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JYMS : Journal of Yeungnam Medical Science

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3 "Biomarkers"
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Prognostic impact of chromogranin A in patients with acute heart failure
Hong Nyun Kim, Dong Heon Yang, Bo Eun Park, Yoon Jung Park, Hyeon Jeong Kim, Se Yong Jang, Myung Hwan Bae, Jang Hoon Lee, Hun Sik Park, Yongkeun Cho, Shung Chull Chae
Yeungnam Univ J Med. 2021;38(4):337-343.   Published online July 8, 2021
DOI: https://doi.org/10.12701/yujm.2020.00843
  • 4,296 View
  • 76 Download
  • 2 Crossref
AbstractAbstract PDFSupplementary Material
Background
Chromogranin A (CgA) levels have been reported to predict mortality in patients with heart failure. However, information on the prognostic value and clinical availability of CgA is limited. We compared the prognostic value of CgA to that of previously proven natriuretic peptide biomarkers in patients with acute heart failure.
Methods
We retrospectively evaluated 272 patients (mean age, 68.5±15.6 years; 62.9% male) who underwent CgA test in the acute stage of heart failure hospitalization between June 2017 and June 2018. The median follow-up period was 348 days. Prognosis was assessed using the composite events of 1-year death and heart failure hospitalization.
Results
In-hospital mortality rate during index admission was 7.0% (n=19). During the 1-year follow-up, a composite event rate was observed in 12.1% (n=33) of the patients. The areas under the receiver-operating characteristic curves for predicting 1-year adverse events were 0.737 and 0.697 for N-terminal pro-B-type natriuretic peptide (NT-proBNP) and CgA, respectively. During follow-up, patients with high CgA levels (>158 pmol/L) had worse outcomes than those with low CgA levels (≤158 pmol/L) (85.2% vs. 58.6%, p<0.001). When stratifying the patients into four subgroups based on CgA and NT-proBNP levels, patients with high NT-proBNP and high CgA had the worst outcome. CgA had an incremental prognostic value when added to the combination of NT-proBNP and clinically relevant risk factors.
Conclusion
The prognostic power of CgA was comparable to that of NT-proBNP in patients with acute heart failure. The combination of CgA and NT-proBNP can improve prognosis prediction in these patients.

Citations

Citations to this article as recorded by  
  • The Role of Congestion Biomarkers in Heart Failure with Reduced Ejection Fraction
    Michele Correale, Francesco Fioretti, Lucia Tricarico, Francesca Croella, Natale Daniele Brunetti, Riccardo M. Inciardi, Anna Vittoria Mattioli, Savina Nodari
    Journal of Clinical Medicine.2023; 12(11): 3834.     CrossRef
  • Novel Biomarkers of Renal Dysfunction and Congestion in Heart Failure
    Agata Zdanowicz, Szymon Urban, Barbara Ponikowska, Gracjan Iwanek, Robert Zymliński, Piotr Ponikowski, Jan Biegus
    Journal of Personalized Medicine.2022; 12(6): 898.     CrossRef
Usefulness of presepsin in predicting the prognosis of patients with sepsis or septic shock: a retrospective cohort study
Jeong Suk Koh, Yoon Joo Kim, Da Hyun Kang, Jeong Eun Lee, Song-I Lee
Yeungnam Univ J Med. 2021;38(4):318-325.   Published online June 15, 2021
DOI: https://doi.org/10.12701/yujm.2021.01018
  • 5,745 View
  • 135 Download
  • 6 Crossref
AbstractAbstract PDF
Background
The diagnosis and prediction of prognosis are important in patients with sepsis, and presepsin is helpful. In this study, we aimed to examine the usefulness of presepsin in predicting the prognosis of sepsis in Korea.
Methods
Patients diagnosed with sepsis according to the sepsis-3 criteria were recruited into the study and classified into surviving and non-surviving groups based on in-hospital mortality. A total of 153 patients (33 and 121 patients with sepsis and septic shock, respectively) were included from July 2019 to August 2020.
Results
Among the 153 patients with sepsis, 91 and 62 were in the survivor and non-survivor groups, respectively. Presepsin (p=0.004) and lactate (p=0.003) levels and the sequential organ failure assessment (SOFA) scores (p<0.001) were higher in the non-survivor group. Receiver operating characteristic curve analysis revealed poor performances of presepsin and lactate in predicting the prognosis of sepsis (presepsin: area under the curve [AUC]=0.656, p=0.001; lactate: AUC=0.646, p=0.003). The SOFA score showed the best performance, with the highest AUC value (AUC=0.751, p<0.001). The prognostic cutoff point for presepsin was 1,176 pg/mL. Presepsin levels of >1,176 pg/mL (odds ratio [OR], 3.352; p<0.001), lactate levels (OR, 1.203; p=0.003), and SOFA score (OR, 1.249; p<0.001) were risk factors for in-hospital mortality.
Conclusion
Presepsin levels were higher in non-survivors than in survivors. Thus, presepsin may be a valuable biomarker in predicting the prognosis of sepsis.

