Journal of Yeungnam Medical Science

Original articles

Endocrinology, Diabetes, and Metabolism
Association between perirenal fat tissue thickness and subclinical atherosclerosis in patients newly diagnosed with type 2 diabetes: a cross-sectional study: Işıl Isel, Mehmet Karagulle, Turgut Karabag; J Yeungnam Med Sci. 2026;43:10. Published online January 6, 2026; DOI: https://doi.org/10.12701/jyms.2026.43.10

730 View
61 Download

Abstract PDF: Background
Perirenal fat is an important endocrine organ that produces and secretes bioactive cytokines and adipokines involved in the pathogenesis of cardiovascular diseases. The association of perirenal and pararenal fat tissue thickness (PPRFT) with subclinical atherosclerosis and myocardial function in patients with newly diagnosed type 2 diabetes mellitus (ND-T2DM) was investigated in this study.
Methods
The study included 111 patients with ND-T2DM (59 males; mean age, 49.7±9.6 years) and 57 individuals without any disease diagnosis as the control group (23 males; mean age, 48.5±7.2 years). PPRFT and carotid intima-media thickness (CIMT) were measured using ultrasonography. Conventional parameters, including epicardial fat tissue (EFT) thickness, were measured using transthoracic echocardiography and myocardial velocities were measured using tissue Doppler echocardiography.
Results
CIMT, EFT thickness, and PPRFT were higher in patients with ND-T2DM than in controls (p<0.001). While the E/A ratio was significantly lower in patients with ND-T2DM than in controls (p<0.001), the E wave deceleration time, and E/E′ septal and lateral ratios were significantly higher in the former (p<0.001, p<0.001, and p=0.002, respectively). PPRFT values were significantly correlated with CIMT and EFT thickness (ρ=0.490, ρ=0.517; p<0.001 and ρ=0.588, ρ=0.574; p<0.001, respectively) and negatively correlated with ejection fraction and mitral E/A ratio (ρ=–0.549, ρ=–0.530; p<0.001 and ρ=–0.512, ρ=–0.465; p<0.001, respectively).
Conclusion
PPRFT values measured using ultrasonography in patients with ND-T2DM are significantly associated with CIMT and EFT, which are indicators of subclinical atherosclerosis.

Endocrinology, Diabetes, and Metabolism
Experiences of healthcare providers and patients with diabetes mellitus regarding continuous glucose monitoring use in South Korea: a multicenter, cross-sectional survey study: Young-Jin Choi, Jung-Hwa Lee, Kyu-Jeung Ahn, Ho-Yeon Chung, Ji Eun Jun, You-Cheol Hwang, Hyuk-Sang Kwon, Young Na, Jae-Hyeon Kim, Kang-Hee Sim, Kun-Ho Yoon, Bok-Rye Song, In-Kyung Jeong; J Yeungnam Med Sci. 2025;42:60. Published online September 26, 2025; DOI: https://doi.org/10.12701/jyms.2025.42.60

1,626 View
105 Download

Abstract PDF Supplementary Material: Background
Despite the increasing use of continuous glucose monitoring (CGM) systems, limited data exist on their perceived benefits and challenges among patients and healthcare providers. This study explored CGM-related experiences in South Korea.
Methods
An anonymous online survey was conducted between January and December 2021 at four university hospitals. Respondents included patients with diabetes mellitus (DM), physicians, and DM education nurses. The survey assessed the use of CGM, its benefits, and barriers. Most devices were first-generation CGMs: FreeStyle Libre 1 (Abbott Diabetes Care), Dexcom G6 (Dexcom Inc.), and Medtronic Guardian 3 (Medtronic MiniMed).
Results
Among 1,010 patients (33.4% with type 1 DM [T1DM], 63.6% with type 2 DM [T2DM], and 3.1% others; mean age, 51.4±14.6 years), 92.7% found CGM helpful. Although 59.6% reported discomfort, 81.9% intended to continue using CGM, indicating that perceived benefits outweighed barriers. The key advantages were glucose monitoring without finger pricks (T1DM, 57.9%; T2DM, 56.2%) and maintenance of target glucose levels. Discomfort was related to discomfort during activities (53.8%), skin problems (45.0%), and pain (43.0%). Healthcare provider recommendations were associated with reduced discomfort (adjusted odds ratio, 0.36; 95% confidence interval, 0.21–0.60). Physicians (n=29) cited high costs as the main barrier (T1DM, 58.9%; T2DM, 64.8%); only 51.9% and 14.5% prescribed CGM for T1DM and T2DM, respectively. Insulin adjustment and glucose control were the main reasons for prescription, while cost (89.3%) and limited consultation time (67.9%) were barriers. DM educators (n=9) reported heavy workloads, with training and follow-up times averaging 31.7±7.5 minutes and 21.7±9.7 minutes, respectively; 77.8% of DM educators identified frequent patient inquiries as their greatest burden.
Conclusion
CGM provides significant clinical benefits but is limited by discomfort, costs, and educational burden. Sustained adoption requires device improvements, insurance support, and workforce expansion.

Nephrology
Effect of pitavastatin on erythrocyte membrane fatty acid content in patients with chronic kidney disease: two-arm parallel randomized controlled trial: Minna Kim, Seong Eun Kim, Su Mi Lee, Won Suk An; J Yeungnam Med Sci. 2024;41(3):188-195. Published online May 8, 2024; DOI: https://doi.org/10.12701/jyms.2024.00094

6,336 View
120 Download
1 Crossref

Abstract PDF Supplementary Material

Background
Statins reduce the risk of cardiovascular events in patients with chronic kidney disease (CKD). Although diabetes mellitus (DM) is a reported side effect of statin treatment, some studies have indicated that pitavastatin does not cause DM. The present study investigated the effect of pitavastatin on the fatty acid (FA) content of erythrocyte membranes, which affects the occurrence of DM and cardiovascular diseases. In addition, changes in adiponectin and glycated hemoglobin (HbA1c) levels were evaluated after pitavastatin treatment.
Methods
A total of 45 patients were enrolled, 28 of whom completed the study. Over 24 weeks, 16 patients received 2 mg pitavastatin and 12 patients received 10 mg atorvastatin. Dosages were adjusted after 12 weeks if additional lipid control was required. There were 10 and nine patients with DM in the pitavastatin and atorvastatin groups, respectively. Erythrocyte membrane FAs and adiponectin levels were measured using gas chromatography and enzyme-linked immunosorbent assay, respectively.
Results
In both groups, saturated FAs, palmitic acid, trans-oleic acid, total cholesterol, and low-density lipoprotein cholesterol levels were significantly lower than those at baseline. The arachidonic acid (AA) content in the erythrocyte membrane increased significantly in the pitavastatin group, but adiponectin levels were unaffected. HbA1c levels decreased in patients treated with pitavastatin. No adverse effects were associated with statin treatment.
Conclusion
Pitavastatin treatment in patients with CKD may improve glucose metabolism by altering erythrocyte membrane AA levels. In addition, pitavastatin did not adversely affect glucose control in patients with CKD and DM.

Citations

Citations to this article as recorded by

The use of hypolipidemic agents in patients with hyperuricemia on the background of type 2 diabetes mellitus and atherosclerosis
A. A. Mosina, Yu. A. Sorokina, L. V. Lovtsova, A. L. Urakov
Meditsinskiy sovet = Medical Council.2025; (6): 265. CrossRef

Focused Review articles

Orthopedics and Sports Medicine
Management of diabetic foot ulcers: a narrative review: Jahyung Kim, Otgonsaikhan Nomkhondorj, Chi Young An, Ye Chan Choi, Jaeho Cho; J Yeungnam Med Sci. 2023;40(4):335-342. Published online September 22, 2023; DOI: https://doi.org/10.12701/jyms.2023.00682

38,721 View
1,225 Download
13 Web of Science
15 Crossref

Abstract PDF

Diabetic foot ulcers (DFUs) are among the most serious complications of diabetes and are a source of reduced quality of life and financial burden for the people involved. For effective DFU management, an evidence-based treatment strategy that considers the patient's clinical context and wound condition is required. This treatment strategy should include conventional practices (surgical debridement, antibiotics, vascular assessment, offloading, and amputation) coordinated by interdisciplinary DFU experts. In addition, several adjuvant therapies can be considered for nonhealing wounds. In this narrative review, we aim to highlight the current trends in DFU management and review the up-to-date guidelines.

Citations

Citations to this article as recorded by

Clinical Efficacy of Type I Collagen Skin Substitutes Versus Human Amnion/Chorion in Treating Diabetic Foot Ulcers Using 55 Patient Randomized Controlled Independent Two Trials, One in India and the Other in the USA
Subramanian Gunasekaran
Biomedical Materials & Devices.2026; 4(1): 97. CrossRef
Advanced strategies for the management of patients with diabetic foot ulcers: a comprehensive review
Ji Min Kim, Chong Hwa Kim, Seon Mee Kang, Jung Hwa Jung, Ki Chun Kim, Sanghyun Ahn, Tae Sun Park, Ie Byung Park
The Korean Journal of Internal Medicine.2026; 41(1): 47. CrossRef
Thermosensitive chitosan hydrogel encapsulating exosomes inhibits NLRP3 activation to promote diabetic foot ulcer healing
Xinnan Song, Chenglin Sun, Fei Meng, Xiaohong Zhang, Lixin Yang
Materials & Design.2026; 263: 115561. CrossRef
Galectins: Role and Therapeutics in Diabetes and Diabetic Foot Ulcers
Alhasan Alobaidi, Rawan Al Judeid, Vikrant Rai
Biomolecules.2026; 16(2): 232. CrossRef
A feature explainability-based deep learning technique for diabetic foot ulcer identification
Pramod Singh Rathore, Abhishek Kumar, Amita Nandal, Arvind Dhaka, Arpit Kumar Sharma
Scientific Reports.2025;[Epub] CrossRef
The hidden impact: frailty and malnutrition in patients with diabetic foot ulcers
Levent Demir, Mustafa Avcı, Murat Kahraman, Selahattin Kılıç
Journal of Health Sciences and Medicine.2025; 8(2): 262. CrossRef
From Control to Cure: Insights into the Synergy of Glycemic and Antibiotic Management in Modulating the Severity and Outcomes of Diabetic Foot Ulcers
Idris Ajibola Omotosho, Noorasyikin Shamsuddin, Hasniza Zaman Huri, Wei Lim Chong, Inayat Ur Rehman
International Journal of Molecular Sciences.2025; 26(14): 6909. CrossRef
Mango ginger-derived exosome-like nanovesicles promotes diabetic wound healing via inducing the promigratory protein, follistatin-like 1.
Anaghapriya Suresh, Jahnavi Ravilla, Janakiraman Narayanan, Gopinath M. Sundaram
International Journal of Biological Macromolecules.2025; 322: 146991. CrossRef
Hydroxytyrosol from Olive Oil Mitigates Endothelial Dysfunction in Diabetic Foot Ulcers via Redox, Inflammatory, and Survival Pathways
Dhayalan Kalavathy GokulRaj, Ravichandran Jayasuriya, Kunka Mohanram Ramkumar
The Journal of Nutrition.2025; 155(12): 4149. CrossRef
Current therapeutic strategies in the management of diabetic foot ulcers
Aniket Gupta, Rishabh Chalotra, Kajal Sharma, Anjali Gupta, Shivani Chib, Rohini Agrawal, Thakur Gurjeet Singh, Randhir Singh
Tissue Barriers.2025;[Epub] CrossRef
Kick-Starting Wound Healing: A Review of Pro-Healing Drugs
Bethany L. Patenall, Kristyn A. Carter, Matthew R. Ramsey
International Journal of Molecular Sciences.2024; 25(2): 1304. CrossRef
Sequence analysis of microbiota in clinical human cases with diabetic foot ulcers from China
Ying Li, Li Zhang, Meifang He, Yuebin Zhao
Heliyon.2024; 10(14): e34368. CrossRef
The future of diabetic wound healing: unveiling the potential of mesenchymal stem cell and exosomes therapy
Sara Memarpour
American Journal of Stem Cells.2024; 13(2): 87. CrossRef
Etiopathophysiology, Novel and Advanced Therapy Options, Management and Care Plan to Prevent Lower Limb Amputations for Diabetic Foot Ulcer
Richa Dayaramani, Nipa Gandhi, Areeg Anwar Ali Shamsher, Nour Aymn Ahmad
Research Journal of Pharmacy and Technology.2024; : 5141. CrossRef
Unveiling the challenges of diabetic foot infections: diagnosis, pathogenesis, treatment, and rehabilitation
Chul Hyun Park
Journal of Yeungnam Medical Science.2023; 40(4): 319. CrossRef

