Journal of Yeungnam Medical Science

Original Articles

The Effects of Ethanol on Cholinesterase Inactivation by Organophosphorous.: Hyoung Chul Choi, Jong Ho Kim, Jeoung Hee Ha, Kwang Yoon Lee, Won Joon Kim, Hyun Jae Woo, Chang Uk Huh, Soo Min Son, Eun Jin Chun; Yeungnam Univ J Med. 1999;16(2):326-332. Published online December 31, 1999; DOI: https://doi.org/10.12701/yujm.1999.16.2.326

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Abstract PDF: BACKGROUND
In korea the agricultural community widely uses organophosphorous, and organophosphorous poisonings are increasing every year. We compared change in activity of acetylcholinesterase and pseudocholinesterase by organophosphorous and by the interaction of ethanol and organophosphorous. We also compared the effect of reversible anticholinesterase drugs, physostigmine and neostigmine. The object of this study is to investigate the effects of several anticholinesterase drugs and on how ethanol influences the activity of cholinesterase. MATERIALS AND METHODS: Fifteen male university students were randomly selected, and blood samples were taken from the antecubital vein. The acetylcholinesterase in the RBC and the pseudocholinesterase in the serum were extracted and separated. The enzyme activity change was measured by the electrometric method. After adding acetylcholine, the pH change was measured with a pH meter. RESULTS AND CONCLUSION: Our results indicated that reversible anticholinesterase drugs decreased the cholinesterase activity more efficiently than organophosphorous. The acetyl cholinesterase and pseudocholinosterase activity were decreased by ethanol. When ethanol was added, oxime a cholinesterase activator, increased acetylcholinesterase activity but dose not increased pseudocholinesterase activity.

The Effects of Anticholinesterase Drugs on Gastric Motility.: Hyoung Chul Choi, Jong Ho Kim, Jeoung Hee Ha, Kwang Yoon Lee, Won Joon Kim, Dong Suk Kwak, Sung Hee Kim, Phil Hyun Song, Ji Hyun Yeo; Yeungnam Univ J Med. 1999;16(2):318-325. Published online December 31, 1999; DOI: https://doi.org/10.12701/yujm.1999.16.2.318

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Abstract PDF: BACKGROUND
Anticholinesterase drug inhibits acetylcholinesterase(AChE), induce accumulation of acetylcholine(ACh) near cholinergic receptors and cholinergic stimulation. This experiment was performed to study the effects of anticholinesterase drugs on gastric motility and the effect of ethanal on anticholinesterase drug-induced motility change. MATERIALS AND METHODS: After excision of stomach, 2x10mm circular musele strips were made, which were then fixed to the isolated muscle chamber. An isometric tension transducer was used to measure the contraction change of the gastric smooth muscle strips after drug addition. RESULTS: Fenthion, and irreversible anticholinesterase drug, increased ACh induced contraction of gastric smooth muscle strips and PAM, a cholinesterase activator, antagnized this action. Physostigmine, a reversible anticholinesterase drug, also increased the ACh induced contraction. The gastric motility was decreased by PAM. Ethanol, which is known to induce smooth muscle relaxation, inhibited the increase of contraction by fenthion. CONCLUSION: These results indicate that irreversible and reversible anticholinesterase drugs increase gastric motility and antagonized by cholinesterase activating drugs. And when exposed to both ethanol and anticholinesterase drug, gastric motility was decreased by the smooth muscle relaxation effect by ethanal.

Effects of Ethanol on Neurobehavioral Performance.: Man Joong Jeon, Joon Sakong, Pock Soo Kang, Moon Chan Kim, Hak Soo Kim; Yeungnam Univ J Med. 1997;14(1):183-196. Published online June 30, 1997; DOI: https://doi.org/10.12701/yujm.1997.14.1.183

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Abstract PDF

An experimental study was performed to investigate. The subjects drank 0.5g/kg ethanol and performed 7 items of SPES(simple reaction time, color word stress, digit classification, finger tapping speed, numerical ability, symbol digit coding, memory digit span). 20 students of medical college participated in the study during August, 1996. After ethanol intake, performance of 4 items(simple reaction time, digit classification, finger tapping speed, symbol digit coding) significantly showed to be decreased. The function of perception - response speed and steady movement were found to be more sensitive to ethanol than that of short - term memory, numerical ability and specification of color. No significant association were found between smoking, alcohol drinking, BMI(body mass index) and the effects of ethanol on neurobehavioral performance.

Citations

Citations to this article as recorded by

Assessment of Availability of Korean Computerized Neurobehavioral Test in Patients with Brain Injury
Tae-Hoon Kim, Man-Joong Jeon, Joon Sakong
The Journal of the Korea Contents Association.2013; 13(6): 339. CrossRef

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