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JYMS : Journal of Yeungnam Medical Science

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Psychiatry and Mental Health
Understanding insomnia as systemic disease
Seokho Yun, Sohye Jo
Yeungnam Univ J Med. 2021;38(4):267-274.   Published online September 13, 2021
DOI: https://doi.org/10.12701/yujm.2021.01424
  • 19,081 View
  • 217 Download
  • 7 Crossref
AbstractAbstract PDF
Sleep plays a critical role in homeostasis of the body and mind. Insomnia is a disease that causes disturbances in the initiation and maintenance of sleep. Insomnia is known to affect not only the sleep process itself but also an individual’s cognitive function and emotional regulation during the daytime. It increases the risk of various neuropsychiatric diseases such as depression, anxiety disorder, and dementia. Although it might appear that insomnia only affects the nervous system, it is also a systemic disease that affects several aspects of the body, such as the cardiovascular, endocrine, and immune systems; therefore, it increases the risk of various diseases such as hypertension, diabetes mellitus, and infection. Insomnia has a wide range of effects on our bodies because sleep is a complex and active process. However, a high proportion of patients with insomnia do not seek treatment, which results in high direct and indirect costs. This is attributed to the disregard of many of the negative effects of insomnia. Therefore, we expect that understanding insomnia as a systemic disease will provide an opportunity to understand the condition better and help prevent secondary impairment due to insomnia.

Citations

Citations to this article as recorded by  
  • ZnO Nanoparticle-Based Electrochemical Immunosensor for One-Step Quantification of Cortisol in Saliva
    M. P. Divyamani, Sachin N. Hegde, S. K. Naveen Kumar, M. P. Dharma Guru Prasad
    ACS Omega.2025; 10(33): 38303.     CrossRef
  • Insomnia and Cardiometabolic Health: Bridging the Gap Between Sleep Deficit and Disease Prevention
    James W. Kim, Akshay B. Jain, Atul Khullar
    Canadian Journal of Diabetes.2025; 49(5-6): 342.     CrossRef
  • Medical service utilization patterns among adults with insomnia: A retrospective cohort study
    Min Kyung Hyun, Jang Won Lee
    European Journal of Integrative Medicine.2024; 67: 102325.     CrossRef
  • Exploring Health Promotion Behaviors, Occupational Burnout, and Sleep Disturbances in Traditional Industry Workers
    Ying-Fen Yu, Yi-Ya Chang, Shu-Hung Chang
    Healthcare.2024; 13(1): 51.     CrossRef
  • Socio-Ecological Context of Sleep: Gender Differences and Couples’ Relationships as Exemplars
    Andrea N. Decker, Alexandra R. Fischer, Heather E. Gunn
    Current Psychiatry Reports.2022; 24(12): 831.     CrossRef
  • Clinical Spectrum and Trajectory of Innovative Therapeutic Interventions for Insomnia: A Perspective
    Yun-Jo Lo, Viraj Krishna Mishra, Hung-Yao Lo, Navneet Kumar Dubey, Wen-Cheng Lo
    Aging and disease.2022;[Epub]     CrossRef
  • Understanding sleep and sleep disturbances in autism spectrum disorder, and management of insomnia: an update
    Hye-Geum Kim
    Yeungnam University Journal of Medicine.2021; 38(4): 265.     CrossRef
Psychiatry and Mental Health
An update on the cause and treatment of sleep disturbance in children and adolescents with autism spectrum disorder
Wan Seok Seo
Yeungnam Univ J Med. 2021;38(4):275-281.   Published online September 13, 2021
DOI: https://doi.org/10.12701/yujm.2021.01410
  • 18,534 View
  • 233 Download
  • 20 Crossref
AbstractAbstract PDF
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by abnormalities in social communication/interaction and restrictive, repetitive patterns of behavior. ASD is a relatively common psychiatric disorder, with a prevalence of approximately 1.7% in children. Although many children and adolescents with ASD visit the hospital for medical help for emotional and behavioral problems such as mood instability and self-harming behavior, there are also many visits for sleep disturbances such as insomnia and sleep resistance. Sleep disturbances are likely to increase fatigue and daytime sleepiness, impaired concentration, negatively impact on daytime functioning, and pose challenges in controlling anger and aggressive behavior. Sleep disturbance in children and adolescents with ASD negatively affects the quality of life, nothing to say the quality of life of their families and school members. In this review, sleep disturbances that are common in children and adolescents with ASD and adolescents are presented. The developmental and behavioral impacts of sleep disturbances in ASD were also considered. Finally, non-pharmacological and pharmacological treatments for sleep disturbances in children and adolescents with ASD and adolescents are reviewed.

