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Original article
Risk factors for prostate-specific antigen persistence in pT3aN0 prostate cancer after robot-assisted laparoscopic radical prostatectomy: a retrospective study
Jun Seop Kim, Jae Hoon Chung, Wan Song, Minyong Kang, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Change Jeong, Seong Il Seo, Hyun Moo Lee, Seong Soo Jeon
J Yeungnam Med Sci. 2023;40(4):412-418.   Published online June 28, 2023
DOI: https://doi.org/10.12701/jyms.2023.00234
  • 1,474 View
  • 38 Download
AbstractAbstract PDF
Background
The aim of this study was to evaluate the risk factors for prostate-specific antigen (PSA) persistence in pathological stage T3aN0 prostate cancer (PCa) after robot-assisted laparoscopic radical prostatectomy (RALP).
Methods
A retrospective study was performed on 326 patients with pT3aN0 PCa who underwent RALP between March 2020 and February 2022. PSA persistence was defined as nadir PSA of >0.1 ng/mL after RALP, and the risk factors for PSA persistence were evaluated using logistic regression analysis.
Results
Among 326 patients, 61 (18.71%) had PSA persistence and 265 (81.29%) had PSA of <0.1 ng/mL after RALP (successful radical prostatectomy [RP] group). In the PSA persistence group, 51 patients (83.61%) received adjuvant treatment. Biochemical recurrence occurred in 27 patients (10.19%) in the successful RP group during the mean follow-up period of 15.22 months. Multivariate analysis showed that the risk factors for PSA persistence were large prostate volume (hazard ratio [HR], 1.017; 95% confidence interval [CI], 1.002–1.036; p=0.046), lymphovascular invasion (LVI) (HR, 2.605; 95% CI, 1.022–6.643; p=0.045), and surgical margin involvement (HR, 2.220; 95% CI, 1.110–4.438; p=0.024).
Conclusion
Adjuvant treatment may be needed for improved prognosis in patients with pT3aN0 PCa after RALP with a large prostate size, LVI, or surgical margin involvement.
Case report
Thyroid storm caused by metastatic papillary thyroid carcinoma tissue after total thyroidectomy: a case report
So Hee Kwon, Min-Ji Kim, Sin Yeong Jung, Jae-Han Jeon
J Yeungnam Med Sci. 2023;40(Suppl):S93-S97.   Published online May 17, 2023
DOI: https://doi.org/10.12701/jyms.2023.00199
  • 1,756 View
  • 71 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDF
Thyroid storm is a life-threatening form of thyrotoxicosis and an endocrinological emergency. We present a case of thyroid storm in a patient with metastatic papillary thyroid cancer. A 67-year-old woman with a history of total thyroidectomy 4 years prior to presentation was admitted with deteriorating mental status, fever, and tachycardia. Laboratory tests revealed severe thyrotoxicosis. Although the patient had no residual thyroid tissue after total thyroidectomy, she had a previously diagnosed metastatic thyroid cancer lesion in the pelvic bone. Despite initial treatment with a standard thyroid storm regimen, the patient died 6 days after hospitalization. The patient had no history of Graves disease; however, a thyroxine receptor antibody was detected postmortem. The patient had a history of exposure to an iodine contrast agent, which is a rare cause of thyrotoxicosis. Thyroxine production from a differentiated thyroid carcinoma is rare but can be a source of clinically significant thyrotoxicosis in patients post-thyroidectomy. Overlapping Graves disease is a common stimulus; however, other causes, such as exogenous iodine, cannot be excluded. This case demonstrates that in the setting of metastatic thyroid carcinoma, thyrotoxicosis cannot be completely ruled out as a cause of suspicious symptoms, even in patients with a history of total thyroidectomy.

