histologic types of solitary endobronchial papillomas. It is known as an uncommon benign neoplasm. No malignant glandular papillomas have been reported. Herein, the first case of granular papilloma with malignant transformation is reported. A 74-year-old man with huge right lung mass extended upper and lower lobe was admitted to the hospital complaining of progressive cough and dyspnea. An open lung biopsy was performed. Microscopically, the tumor showed papillary growth pattern with thick fibrovascular cores. The stroma of the fibrovascular cores shown the infiltration of lymphoplasmacytic cells and proliferation of capillaries. The epithelial cells surrounding the papillary fronds were cilliated columnar cells with focal cellar atypia, and frequent mitoses. Suspicious pleural invasion foci were identified. The Ki-67 labeling index was about 24.3% and p53 labeling index was about 31.7%. Glandular papilloma is known as a benign neoplasm, which is lack of atypia and mitosis. In present case, there were several indications of malignant transformation, such as cellular atypia, frequent mitosis, architectural distortion, and pleural invasion. Pathologists must be aware that glandular papilloma can have a changes of malignant transformation. Further studies about disease behavior and molecular characteristics are needed.

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Glanduläres Papillom im linken Hauptbronchus – eine extrem seltene bronchoskopische Diagnose
Constantin Blanke-Roeser, Christoph Petermann, Keith Koreuber, Wera Weisser, Gunther H. Wiest
Onkologische Welt.2026; 17(03): 186. CrossRef
Glanduläres Papillom im linken Hauptbronchus – eine extrem seltene bronchoskopische Diagnose
Constantin Blanke-Roeser, Christoph Petermann, Keith Koreuber, Wera Weisser, Gunther H. Wiest
Pneumologie.2025; 79(12): 971. CrossRef
Adenocarcinoma-Papillary Cystic Pattern Arising in a Mixed Squamous and Glandular Papilloma of the Lung
Ae Ri An, Seung Yong Park, Jong Hun Kim, Kum Ju Chae, Myoung Ja Chung
International Journal of Surgical Pathology.2020; 28(6): 658. CrossRef

Hematology
Relapsed plasmacytoma in central nervous system after complete remission of extramedullary plasmacytoma.: Sun Mi Kang, Seong Gyu Kim, Ji Ho Seo, Ji Yoon Kim, Woo Jung Sung, Sung Hwa Bae, Hun Mo Ryoo; Yeungnam Univ J Med. 2014;31(1):43-47. Published online June 30, 2014; DOI: https://doi.org/10.12701/yujm.2014.31.1.43

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Abstract PDF: Extramedullary plasmacytoma (EMP) is a rare disease that occurs in 3% to 5% of patients with plasma cell disorder. It occurs most commonly in the upper respiratory tract and the oral cavity. Very few EMP cases have been reported in the central nervous system (CNS). We report herein an unusual case of EMP in the nasal cavity that recurred in the CNS without systemic involvement. A 67-year-old man visited our hospital due to a month-long bout with exophthalmos. He was diagnosed with EMP in the nasal cavity, paranasal sinus, and orbital cavity. He received radiotherapy to which he had complete responses. After 2 years, he visited our hospital because of a month-long headache. He was diagnosed with EMP recurrence in the CNS via brain magnetic resonance imaging and cerebrospinal fluid analysis. He was treated with whole brain radiotherapy and intrathecal chemotherapy with methotrexate, but he expired due to pneumonia.

Pathology and Forensic Medicine
Angiomatoid Fibrous Histiocytoma: A Case Report.: Joon Hyuk Choi, Woo Jung Sung, Nam Hyuk Lee; Yeungnam Univ J Med. 2007;24(2):315-321. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2.315

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Angiomatoid fibrous histiocytoma is a rare soft tissue tumor that generally affects children and young adults. We report a case of angiomatoid fibrous histiocytoma in an 11-year-old boy who complained of a back mass for 3 years. Surgical excision was performed. The excised specimen showed a 4.0 x 3.6 x 3.0 cm, well circumscribed, grayish white tumor, with multicystic changes. Histological examination showed proliferation of spindle or round shaped tumor cells. There was a dense fibrous pseudocapsule with prominent chronic inflammatory cell infiltrates.

Citations

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Imaging of childhood angiomatoid fibrous histiocytoma with pathological correlation
Ali Yikilmaz, Bo-Yee Ngan, Oscar M. Navarro
Pediatric Radiology.2015; 45(12): 1796. CrossRef

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