Citations

Citations to this article as recorded by  
  • Free Radical–Associated Gene Signature Predicts Survival in Sepsis Patients
    Anlin Feng, Marissa D. Pokharel, Ying Liang, Wenli Ma, Saurabh Aggarwal, Stephen M. Black, Ting Wang
    International Journal of Molecular Sciences.2024; 25(8): 4574.     CrossRef
  • Presepsin in Critical Illness: Current Knowledge and Future Perspectives
    Paolo Formenti, Miriam Gotti, Francesca Palmieri, Stefano Pastori, Vincenzo Roccaforte, Alessandro Menozzi, Andrea Galimberti, Michele Umbrello, Giovanni Sabbatini, Angelo Pezzi
    Diagnostics.2024; 14(12): 1311.     CrossRef
  • Diagnostic and Prognostic Roles of C-Reactive Protein, Procalcitonin, and Presepsin in Acute Kidney Injury Patients Initiating Continuous Renal Replacement Therapy
    Suyeon Han, Moo-Jun Kim, Ho-Joon Ko, Eu-Jin Lee, Hae-Ri Kim, Jae-Wan Jeon, Young-Rok Ham, Ki-Ryang Na, Kang-Wook Lee, Song-I. Lee, Dae-Eun Choi, Heyrim Park
    Diagnostics.2023; 13(4): 777.     CrossRef
  • Existe Relação entre Miocardite Aguda e a Permeabilidade Intestinal? Dois Biomarcadores nos Ajudam a Responder a esta Pergunta
    Fernando Arturo Effio Solis, Adriana Brentegani, Marcelo Luiz Campos Vieira
    Arquivos Brasileiros de Cardiologia.2023;[Epub]     CrossRef
  • Biomarkers in sepsis-looking for the Holy Grail or chasing a mirage!
    Neelmani Ahuja, Anjali Mishra, Ruchi Gupta, Sumit Ray
    World Journal of Critical Care Medicine.2023; 12(4): 188.     CrossRef
  • Presepsin as a Novel Biomarker in predicting In‐hospital Mortality in Patients With COVID‐19 Pneumonia
    Hebatallah Hany Assal, Safaa Mohamed Abdelrahman, Maha AlyAlden Abdelbasset, Mai Abdelaziz, Irene Mohamed Sabry, Marwa Moawad Shaban
    International Journal of Infectious Diseases.2022; 118: 155.     CrossRef
Significance of albumin to globulin ratio as a predictor of febrile urinary tract infection after ureteroscopic lithotripsy
Seung Yun Yi, Dong Jin Park, Kyungchan Min, Jae-Wook Chung, Yun-Sok Ha, Bum Soo Kim, Hyun Tae Kim, Tae-Hwan Kim, Eun Sang Yoo
Yeungnam Univ J Med. 2021;38(3):225-230.   Published online April 20, 2021
DOI: https://doi.org/10.12701/yujm.2021.00955
  • 4,502 View
  • 62 Download
  • 4 Crossref
AbstractAbstract PDF
Background
We aimed to analyze the effectiveness of albumin to globulin ratio (AGR) in predicting postoperative febrile urinary tract infection (fUTI) after ureteroscopic lithotripsy (URS) and retrograde intrarenal surgery (RIRS).
Methods
From January 2013 to May 2018, 332 patients underwent URS and RIRS. The rate of postoperative fUTI and risk factors for postoperative fUTI were analyzed using logistic regression. Patients were divided into postoperative fUTI and non-postoperative fUTI (non-fUTI) groups. AGR with other demographic and perioperative data were compared between the two groups to predict the development of fUTI after URS.
Results
Of the 332 patients, postoperative fUTI occurred in 41 (12.3%). Preoperative pyuria, microscopic hematuria, diabetes mellitus, hypoalbuminemia, and hyperglobulinemia were more prevalent in the fUTI group. Patients in the fUTI group had larger stone size, lower preoperative AGR, longer operation time, and longer preoperative antibiotic coverage period. In a multivariable logistic analysis, preoperative pyuria, AGR, and stone size were independently correlated with postoperative fUTI (p<0.001, p=0.008, and p=0.041, respectively). Receiver operating curve analysis showed that the cutoff value of AGR that could predict a high risk of fUTI after URS was 1.437 (sensitivity, 77.3%; specificity, 76.9%), while the cutoff value of stone size was 8.5 mm (sensitivity, 55.3%; specificity, 44.7%).
Conclusion
This study demonstrated that preoperative pyuria, AGR, and stone size can serve as prognostic factors for predicting fUTI after URS.

Citations

Citations to this article as recorded by  
  • Common hematological and biochemical parameters for predicting urinary tract infections in geriatric patients with hip fractures
    Wanyun Tang, Wei Yao, Wei Wang, Qiaomei Lv, Wenbo Ding, RenJian He
    Frontiers in Medicine.2024;[Epub]     CrossRef
  • An analysis of bacteriuria rates after endourological procedures
    Nethravathy Billava Seenappa, Maneesh Sinha, Thyagaraj Krishna Prasad, Venkatesh Krishnamoorthy
    International Journal of Urological Nursing.2023; 17(1): 45.     CrossRef
  • Nutritional and Inflammatory Indices and the Risk of Surgical Site Infection After Fragility Hip Fractures: Can Routine Blood Test Point to Patients at Risk?
    Tal Frenkel Rutenberg, Rana Gabarin, Vitali Kilimnik, Efrat Daglan, Moti Iflah, Shani Zach, Shai Shemesh
    Surgical Infections.2023; 24(7): 645.     CrossRef
  • Prognostic value of albumin-to-globulin ratio in COVID-19 patients: A systematic review and meta-analysis
    Juan R. Ulloque-Badaracco, Melany D. Mosquera-Rojas, Enrique A. Hernandez-Bustamante, Esteban A. Alarcón-Braga, Percy Herrera-Añazco, Vicente A. Benites-Zapata
    Heliyon.2022; 8(5): e09457.     CrossRef

JYMS : Journal of Yeungnam Medical Science