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  • Data Analysis and Systematic Scoping Review on the Pathogenesis and Modalities of Treatment of Thyroid Storm Complicated with Myocardial Involvement and Shock
    Eman Elmenyar, Sarah Aoun, Zain Al Saadi, Ahmed Barkumi, Basar Cander, Hassan Al-Thani, Ayman El-Menyar
    Diagnostics.2023; 13(19): 3028.     CrossRef
Original articles
Novel cystography parameter to predict early recovery from urinary continence after radical prostatectomy for prostate cancer: a retrospective study
Yeong Uk Kim
J Yeungnam Med Sci. 2023;40(3):252-258.   Published online July 21, 2022
DOI: https://doi.org/10.12701/jyms.2022.00311
  • 2,571 View
  • 89 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDF
Background
The purpose of this study was to investigate whether postoperative cystography findings can predict early and long-term recovery from incontinence after radical prostatectomy (RP), compared with the other cystography parameters.
Methods
I retrospectively reviewed 118 patients who underwent robot-assisted RP (RARP) for localized prostate cancer at single institution between January 2016 and April 2021. One hundred and seven patients were included in the study. Postoperative cystography was routinely performed 7 days after surgery. The bladder neck to pubic symphysis ratio, vesicourethral angle, and bladder neck anteroposterior length (BNAP) ratio (the bladder neck-posterior margin distances divided by the anteroposterior lengths) were evaluated. Continence was defined as cessation of pad use. The association between these variables and urinary incontinence was also analyzed.
Results
The urinary incontinence recovery rates 1, 3, 6, and 12 months after RARP were 43.92%, 66.35%, 87.85%, and 97.19%, respectively. Multivariate logistic regression analysis demonstrated that a lower BNAP ratio and wider vesicourethral angle were significantly associated with continence restoration at 1, 3, and 6 months after surgery. In addition, in terms of days of pad usage, lower BNAP ratio, wider vesicourethral angle, and bladder neck preservation were significantly associated with recovery from urinary incontinence within 12 months as assessed by Cox proportional hazard analysis.
Conclusion
This study demonstrated that vesicourethral angle and BNAP ratio were independent predictors of early recovery from post-prostatectomy incontinence. I suggest that both the sagittal and coronal views of postoperative cystography help anticipate early continence restoration after RARP.

Citations

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  • A single‐center retrospective comparative analysis of urinary continence in robotic prostatectomy with a combination of umbilical ligament preservation and Hood technique
    Hiroaki Shimmura, Taro Banno, Kazutaka Nakamura, Anju Murayama, Haruki Shigeta, Toyoaki Sawano, Yukiko Kouchi, Akihiko Ozaki, Fumito Yamabe, Junpei Iizuka, Toshio Takagi
    International Journal of Urology.2023; 30(10): 889.     CrossRef
The effect and therapeutic compliance of adjuvant therapy in patients with cholangiocarcinoma after R0 resection: a retrospective study
Han Taek Jeong, Joonkee Lee, Hyeong Ho Jo, Ho Gak Kim, Jimin Han
J Yeungnam Med Sci. 2023;40(1):65-77.   Published online May 26, 2022
DOI: https://doi.org/10.12701/jyms.2022.00213
  • 3,293 View
  • 62 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDF
Background
This study aimed to compare clinical outcomes between surveillance and adjuvant therapy (AT) groups after R0 resection for cholangiocarcinoma (CCA).
Methods
A total of 154 patients who underwent R0 resection for CCA at the Daegu Catholic University Medical Center between January 2010 and December 2019 were included. Overall survival (OS) and progression-free survival (PFS) were analyzed.
Results
The median follow-up duration was 899 days. There were 109 patients in the AT group and 45 patients in the surveillance group. The patients in the AT group were younger (67 years vs. 74 years, p<0.001) and included more males (64.2% vs. 46.7%, p=0.044). The proportion of patients with stage III CCA was larger in the AT group than in the surveillance group (13.8% vs. 2.2%, p=0.005). In addition, AT did not improve OS (5-year OS rate, 69.3% in the AT group vs. 64.2% in the surveillance group, p=0.806) or PFS (5-year PFS rate, 42.6% in the AT group vs. 48.9% in the surveillance group, p=0.113). In multivariate analysis using the Cox proportional hazards model, stage III CCA (hazard ratio [HR], 10.81; 95% confidence interval [CI], 2.92–40.00; p<0.001) was a significant predictor of OS. American Society of Anesthesiologists classification II (HR, 0.50; 95% CI, 0.31–0.81; p=0.005), and American Joint Committee on Cancer stages II (HR, 3.14; 95% CI, 1.25–7.89; p=0.015) and III (HR, 8.08; 95% CI, 2.80–23.32; p<0.001) were independent predictors of PFS.
Conclusion
AT after R0 resection for CCA did not improve OS or PFS.