Citations

Citations to this article as recorded by  
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    Molecular Psychiatry.2026; 31(7): 4124.     CrossRef
  • Sleep and Psychiatric Comorbidities
    Davis C. Thomas, Anu Priya Guruswamy Pandian, Simran Gupta, Jonathan Betlinski
    Medical Clinics of North America.2026;[Epub]     CrossRef
  • Exploring Occupational Therapists’ Sleep Intervention Approaches and Perspectives for Children With Autism Spectrum Disorder: A Malaysian Qualitative Study
    Muhammad Radhi Rahimi Abu Bakar, Akehsan Dahlan, Zul-′ Izzat Ikhwan Zaini, Hanif Farhan Mohd Rasdi, Shashank Kaushik
    Occupational Therapy International.2026;[Epub]     CrossRef
  • Therapeutic dilemma: how to treat severe chronic sleep concerns in youth with neurodevelopmental disorders
    Jessica Youssef, Megan Thomas
    Paediatrics & Child Health.2026;[Epub]     CrossRef
  • From restless nights to peaceful sleep: mothers’ lived experiences in dealing with sleep problems among children with autism spectrum disorder
    Bhagawaty Kalikotay, D. Rajeswari, Helen Shaji J C
    BMC Psychology.2026;[Epub]     CrossRef
  • Prolonged-Release Melatonin for Sleep Disturbances in Autism Spectrum Disorder
    Eva Arias Vivas, Adrián García Ron, Elena González Alguacil, Marta Bote Gascón, María Teresa de Santos Moreno, Elsa Santana Cabrera, Guillermo Ruiz-Ocaña de las Cuevas, Juan José García Peñas, Rafael Sánchez-del Hoyo, Víctor Soto Insuga
    Annals of Child Neurology.2025; 33(1): 1.     CrossRef
  • Melatonin Interventions in Autism Spectrum Disorder: Sleep Regulation, Behavioral Outcomes, and Challenges Across the Lifespan
    Geir Bjørklund, Oleksandra Oleshchuk, Yana Ivankiv, Olena Venger, Olha Liuta, Khrystyna Mocherniuk, Mariana Lukanyuk, Mariia Shanaida
    Molecular Neurobiology.2025; 62(8): 9710.     CrossRef
  • Association between sleep disturbance and metabolic dysfunctions in adipose tissue: Insights into melatonin's role
    Mishthi Ratwani, Shradha Bisht, Swati Prakash
    Biochemical and Biophysical Research Communications.2025; 770: 151978.     CrossRef
  • Current Pharmacological Treatment for Sleep Disorders in Children and Adolescents with Autism Spectrum Disorder
    Hatice Altun, Semiha Cömertoğlu Arslan
    European Journal of Therapeutics.2024; 30(2): 227.     CrossRef
  • Forensic psychiatric assessment in autism spectrum disorder: Experience of a forensic psychiatry inpatient clinic from Türkiye
    Muhammed Emin Boylu, İlker Taşdemir, Mehmet Doğan, Tuba Özcanlı
    Journal of Forensic Sciences.2024; 69(6): 2091.     CrossRef
  • Pattern of sleep disorders among children with autism spectrum disorder
    Muaath Ahmed Mohammed, Elham Mohammed Abdalkhalig, Ibrahim Abdelrhim Ali, Salma Shakir Hassan, Hayat Osman
    BMC Psychiatry.2024;[Epub]     CrossRef
  • Review of Sleep Disorders and Therapeutic Approaches in Patients With Autism Spectrum Disorder and Rett Syndrome
    Katelyn Bricker, Bradley V. Vaughn
    Sleep Medicine Research.2024; 15(4): 228.     CrossRef
  • Sleep and Autism Spectrum Disorder: A Comprehensive Review of Diagnosis, Markers, Interventions, and Treatments
    Deepa Burman, Karthikeyan Ramanujam, Dilshad Manzar, Vijay Kumar Chattu, David Warren Spence, Nevin F. W. Zaki, Haitham Jahrami, Seithikurippu R. Pandi-Perumal
    Sleep and Vigilance.2023; 7(1): 9.     CrossRef