Endocrinology, Diabetes, and Metabolism
Management and rehabilitation of moderate-to-severe diabetic foot infection: a narrative review: Chi Young An, Seung Lim Baek, Dong-Il Chun; J Yeungnam Med Sci. 2023;40(4):343-351. Published online September 19, 2023; DOI: https://doi.org/10.12701/jyms.2023.00717

14,840 View
255 Download
1 Web of Science
2 Crossref

Abstract PDF

Diabetic foot is one of the most devastating consequences of diabetes, resulting in amputation and possibly death. Therefore, early detection and vigorous treatment of infections in patients with diabetic foot are critical. This review seeks to provide guidelines for the therapy and rehabilitation of patients with moderate-to-severe diabetic foot. If a diabetic foot infection is suspected, bacterial cultures should be initially obtained. Numerous imaging studies can be used to identify diabetic foot, and recent research has shown that white blood cell single-photon emission computed tomography/computed tomography has comparable diagnostic specificity and sensitivity to magnetic resonance imaging. Surgery is performed when a diabetic foot ulcer is deep and is accompanied by bone and soft tissue infections. Patients should be taught preoperative rehabilitation before undergoing stressful surgery. During surgical procedures, it is critical to remove all necrotic tissue and drain the inflammatory area. It is critical to treat wounds with suitable dressings after surgery. Wet dressings promote the formation of granulation tissues and new blood vessels. Walking should begin as soon as the patient’s general condition allows it, regardless of the wound status or prior walking capacity. Adequate treatment of comorbidities, including hypertension and dyslipidemia, and smoking cessation are necessary. Additionally, broad-spectrum antibiotics are required to treat diabetic foot infections.

Citations

Citations to this article as recorded by

Therapeutic options and prognostic risk factors in diabetic foot osteomyelitis: a narrative review
Zi-Xian Liu, Mou-Zhang Huang, Ming-Cong Ding, Xin-Ping Ma, Nan Jiang
International Journal of Surgery.2026; 112(2): 4799. CrossRef
Unveiling the challenges of diabetic foot infections: diagnosis, pathogenesis, treatment, and rehabilitation
Chul Hyun Park
Journal of Yeungnam Medical Science.2023; 40(4): 319. CrossRef

Original article

Obstetrics, Gynecology, and Reproductive Medicine
Analysis of single nucleotide polymorphisms associated with the vitamin D pathway in the placentas of women with gestational diabetes mellitus: a laboratory study: Mi Ju Kim, Hyun Mi Kim, Hyun-Hwa Cha, Won Joon Seong; J Yeungnam Med Sci. 2023;40(Suppl):S9-S16. Published online May 8, 2023; DOI: https://doi.org/10.12701/jyms.2023.00150

4,818 View
86 Download
1 Web of Science
1 Crossref

Abstract PDF

Background
The aim of this study was to analyze the single nucleotide polymorphisms (SNPs) of genes known to be involved in vitamin D metabolism in the placenta using the placental tissue of mothers diagnosed with gestational diabetes mellitus (GDM) to determine whether the SNPs and occurrence of GDM are related.
Methods
We enrolled 80 women of the same gestational age, 40 with and 40 without GDM. The placenta was obtained from each woman after delivery and SNP genotyping was performed on seven SNPs in the CYP27B1 (rs10877012), CYP24A1 (rs2248359, rs6013897, and rs2209314), and GC (rs2282679, rs16847024, and rs3733359) genes. Maternal serum 25-hydroxyvitamin D levels were measured during the first trimester of pregnancy and before delivery.
Results
At the time of delivery, vitamin D levels were lower (21.05±12.05 mg/dL vs. 31.31±20.72 mg/dL, p=0.012) and the frequency of vitamin D deficiency was higher (60.7% vs. 32.5%, p=0.040) in the GDM group. In women with GDM, the G allele of rs10877012 was more common (86.3% vs. 65.0%, p=0.002). The rs10877012 GG genotype was more common in the GDM group (72.5% vs. 42.5%, p=0.007) and the rs10877012 TT genotype was more common in the control group (12.5% vs. 0%, p=0.007).
Conclusion
Mothers with GDM have lower serum concentrations of vitamin D before delivery than healthy controls and vitamin D deficiency is common. A polymorphism in CYP27B1 (rs10877012), is considered to be a cause of GDM pathogenesis.

Citations

Citations to this article as recorded by

Gestational diabetes mellitus affects the cross-talk among placental, maternal and umbilical cord vitamin D metabolites but fetal transfer is not compromised
Layla G. Ranquine, Deborah Bauer, Nathalia Zuniga, Brenda A. Nagagata, Gabriela D.A. Pinto, Carolina S. Ferreira, Vanessa A. Goes, Daniela B. Mucci, Lívia Belcastro, Fatima Sardinha, Claudio J. Struchiner, Alexandre G. Torres, Sarah R. Meadows, Kerry S. J
Placenta.2026; 173: 40. CrossRef

Communications

Endocrinology, Diabetes, and Metabolism
The art of diabetes care: guidelines for a holistic approach to human and social factors: Muhammad Jawad Hashim; J Yeungnam Med Sci. 2023;40(2):218-222. Published online November 11, 2022; DOI: https://doi.org/10.12701/jyms.2022.00577

5,014 View
115 Download
2 Web of Science

Abstract PDF: A holistic approach to diabetes considers patient preferences, emotional health, living conditions, and other contextual factors, in addition to medication selection. Human and social factors influence treatment adherence and clinical outcomes. Social issues, cost of care, out-of-pocket expenses, pill burden (number and frequency), and injectable drugs such as insulin, can affect adherence. Clinicians can ask about these contextual factors when discussing treatment options with patients. Patients’ emotional health can also affect diabetes self-care. Social stressors such as family issues may impair self-care behaviors. Diabetes can also lead to emotional stress. Diabetes distress correlates with worse glycemic control and lower overall well-being. Patient-centered communication can build the foundation of a trusting relationship with the clinician. Respect for patient preferences and fears can build trust. Relevant communication skills include asking open-ended questions, expressing empathy, active listening, and exploring the patient’s perspective. Glycemic goals must be personalized based on frailty, the risk of hypoglycemia, and healthy life expectancy. Lifestyle counseling requires a nonjudgmental approach and tactfulness. The art of diabetes care rests on clinicians perceiving a patient’s emotional state. Tailoring the level of advice and diabetes targets based on a patient’s personal and contextual factors requires mindfulness by clinicians.

Original articles

Nephrology
Association of advanced chronic kidney disease with diabetic retinopathy severity in older patients with diabetes: a retrospective cross-sectional study: Geun Woo Lee, Chul Ho Lee, Seong Gyu Kim; J Yeungnam Med Sci. 2023;40(2):146-155. Published online May 26, 2022; DOI: https://doi.org/10.12701/jyms.2022.00206

8,393 View
123 Download
4 Web of Science
7 Crossref

Abstract PDF

Background
Despite the recent increasing trend in the prevalence of type 2 diabetes among older individuals, the relationship between diabetic retinopathy (DR) and chronic kidney disease (CKD) in these patients remains unclear. This study investigated the severity of renal dysfunction according to the degree of DR in older patients with type 2 diabetes.
Methods
A total of 116 patients with diabetes and CKD stage ≥3 who visited both the nephrology and ophthalmology outpatient departments between July 2021 and January 2022 were screened. There were 53 patients in the no DR group, 20 in the nonproliferative DR (NPDR) group, and 43 in the proliferative DR (PDR) group.
Results
DR severity was related to the deterioration of renal function. The proportion of patients with advanced CKD significantly increased with DR severity (p for trend <0.001). In the multivariate regression model adjusted for age of ≥80 years, male sex, poorly controlled diabetes, macroalbuminuria, insulin use, diabetes duration of ≥10 years, cerebrovascular accident, hypertension, hyperlipidemia, and cardiovascular disease history, the odds ratio compared with the no DR group was approximately 4.6 for the NPDR group and approximately 11.8 for the PDR group, which were both statistically significant (p=0.025 and p<0.001, respectively).
Conclusion
DR severity in older patients with diabetes may be associated with deterioration of renal function and high prevalence of advanced CKD. Therefore, periodic examination for DR in older patients with diabetes is important for predicting renal function deterioration and CKD progression.

Citations

Citations to this article as recorded by

Development and validation of a model that predicts the risk of diabetic kidney disease in type 2 diabetes mellitus patients: a retrospective study
Zhiling Deng, Jian Yang, Hairong Zhou
Frontiers in Endocrinology.2026;[Epub] CrossRef
Association of Albumin‐To‐Creatinine Ratio With Diabetic Retinopathy Among US Adults (NHANES 2009–2016)
Han Dai, Ling Liu, Weiwei Xu
Endocrinology, Diabetes & Metabolism.2025;[Epub] CrossRef
Complications and Comorbidities in Individuals >80 Years with Diabetes: A Scoping Review
Christian Ward-Bradley, Adam Erwin, Tunde Peto, Laura N. Cushley, Katie Curran
Diabetology.2025; 6(12): 152. CrossRef
Diabetic Macular Edema Is Predictive of Renal Failure in Patients With Diabetes Mellitus and Chronic Kidney Disease
Shih-Hsiang Ou, Wei-Che Chang, Ling-Ying Wu, Shiow-Ing Wang, James Cheng-Chung Wei, Po-Tsang Lee
The Journal of Clinical Endocrinology & Metabolism.2024; 109(3): 761. CrossRef
Study on Correlation between Renal Function and Diabetic Retinopathy
卓越郑
Advances in Clinical Medicine.2024; 14(03): 513. CrossRef
Evaluating the potential of retinal photography in chronic kidney disease detection: a review
Nur Asyiqin Amir Hamzah, Wan Mimi Diyana Wan Zaki, Wan Haslina Wan Abdul Halim, Ruslinda Mustafar, Assyareefah Hudaibah Saad
PeerJ.2024; 12: e17786. CrossRef
The Pathophysiology and Vascular Complications of Diabetes in Chronic Kidney Disease: A Comprehensive Review
Wilhelmina N Hauwanga, Tibyan Y Abdalhamed , Lynda A Ezike, Ifeoma S Chukwulebe, Aung Ko Oo, Amal Wilfred, Abdul Rahman Anuz Khan A Khan, Johnny Chukwuwike, Edisond FLORIAL, Habeebah Lawan, Asaju Felix, Billy McBenedict
Cureus.2024;[Epub] CrossRef