Citations

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  • Robotic Complete ALPPS (rALPPS)—First German Experiences
    Jörg Arend, Mareike Franz, Alexander Rose, Christine March, Mirhasan Rahimli, Aristotelis Perrakis, Eric Lorenz, Roland Croner
    Cancers.2024; 16(5): 1070.     CrossRef
Review articles
Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review
Hyun Uk Chung, Jun Hyuk Son
J Yeungnam Med Sci. 2022;39(1):3-11.   Published online September 15, 2021
DOI: https://doi.org/10.12701/yujm.2021.01263
  • 5,576 View
  • 159 Download
  • 8 Web of Science
  • 6 Crossref
AbstractAbstract PDF
Lymphoma is the most common primary tumor of the orbit, accounting for 55% of all orbital malignancies. When divided into histopathological subtypes, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) comprises the largest proportion. Clinical manifestations are unspecific, but in patients with slow-growing painless orbital mass, or red conjunctival lesion suggestive of ‘salmon patch’, ocular adnexa lymphoma (OAL) should be suspected. Although the pathogenetic mechanism of ocular adnexal MALT lymphoma (OAML) is not yet fully understood, the relationship between OAML and Chlamydia psittaci has been hypothesized recently, similar to that between gastric MALT lymphoma and Helicobacter pylori. This suggests a new treatment option for OAML; bacterial eradication therapy with systemic antibiotics. Several other treatment methods for OAML have been introduced, but no treatment guidelines have been established yet. In this article, we summarize the current knowledge on the clinical features, pathogenesis, diagnostic methods, therapeutic strategies, and prognosis of OAML.

Citations

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  • Unusual Pediatric Red Eye
    Carson W. Ercanbrack, Jamal O. Azhari, David B. Warner, Maher Abulfaraj, Abdelrahman M. Elhusseiny
    The Journal of Pediatrics.2024; 267: 113924.     CrossRef
  • The Possible Role of Pathogens and Chronic Immune Stimulation in the Development of Diffuse Large B-Cell Lymphoma
    Lajos Gergely, Miklos Udvardy, Arpad Illes
    Biomedicines.2024; 12(3): 648.     CrossRef
  • Radiomics analysis of T1WI and T2WI magnetic resonance images to differentiate between IgG4-related ophthalmic disease and orbital MALT lymphoma
    Yuchao Shao, Yuqing Chen, Sainan Chen, Ruili Wei
    BMC Ophthalmology.2023;[Epub]     CrossRef
  • Etiopathogenesis of primary acquired nasolacrimal duct obstruction (PANDO)
    Mohammad Javed Ali
    Progress in Retinal and Eye Research.2023; 96: 101193.     CrossRef
  • The Biology of Ocular Adnexal Marginal Zone Lymphomas
    Patricia Johansson, Anja Eckstein, Ralf Küppers
    Cancers.2022; 14(5): 1264.     CrossRef
  • One Case of Conjunctival MALT Lymphoma and Literature Review
    旭霞 李
    Advances in Clinical Medicine.2022; 12(08): 7586.     CrossRef
An update on immunotherapy with PD-1 and PD-L1 blockade
Sung Ae Koh
Yeungnam Univ J Med. 2021;38(4):308-317.   Published online September 9, 2021
DOI: https://doi.org/10.12701/yujm.2021.01312
  • 4,463 View
  • 95 Download
  • 2 Crossref
AbstractAbstract PDF
Cancer is the leading cause of death and is on the rise worldwide. Until 2010, the development of targeted treatment was mainly focused on the growth mechanisms of cancer. Since then, drugs with mechanisms related to tumor immunity, especially immune checkpoint inhibitors, have proven effective, and most pharmaceutical companies are striving to develop related drugs. Programmed cell death-1 and programmed cell death ligand-1 inhibitors have shown great success in various cancer types. They showed durable and sustainable responses and were approved by the U.S. Food and Drug Administration. However, the response to inhibitors showed low percentages of cancer patients; 15% to 20%. Therefore, combination strategies with immunotherapy and conventional treatments were used to overcome the low response rate. Studies on combination therapy have typically reported improvements in the response rate and efficacy in several cancers, including non-small cell lung cancer, small cell lung cancer, breast cancer, and urogenital cancers. The combination of chemotherapy or targeted agents with immunotherapy is one of the leading pathways for cancer treatment.