  • Efficacy of Melatonin for Insomnia in Children with Autism Spectrum Disorder: A Meta-analysis
    Mei Xiong, Fang Li, Zhaohua Liu, Xin Xie, Hongli Shen, Weiteng Li, Liping Wei, Rongfang He
    Neuropediatrics.2023; 54(03): 167.     CrossRef
  • Sleep disturbances and emotional dysregulation in young children with autism spectrum, intellectual disability, or global developmental delay
    Irene Favole, Chiara Davico, Daniele Marcotulli, Roberta Sodero, Barbara Svevi, Federico Amianto, Federica S. Ricci, G. Maurizio Arduino, Benedetto Vitiello
    Sleep Medicine.2023; 105: 45.     CrossRef
  • Where I am from matters: factors influencing behavioral and emotional changes in autistic individuals during COVID-19 in Latin America
    María Cecilia Montenegro, Ana C. Ramírez, Juventino Hernandez Rodriguez, Bianca T. Villalobos, Gabriela Garrido, Cecilia Amigo, Daniel Valdez, Natalia Barrios, Sebastián Cukier, Alexia Rattazzi, Analía Rosoli, Ricardo García, Cristiane S. Paula, Georgina
    Frontiers in Psychiatry.2023;[Epub]     CrossRef
  • A novel case of prolonged Ifosfamide encephalopathy and long-term treatment with methylene blue: a case report and review of literature
    Gabriel Chain, Mudit Kalia, Karen Kestenbaum, Lara Pappas, Anna Sechser-Perl, Gadi Abebe Campino, Nibal Zaghloul
    BMC Pediatrics.2022;[Epub]     CrossRef
  • Sleep Disturbances in Children Affected by Autism Spectrum Disorder
    Jessica Galli, Erika Loi, Lucrezia Maria Visconti, Paola Mattei, Anna Eusebi, Stefano Calza, Elisa Fazzi
    Frontiers in Psychiatry.2022;[Epub]     CrossRef
  • Analysis of sleep problem in children aged 1–3 years with autism spectrum disorder in Zhejiang province, China
    Dan Yao, Shasha Wang, Fangfang Li, Minjie Gao, Jie Shao
    Frontiers in Psychiatry.2022;[Epub]     CrossRef
  • Understanding sleep and sleep disturbances in autism spectrum disorder, and management of insomnia: an update
    Hye-Geum Kim
    Yeungnam University Journal of Medicine.2021; 38(4): 265.     CrossRef
Psychiatry and Mental Health
Effects and mechanisms of a mindfulness-based intervention on insomnia
Hye-Geum Kim
Yeungnam Univ J Med. 2021;38(4):282-288.   Published online January 14, 2021
DOI: https://doi.org/10.12701/yujm.2020.00850
  • 61,069 View
  • 249 Download
  • 9 Crossref
AbstractAbstract PDF
Medication alone is not sufficient to treat insomnia. In addition, the side effects of sleep medications themselves cannot be ignored during treatment. Insomnia begins with poor sleep quality and discomfort, but as it continues, patients fall into a vicious circle of insomnia with negative thoughts and dysfunctional and distorted perceptions related to sleep. Mindfulness-based intervention for insomnia corrects these sequential cognitive and behavioral processes. The mindfulness technique basically recognizes all the thoughts, feelings, and experiences that occur to us as they are, nonjudgmentally, and then trains them to return to the senses of our body. In this way, while noticing all the processes of the sequential vicious cycle and training them to return to our bodies (e.g., breathing), mindfulness determines whether we are really sleepy or just fatigued. This mindfulness-based intervention can be a useful nonpharmaceutical intervention for insomnia, and its stability and efficacy has been proven by many studies.

