Journal of Yeungnam Medical Science

Review Article

Potential health effects of emerging environmental contaminants perfluoroalkyl compounds: Youn Ju Lee; Yeungnam Univ J Med. 2018;35(2):156-164. Published online December 31, 2018; DOI: https://doi.org/10.12701/yujm.2018.35.2.156

7,771 View
101 Download
7 Crossref

Environmental contaminants are one of the important causal factors for development of various human diseases. In particular, the perinatal period is highly vulnerable to environmental toxicants and resultant dysregulation of fetal development can cause detrimental health outcomes potentially affecting life-long health. Perfluoroalkyl compounds (PFCs), emerging environmental pollutants, are man-made organic molecules, which are widely used in diverse industries and consumer products. PFCs are non-degradable and bioaccumulate in the environment. Importantly, PFCs can be found in cord blood and breast milk as well as in the general population. Due to their physicochemical properties and potential toxicity, many studies have evaluated the health effects of PFCs. This review summarizes the epidemiological and experimental studies addressing the association of PFCs with neurotoxicity and immunotoxicity. While the relationships between PFC levels and changes in neural and immune health are not yet conclusive, accumulative studies provide evidence for positive associations between PFC levels and the incidence of attention deficit hyperactivity disorder and reduced immune response to vaccination both in children and adults. In conclusion, PFCs have the potential to affect human health linked with neurological disorders and immunosuppressive responses. However, our understanding of the molecular mechanism of the effects of PFCs on human health is still in its infancy. Therefore, along with efforts to develop methods to reduce exposure to PFCs, studies on the mode of action of these chemicals are required in the near future.

Citations

Citations to this article as recorded by

Modifiable contributing factors to COVID-19: A comprehensive review
Ronald Neil Kostoff, Michael Brandon Briggs, Darja Kanduc, Saikat Dewanjee, Ramesh Kandimalla, Yehuda Shoenfeld, Alan L. Porter, Aristidis Tsatsakis
Food and Chemical Toxicology.2023; 171: 113511. CrossRef
Effect of prenatal perfluoroheptanoic acid exposure on spermatogenesis in offspring mice
Yijie Zhou, Weilian Sun, Qiuqin Tang, Yiwen Lu, Mei Li, Jing Wang, Xiumei Han, Di Wu, Wei Wu
Ecotoxicology and Environmental Safety.2023; 260: 115072. CrossRef
A Systematic Review of Contaminants of Concern in Uganda: Occurrence, Sources, Potential Risks, and Removal Strategies
Gabson Baguma, Gadson Bamanya, Allan Gonzaga, Wycliffe Ampaire, Patrick Onen
Pollutants.2023; 3(4): 544. CrossRef
Association between maternal serum concentration of perfluoroalkyl substances (PFASs) at delivery and acute infectious diseases in infancy
Zixia Wang, Rong Shi, Guodong Ding, Qian Yao, Chengyu Pan, Yu Gao, Ying Tian
Chemosphere.2022; 289: 133235. CrossRef
The Association between ADHD and Environmental Chemicals—A Scoping Review
Sonja Moore, Laura Paalanen, Lisa Melymuk, Andromachi Katsonouri, Marike Kolossa-Gehring, Hanna Tolonen
International Journal of Environmental Research and Public Health.2022; 19(5): 2849. CrossRef
The Occurrence and Distributions of Per- and polyfluoroalkyl substances (PFAS) in groundwater after a PFAS leakage incident in 2018
Zhi Yuan Yong, Ki Yong Kim, Jeong-Eun Oh
Environmental Pollution.2020; : 115395. CrossRef
Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults
Zhanghua Chen, Tingyu Yang, Douglas I. Walker, Duncan C. Thomas, Chenyu Qiu, Leda Chatzi, Tanya L. Alderete, Jeniffer S. Kim, David V. Conti, Carrie V. Breton, Donghai Liang, Elizabeth R. Hauser, Dean P. Jones, Frank D. Gilliland
Environment International.2020; 145: 106091. CrossRef

First
Prev
Page of 1
Next
Last

Search