Citations

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  • Immune checkpoint inhibitors associated cardiovascular immune-related adverse events
    Wonyoung Jo, Taejoon Won, Abdel Daoud, Daniela Čiháková
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Therapeutic targeting of thioredoxin reductase 1 causes ferroptosis while potentiating anti-PD-1 efficacy in head and neck cancer
    Ming-Shou Hsieh, Hang Huong Ling, Syahru Agung Setiawan, Mardiah Suci Hardianti, Iat-Hang Fong, Chi-Tai Yeh, Jia-Hong Chen
    Chemico-Biological Interactions.2024; 395: 111004.     CrossRef
Case reports
Multilocular cystic hemangioma of the liver mimicking mucinous cystic neoplasm: a case report
Nam Kyung Lee, Suk Kim, Seung Baek Hong, So Jeong Lee, Hyung Il Seo
J Yeungnam Med Sci. 2022;39(1):53-57.   Published online April 7, 2021
DOI: https://doi.org/10.12701/yujm.2021.00969
  • 9,349 View
  • 106 Download
AbstractAbstract PDF
Hepatic hemangiomas infrequently exhibit atypical imaging features, which may cause diagnostic confusion with hepatic malignancies and lead to unnecessary surgery. We report a rare case of multilocular cystic hemangioma of the liver mimicking a mucinous cystic neoplasm of the liver in a 48-year-old female, focusing on computed tomography and magnetic resonance imaging features and their differential diagnosis.
Pancreatic metastasis from malignant phyllodes tumor of the breast
Seung Eun Lee, Young Kyung Bae, Joon Hyuk Choi
Yeungnam Univ J Med. 2021;38(1):78-82.   Published online November 27, 2020
DOI: https://doi.org/10.12701/yujm.2020.00759
  • 4,788 View
  • 67 Download
  • 3 Crossref
AbstractAbstract PDF
Pancreatic metastasis from malignant phyllodes tumor (PT) of the breast is rare, and only a few cases have been reported in the literature. Here, we report a case of pancreatic metastasis from malignant PT of the breast in a 48-year-old woman. She had had three episodes of recurrence of malignant PT in her right breast. She presented with epigastric pain for 2 months. Computed tomography and magnetic resonance imaging revealed a 6 cm-sized, well-defined, heterogeneous mass with peripheral enhancement in the body of the pancreas. Endoscopic ultrasonography-guided fine-needle aspiration was performed, and the pathologic report suggested spindle cell mesenchymal neoplasm. Subsequently, surgical excision was performed, and the mass was confirmed as a metastatic malignant PT. The imaging findings are discussed and the literature is briefly reviewed in this report.