Pediatrics, Perinatology, and Child Health
Increase in blood glucose level and incidence of diabetic ketoacidosis in children with type 1 diabetes mellitus in the Daegu-Gyeongbuk area during the coronavirus disease 2019 (COVID-19) pandemic: a retrospective cross-sectional study: Mi Seon Lee, Rosie Lee, Cheol Woo Ko, Jung Eun Moon; J Yeungnam Med Sci. 2022;39(1):46-52. Published online August 26, 2021; DOI: https://doi.org/10.12701/yujm.2021.01221

11,256 View
107 Download
11 Web of Science
14 Crossref

Abstract PDF

Background
The coronavirus disease 2019 (COVID-19) outbreak in the Daegu-Gyeongbuk area in 2020 has caused difficulties in the daily life and hospital care of children with type 1 diabetes mellitus (T1DM). We detected an increase in blood sugar levels in these children and the number of patients hospitalized with more severe diabetic ketoacidosis (DKA) compared to those before COVID-19.
Methods
This single-center study was conducted at Kyungpook National University Children’s Hospital. The following patient groups were included; 45 returning patients diagnosed with T1DM and undergoing insulin treatment for more than 2 years and 20 patients newly diagnosed with T1DM before and after COVID-19 were selected by age matching. Returning patients before and after the outbreak were selected, and changes in hemoglobin A1c (HbA1c) levels were retrospectively reviewed. The HbA1c levels and severity of symptoms in newly diagnosed patients during hospitalization were examined.
Results
HbA1c levels in returning patients with T1DM were significantly increased after COVID-19 (before, 7.70%±1.38% vs. after, 8.30%±2.05%; p=0.012). There were 10 and 10 newly diagnosed patients before and after COVID-19, respectively. The proportion of patients with drowsiness and dyspnea at the time of admission was higher after COVID-19 than before (before, 2 of 10 vs. after, 4 of 10). The HbA1c levels were higher in newly diagnosed patients hospitalized after COVID-19 than before (before, 11.15% vs. after, 13.60%; p=0.036).
Conclusion
Due to COVID-19 in the Daegu-Gyeongbuk area, there was an increase in blood glucose levels in children with T1DM and in the incidence of severe DKA in newly diagnosed diabetes mellitus patients.

Citations

Citations to this article as recorded by

Commentary on "Incidence rate and characteristics of newly diagnosed type 1 diabetes in a Vietnamese tertiary pediatric center: challenges in early detection"
Young Suk Shim
Annals of Pediatric Endocrinology & Metabolism.2025; 30(5): 227. CrossRef
Incidences of newly diagnosed childhood diabetes and onset severity: a multicenter regional study in Thailand over two decades and during the COVID-19 pandemic
Pattharaporn Sinthuprasith, Karn Wejaphikul, Dolrutai Puttawong, Hataitip Tang-Ngam, Naphatsorn Sanrattana, Kevalee Unachak, Prapai Dejkhamron
Journal of Pediatric Endocrinology and Metabolism.2024; 37(6): 487. CrossRef
COVID-19 infection and inactivated vaccination: Impacts on clinical and immunological profiles in Chinese children with type 1 diabetes
Zhen-Ran Xu, Li Xi, Jing Wu, Jin-Wen Ni, Fei-Hong Luo, Miao-Ying Zhang
World Journal of Diabetes.2024; 15(12): 2276. CrossRef
Incidence of diabetic ketoacidosis during COVID-19 pandemic: a meta-analysis of 124,597 children with diabetes
Anas Elgenidy, Ahmed K. Awad, Khaled Saad, Mostafa Atef, Hatem Helmy El-Leithy, Ahmed A. Obiedallah, Emad M. Hammad, Faisal-Alkhateeb Ahmad, Ahmad M. Ali, Hamad Ghaleb Dailah, Amira Elhoufey, Samaher Fathy Taha
Pediatric Research.2023; 93(5): 1149. CrossRef
Comments on Rahmati et al., The global impact of COVID‐19 pandemic on the incidence of pediatric new‐onset type 1 diabetes and ketoacidosis: A systematic review and meta‐analysis. J Med Virol. 2022; 1‐16 (doi: 10.1002/jmv.27996)
Joachim Rosenbauer, Anna Stahl‐Pehe, Sabrina Schlesinger, Oliver Kuß
Journal of Medical Virology.2023;[Epub] CrossRef
Impact of the COVID-19 Pandemic on Children and Adolescents with New-Onset Type 1 Diabetes
Clemens Kamrath, Alexander J. Eckert, Reinhard W. Holl, Joachim Rosenbauer, Andrea Scaramuzza
Pediatric Diabetes.2023; 2023: 1. CrossRef
Difficulties in differential diagnosis of carbohydrate metabolism disorders in patients with coronavirus infection in real clinical practice. Case report
Tatyana N. Markova, Mukhamed S. Stas, Valentina V. Chibisova, Anastasia A. Anchutina
Consilium Medicum.2023; 25(4): 241. CrossRef
Endocrinological Involvement in Children and Adolescents Affected by COVID-19: A Narrative Review
Valeria Calcaterra, Veronica Maria Tagi, Raffaella De Santis, Andrea Biuso, Silvia Taranto, Enza D’Auria, Gianvincenzo Zuccotti
Journal of Clinical Medicine.2023; 12(16): 5248. CrossRef
Glycemic control and complications of type 2 diabetes mellitus in children and adolescents during the COVID-19 outbreak
Kyeong Eun Oh, Yu Jin Kim, Ye Rim Oh, Eungu Kang, Hyo-Kyoung Nam, Young-Jun Rhie, Kee-Hyoung Lee
Annals of Pediatric Endocrinology & Metabolism.2023; 28(4): 275. CrossRef
Incidence of Diabetic Ketoacidosis Among Pediatrics With Type 1 Diabetes Prior to and During COVID-19 Pandemic: A Meta-Analysis of Observational Studies
Osamah M. Alfayez, Kholood S. Aldmasi, Nada H. Alruwais, Nouf M. Bin Awad, Majed S. Al Yami, Omar A. Almohammed, Abdulaali R. Almutairi
Frontiers in Endocrinology.2022;[Epub] CrossRef
Comparison of Initial Presentation of Pediatric Diabetes Before and During the Coronavirus Disease 2019 Pandemic Era
Yoonha Lee, Minseung Kim, Kyeongeun Oh, Eungu Kang, Young-Jun Rhie, Jieun Lee, Yong Hee Hong, Young-Lim Shin, Jae Hyun Kim
Journal of Korean Medical Science.2022;[Epub] CrossRef
The global impact of COVID‐19 pandemic on the incidence of pediatric new‐onset type 1 diabetes and ketoacidosis: A systematic review and meta‐analysis
Masoud Rahmati, Maryam Keshvari, Shahrzad Mirnasuri, Dong K. Yon, Seung W. Lee, Jae Il Shin, Lee Smith
Journal of Medical Virology.2022; 94(11): 5112. CrossRef
COVID-19 and diabetes: What do we know so far?
Prakash Gangadaran, Himabindu Padinjarathil, Shri Hari Subhashri Rajendran, Manasi P Jogalekar, Chae Moon Hong, Baladhandapani Aruchamy, Uma Maheswari Rajendran, Sridharan Gurunagarajan, Anand Krishnan, Prasanna Ramani, Kavimani Subramanian
Experimental Biology and Medicine.2022; 247(15): 1330. CrossRef
Stress hyperglycemia, Diabetes mellitus and COVID-19 infection: The impact on newly diagnosed type 1 diabetes
Ioanna Farakla, Theano Lagousi, Michael Miligkos, Nicolas C. Nicolaides, Ioannis-Anargyros Vasilakis, Maria Mpinou, Maria Dolianiti, Elina Katechaki, Anilia Taliou, Vasiliki Spoulou, Christina Kanaka-Gantenbein
Frontiers in Clinical Diabetes and Healthcare.2022;[Epub] CrossRef

Endocrinology, Diabetes, and Metabolism
Risk factors affecting amputation in diabetic foot: Jun Ho Lee, Ji Sung Yoon, Hyoung Woo Lee, Kyu Chang Won, Jun Sung Moon, Seung Min Chung, Yin Young Lee; Yeungnam Univ J Med. 2020;37(4):314-320. Published online May 6, 2020; DOI: https://doi.org/10.12701/yujm.2020.00129

11,460 View
256 Download
19 Crossref

Abstract PDF

Background
A diabetic foot is the most common cause of non-traumatic lower extremity amputations (LEA). The study seeks to assess the risk factors of amputation in patients with diabetic foot ulcers (DFU).
Methods
The study was conducted on 351 patients with DFUs from January 2010 to December 2018. Their demographic characteristics, disease history, laboratory data, ankle-brachial index, Wagner classification, osteomyelitis, sarcopenia index, and ulcer sizes were considered as variables to predict outcome. A chi-square test and multivariate logistic regression analysis were performed to test the relationship of the data gathered. Additionally, the subjects were divided into two groups based on their amputation surgery.
Results
Out of the 351 subjects, 170 required LEA. The mean age of the subjects was 61 years and the mean duration of diabetes was 15 years; there was no significant difference between the two groups in terms of these averages. Osteomyelitis (hazard ratio [HR], 6.164; 95% confidence interval [CI], 3.561−10.671), lesion on percutaneous transluminal angioplasty (HR, 2.494; 95% CI, 1.087−5.721), estimated glomerular filtration rate (eGFR; HR, 0.99; 95% CI, 0.981−0.999), ulcer size (HR, 1.247; 95% CI, 1.107−1.405), and forefoot ulcer location (HR, 2.475; 95% CI, 0.224−0.73) were associated with risk of amputation.
Conclusion
Osteomyelitis, peripheral artery disease, chronic kidney disease, ulcer size, and forefoot ulcer location were risk factors for amputation in diabetic foot patients. Further investigation would contribute to the establishment of a diabetic foot risk stratification system for Koreans, allowing for optimal individualized treatment.

