Journal of Yeungnam Medical Science

Review

The Cytokines: An Overview.: Hee Sun Kim; Yeungnam Univ J Med. 2010;27(1):1-7. Published online June 30, 2010; DOI: https://doi.org/10.12701/yujm.2010.27.1.1

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Having an understanding of the properties of cytokines is essential for the immunologist, the researcher and the medical practitioner who need to understand immunologic diseases and immunological therapeutic approaches. Cytokines are redundant in their actions on target cells and promiscuous in their receptor reactions. (ED note: That is some cool use of English!) Moreover, many cells concomitantly produce several cytokines that have overlapping actions. Here this review provides conceptual framework to understand the intriguing aspects of the cytokine system.

Citations

Citations to this article as recorded by

Modulatory Effects of Herbal Medicines Extracts on Cytokine Release in Immune Response of RAW 264.7 and TK-1
Su-kyoung Bae, Se-hee Cho, Tae-kyu Ahn, Jee-in Kim, Bong-hyun Kim, Jae-hwan Lim
The Journal of Internal Korean Medicine.2018; 39(6): 1244. CrossRef
Anti-inflammatory Effect of Angelicae acutilobae Radix Water Extract on LPS-stimulated Mouse Macrophages
Hyo-Sang Han
The Korea Journal of Herbology.2013; 28(6): 129. CrossRef

Original Article

The Analysis of the Cytokine Expression in Musculoskeletal Tumors.: Joon Han Lee, Eun Seok Kwak, Oog Jin Shon, Hee Sun Kim, Duk Seop Shin; Yeungnam Univ J Med. 2003;20(2):187-196. Published online December 31, 2003; DOI: https://doi.org/10.12701/yujm.2003.20.2.187

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Abstract PDF: The cytokines are the hormone-like proteins, which are produced in the mononuclear cells. They have many roles, such as immune mediators, cell differentiations, angiogenesis. The chemokines have chemotactic effects which control the host immune response. There were few reports about the cytokines associated with musculoskeletal tumors. From late 1980s, the cytokine studies of bone tumors such as osteosarcoma were started, but most studies for benign and malignant musculoskeletal tumors were left to be explored. To evaluate the characteristics of the cytokines in variable musculoskeletal tumors, tissues were obtained from the seven patients who visited the Yeungnam University hospital from February to July 2000. They were lipoma (1 case), parosteal osteoma (1 case), enchondroma (2 cases), pigmented villonodular synovitis (1 case), ganglion (1 case), and metastaic squamous cell carcinoma (1 case). The gene experession of the cytokines were analyzed by RNase protection assay (RPA) and reverse transcription-polymerase chain reaction (RT-PCR). The lipoma and parosteal osteoma expressed MIP-1beta, and IP-10 genes. The two enchondromas showed different results, one expressed all of MIP-1alpha, MIP-1beta and IP-10 genes but the other expressed none of above. The pigmented villonodular synovitis strongly expressed MIP-1alpha and IP-10 when compared with the other cases. The ganglion did not express all of the chemokines mentioned above. And the metastatic squamous cell carcinoma expressed all of the chemokines and especially IP-10 was highly expressed. Even though this study has only a few cases, these results provide a basis for the cytokine mediating network study in musculoskeletal tumors.

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