Citations

Citations to this article as recorded by  
  • Integrating single‐cell and spatial transcriptomes reveals COL4A1/2 facilitates the spatial organisation of stromal cells differentiation in breast phyllodes tumours
    Xia Li, Xuewen Yu, Jiaxin Bi, Xu Jiang, Lu Zhang, Zhixin Li, Mumin Shao
    Clinical and Translational Medicine.2024;[Epub]     CrossRef
  • Case report: Osteosarcomatous differentiation in the lung metastasis of a malignant phyllodes tumor
    Ruijing Liu, Jingli Xue, Wen Liu, Beibei Jiang, Fuyun Shi, Zhenzheng Wang, Peifeng Li
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • Diagnostic approach to fibroepithelial tumors of the breast
    Frances Tresserra, María Angeles Martinez-Lanao, Melissa Fernandez-Acevedo, Cristina Castellet, Sonia Baulies
    Revista de Senología y Patología Mamaria.2022; 35: S22.     CrossRef
Original article
A retrospective analysis of etiology and outcomes of hemophagocytic lymphohistiocytosis in children and adults
Abraham Kwak, Nani Jung, Ye Jee Shim, Heung Sik Kim, Hyun Ji Lim, Jae Min Lee, Mi Hwa Heo, Young Rok Do
Yeungnam Univ J Med. 2021;38(3):208-218.   Published online November 27, 2020
DOI: https://doi.org/10.12701/yujm.2020.00591
  • 6,825 View
  • 148 Download
  • 6 Crossref
AbstractAbstract PDF
Background
Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe, life-threatening inflammatory condition if untreated. We aimed to investigate the etiologies, outcomes, and risk factors for death in children and adults with HLH.
Methods
The medical records of patients who met the HLH criteria of two regional university hospitals in Korea between January 2001 and December 2019 were retrospectively investigated.
Results
Sixty patients with HLH (35 children and 25 adults) were included. The median age at diagnosis was 7.0 years (range, 0.1–83 years), and the median follow-up duration was 8.5 months (range, 0–204 months). Four patients had primary HLH, 48 patients had secondary HLH (20 infection-associated, 18 neoplasm-associated, and 10 autoimmune-associated HLH), and eight patients had HLH of unknown cause. Infection was the most common cause in children (14/35, 40.0%), whereas neoplasia was the most common cause in adults (13/25, 52.0%). Twenty-eight patients were treated with HLH-2004/94 immunochemotherapy. The 5-year overall survival (OS) rate for all HLH patients was 59.9%. The 5-year OS rates for patients with primary, infection-associated, neoplasm-associated, autoimmune-associated, and unknown cause HLH were 25.0%, 85.0%, 26.7%, 87.5%, and 62.5%, respectively. Using multivariate analysis, neoplasm-induced HLH (p=0.001) and a platelet count <50×109/L (p=0.008) were identified as independent risk factors for poor prognosis in patients with HLH.
Conclusion
Infection was the most common cause of HLH in children, while it was neoplasia in adults. The 5-year OS rate for all HLH patients was 59.9%. HLH caused by an underlying neoplasm or a low platelet count at the time of diagnosis were risk factors for poor prognosis.

Citations

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  • Prevalence and mortality of haemophagocytic lymphohistiocytosis in dengue fever: a systematic review and meta-analysis
    Leong Tung Ong, Roovam Balasubramaniam
    Transactions of The Royal Society of Tropical Medicine and Hygiene.2024;[Epub]     CrossRef
  • Predicting relapsed/refractory disease in childhood hemophagocytic lymphohistiocytosis based on clinical features at diagnosis: A 13-year single-institute retrospective study in Thailand
    Pattranan Kusontammarat, Chane Choed-Amphai, Lalita Sathitsamitphong, Watchareewan Sontichai, Rungrote Natesirinilkul, Pimlak Charoenkwan
    Annals of Hematology.2024;[Epub]     CrossRef
  • Spontaneous resolution of hemophagocytic lymphohistiocytosis in a child infected with epstein–Barr virus
    Rita Alfattal, Hussain Sadeq, Abdullah Ali
    Journal of Applied Hematology.2023; 14(1): 57.     CrossRef
  • Pediatric inborn errors of immunity causing hemophagocytic lymphohistiocytosis: Case report and review of the literature
    María Soledad Caldirola, Andrea Gómez Raccio, Daniela Di Giovanni, María Isabel Gaillard, María Victoria Preciado
    Journal of Leukocyte Biology.2022; 112(4): 607.     CrossRef
  • Secondary Hemophagocytic Lymphohistiocytosis and Autoimmune Cytopenias: Case Description and Review of the Literature
    Bruno Fattizzo, Marta Ferraresi, Juri Giannotta, Wilma Barcellini
    Journal of Clinical Medicine.2021; 10(4): 870.     CrossRef
  • HLH-Like Syndrome and Rhabdomyolysis in an Adolescent Patient
    Lauren T. Maloney, Bronwyn Baz, Dia Hazra
    Pediatrics.2021;[Epub]     CrossRef
Case report
Early surgical intervention for unusually located cardiac fibroelastomas
Eui Suk Chung, Jae Hoon Lee, Jong Kwon Seo, Byung Gyu Kim, Gwang Sil Kim, Hye Young Lee, Young Sup Byun, Hyun Jung Kim
Yeungnam Univ J Med. 2020;37(4):345-348.   Published online August 5, 2020
DOI: https://doi.org/10.12701/yujm.2020.00556
  • 4,160 View
  • 56 Download
  • 2 Crossref
AbstractAbstract PDF
Papillary fibroelastomas are the second most common primary cardiac tumor in adults. Over 80% of fibroelastomas occur on the cardiac valves, usually on the left side of the heart, while the remaining lesions are typically scattered throughout the atria and ventricles. Although the optimal timing for surgery is controversial and depends on tumor size and location, prompt surgical resection is warranted in patients at high risk of embolism. A tumor on the cardiac valve can be removed using the slicing excision technique without leaflet injury. Here we present two cases of papillary fibroelastomas occurring on the ventricular surface of the aortic valve and in the right ventricle.