Citations

Citations to this article as recorded by

Sarcopenia Influences Clinical Outcome in Hospitalized Patients with Peripheral Artery Disease Aged 75 Years and Older
Volker H. Schmitt, Lukas Hobohm, Christoph Brochhausen, Christine Espinola-Klein, Philipp Lurz, Thomas Münzel, Omar Hahad, Karsten Keller
Annals of Vascular Surgery.2025; 110: 54. CrossRef
THE PREVALENCE OF ANISOMELIA AND NEUROSENSORY IMPAIRMENT AS RISK FACTORS FOR TROPHIC ULCER FORMATION IN DIABETIC PATIENTS
Anna Ivanova, Oksana Melekhovets
Eastern Ukrainian Medical Journal.2025; 13(1): 130. CrossRef
A comprehensive approach to diabetic foot ulcers treatment in patients with anisomelia
A.S. Ivanova, O.K. Melekhovets, I.V. Melekhovets
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2025; 21(2): 140. CrossRef
Risk Factors for Amputation Among Patients with Diabetic Foot Disease in a Tertiary Hospital
Anna Colleen Rossi, Francis Pekdasen Solang, Isagani Garin
Philippine Journal of Orthopaedics.2025; 40(3): 36. CrossRef
Efficacy of Chinese and Western Medical Techniques in Treating Diabetic Foot Ulcers With Necrotizing Fasciitis of the Lower Leg
Yongchong Chen, Yunzhu Wang, TaiAn Zhang, Chao Meng, Qing Li, Bohui Zhang, Kai Zhang, Chunfang Qin
The International Journal of Lower Extremity Wounds.2024; 23(1): 70. CrossRef
Classification of foot ulcers in people with diabetes: A systematic review
Matilde Monteiro‐Soares, Emma J. Hamilton, David A. Russell, Gulapar Srisawasdi, Edward J. Boyko, Joseph L. Mills, William Jeffcoate, Fran Game
Diabetes/Metabolism Research and Reviews.2024;[Epub] CrossRef
Atherogenic markers and 1-year amputation risk in adults with diabetic foot in a tertiary level hospital: A retrospective cohort study
Jerry K. Benites-Meza, Jussara Malo-Castillo, Percy Herrera-Añazco, Vicente A. Benites-Zapata
Journal of Diabetes and its Complications.2024; 38(9): 108810. CrossRef
Lower extremity amputation rates in patients with chronic kidney disease: A database study comparing patients with and without diabetes mellitus
Dhruv Nandakumar, Matthew J. Johnson, Lawrence A. Lavery, Benjamin M. Conover, Katherine M. Raspovic, David H. Truong, Dane K. Wukich
Journal of Diabetes and its Complications.2024; 38(11): 108876. CrossRef
Analysis of clinical characteristics in patients with diabetic foot ulcers undergoing amputation and establishment of a nomogram prediction model
Tiantian Xu, Lianqi Hu, Banglin Xie, Gendong Huang, Xiaolong Yu, Fengbo Mo, Wei Li, Meisong Zhu
Scientific Reports.2024;[Epub] CrossRef
Survival rate of diabetic-related lower extremity amputees in hospitals in the Eastern Cape
Aviwe S. Mgibantaka, Alfred Musekiwa, Moleen Zunza
African Journal of Disability.2024;[Epub] CrossRef
Renal function is highly associated with podiatric risk in diabetic patients
Jean-Baptiste Bonnet, Ilan Szwarc, Antoine Avignon, Sébastien Jugant, Ariane Sultan
Clinical Kidney Journal.2023; 16(11): 2156. CrossRef
Risk factor analysis for diabetic foot ulcer‐related amputation including Controlling Nutritional Status score and neutrophil‐to‐lymphocyte ratio
Yandan Zhu, Hongtao Xu, Yuzhen Wang, Xia Feng, Xinyu Liang, Liying Xu, Zhiqiang Liang, Zhongjia Xu, Yawen Li, Yi Le, Manchen Zhao, Jianfei Yang, Ji Li, Yemin Cao
International Wound Journal.2023; 20(10): 4050. CrossRef
The association between estimated glomerular filtration rate and prognosis in patients with diabetic foot osteomyelitis
Jinghang Zhang, Dong Chen, Xuemei Li, Min Ding, Jun Xu, Meijun Wang, Bai Chang
International Wound Journal.2022; 19(7): 1650. CrossRef
Renal Function Status in Patients with Diabetes Mellitus Having Diabetic Foot Infection and Role of Antibiotics
Shabab Hussain, . Arrham, Syeda Javeriya Saeed, Ahmad Murtaza Anwar, Asif Khan, Saifullah Brohi
Pakistan Journal of Health Sciences.2022; : 189. CrossRef
Re-understanding and focusing on normoalbuminuric diabetic kidney disease
Na An, Bi-tao Wu, Yu-wei Yang, Zheng-hong Huang, Jia-fu Feng
Frontiers in Endocrinology.2022;[Epub] CrossRef
The effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial
Mehrdad Mokhtari, Reza Razzaghi, Mansooreh Momen‐Heravi
Phytotherapy Research.2021; 35(4): 2099. CrossRef
Prevalence of Sarcopenia and Its Association With Diabetes: A Meta-Analysis of Community-Dwelling Asian Population
Seung Min Chung, Jun Sung Moon, Min Cheol Chang
Frontiers in Medicine.2021;[Epub] CrossRef
Clinical outcomes among patients with chronic kidney disease hospitalized with diabetic foot disorders: A nationwide retrospective study
Michael Salim
Endocrinology, Diabetes & Metabolism.2021;[Epub] CrossRef
Diabetic foot infections: Profile and antibiotic susceptibility patterns of bacterial isolates in a tertiary care hospital of Oman
Mohan Bilikallahalli Sannathimmappa, Vinod Nambiar, Rajeev Aravindakshan, Mohammad Saleem Jawad Al Khabori, Asma Hamed Sulaiman Al-Flaiti, Kadhiya Nasser Mohamed Al-Azri, Ali Khamis Saif Al-Reesi, Alya Rashid Mohammad Al Kiyumi
Journal of Education and Health Promotion.2021;[Epub] CrossRef

Review articles

Pediatrics, Perinatology, and Child Health
Maturity-onset diabetes of the young: update and perspectives on diagnosis and treatment: Kyung Mi Jang; Yeungnam Univ J Med. 2020;37(1):13-21. Published online January 9, 2020; DOI: https://doi.org/10.12701/yujm.2019.00409

22,549 View
437 Download
31 Crossref

Abstract PDF

Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of monogenic disorders characterized by ß-cell dysfunction. MODY accounts for between 2% and 5% of all diabetes cases, and distinguishing it from type 1 or type 2 diabetes is a diagnostic challenge. Recently, MODY-causing mutations have been identified in 14 different genes. Sanger DNA sequencing is the gold standard for identifying the mutations in MODY-related genes, and may facilitate the diagnosis. Despite the lower frequency among diabetes mellitus cases, a correct genetic diagnosis of MODY is important for optimizing treatment strategies. There is a discrepancy in the disease-causing locus between the Asian and Caucasian patients with MODY. Furthermore, the prevalence of the disease in Asian populations remains to be studied. In this review, the current understanding of MODY is summarized and the Asian studies of MODY are discussed in detail.