Citations

Citations to this article as recorded by  
  • Suicidal risk, insomnia symptoms, and interoceptive sensitivity: Network analysis in a university student population
    Julie Faccini, Sophie Bayard, Clarisse Madiouni, Jonathan Del-Monte
    Journal of American College Health.2026; 74(4): 1021.     CrossRef
  • Effects of the Adapted Online Version of the Mindfulness-Based Relapse Prevention (MBRP) Protocol on Brazilian College Students: A Randomized Controlled Trial
    Beatriz Iannotta da Silva, Ana Cristina Melo Atanes, André Bedendo, Joyce Salgado Santos, Marina Noto Faria, Larissa Carvalho Saletti, Ana Regina Noto
    Journal of Rational-Emotive & Cognitive-Behavior Therapy.2026;[Epub]     CrossRef
  • Effects of mindfulness meditation combined with progressive muscle relaxation on sleep disorders, anxiety, and depression in patients with sarcopenia undergoing hemodialysis
    Yongyao Wu, Haojie Zhang, Lei Jiang, Zhiping Liu, Xinfei Li, Bei Guo, Junyuan Li, Pengjie Xu, Jiang Liu, Rizhen Yu
    Frontiers in Psychiatry.2025;[Epub]     CrossRef
  • Comparative efficacy and acceptability of interventions for insomnia in breast cancer patients: A protocol for systematic review and network meta-analysis
    Zhifan Li, Qian Wang, Junxia Xu, Qihua Song, Xiaoling Ling, Ya Gao, Junqiang Lei, Andrea Giannini
    PLOS ONE.2023; 18(3): e0282614.     CrossRef
  • Cognitive and Somatic Mediators of the Effects of Trait Mindfulness on Mental Health Adjustment Following Bereavement
    Mariel Emrich, Crystal L. Park, Adam B. David, Lucy Finkelstein-Fox
    Mindfulness.2023; 14(12): 2932.     CrossRef
  • THE DEVELOPMENT AND VALIDITY OF MINDFULNESS DHIKR BREATHING THERAPY FOR INSOMNIA
    Setiyo Purwanto, Mahadir Ahmad, Zaini Said, Nisa Rachmah Nur Anganthi, Mutalazimah, Siti Zulaekah
    The Indonesian Journal of Public Health.2023; 18(3): 382.     CrossRef
  • Effectiveness of a 4-Day Mindfulness-Based Intervention in a 2-Month Follow-Up for Chinese Incarcerated People
    Jieting Zhang, Zening Zheng, Lina Wang, Christina M. Luberto, Man (Sophie) Zhang, Yuhua Wen, Qi Su, Can Jiao
    Behavior Therapy.2022; 53(5): 981.     CrossRef
  • Understanding sleep and sleep disturbances in autism spectrum disorder, and management of insomnia: an update
    Hye-Geum Kim
    Yeungnam University Journal of Medicine.2021; 38(4): 265.     CrossRef
  • Effects of mindful breathing combined with sleep-inducing exercises in patients with insomnia
    Hui Su, Li Xiao, Yue Ren, Hui Xie, Xiang-Hong Sun
    World Journal of Clinical Cases.2021; 9(29): 8740.     CrossRef

JYMS : Journal of Yeungnam Medical Science
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