Citations

Citations to this article as recorded by  
  • A Importância da Multimodalidade de Imagem no Diagnóstico de um Raro Caso de Fibroelastoma Papilar no Ápice do Ventrículo Esquerdo
    Marcio Mendes Pereira, Vinícius José da Silva Nina, José Xavier de Melo Filho, Rodrigo de Jesus Louzeiro Melo, Marco Túlio Hercos Juliano, Luma Sayonara Martins Pereira
    ABC Imagem Cardiovascular.2023;[Epub]     CrossRef
  • The Importance of Imaging Multimodality in the Diagnosis of a Rare Case of Papillary Fibroelastoma in the Left Ventricular Apex
    Marcio Mendes Pereira, Vinícius José da Silva Nina, José Xavier de Melo, Rodrigo de Jesus Louzeiro Melo, Marco Túlio Hercos Juliano, Luma Sayonara Martins Pereira
    ABC Imagem Cardiovascular.2023;[Epub]     CrossRef
Review article
Gallbladder polyps: evolving approach to the diagnosis and management
Kook Hyun Kim
Yeungnam Univ J Med. 2021;38(1):1-9.   Published online May 15, 2020
DOI: https://doi.org/10.12701/yujm.2020.00213
  • 23,581 View
  • 485 Download
  • 6 Crossref
AbstractAbstract PDF
Gallbladder (GB) polyp is a mucosal projection into the GB lumen. With increasing health awareness, GB polyps are frequently found using ultrasonography during health screening. The prevalence of GB polyps ranges between 1.3% and 9.5%. Most patients are asymptomatic and have benign characteristics. Of the nonneoplastic polyps, cholesterol polyps are most common, accounting for 60%–70% of lesions. However, a few polyps have malignant potential. Currently, the guidelines recommend laparoscopic cholecystectomy for polyps larger than 1 cm in diameter due to their malignan potential. The treatment algorithm can be influenced by the size, shape, and numbers of polyps, old age (>50 years), the presence of primary sclerosing cholangitis, and gallstones. This review summarizes the commonly recognized concepts on GB polyps from diagnosis to an algorithm of treatment.

