Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune paraneoplastic syndrome associated with ovarian teratomas. Most patients develop neurologic symptoms, including psychosis, memory deficits, seizures, or abnormal movements, and experience abdominal pain related to ovarian neoplasm. We present a case report of three patients diagnosed with anti-NMDAR encephalitis accompanied by ovarian teratomas at Ajou University Hospital in Korea. The patients demonstrated a different clinical course of the disease. However, upon diagnosis, all patients underwent surgical removal of the ovarian teratoma followed by intensive immunotherapy. The symptoms progressively improved following treatment. This is a case report of a rare autoimmune anti-NMDAR encephalitis associated with ovarian neoplasms, including immature teratoma.
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Patterns of Neuropsychiatric Manifestations of Ovarian Teratomas: A Systematic Review of Case Reports Gaelle Umutoni Mihigo, Luigjina Uljic, Jasrina Kaushal, Shannia Amoah, Kudrat Jha, Ayodeji Jolayemi Cureus.2024;[Epub] CrossRef
Ovarian teratoma-associated Anti-NMDAR encephalitis in women with first-time neuropsychiatric symptoms: A meta-analysis and systematic review of reported cases Weronika Banach, Paulina Banach, Hanna Szweda, Andrzej Wiśniewski, Mirosław Andrusiewicz, Igor Gurynowicz, Wioletta K. Szepieniec, Paweł Szymanowski Heliyon.2024; 10(19): e36042. CrossRef
Association of ovarian teratoma with anti-N-methyl-D-aspartate receptor encephalitis: a case report and narrative review Konrad Joseph, Sarah van der Hock, Ishith Seth, Nipuni Hapangama, Lara Gibson, Roberto Cuomo, Warren M. Rozen, Nita Dhupar Archives of Gynecology and Obstetrics.2024;[Epub] CrossRef
To investigate the effect of bile acid on gastric mucosa, we performed biologic test using Sprague-Dawley rat. Mixture solution of TDCA 15mM and Hcl of pH 3 was given into stomach to one group and HCl of pH 3 was given into stomach to another group. The significant gastric mucosal change was vasodilation and edema, that was disappeared progressively. These findings suggest the bile acid and damage gastric mucosa.