Citations

Citations to this article as recorded by

Characterization of monogenic diabetes among Sudanese children: a multi-center experience from a population with high consanguinity
Samar S. Hassan, Salwa A. Musa, Elisa De Franco, Rebbeca Myers, Racheal Van Heugten, Omer O. Babiker, Areej A. Ibrahim, Ghassan F. MohamadSalih, Amna Ahmed, Jouyriah A. Shatta, Olivia A. Al-Hassan, Kashyap A. Patel, Mohamed A. Abdullah
Journal of Pediatric Endocrinology and Metabolism.2026; 39(1): 65. CrossRef
ABCC8-associated with maturity-onset diabetes in a young woman: clinical features and genetic analysis
O. D. Rymar, S. V. Mustafina, A. K. Ovsyannikova, E. V. Shakhtshneider, D. E. Ivanoshchuk, E. D. Ruzaeva, Yu. A. Dolinskaya, V. A. Stoyakina, A. A. Radionova
Сибирский научный медицинский журнал.2026; 45(6): 279. CrossRef
The Genetic Landscape of Diabetes Mellitus: Lessons from Monogenic and Polygenic Forms
Davide Nilo, Roberto Nilo, Marta Chiara Sircana, Ferdinando Carlo Sasso, Carlo Acierno, Leonilde Bonfrate, Alfredo Caturano
Life.2026; 16(3): 399. CrossRef
Caracterización clínica de pacientes con diabetes tipo MODY: Reporte de casos
Lizeth Carolina Montaño-Candelo, Liliana Mejia-de Beldjena
Iatreia.2025;[Epub] CrossRef
Maturity-onset diabetes of the young type 7 (MODY7) and mutation in the Krüppel-like transcription factor 11 (KLF11) gene
Y Wang, X Ye, X Chen, H Zang, Q Shen, L Chen
QJM: An International Journal of Medicine.2024; 117(3): 219. CrossRef
Molecular Dynamics Simulation of Kir6.2 Variants Reveals Potential Association with Diabetes Mellitus
Mohamed E. Elangeeb, Imadeldin Elfaki, Ali M. S. Eleragi, Elsadig Mohamed Ahmed, Rashid Mir, Salem M. Alzahrani, Ruqaiah I. Bedaiwi, Zeyad M. Alharbi, Mohammad Muzaffar Mir, Mohammad Rehan Ajmal, Faris Jamal Tayeb, Jameel Barnawi
Molecules.2024; 29(8): 1904. CrossRef
Glucose Disorders
Juan A. Perez
Primary Care: Clinics in Office Practice.2024; 51(3): 375. CrossRef
The Importance of Molecular Genetic Testing for Precision Diagnostics, Management, and Genetic Counseling in MODY Patients
Lăcrămioara Ionela Butnariu, Delia Andreia Bizim, Carmen Oltean, Cristina Rusu, Monica Cristina Pânzaru, Gabriela Păduraru, Nicoleta Gimiga, Gabriela Ghiga, Ștefana Maria Moisă, Elena Țarcă, Iuliana Magdalena Starcea, Setalia Popa, Laura Mihaela Trandafir
International Journal of Molecular Sciences.2024; 25(12): 6318. CrossRef
MODY diabetes as an orphan disease: literature review
A.V. Garnytska, O.S. Orlyk, L.M. Zenkina, S.O. Osadcha
Infusion & Chemotherapy.2024; (2): 32. CrossRef
The Elusive Nature of ABCC8-related Maturity-Onset Diabetes of the Young (ABCC8-MODY). A Review of the Literature and Case Discussion
Marella Marassi, Mario Luca Morieri, Viola Sanga, Giulio Ceolotto, Angelo Avogaro, Gian Paolo Fadini
Current Diabetes Reports.2024; 24(9): 197. CrossRef
MODY calculator applied in patients with clinical diagnosis of type 1 diabetes mellitus: Is a higher cutoff needed?
Vinícius Vigliazzi Peghinelli, Maria Teresa De Sibio, Igor de Carvalho Depra, Milena Gurgel Teles Bezerra, Marna Eliana Sakalem, Adriano Francisco De Marchi Júnior, Paula Barreto da Rocha, Helena Paim Tilli, Bianca Mariani Gonçalves, Ester Mariane Vieira,
Heliyon.2024; 10(16): e36006. CrossRef
Generational Diet-Induced Obesity Remodels the Omental Adipose Proteome in Female Mice
Naviya Schuster-Little, Morgan McCabe, Kayla Nenninger, Reihaneh Safavi-Sohi, Rebecca J. Whelan, Tyvette S. Hilliard
Nutrients.2024; 16(18): 3086. CrossRef
Novel gene mutation in maturity-onset diabetes of the young: A case report
Na Zhang, Hui Zhao, Cui Li, Feng-Zhi Zhang
World Journal of Clinical Cases.2023; 11(5): 1099. CrossRef
Cardio-cerebrovascular Outcomes in MODY, Type 1 Diabetes, and Type 2 Diabetes: A Prospective Cohort Study
Hui-Xuan Wu, Tian-Yao Chu, Junaid Iqbal, Hong-Li Jiang, Long Li, Yan-Xuan Wu, Hou-De Zhou
The Journal of Clinical Endocrinology & Metabolism.2023; 108(11): 2970. CrossRef
Genetic and Clinical Characterization of Patients with HNF1B-Related MODY in Croatia
Maja Baretić, Domagoj Caban, Jadranka Sertić
Journal of Personalized Medicine.2023; 13(7): 1063. CrossRef
Quantitative profiling and diagnostic potential of one-carbon and central metabolism pools in MODY2 and T1DM
Jieying Liu, Ziyan Xie, Junling Fu, Miao Yu, Tong Wang, Cuijuan Qi, Peng Liu, Xiangyi Hui, Dongmei Wang, Lu Ding, Qian Zhang, Ting Xie, Xinhua Xiao
Diabetology & Metabolic Syndrome.2023;[Epub] CrossRef
When do we need to suspect maturity onset diabetes of the young in patients with type 2 diabetes mellitus?
Özlem Üstay, Tugçe Apaydın, Onur Elbasan, Hamza Polat, Gizem Günhan, Ceyda Dinçer, Lamia Şeker, Esra Arslan Ateş, Ayşegül Yabacı, Ahmet lter Güney, Dilek Gogas Yavuz
Archives of Endocrinology and Metabolism.2022;[Epub] CrossRef
Meta-analysis of HNF1A-MODY3 variants among human population
Rachna Behl, Nishtha Malhotra, Vinay Joshi, Shruti Poojary, Sanniya Middha, Shalini Gupta, Arinola B. Olaonipekun, Ikechukwu Okoye, Bhushan Wagh, Dibyendu Biswas, Chukwuemelie Aginah, Bhavya Saini, Chinaza Nwanya, Sopuluchukwu Ugwu, Modupe M. Anthony, Xua
Journal of Diabetes & Metabolic Disorders.2022; 21(1): 1037. CrossRef
Unusual manifestations of young woman with MODY5 based on 17q12 recurrent deletion syndrome
Ying Cheng, Da-Peng Zhong, Li Ren, Hang Yang, Chen-Fu Tian
BMC Endocrine Disorders.2022;[Epub] CrossRef
Diagnosis and Treatment of Monogenic Forms of Diabetes Mellitus: Focus on Mody-Diabetes
K. A. Aitbaev, I. T. Murkamilov, Zh. A. Murkamilova, V. V. Fomin, I. O Kudaibergenova, F. A. Yusupov
The Russian Archives of Internal Medicine.2022; 12(6): 430. CrossRef
Monogenic diabetes: recent updates on diagnosis and precision treatment: A narrative review
Kyung Mi Jang
Precision and Future Medicine.2022; 6(4): 209. CrossRef
Modeling Maturity Onset Diabetes of the Young in Pluripotent Stem Cells: Challenges and Achievements
Carmel Braverman-Gross, Nissim Benvenisty
Frontiers in Endocrinology.2021;[Epub] CrossRef
Gençlerin Erişkin Başlangıçlı Diyabeti (MODY) Sorumlu HNF4A, GCK ve HNF1 Gen Varyasyonlarının Dünya Genelinde Coğrafik Dağılımı
Deniz KANCA DEMİRCİ, Nurdan GÜL, İlhan SATMAN, Oguz OZTURK, Hülya YILMAZ AYDOĞAN
Haliç Üniversitesi Fen Bilimleri Dergisi.2021; 4(1): 41. CrossRef
ABCC8 variants in MODY12: Review of the literature and report of a case with severe complications
Marijke Timmers, Eveline Dirinck, Patrick Lauwers, Wim Wuyts, Christophe De Block
Diabetes/Metabolism Research and Reviews.2021;[Epub] CrossRef
Monogenic Childhood Diabetes: Dissecting Clinical Heterogeneity by Next-Generation Sequencing in Maturity-Onset Diabetes of the Young
Deniz Kanca Demirci, Feyza Darendeliler, Sukran Poyrazoglu, Asli Derya Kardelen Al, Nurdan Gul, Yildiz Tutuncu, Gizem Gulfidan, Kazim Yalcin Arga, Canan Cacina, Oguz Ozturk, Hulya Yilmaz Aydogan, Ilhan Satman
OMICS: A Journal of Integrative Biology.2021; 25(7): 431. CrossRef
A Comprehensive Analysis of Hungarian MODY Patients—Part II: Glucokinase MODY Is the Most Prevalent Subtype Responsible for about 70% of Confirmed Cases
Zsolt Gaál, Zsuzsanna Szűcs, Irén Kántor, Andrea Luczay, Péter Tóth-Heyn, Orsolya Benn, Enikő Felszeghy, Zsuzsanna Karádi, László Madar, István Balogh
Life.2021; 11(8): 771. CrossRef
A Comprehensive Analysis of Hungarian MODY Patients—Part I: Gene Panel Sequencing Reveals Pathogenic Mutations in HNF1A, HNF1B, HNF4A, ABCC8 and INS Genes
Zsolt Gaál, Zsuzsanna Szűcs, Irén Kántor, Andrea Luczay, Péter Tóth-Heyn, Orsolya Benn, Enikő Felszeghy, Zsuzsanna Karádi, László Madar, István Balogh
Life.2021; 11(8): 755. CrossRef
Diagnosis and Treatment of MODY: An Updated Mini Review
Abegail Tshivhase, Tandi Matsha, Shanel Raghubeer
Applied Sciences.2021; 11(20): 9436. CrossRef
Functional Genomics in Pancreatic β Cells: Recent Advances in Gene Deletion and Genome Editing Technologies for Diabetes Research
Ming Hu, Ines Cherkaoui, Shivani Misra, Guy A. Rutter
Frontiers in Endocrinology.2020;[Epub] CrossRef
Update on Monogenic Diabetes in Korea
Ye Seul Yang, Soo Heon Kwak, Kyong Soo Park
Diabetes & Metabolism Journal.2020; 44(5): 627. CrossRef
The epidemiology, molecular pathogenesis, diagnosis, and treatment of maturity-onset diabetes of the young (MODY)
Ken Munene Nkonge, Dennis Karani Nkonge, Teresa Njeri Nkonge
Clinical Diabetes and Endocrinology.2020;[Epub] CrossRef

Psychiatry and Mental Health
Cognitive dysfunctions in individuals with diabetes mellitus: Hye-Geum Kim; Yeungnam Univ J Med. 2019;36(3):183-191. Published online July 24, 2019; DOI: https://doi.org/10.12701/yujm.2019.00255

26,619 View
539 Download
63 Crossref

Abstract PDF

Some patients with type 1 and type 2 diabetes mellitus (DM) present with cognitive dysfunctions. The pathophysiology underlying this complication is not well understood. Type 1 DM has been associated with a decrease in the speed of information processing, psychomotor efficiency, attention, mental flexibility, and visual perception. Longitudinal epidemiological studies of type 1 DM have indicated that chronic hyperglycemia and microvascular disease, rather than repeated severe hypoglycemia, are associated with the pathogenesis of DM-related cognitive dysfunction. However, severe hypoglycemic episodes may contribute to cognitive dysfunction in high-risk patients with DM. Type 2 DM has been associated with memory deficits, decreased psychomotor speed, and reduced frontal lobe/executive function. In type 2 DM, chronic hyperglycemia, long duration of DM, presence of vascular risk factors (e.g., hypertension and obesity), and microvascular and macrovascular complications are associated with the increased risk of developing cognitive dysfunction. The pathophysiology of cognitive dysfunction in individuals with DM include the following: (1) role of hyperglycemia, (2) role of vascular disease, (3) role of hypoglycemia, and (4) role of insulin resistance and amyloid. Recently, some investigators have proposed that type 3 DM is correlated to sporadic Alzheimer’s disease. The molecular and biochemical consequences of insulin and insulin-like growth factor resistance in the brain compromise neuronal survival, energy production, gene expression, plasticity, and white matter integrity. If patients claim that their performance is worsening or if they ask about the effects of DM on functioning, screening and assessment are recommended.

