Journal of Yeungnam Medical Science

Original article

Endocrinology, Diabetes, and Metabolism
Adult height in girls with central precocious puberty without gonadotropin-releasing hormone agonist treatment: a retrospective case-control study: Hyun Ji Jang, Min Jung Kwak, Young Mi Kim, Soo-Han Choi, Kyung Hee Park, Hye Won Yoo, Su Jeong Park, Yoon Hee Jo, Ha Young Jo; J Yeungnam Med Sci. 2023;40(Suppl):S81-S86. Published online November 7, 2023; DOI: https://doi.org/10.12701/jyms.2023.00801

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Background
The primary aim of this study was to investigate the final adult height (FAH) of girls diagnosed with central precocious puberty (CPP) who were untreated.
Methods
We retrospectively analyzed the medical records of 36 girls diagnosed with CPP between 8 and 9 years of age who did not receive treatment, and 206 girls diagnosed with CPP within the same age range who received gonadotropin-releasing hormone (GnRH) agonist treatment. Midparental height (MPH), predicted adult height (PAH) obtained using height and bone age (BA) at the time of diagnosis (PAH for BA), and PAH obtained using the Bayley-Pinneau method (PAH by BP) were calculated. Additionally, height at the time of growth completion was compared with the predicted height.
Results
The FAHs were 160.71±4.56 cm in the untreated group and 159.31±4.26 cm in the treated group. In the untreated group, the FAH was 0.99±4.50 cm shorter than the MPH but 4.29±3.33 cm and 3.46±3.93 cm greater than the PAH for BA and PAH by BP, respectively.
Conclusion
In children diagnosed with CPP between 8 and 9 years of age who were untreated, FAH was greater than PAH for BA and PAH by BP at the time of diagnosis, indicating that the prognosis of FAH was not poor. Therefore, for girls diagnosed with CPP, it is recommended to consider various conditions, such as pubertal onset, height at diagnosis, BA, peak luteinizing hormone level, predicted height, and speed of puberty, when deciding whether to administer GnRH agonists.

Citations

Citations to this article as recorded by

Height benefits after GnRHa treatment in girls aged over 6 years with central precocious puberty: a meta-analysis
Ming Chen, Jie-yu Sun, Xing Ji, Ming-ming Ni
Endocrine.2025; 89(3): 686. CrossRef
Comparison of Methods Used for Final Height Prediction in Central Precocious Puberty Patients
Nisa Nur Turan, Aşan Önder Çamaş, Burçin Çiçek, Merve Nur Hepokur, Hamdi Cihan Emeksiz
Journal of Clinical Research in Pediatric Endocrinology.2025;[Epub] CrossRef
LONG TERM CONSEQUENCES OF PRECOCIOUS PUBERTY - EXPLORING HEALTH, METABOLIC, AND PSYCHIATRIC CHALLENGES
Justyna Popczyńska, Agnieszka Raczyńska, Natalia Pacocha, Oliwia Krzemień, Kinga Kosiec, Jakub Jędrychowski, Natalia Karpowicz, Julia Kaszucka, Małgorzata Krzyżanowska, Marta Zgierska
International Journal of Innovative Technologies in Social Science.2024;[Epub] CrossRef

Case Reports

Pulmonary and Respiratory Medicine
A Case of Severe Enterovirus Pneumonia in an Immunocompetent Adult.: Dong Won Lee, Eun Young Choi; Yeungnam Univ J Med. 2013;30(1):58-61. Published online June 30, 2013; DOI: https://doi.org/10.12701/yujm.2013.30.1.58

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Abstract PDF: Enterovirus commonly causes neurologic diseases (aseptic meningitis, encephalitis, etc.), hand-foot-mouth disease, herpangina, and acute hemorrhagic conjunctivitis. However, it rarely causes pneumonia in immunocompetent adults. In Korea, no case has been reported about pneumonia caused by enterovirus in healthy adults. We can cite the case of a 20-year-old woman who presented severe community-acquired pneumonia caused by enterovirus. The diagnosis was based on reverse transcriptase polymerase chain reaction (RT-PCR) of a respiratory specimen.

