Journal of Yeungnam Medical Science

Original article

Dentistry
Therapeutic efficacy of mesenchymal stem cells in periodontal regeneration: a systematic review and meta-analysis of clinical trials: Fiki Muhammad Ridho, Anis Irmawati, Raed Labib, Hayyu Norma Almira, Ridwan Alfatah, Bayu Cahyo Bintoro; J Yeungnam Med Sci. 2026;43:42. Published online June 24, 2026; DOI: https://doi.org/10.12701/jyms.2026.43.42

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Abstract PDF Supplementary Material: Background
Periodontitis is a major global health problem that leads to destruction and loss of periodontal tissues. As conventional therapy has a limited capacity to restore the complex architecture of the periodontium, regenerative approaches have been explored. This meta-analysis evaluates the therapeutic efficacy of mesenchymal stem cells (MSCs) for periodontal regeneration in patients with periodontal defects.
Methods
PubMed, Scopus, Web of Science, Dentistry & Oral Sciences Source, and the Cochrane Library were searched for clinical trials. The risk of bias was assessed using Cochrane RoB2. Random- or fixed-effects meta-analyses were used in the pooled analysis and reported as mean differences (MDs) and 95% confidence intervals (CIs). Certainty of evidence was rated using Grading of Recommendations, Assessment, Development, and Evaluation (GRADE).
Results
Ten clinical trials were included in the analysis. MSCs significantly improved probing pocket depth (MD, –0.51; 95% CI, –0.84 to –0.19; p<0.01; I2=62%), clinical attachment level (MD, –0.75; 95% CI, –0.95 to –0.54; p<0.01; I2=40%), cementoenamel junction to the base of defect (MD, –0.49; 95% CI, –0.95 to –0.02; p=0.04; I2=63%), and intrabony defect (MD, –1.09; 95% CI, –1.60 to –0.57; p<0.01; I2=71%). However, no significant improvement in gingival recession was observed (MD, –0.18; 95% CI, –0.38 to 0.01; p=0.07; I2=0%). The GRADE assessment indicated a high-to-moderate certainty.
Conclusion
MSCs represent a promising strategy for periodontal regeneration. Nevertheless, the limited number of studies and the observed heterogeneity warrant cautious interpretation. Larger methodologically rigorous trials are needed to clarify the true contribution of MSCs to periodontal regeneration.

Review article

Orthopedics and Sports Medicine
Current perspectives in stem cell therapies for osteoarthritis of the knee: Gi Beom Kim, Oog-Jin Shon; Yeungnam Univ J Med. 2020;37(3):149-158. Published online April 13, 2020; DOI: https://doi.org/10.12701/yujm.2020.00157

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Mesenchymal stem cells (MSCs) are emerging as an attractive option for osteoarthritis (OA) of the knee joint, due to their marked disease-modifying ability and chondrogenic potential. MSCs can be isolated from various organ tissues, such as bone marrow, adipose tissue, synovium, umbilical cord blood, and articular cartilage with similar phenotypic characteristics but different proliferation and differentiation potentials. They can be differentiated into a variety of connective tissues such as bone, adipose tissue, cartilage, intervertebral discs, ligaments, and muscles. Although several studies have reported on the clinical efficacy of MSCs in knee OA, the results lack consistency. Furthermore, there is no consensus regarding the proper cell dosage and application method to achieve the optimal effect of stem cells. Therefore, the purpose of this study is to review the characteristics of various type of stem cells in knee OA, especially MSCs. Moreover, we summarize the clinical issues faced during the application of MSCs.

Citations

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Review Article

Anatomy
Adult Mesenchymal Stem Cells for Cell Therapy in Clinical Application.: In Hwan Song; Yeungnam Univ J Med. 2009;26(1):1-14. Published online June 30, 2009; DOI: https://doi.org/10.12701/yujm.2009.26.1.1

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Abstract PDF

Human bone marrow-derived mesenchymal stem cells (MSCs) are a rare population of undifferentiated cells that have the capacity of self renewal and the ability to differentiate into mesodermal phenotypes, including osteocytes, chondrocytes, and adipocytes in vitro. Recently, MSCs have been shown to reside within the connective tissue of most organs, and their surface phenotype has been well analyzed. Many reports showed that transplanted MSCs enhanced regeneration as well as functional improvement of damaged organs and tissues. The wide differentiation plasticity of MSCs was expected to contribute to their demonstrated efficacy in a wide variety of experimental animal models and in human clinical trials. However, new findings suggest that the ability of MSCs to alter the tissue microenvironment via secretion of soluble factors may contribute more significantly than their capacity for differentiation in tissue repair. This review describes what is known about the cellular characteristics and differentiation potential of MSCs, which represent a promising stem cell population for further applications in regenerative medicine.

Citations

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