Citations

Citations to this article as recorded by

Diurnal cortisol cycle and cognitive performance in older people with Type 2 diabetes
Lorena Vallejo, Mariola Zapater-Fajarí, Teresa Montoliu, Vanesa Hidalgo, Alicia Salvador
Psychoneuroendocrinology.2026; 185: 107718. CrossRef
Dorzagliatin shows potential in preventing cognitive impairment in diabetes: evidence from Mendelian randomization analysis and animal study
Jiangxia Ni, Ke Wang, Lingge Feng, Chuyi Wang, Changhong Li, Yelin Chen, Li Chen
Frontiers in Endocrinology.2026;[Epub] CrossRef
Assessment of Hippocampal, Prefrontal Cortical, and Striatal Dopaminergic Circuitry Underlying Altered Social Behavior in Diabetes
Arun Parashar, Vineet Mehta, Udayabanu Malairaman, Muskan Thakur, Varsha Sharma
Molecular Neurobiology.2026;[Epub] CrossRef
Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
Xueting Yu, Huimei He, Jie Wen, Xiuyuan Xu, Zhaojuan Ruan, Rui Hu, Fang Wang, Haibing Ju
Open Medicine.2025;[Epub] CrossRef
Exploring the therapeutic potentials of cuminaldehyde: a comprehensive review of biological activities, mechanisms, and novel delivery systems
Abhik Paul, Sai Satyaprakash Mishra, Avik Maji, Ajeya Samanta, Sourin Nahar, Tapan Kumar Maity
Phytochemistry Reviews.2025; 24(6): 5207. CrossRef
Health benefits of okra (Abelmoschus esculentus) against diabetes mellitus and cognitive dysfunction: a review
Nazir Ahmad, Kaisun Nesa Lesa, Zullies Ikawati, Nanang Fakhrudin
Food Production, Processing and Nutrition.2025;[Epub] CrossRef
Predictive value and weight of factors associated with cognitive performance in Hispanics/Latinos enrolled in the Health and Aging Brain Study: Health Disparities
Raul Vintimilla, Darian Johnson, Douglas Taylor, James Hall, Fan Zhang, Sid O'Bryant
Alzheimer's & Dementia: Translational Research & Clinical Interventions.2025;[Epub] CrossRef
Specific Cognitive Functions Associated With Self-Care Behaviors in Older Adults With Type 2 Diabetes and Mild Cognitive Impairment
Cheng-Chen Chou, Hua-Fen Chen, Yuan-Mei Liao, Chi-Wen Chen, Pei-Ching Liu, An-Yun Yeh
Western Journal of Nursing Research.2025; 47(7): 605. CrossRef
Effect of Trans‐Auricular Vagal Nerve Stimulation on Cognitive Functions in Diabetic Polyneuropathy Patients
Moshera H. Darwish, Mohamed S. El‐Tamawy, Saleh M. Alhirsan, Mariam El‐Anany, Heba A. Khalifa
Physiotherapy Research International.2025;[Epub] CrossRef
Risk Factors, Pathological Changes, and Potential Treatment of Diabetes‐Associated Cognitive Dysfunction
Xiaoyu Meng, Haiyang Du, Danpei Li, Yaming Guo, Peiqiong Luo, Limeng Pan, Ranran Kan, Peng Yu, Yuxi Xiang, Beibei Mao, Yi He, Siyi Wang, Wenjun Li, Yan Yang, Xuefeng Yu
Journal of Diabetes.2025;[Epub] CrossRef
Investigating the neuroprotective role of Synta-66 in type-2 diabetes mellitus-induced dementia in rats
Ashi Mannan, Maneesh Mohan, Shareen Singh, Sonia Dhiman, Thakur Gurjeet Singh
Journal of Pharmacy and Pharmacology.2025; 77(9): 1222. CrossRef
The Effect of Intermittent Fasting and Vitamin Supplement on Cognitive Functions in Type 2 Diabetes Mellitus
Radwa M. Al-sayed, Mai M. Hasan, Samia Hussein, Aya M. Mohammed, Abdallah S. Abdelazem, Eman M. Abdelghany, Yassmen M. El-sayed, Eman Abdel Raouf Mohammed
Bratislava Medical Journal.2025; 126(9): 2157. CrossRef
Exploration of Imatinib involved in amyloidogenesis as a common foundation for type-2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD)
Ashi Mannan, Shareen Singh, Maneesh Mohan, Thakur Gurjeet Singh
Metabolic Brain Disease.2025;[Epub] CrossRef
Prevalence and Associated Factors of Cognitive Dysfunction Among Middle-Aged Type 2 Diabetes Mellitus Patients in South India: A Cross-Sectional Study
Dhrubajyoti J Debnath, Siva Santosh Kumar Pentapati, Hitesh Babu Sarihaddu
Cureus.2025;[Epub] CrossRef
Interplay between physical activity, inflammation, and cognitive performance in women with type 2 diabetes: an observational study focused on IL-6 pathway mediators
Zakieh Heidari, Mahdieh Molanouri Shamsi, Amin Kadkhodaei, Mehrdad Behmanesh, Shahnaz Shahrbanian, Sara Soudi
Diabetology & Metabolic Syndrome.2025;[Epub] CrossRef
Mitochondrial Reactive Oxygen Species Production in Vascular Dementia Following Experimental Diabetes
Ed Wilson Santos, Subika Khatoon, Yun-Min Zheng, Yong-Xiao Wang
Cells.2025; 14(16): 1260. CrossRef
Study on the impact of diabetes on neuro-psycho-behavioral functions, Kénitra, Morocco
Hajar Lerhlibi, Soukaina Chehab, Khalid Chakhtoura, Mostafa Slim
Multidisciplinary Reviews.2025; 9(6): 2026277. CrossRef
The impact of APOE ε4 on cognition in Brazilians with type 2 diabetes: exploring ethnicity effects
Rafael Lara Nohmi, Mozania Reis de Matos, Sueli Mieko Oba‐Shinjo, Bruno Fukelmann Guedes, Paula Rodrigues Sola, Miyuki Uno, Marisa Passarelli, Sonia Maria Dozzi Brucki, Michal Schnaider Beeri, Sharon Sanz Simon, Maria Lucia Correa‐Giannella, Suely Kazue N
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring.2025;[Epub] CrossRef
Herbal Remedy for Diabetes Mellitus: Investigation of Antidiabetic, Hepatoprotective and Antioxidant Properties of the Plant Acacia leucophloea (Roxb.) Willd
Md Nadeem Bari, Md Rizwan Ansari, Imran Mohammad, Mohammad Anwar
Advances in Human Biology.2025;[Epub] CrossRef
Diabetic Encephalopathy: Role of Oxidative and Nitrosative Factors in Type 2 Diabetes
Debashree Mazumdar, Santosh Singh
Indian Journal of Clinical Biochemistry.2024; 39(1): 3. CrossRef
Nephroprotective properties of Achillea millefolium green-formulated Au NPs in streptozotocin-induced diabetic nephropathy in mice: Introducing a novel therapeutic drug for the treatment of nephropathy
Nana Li, Xiu Wang, Shanshan Kong
Inorganic Chemistry Communications.2024; 161: 112103. CrossRef
Changes in selected hematological parameters in patients with type 1 and type 2 diabetes: a systematic review and meta-analysis
Getachew Mesfin Bambo, Daniel Asmelash, Ermiyas Alemayehu, Alemu Gedefie, Tadesse Duguma, Samuel Sahile Kebede
Frontiers in Medicine.2024;[Epub] CrossRef
A new nomogram model for the individualized prediction of mild cognitive impairment in elderly patients with type 2 diabetes mellitus
Yuanyuan Jiang, Xueyan Liu, Huiying Gao, Jingzheng Yan, Yingjuan Cao
Frontiers in Endocrinology.2024;[Epub] CrossRef
Sex Differences in the Trajectories of Cognitive Decline and Affected Cognitive Domains Among Older Adults With Controlled and Uncontrolled Glycemia
Natália Cochar-Soares, Dayane C de Oliveira, Mariane M Luiz, Márlon J R Aliberti, Claudia K Suemoto, Andrew Steptoe, Cesar de Oliveira, Tiago S Alexandre, Jay Magaziner
The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences.2024;[Epub] CrossRef
The PI3K/Akt signaling axis and type 2 diabetes mellitus (T2DM): From mechanistic insights into possible therapeutic targets
Rana Taheri, Yazdan Mokhtari, Amir‐Mohammad Yousefi, Davood Bashash
Cell Biology International.2024; 48(8): 1049. CrossRef
The Role of Insulin Deficiency in Cognitive Dysfunction in Patients with Type 1 Diabetes Mellitus
Yu. V. Bykov
Fundamental and Clinical Medicine.2024; 9(2): 94. CrossRef
Prevalence of Candida albicans Infection Among Diabetic Foot Ulcer Patients in Al-Yarmouk Teaching Hospital
Fatin Ali Al-Chalabi, Rabab Majead Abed, Mohsen Hashim Risan, Younus Desher Jabr
Medical Journal of Babylon.2024; 21(Suppl 1): S137. CrossRef
Daphnetin modulates GLP-1R to alleviate cognitive dysfunction in diabetes: implications for inflammation and oxidative stress
Feng Liang, Xinyi Tian, Lining Ding
Frontiers in Pharmacology.2024;[Epub] CrossRef
Metabolic kinetics and muscle and brain health markers in older adults, and the role of age and presence of chronic morbidities: A large cross-sectional cohort study
Minchae C. Kang, Nicolaas E.P. Deutz, Sarah K. Kirschner, Mariëlle P.K.J. Engelen
Clinical Nutrition.2024; 43(12): 36. CrossRef
Cognitive changes in people with diabetes with lower extremity complications compared to people with diabetes without lower extremity complications: a systematic review and meta-analysis
Nimantha Karunathilaka, Christina Parker, Peter A. Lazzarini, Pamela Chen, Chloe Katsanos, Margaret MacAndrew, Kathleen Finlayson
BMC Endocrine Disorders.2024;[Epub] CrossRef
Metformin Prevents NDEA-Induced Memory Impairments Associated with Attenuating Beta-Amyloid, Tumor Necrosis Factor-Alpha, and Interleukin-6 Levels in the Hippocampus of Rats
Teresa Ponce-Lopez, José Antonio González Álvarez Tostado, Fernando Dias, Keren Happuck Montiel Maltez
Biomolecules.2023; 13(9): 1289. CrossRef
Quercetin: an effective polyphenol in alleviating diabetes and diabetic complications
Lei Yan, Mostafa Vaghari-Tabari, Faezeh Malakoti, Soheila Moein, Durdi Qujeq, Bahman Yousefi, Zatollah Asemi
Critical Reviews in Food Science and Nutrition.2023; 63(28): 9163. CrossRef
Hyperglycemic microenvironment compromises the homeostasis of communication between the bone-brain axis by the epigenetic repression of the osteocalcin receptor, Gpr158 in the hippocampus
Ericka Patricia da Silva, Geórgia da Silva Feltran, Sérgio Alexandre Alcântara dos Santos, Rodrigo Cardoso de Oliveira, Rahyza I.F. Assis, Luis Antônio Justulin Junior, Denise Carleto Andia, Willian F. Zambuzzi, Alexandra Latini, Rodrigo A. Foganholi da S
Brain Research.2023; 1803: 148234. CrossRef
Research Progress on Lipocalin-2 in Diabetic Encephalopathy
Wenjie Zhang, Shihong Chen, Xianghua Zhuang
Neuroscience.2023; 515: 74. CrossRef
The Management of Diabetes Mellitus Using Medicinal Plants and Vitamins
Clement G. Yedjou, Jameka Grigsby, Ariane Mbemi, Daryllynn Nelson, Bryan Mildort, Lekan Latinwo, Paul B. Tchounwou
International Journal of Molecular Sciences.2023; 24(10): 9085. CrossRef
Gender differences in cognitive function and its associated factors among older adults with type 2 diabetes
Hua-Fen Chen, Ju Ying Jiang, Mei-Hsiu Chen, Rong Lin, Seng Wei Ooi Jerence, Chin-Huan Chang, Cheng-Chen Chou
Geriatric Nursing.2023; 52: 165. CrossRef
Exploring the Potential of Antidiabetic Agents as Therapeutic Approaches for Alzheimer's and Parkinson's Diseases: A Comprehensive Review
Mahima Koshatwar, Sourya Acharya, Roshan Prasad, Tejaswee Lohakare, Mayur Wanjari, Avinash B Taksande
Cureus.2023;[Epub] CrossRef
Isolation and characterization of bacteria from diabetic foot ulcer: amputation, antibiotic resistance and mortality rate
Muamar M. A. Shaheen, Sewar Al Dahab, Maryiam Abu Fada, Rawand Idieis
International Journal of Diabetes in Developing Countries.2022; 42(3): 529. CrossRef
Genetic mutations of APOEε4 carriers in cardiovascular patients lead to the development of insulin resistance and risk of Alzheimer's disease
Komal Jabeen, Kanwal Rehman, Muhammad Sajid Hamid Akash
Journal of Biochemical and Molecular Toxicology.2022;[Epub] CrossRef
Aqueous Ajwa dates seeds extract improves memory impairment in type-2 diabetes mellitus rats by reducing blood glucose levels and enhancing brain cholinergic transmission
Vasudevan Mani, Minhajul Arfeen, Sultan Sajid, Yasser Almogbel
Saudi Journal of Biological Sciences.2022; 29(4): 2738. CrossRef
Diabetes Mellitus-Related Neurobehavioral Deficits in Mice Are Associated With Oligodendrocyte Precursor Cell Dysfunction
Li-Ping Wang, Jieli Geng, Chang Liu, Yuyang Wang, Zhijun Zhang, Guo-Yuan Yang
Frontiers in Aging Neuroscience.2022;[Epub] CrossRef
Single-Cell Sequencing Analysis of the db/db Mouse Hippocampus Reveals Cell-Type-Specific Insights Into the Pathobiology of Diabetes-Associated Cognitive Dysfunction
Shizhan Ma, Wenkai Bi, Xueying Liu, Shangbin Li, Yaxin Qiu, Chengcheng Huang, Renjun Lv, Qingqing Yin
Frontiers in Endocrinology.2022;[Epub] CrossRef
Impact of time in range during hospitalization on clinical outcomes in diabetic patients with toe amputation: a propensity score matching analysis
Su Li, Ze-Xin Huang, Dong-hao Lou, Ye-Yong Jiang, Sheng Zhao
BMC Surgery.2022;[Epub] CrossRef
Aberrant brain functional networks in type 2 diabetes mellitus: A graph theoretical and support-vector machine approach
Lin Lin, Jindi Zhang, Yutong Liu, Xinyu Hao, Jing Shen, Yang Yu, Huashuai Xu, Fengyu Cong, Huanjie Li, Jianlin Wu
Frontiers in Human Neuroscience.2022;[Epub] CrossRef
Does diabetes affect the risk of involvement in a motor vehicle crash?
Jamie Dow, Lucie Boucher, David Carr, Judith L. Charlton, Linda Hill, Sjaan Koppel, Roy Lilley, Richard Marotolli, Desmond O'Neill, Mark Rapoport, Christine Roy, Neil Swirsky, Vincent Woo, Emmanuelle Gagné, Claude Giroux, Tamara Rader
Journal of Transport & Health.2022; 27: 101509. CrossRef
No Effects of Acute Psychosocial Stress on Working Memory in Older People With Type 2 Diabetes
Lorena Vallejo, Mariola Zapater-Fajarí, Teresa Montoliu, Sara Puig-Perez, Juan Nacher, Vanesa Hidalgo, Alicia Salvador
Frontiers in Psychology.2021;[Epub] CrossRef
Neurovascular coupling alterations in type 2 diabetes: a 5-year longitudinal MRI study
Yang Zhang, Xiaolu Zhang, Guangyang Ma, Wen Qin, Jiayang Yang, Jiahui Lin, Quan Zhang
BMJ Open Diabetes Research & Care.2021; 9(1): e001433. CrossRef
Ameliorative effects of endurance training and Matricaria chamomilla flowers hydroethanolic extract on cognitive deficit in type 2 diabetes rats
Ali Heidarianpour, Fereshteh Mohammadi, Maryam Keshvari, Naser Mirazi
Biomedicine & Pharmacotherapy.2021; 135: 111230. CrossRef
The Link Between Nutrition and Alzheimer’s Disease: From Prevention to Treatment
Laís Bhering Martins, Ana Letícia Malheiros Silveira, Antonio Lúcio Teixeira
Neurodegenerative Disease Management.2021; 11(2): 155. CrossRef
Peripheral Polyneuropathy and Cognitive Impairment in Type II Diabetes Mellitus
Rasha Elbialy Elsharkawy, Ghada Saed Abdel Azim, Marwa Abdellah Osman, Hend Maghraby Maghraby, Rehab Abdelfattah Mohamed, Eman Mahmoud Abdelsalam, Eman Elshohat Ebrahem, Nora Mohamed Ahmed Seliem
Neuropsychiatric Disease and Treatment.2021; Volume 17: 627. CrossRef
SLC40A1 Mediates Ferroptosis and Cognitive Dysfunction in Type 1 Diabetes
Lijun Hao, Jun Mi, Liping Song, Yinnan Guo, Yanli Li, Yiru Yin, Ce Zhang
Neuroscience.2021; 463: 216. CrossRef
Relationship between peripheral neuropathy and cognitive performance in the elderly population
Yu-Jen Lin, Tung-Wei Kao, Wei-Liang Chen
Medicine.2021; 100(20): e26071. CrossRef
The Association Between Diabetes Mellitus and Mild Behavioral Impairment Among Mild Cognitive Impairment: Findings from Singapore
See Ann Soo, Kok Pin Ng, Fennie Wong, Seyed Ehsan Saffari, Chathuri Yatawara, Zahinoor Ismail, Nagaendran Kandiah
Journal of Alzheimer's Disease.2021; 82(1): 411. CrossRef
Repurposing of Anti-Diabetic Agents as a New Opportunity to Alleviate Cognitive Impairment in Neurodegenerative and Neuropsychiatric Disorders
Qian Chen, Ting Cao, NaNa Li, Cuirong Zeng, Shuangyang Zhang, Xiangxin Wu, Bikui Zhang, Hualin Cai
Frontiers in Pharmacology.2021;[Epub] CrossRef
Mitochondrial remodelling—a vicious cycle in diabetic complications
Bhoomika Sherkhane, Gundu Chayanika, Anika Sood, Dharmendra Kumar Khatri, Shashi Bala Singh
Molecular Biology Reports.2021; 48(5): 4721. CrossRef
The Association between the Binding Processes of Working Memory and Vascular Risk Profile in Adults
Eirini Bika, Despina Moraitou, Elvira Masoura, George Kolios, Georgia Papantoniou, Maria Sofologi, Vasileios Papaliagkas, Georgios Ntritsos
Brain Sciences.2021; 11(9): 1140. CrossRef
The effect of cordycepin on brain oxidative stress and protein expression in streptozotocin-induced diabetic mice
Krittika SRISUKSAI, Kongphop PARUNYAKUL, Narumon PHAONAKROP, Sittiruk ROYTAKUL, Wirasak FUNGFUANG
Journal of Veterinary Medical Science.2021; 83(9): 1425. CrossRef
The Candidate Schizophrenia Risk Gene Tmem108 Regulates Glucose Metabolism Homeostasis
Jianbo Yu, Xufeng Liao, Yanzi Zhong, Yongqiang Wu, Xinsheng Lai, Huifeng Jiao, Min Yan, Yu Zhang, Chaolin Ma, Shunqi Wang
Frontiers in Endocrinology.2021;[Epub] CrossRef
Impact of diabetes on the accuracy and speed of accessing information from episodic and working memory
Selene Cansino, Frine Torres-Trejo, Cinthya Estrada-Manilla, Eira Castellanos-Domínguez, Ana Zamora-Olivares, Silvia Ruiz Velasco, Jim Grange
Cogent Psychology.2021;[Epub] CrossRef
Ингибиторы натрий-глюкозного котранспортера способны положительно влиять на состояние головного мозга
Олег Леонидович Колесников , Алла Алексеевна Колесникова , Юлия Олеговна Тарабрина
Естественные и Технические Науки.2021; (№11): 149. CrossRef
Melatonin: new insights on its therapeutic properties in diabetic complications
Mohammad Hossein Pourhanifeh, Azam Hosseinzadeh, Ehsan Dehdashtian, Karim Hemati, Saeed Mehrzadi
Diabetology & Metabolic Syndrome.2020;[Epub] CrossRef
Diabetic encephalopathy causes the imbalance of neural activities between hippocampal glutamatergic neurons and GABAergic neurons in mice
Chun Wang, Juan Li, Shidi Zhao, Li Huang
Brain Research.2020; 1742: 146863. CrossRef
Link between Diabetes and Alzheimer’s Disease Due to the Shared Amyloid Aggregation and Deposition Involving Both Neurodegenerative Changes and Neurovascular Damages
Gabriela Dumitrita Stanciu, Veronica Bild, Daniela Carmen Ababei, Razvan Nicolae Rusu, Alina Cobzaru, Luminita Paduraru, Delia Bulea
Journal of Clinical Medicine.2020; 9(6): 1713. CrossRef