Hematology
A Case of Cytomegalovirus Colitis in Chronic Adult T-Cell Leukemia/Lymphoma.: Han Seung Park, Dae Young Kim, Ji Beom Kim, Yun Ku Kim, Min Soo Cho, Tae Jin Ok, Sun Joo Jang, Kyoo Hyung Lee; Yeungnam Univ J Med. 2011;28(2):187-191. Published online December 31, 2011; DOI: https://doi.org/10.12701/yujm.2011.28.2.187

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Abstract PDF: Adult T-cell leukemia/lymphoma (ATLL) is a malignancy of mature T-cells caused by the human T-cell lymphotrophic virus type I (HTLV-I). HTLV-I is endemic in some areas in Japan, the Caribbean basin, and Africa but has low prevalence in South Korea. Patients with ATLL are susceptible to opportunistic infections such as cytomegalovirus (CMV) infection, but CMV infection in chronic ATLL is uncommon. Reported herein is a case involving a 44-year-old woman with chronic ATLL who presented the symptoms of fever and diarrhea. She was suspected to have acute-type ATLL but was later diagnosed with CMV colitis.

Reumatology
A Case of Systemic Lupus Erythematosus Misdiagnosed as Adult-onset Still's Disease.: Myung Jin Oh, Hyun Je Kim, Han Sol Lee, Ji An Hur, Young Hoon Hong, Choong Ki Lee; Yeungnam Univ J Med. 2010;27(1):78-84. Published online June 30, 2010; DOI: https://doi.org/10.12701/yujm.2010.27.1.78

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Abstract PDF: Adult-onset Still's disease (AOSD) is an inflammatory disorder that's characterized by daily, spiking high fever, arthritis and an evanescent, salmon-pink rash. AOSD is diagnosed purely on the basis of the typical clinical features of the illness. The symptoms commonly include swelling of the lymph nodes, enlargement of the spleen and liver, and a sore throat. AOSD is difficult to differentiate from systemic lupus erythematosus (SLE) due to the similar clinical manifestations. We report here on a case of a 16-year-old female patient with autism and epilepsy and who complained of daily spiking fever for 20 days. The patient had maculopapular skin rashes on the face and whole body and lymphadenopathy. The liver function tests were elevated mildly. The initial rheumatoid factor (RF) and antinuclear antibody (ANA) tests were negative. We diagnosed her as having adult-onset Still's disease according to the criteria of Yamaguchi. We successfully treated her with oral prednisolone. But her antinuclear antibody test was changed to positive after discharge. So we finally diagnosed her as having SLE.

Original Articles

Urology
Clinical Outcome of Ureteropelvic Junction Obstruction in the Pediatric and Adult Population.: Phill Hyun Song, Sang Taek Kwon, Ji Hyun Yeo, Yong Hoon Park, Ki Hak Moon; Yeungnam Univ J Med. 2004;21(1):67-73. Published online June 30, 2004; DOI: https://doi.org/10.12701/yujm.2004.21.1.67

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Abstract PDF: BACKGROUND
A ureteropelvic junction (UPJ) obstruction is a congenital anomaly commonly afflicting the pediatric population. However, it occurs more frequently in adults than is generally appreciated. To assess their characteristics, we have here compared and analyzed the clinical manifestations, causes, and outcomes of UPJ obstruction found in children and adults. MATERIALS AND METHODS: 102 patients (118 renal units) out of 182 patients (218 renal units), with diagnosed UPJ obstruction, were available for follow up. The follow-ups were retrospectively reviewed to determine the presenting symptoms, treatments, and clinical outcomes. Patients who were younger than 18 years of age were assigned to the pediatric group (44 patients), others the adult group (58 patents). RESULTS: The majority of the patients presented with flank pain (pediatric group: 68%, adult group: 76%). The majority of patients underwent a pyeloplasty (pediatric group: 50.9%, adult group: 62.3%). And the major cause of the UPJ obstruction was an intrinsic stenosis (pediatric group: 53%, adult group: 56%). CONCLUSION: The prevalence of bilateral UPJ obstruction in adults is evidently less prevalent than in pediatrics, and despite the late diagnosis, the surgical outcome is similar. A further investigation of UPJ obstruction will lead us to a more comprehensive understanding of the disease.

Cardiology and Cardiovascular Medicine
Comparision of signal - averaged electrocardiography (SAECG) determined by flank lead system (FLS) and pyramidal lead system (PLS) in healthy young adults.: Byeong Ik Jang, Seung Ho Kang, Hyeung Il Kim, Dong Gu Sin, Young Jo Kim, Bong Sup Shim, Hyun Woo Lee; Yeungnam Univ J Med. 1993;10(1):179-189. Published online June 30, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.1.179