Citations

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  • Endoscopic ultrasound-guided gallbladder endoscopic mucosal resection: a pilot porcine study
    Huifang Pang, Quan Man, Li Min, Zheng Zhang, Shengtao Zhu, Shuyue Yang, Yao Xu, Haijun Hou, Shutian Zhang, Peng Li
    Minimally Invasive Therapy & Allied Technologies.2023; 32(1): 24.     CrossRef
  • The link between Helicobacter pylori infection and gallbladder and biliary tract diseases: A review
    Klay Puay Khim Lim, Aaron Jia Loong Lee, Xiuting Jiang, Thomas Zheng Jie Teng, Vishal G. Shelat
    Annals of Hepato-Biliary-Pancreatic Surgery.2023; 27(3): 241.     CrossRef
  • The gallbladder: what’s new in 2022?
    Rachel Runde, Edward D. Auyang, Raye Ng, Kaysey Llorente, Hina Arif Tiwari, Shana Elman, William M. Thompson
    Abdominal Radiology.2022; 48(1): 2.     CrossRef
  • Gallbladder polyps: diagnosis and treatment tactics (literature review)
    S. N. Perekhodov, D. V. Nikolaev, S. S. Saidov
    Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH).2021; 11(4): 88.     CrossRef
  • Is there a role for growth status in distinguishing gallbladder adenomas from cholesterol polyps? – A retrospective study based on 520 cholecystectomy patients
    Wenqing Bao, Anan Xu, Shubin Ni, Bo Wang, Humaira Urmi, Bin Zhao, Yongmei You, Hai Hu
    Scandinavian Journal of Gastroenterology.2021; 56(12): 1450.     CrossRef
  • Polyps and cancer of the biliary system (lecture for medical practitioners)
    G. V. Shavkuta
    South Russian Journal of Therapeutic Practice.2020; 1(2): 78.     CrossRef
Original article
Clinical and histopathologic analysis of gynecological cancer: a single institute experience over 7 years
Soo-Young Lee, Eunbyeol Kim, Hyo-Shin Kim, Yu-Jin Koo, Dae-Hyung Lee
Yeungnam Univ J Med. 2020;37(3):179-185.   Published online March 5, 2020
DOI: https://doi.org/10.12701/yujm.2019.00451
  • 5,820 View
  • 169 Download
  • 2 Crossref
AbstractAbstract PDF
Background
Approximately 100,000 women are diagnosed with cancer each year in Korea. According to a survey by the Korean central cancer registry in 2016, uterine cervical cancer, uterine corpus cancer, and ovarian cancer were the 5th, 7th, and 8th most prevalent cancers respectively among Korean women. The present study aims to review the clinico-pathologic characteristics of patients who were treated for major gynecological malignancies at Yeungnam University Medical Center.
Methods
Patients with invasive gynecological cancers from January 2012 to February 2019 were retrospectively identified. We analyzed the clinical features, demographic profiles, pathologic data, treatment modality used, adjuvant treatment used, complications, recurrence, and survival outcomes.
Results
A total of 287 patients (cervical cancer 115; corporal cancer 86; and ovarian, tubal, or primary peritoneal cancer 90) were included. Most cervical (82.7%) and corporal cancers (89.5%) were diagnosed in the early stages (stage I or II), while more than half (58.9%) the cases of ovarian, tubal or peritoneal cancers were diagnosed in the advanced stages (stage III or IV). Surgical complications were observed in 12.2% of cervical cancers, 16.3% of uterine corpus cancers, and 11.1% of ovarian, tubal, and peritoneal cancers, respectively. The 5-year overall survival rate was 94.1%, 91.0%, and 77.1% for cervical, corporal, and ovarian, tubal, or peritoneal cancers, respectively.
Conclusion
Surgical treatment was satisfactory in terms of the incidence of complications, and survival outcomes were generally good. Clinicians should be aware of the clinical and histopathological characteristics of patients with gynecological cancers to be able to provide optimal strategies and counseling.

Citations

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  • Molecular landscape of recurrent cervical cancer
    Divya Adiga, Sangavi Eswaran, Deeksha Pandey, Krishna Sharan, Shama Prasada Kabekkodu
    Critical Reviews in Oncology/Hematology.2021; 157: 103178.     CrossRef
  • Histopathological Study of Gynecological Cancers in Patients Admitted to Baqiyatallah Hospital in Tehran during 2011-2019
    Seyedeh Razieh Hashemi, Mohammad Reza Akbari, Zahra Soleimani
    Avicenna Journal of Clinical Medicine.2021; 28(1): 42.     CrossRef
Case reports
Impressive effect of cisplatin monotherapy on a patient with heavily pretreated triple-negative breast cancer with poor performance
Dong Won Baek, Ji-Young Park, Soo Jung Lee, Yee Soo Chae
Yeungnam Univ J Med. 2020;37(3):230-235.   Published online January 22, 2020
DOI: https://doi.org/10.12701/yujm.2019.00423
  • 7,918 View
  • 154 Download
  • 8 Crossref
AbstractAbstract PDF
Systemic therapy for metastatic triple-negative breast cancer (TNBC) still remains challenging because there are no targeted agents or endocrine therapies currently available. The present case report documents the successful use of cisplatin monotherapy to manage a heavily pretreated TNBC patient showing poor response to therapy. The patient was a 51-year-old woman who had already undergone several lines of systemic chemotherapy for widespread TNBC. Although the mutation analysis performed on DNA isolated from blood cells and progressed lesion samples confirmed the tumor to be germline BRCA wild-type, cisplatin monotherapy was administered based on the increasing evidence of safety and efficacy of platinum for breast cancer. After three cycles of cisplatin treatment, the patient’s metastatic lesions dramatically improved without any major toxicity, and she completed 17 cycles with good response. This case study indicates that patients with heavily pretreated TNBC can potentially achieve a good response to cisplatin monotherapy.