Original Article

Anesthesiology and Pain Medicine
Comparison of sevoflurane and propofol anesthesia on the incidence of hyperglycemia in patients with type 2 diabetes undergoing lung surgery: Hyuckgoo Kim, Jisoo Han, Sung Mee Jung, Sang-Jin Park, Nyeong Keon Kwon; Yeungnam Univ J Med. 2018;35(1):54-62. Published online June 30, 2018; DOI: https://doi.org/10.12701/yujm.2018.35.1.54

10,915 View
124 Download
7 Crossref

Abstract PDF

Background
The type and regimen of anesthesia may affect perioperative hyperglycemia following major surgical stress. This study compared the effects of sevoflurane and propofol on the incidence of hyperglycemia and clinical outcomes in diabetic patients undergoing lung surgery.
Methods
This retrospective study included 176 patients with type 2 diabetes mellitus who had undergone lung surgery. Blood glucose levels and clinical outcomes from the preoperative period to the first 2 postoperative days (PODs) were retrospectively examined in patients who received sevoflurane (group S, n= 87) and propofol (group P, n=89) for maintenance of general anesthesia. The primary endpoint was the incidence of persistent hyperglycemia (2 consecutive blood glucose levels >180 mg/dL [10.0 mmol/L]) during the perioperative period. The secondary composite endpoint was the incidence of major postoperative complications and 30-day mortality rate after surgery.
Results
Blood glucose levels similarly increased from the preoperative period to the second POD in both groups (p=0.857). Although blood glucose levels at 2 hours after surgery were significantly lower in group P than in group S (p=0.022; 95% confidence interval for mean difference, -27.154 to -2.090), there was no difference in the incidence of persistent hyperglycemia during the perioperative period (group S, 70%; group P, 69%; p=0.816). The composite of major postoperative complications and all-cause in-hospital and 30-day mortality rates were also comparable between the two groups.
Conclusion
Sevoflurane and propofol were associated with a comparable incidence of perioperative hyperglycemia and clinical outcomes in diabetic patients undergoing lung surgery.

Citations

Citations to this article as recorded by

Effects of Intravenous or Inhalation Anesthesia on Blood Glucose in Patients with Type 2 Diabetes Mellitus: A PRISMA-Compliant Systematic Review and Meta-Analysis
Sang Min Yoon, Hyun Kang, Yoon Ji Choi, Sang Hun Kim, Seongtae Jeong, Sejong Jin
Medicina.2026; 62(1): 128. CrossRef
Propofol-Induced Hyperglycemia in the Critically Ill: An Unfamiliar Side Effect of a Common Anesthetic
Muhammad A Qureshi, Greeshma A Thomas, Tijin Mathew, FNU Anshul
Cureus.2024;[Epub] CrossRef
The Maternal and Neonatal Glycemic Stress Response in Normal Vaginal Delivery: A Comparative Study Between Epidural and Parenteral Opioids Analgesia
Ala”a Alhowary, Omar Altal, Diab Bani Hani, Anas Alrusan, Yaser Ba Jusair, Rania Al-Bataineh, Ahmed Al Sharie, Abdelwahab Aleshawi
Local and Regional Anesthesia.2024; Volume 17: 117. CrossRef
Strategies for intraoperative glucose management: a scoping review
Nathaniel Morin, Sarah Taylor, Danae Krahn, Leyla Baghirzada, Michael Chong, Tyrone G. Harrison, Anne Cameron, Shannon M. Ruzycki
Canadian Journal of Anesthesia/Journal canadien d'anesthésie.2023; 70(2): 253. CrossRef
Impact of total intravenous anesthesia and total inhalation anesthesia as the anesthesia maintenance approaches on blood glucose level and postoperative complications in patients with type 2 diabetes mellitus: a double-blind, randomized controlled trial
Xinghui Xiong, Yong He, Cheng Zhou, Qin Zheng, Chan Chen, Peng Liang
BMC Anesthesiology.2023;[Epub] CrossRef
Current trends in management of hyperglycaemia in surgical patients with diabetes mellitus: a review
Vladimir N. Kuklin, J. Matri, N. P. Barlow, S. H. Tveit, J. E. Kvernberg, E. -M. Ringvold, V. Dahl
Annals of Critical Care.2022; (4): 33. CrossRef
Effects of sevoflurane anesthesia and abdominal surgery on the systemic metabolome: a prospective observational study
Yiyong Wei, Donghang Zhang, Jin Liu, Mengchan Ou, Peng Liang, Yunxia Zuo, Cheng Zhou
BMC Anesthesiology.2021;[Epub] CrossRef

Review Article

Endocrinology, Diabetes, and Metabolism
Diabetes and depression: Eon-Ju Jeon; Yeungnam Univ J Med. 2018;35(1):27-35. Published online June 30, 2018; DOI: https://doi.org/10.12701/yujm.2018.35.1.27

13,671 View
176 Download
10 Crossref

Abstract PDF

Diabetes and depression are serious chronic conditions. As a result of their increasing prevalence, diabetes and depression, together with population growth and aging, are public health issues. The rate of depression in adults with either type 1 diabetes or type 2 diabetes is high relative to the general population. The coexistence of diabetes and depression has attracted much interest. Although it is unclear whether diabetes and depression are causally linked, most studies have shown that the association between diabetes and depression might be bidirectional. Currently, emotional well-being is becoming an increasingly important aspect of diabetes care and self-management. Psychiatric disorders and diabetic distress among people with diabetes may increase the risk of diabetes complication and mortality. Thus, assessment and appropriate management of depression in people with diabetes should be considered to achieve psychological well-being and optimize medical outcomes.