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Abstract PDF: It has recently become possible to record electrical activity originationg from abnormally conducting myocardium from the body surface with high-gain amplification and averaging technique. These signals, which result from delayed ventricular activation(late potentials), have been recorded in patients with documented ventricular tachyarrythmia. Several electrode lead system for detecting ventricular late potential were introduced. Pyramidal electrode lead system(PLS) is useful. Also interpretation of SAECG in the young could be of value in detecting those at risk for episodic ventricular tachycardia, but suffer from a lack of data in normal young people. There was no difference between normal values, determined by FLS and PLS at high pass filtering of 25 Hz and 80 Hz, but significant, difference was found in HFLAD and RMS-40 of 40 Hz (p<0.05). These results will provide a basis for interpretations of SAECG, determined by FLS and PLS in healthy young adults with normal QRS duration. SELECTION OF SUBJECTS: For this study, normal healthy young adult volunteers (age : mean 24 years) were recruited from the medical students at Yeungnam University Hospital, Internal Medicine. Twenty fourths male and seventeenths female subjects were selected. All subjects had normal resting ECGs as judged from both the standard 12 channel lead and echocardiography, and none had a history of cardiovascular disease. All subjects were considered to be in good general physical condition. SIGNAL-AVERAGED ELECTROCARDIOGRAPHY: In order to obtain low noise recordings with a small number of averaging cycles, all subject ware asked to relax completely in the supine position. Silver/silver chloride electrodes were attached after the skin was cleaned with alcohol, to constitute classic flank lead system(FLS) and pyramidal lead system(PLS). Signals were recorded and processed using a commercially available microprocessor-augmented ECG cart(Marquette Electronics, USA) suitable for portable bedside recording.

Hematology
Hematological reference values in the healthy adults.: Young Jin Kim, Myung Soo Hyun, Hyun Woo Lee; Yeungnam Univ J Med. 1991;8(1):154-165. Published online June 30, 1991; DOI: https://doi.org/10.12701/yujm.1991.8.1.154

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Abstract PDF: To establish the hematological reference values in the healthy adults visited our hospitals, following examination were done on 2823 persons by Coulter Counter Model S-plus II ; white blood cell count (WBC), red blood cell count (RBC), hemoglobin (Hb), hematocrit (Hct), meant corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), platelet, plateletcrit, mean platelet volume (MPV) and platelet distribution width (PDW). The following results are obtained. 1) Male, mean value of WBC; 6,800±2,680 (2SD)/µl Female, mean value of WBC; 5,950±2,380 (2SD)/µl 2) Male, mean value of RBC; 428±60 (2SD)x104/µl Female, mean value of RBC; 415±56 (2SD)x104/µl 3) Male, mean value of Hb; 15.4±1.8 (2SD) g/dL Female, mean value of Hb; 13.0±1.6 (2SD) g/dL 4) Male, mean value of Hct; 45.3±5.0 (2SD)% Female, mean value of Hct; 38.2±4.6 (2SD)% 5) Male, mean value of MCV; 93.8±5.8 (2SD) fL Female, mean value of MCV; 92.2±7.4 (2SD) fL 6) Male, mean value of MCH; 31.8±2.2 (2SD) pg Female, mean value of MCH; 31.4±2.8 (2SD) pg 7) Male, mean value of MCHC; 34.0±1.2 (2SD)% Female, mean value of MCHC; 33.9±1.2 (2SD)% 8) Male, mean value of RDW; 12.7±1.0 (2SD)% Female, mean value of RDW; 12.6±1.4 (2SD)% 9) Male, mean value of Platelet; 242.9±87.8 (2SD) X103/µl Female, mean value of Platelet; 242.2±89.0 (2SD) X103/µl 10) Male, mean value of Plateletcrit; 0.201±0.076 (2SD)% Female, mean value of Plateletcrit; 0.204±0.076 (2SD)% 11) Male, mean value of MPV; 8.20±1.70 (2SD) fl Female, mean value of MPV; 8.36±1.82 (2SD) fl 12) Male, mean value of PDW; 16.1±0.8 (2SD)% Female, mean value of PDW; 16.0±0.8 (2SD)%

Dentistry
Roentgenographic Cephalometric Study for Normal Occlusion in Korean Adults According to the Ricketts Analysis.: Byung Rho Chin; Yeungnam Univ J Med. 1990;7(2):131-139. Published online December 31, 1990; DOI: https://doi.org/10.12701/yujm.1990.7.2.131

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Abstract PDF: The purpose of this study was to assess the skeletal characteristics of the maxillofacial norms and the interpretation of craniofacial relations in Korean adults by applying the Ricketts Analysis. The factors of the applied lateral cephalometric measurements were composed of the 10 factor analysis (Summary Analysis) and 7 internal structures to be suggested by Ricketts. Lateral cephalograms were obtained from 60 subjects over 21 years old that consisted of 30 males and 30 females with normal occlusion, acceptable profile. The results were as follow: 1. The tables of means, standard deviations in each item and sex were made. 2. The author performed whether there was significance (P<0.05) between the registered male and female's measurement in each item.

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