Citations

Citations to this article as recorded by

Mind Matters: Mental Health and Diabetes Management
Karen Tenreiro, Betul Hatipoglu
The Journal of Clinical Endocrinology & Metabolism.2025; 110(Supplement): S131. CrossRef
Impact of GLP‐1 Receptor Agonists on Suicide Behavior: A Meta‐Analysis Based on Randomized Controlled Trials
Jingqi Chen, Qiufeng Zhang, Qingping Wu, Xiaoming Zhang, Zhiyi Xiang, Sidong Zhu, Tianfu Dai, Yuexiu Si
Journal of Diabetes.2025;[Epub] CrossRef
Interaction between dietary quality and depression on glycaemic control in type 2 diabetics
Yixue Jiang, Heqing Lou, Zeyuan Yin, Chunrong Xu, Joseph Adu‐Amankwaah, Zongmei Dong, De Liu, Dong Dong, Cheng Qiao, Pan Zhang, Fang Chen
BMC Public Health.2025;[Epub] CrossRef
RETRACTED: Investigating the association between diabetes and carpal tunnel syndrome: A systematic review and meta-analysis approach
Elaheh Sanjari, Hadi Raeisi Shahraki, Lusine G. Khachatryan, Abdollah Mohammadian-Hafshejani, Rami M. Elshazli
PLOS ONE.2024; 19(4): e0299442. CrossRef
Low Social Support and Risk for Depression in People With Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis
Akhmad Azmiardi, Bhisma Murti, Ratih Puspita Febrinasari, Didik Gunawan Tamtomo
Journal of Preventive Medicine and Public Health.2022; 55(1): 37. CrossRef
Biopsychosocial and Nutritional Factors of Depression among Type 2 Diabetes Mellitus Patients: A Systematic Review
Norizzati Amsah, Zaleha Md Isa, Norfazilah Ahmad
International Journal of Environmental Research and Public Health.2022; 19(8): 4888. CrossRef
Depressive Disorder and Diabetes
Eonju Jeon
The Journal of Korean Diabetes.2022; 23(3): 178. CrossRef
The differentiation of health behaviors by depression in U.S. diabetic patients
Ying Liu, Candice Collins
MOJ Public Health.2022; 11(2): 122. CrossRef
Bioinformatics and Network Pharmacology-Based Approaches to Explore the Potential Mechanism of the Antidepressant Effect of Cyperi Rhizoma through Soothing the Liver
Yuhe Lei, Mingquan Du, Ge Zhang, Lei Chen, Yanli Fu, Yinqin Zhong, Enxin Zhang, Junqing Huang
Evidence-Based Complementary and Alternative Medicine.2021; 2021: 1. CrossRef
Habenula lesions improve glucose metabolism in rats with type 2 diabetes by increasing insulin sensitivity and inhibiting gluconeogenesis
Peng Qu, Yachun Wang, Lei Liu, Mengmeng Qi, Yimeng Sun, Siyang Zheng, Zichen Xu, Changhong Liu, Xiaoyan Bai, Qinggao Zhang, Limin Yang
BMJ Open Diabetes Research & Care.2020; 8(1): e001250. CrossRef

Case Reports

Endocrinology, Diabetes, and Metabolism
A Case of Membranoproliferative Glomerulonephritis in a Patient with Type 2 Diabetes Mellitus.: Dong Hyun Kim, Jang Won Lee, Min Suk Jung, Seung Hyun Lee, Byung Cheol Min, Hyun Ju Kim; Yeungnam Univ J Med. 2013;30(2):136-140. Published online December 31, 2013; DOI: https://doi.org/10.12701/yujm.2013.30.2.136

3,229 View
30 Download

Abstract PDF: Diabetic nephropathy (DN) is a common complication and the leading cause of end-stage renal disease (ESRD) in diabetic patients. The occurrence of non-diabetic renal disease (NDRD) in diabetic patients has been increasingly recognized in recent years. Generally, renal injuries in DN are deemed difficult to reverse, whereas some NDRDs are often treatable and even remittable. Thus, the diagnosis of NDRD in patients with diabetes mellitus (DM) via a kidney biopsy would be significant for its prognosis and therapeutic strategy. According to recent studies, the most common NDRD is IgA nephropathy in type 2 diabetic patients, and some cases of minimal change disease and membranous glomerulonephritis have been reported in Korea. However, membranoproliferative glomerulonephritis (MPGN) is an uncommon condition in diabetic patients. To our knowledge, there has been no case yet of MPGN, except in a child with type 1 DM. We present an unusual case of a 27-year-old woman who had type 2 DM with MPGN, as confirmed via a kidney biopsy.

Endocrinology, Diabetes, and Metabolism
Langerhans Cell Histiocytosis with Central Diabetes Insipidus: A Case Report.: Jin Ho Kim, Jun Sung Moon, Sun Jung Mun, Ji Eun Lee, Jae Won Choi, Mi Jung Eun, Kyung A Chun, Ihn Ho Cho, Ji Sung Yoon, Kyu Chang Won, Kyung Hee Lee, Duk Seop Shin, Hyoung Woo Lee; Yeungnam Univ J Med. 2005;22(2):259-265. Published online December 31, 2005; DOI: https://doi.org/10.12701/yujm.2005.22.2.259

2,524 View
11 Download

Abstract PDF: Central diabetes insipidus (DI) is a syndrome characterized by thirst, polydipsia and polyuria. Langerhans cell histiocytosis is one of the etiologies of DI. Recently we experienced a central DI associated with Langerhans cell histiocytosis. The 44 years old female patient complained right hip pain, polydipsia and polyuria. We carried out water deprivation test. After vasopressin injection, urine osmotic pressure was increased from 109 mOsmol/kg to 327 mOsmol/kg (300%). Brain MRI showed a thickened pituitary stalk and air bubble like lesions sized with 5cm, 7cm was shown on fifth L-spine and right hip bone at hip bone CT. CT guided biopsy revealed abnormal histiocytes proliferation and abundant lymphocytes. The final diagnosis was central DI associated with systemic Langerhans cell histiocytosis invading hip bone, L-spine and pituitary stalk. Desmopressin and etoposide chemotherapy were performed to the patient.

Original Articles

Physiology
The effect of regular physical exercise on glucose uptake in soleus and intravenous glucose tolerance in streptozotocin diabetic rats.: Myung Heup Chun, Yong Woon Kim, Jong Yeon Kim, Young Man Lee, Suck Kang Lee; Yeungnam Univ J Med. 1992;9(1):121-129. Published online June 30, 1992; DOI: https://doi.org/10.12701/yujm.1992.9.1.121

2,600 View
8 Download

Abstract PDF: The effect of exercise on plasma insulin, free fatty acid, and glucose uptake and glycogen concentration in soleus, and intravenous glucose tolerance of streptozotocin treated, diabetic Sprague-Dawley rats were studied. Diabetic-trained animals were subjected to a regular program of treadmill running for 4 weeks. Seventy-two hours after the last training session, basal and insulin-stimulated glucose uptake was studied in incubated strips (about 20 mg) of soleus muscle in vitro. Glucose tolerance was measured with intravenous infusion of 0.5 g glucose/kg body weight. In diabetic rats, training was associated with increase glucose uptake in basal and maximal insulin concentrations, decreased fasting glucose concentrations, and increased muscle glycogen levels, but there were no changes in glucose tolerance curve and plasma insulin concentrations. These results suggest that regular running program for 4 weeks improve responsiveness of insulin on soleus muscle, but fails to cause improvement of impaired intravenous glucose tolerance in mild degree streptozotocin induced diabetic rats.

Pathology and Forensic Medicine
Effects of insulin and exercise on glucose uptake of skeletal muscle in diabetic rats.: Jin Hyun Park, Young Woon Kim, Jong Yeon Kim, Suck Kang Lee; Yeungnam Univ J Med. 1990;7(1):29-37. Published online June 30, 1990; DOI: https://doi.org/10.12701/yujm.1990.7.1.29

2,605 View
4 Download

Abstract PDF: The effects of insulin and exercise on glucose uptake of skeletal muscle were investigated in soleus muscle isolated from low dose streptozotocin induced diabetic rat in vitro. Glucose uptake was assessed by measuring ³H-methylglucose uptake in vitro. Basal glucose uptake in diabetes was reduced by approximately one-third of the control value (5.6±0.73µMol/g/20min. in diabetes versus 8.4±0.77 in control, P<0.01). There was also a significant decrease (P<0.01) in glucose uptake of diabetes at physiologic insulin concentration (200 µIU/ml) by 40% (6.1±1.20 versus 10.0±0.81). Furthermore, maximal insulin (20000 µIU/ml)-stimulated glucose uptake was 36% lower in diabetes as compared with control (7.3±1.29 versus 11.4±1.29, P<0.01). In contrast, exercise (1.0 km/hr, treadmill running for 45 min.) effect on glucose uptake was so dramatic in diabetes that glucose uptake at basal state was 8.+1.09 and insulin stimulated-glucose uptake were 10.2±1.47 and 11.9±1.64, in 200 and 20000 µIU/ml added insulin, respectively. These results suggest that insulin insensitivity develops in skeletal muscle after 2 weeks of streptozotocin-induced diabetes, but these insensitivity was recovered significantly by single session of running exercise.

Case Report

Nephrology
Metformin induced acute pancreatitis and lactic acidosis in a patient on hemodialysis.: Yeon Kyung Lee, Kihyun Lim, Su Hyun Hwang, Young Hwan Ahn, Gyu Tae Shin, Heungsoo Kim, In Whee Park; Yeungnam Univ J Med. 2016;33(1):33-36.; DOI: https://doi.org/10.12701/yujm.2016.33.1.33

4,313 View
21 Download
1 Crossref

Abstract PDF

Metformin, commonly prescribed for type 2 diabetes, is considered safe with minimal side-effect. Acute pancreatitis is rare but potentially fatal adverse side-effect of metformin. We report a patient on hemodialysis with metformin-related acute pancreatitis and lactic acidosis. A 62-year-old woman with diabetic nephropathy and hypertension presented with nausea and vomiting for a few weeks, followed by epigastric pain. At home, the therapy of 500 mg/day metformin and 50 mg/day sitagliptin was continued, despite symptoms. Laboratory investigations showed metabolic acidosis with high levels of lactate, amylase at 520 U/L (range, 30-110 U/L), and lipase at 1,250 U/L (range, 23-300 U/L). Acute pancreatitis was confirmed by computed tomography. No recognized cause of acute pancreatitis was identified. Metformin was discontinued. Treatment with insulin and intravenous fluids resulted in normalized amylase, lipase, and lactate. When she was re-exposed to sitagliptin, no symptoms were reported.

Citations

Citations to this article as recorded by

Sex-differences in [68Ga]Ga-DOTANOC biodistribution
A. Leisser, K. Lukic, M. Nejabat, W. Wadsak, M. Mitterhauser, M. Mayerhöfer, G. Karnaikas, M. Raderer, M. Hacker, A.R. Haug
Nuclear Medicine and Biology.2019; 76-77: 15. CrossRef

First
Prev
Page of 1
Next
Last

Search