Citations

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  • Zeolitic Imidazole Framework/Silica Nanocomposite for Targeted Cancer Therapeutics: Comparative Study of Chemo-Drug Cisplatin (CPt) and Green Platinum (GPt) Efficacy
    Hend Ghnaim Alotaibi, Eman Al-Abbad, Dana Almohazey, Vijaya Ravinayagam, Sultan Akhtar, Hatim Dafalla, B. Rabindran Jermy
    International Journal of Molecular Sciences.2024; 25(6): 3157.     CrossRef
  • Cisplatin Monotherapy as a Treatment Option for Patients with HER-2 Negative Breast Cancer Experiencing Hepatic Visceral Crisis or Impending Visceral Crisis
    Mirosława Püsküllüoğlu, Małgorzata Pieniążek, Agnieszka Rudzińska, Agnieszka Pietruszka, Renata Pacholczak-Madej, Aleksandra Grela-Wojewoda, Marek Ziobro
    Oncology and Therapy.2024;[Epub]     CrossRef
  • Hypoxia: syndicating triple negative breast cancer against various therapeutic regimens
    Nityanand Srivastava, Salman Sadullah Usmani, Rajasekaran Subbarayan, Rashmi Saini, Pranav Kumar Pandey
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Extramedullary tanycytic ependymoma of the lumbar spinal cord
Dong Ja Kim, Man-Hoon Han, SangHan Lee
Yeungnam Univ J Med. 2020;37(2):128-132.   Published online November 11, 2019
DOI: https://doi.org/10.12701/yujm.2019.00367
  • 5,901 View
  • 122 Download
  • 3 Crossref
AbstractAbstract PDF
Tanycytic ependymoma is a rare variant of ependymoma that commonly affects the cervical and thoracic spinal cord. It usually arises as intramedullary lesions, and extramedullary cases are extremely rare. We report a case of a 44-year-old woman who was diagnosed with tanycytic ependymoma in her lumbar spine at level 2-3. The tumor mass developed in an intradural extramedullary location. Histopathologically, tanycytic ependymoma can be misdiagnosed as schwannoma or pilocytic astrocytoma. Immunohistochemical findings such as strong positivity for glial fibrillary acidic protein, perinuclear dot-like positive patterns for epithelial membrane antigen, and focal positivity for S-100 are helpful in diagnosing tanycytic ependymoma. It is important to be aware of this rare tumor to ensure appropriate patient management and accurate prognosis.

Citations

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  • Whorling Sclerosing Ependymoma of the Cervical Spinal Cord Presenting Tanycytic Histopathologic Features: A Rare Case Report
    Cumhur Kaan Yaltırık, Emin Oğuzcan Yamaner, Öznur Suakar, Sezin Gürkan, Aydın Sav, Uğur Türe
    International Journal of Surgical Pathology.2023; 31(2): 239.     CrossRef
  • Stretched intradural extramedullary tanycytic ependymoma of the thoracic spine
    Nicola Montemurro, Daniele Lorenzini, Valerio Ortenzi, Jacopo Giorgetti
    Surgical Neurology International.2022; 13: 426.     CrossRef
  • Intradural extramedullary tanycytic ependymoma of the cervical spine: A case report
    Mahmoud M. Taha, Mazen M. Taha, Mohamed Kh. Elbadawy, Mohammad Ezzat
    Interdisciplinary Neurosurgery.2021; 26: 101319.     CrossRef
Review article
Endoscopic features aiding the diagnosis of gastric mucosa-associated lymphoid tissue lymphoma
Byung Sam Park, Si Hyung Lee
Yeungnam Univ J Med. 2019;36(2):85-91.   Published online February 26, 2019
DOI: https://doi.org/10.12701/yujm.2019.00136
  • 10,073 View
  • 213 Download
  • 16 Crossref
AbstractAbstract PDF
The incidence of gastric mucosa-associated lymphoid tissue (MALT) lymphoma is increasing worldwide, but the diagnosis is difficult. Most patients are asymptomatic or complain of nonspecific gastrointestinal symptoms. As the endoscopic features of gastric MALT lymphoma are variable and nonspecific, the possibility of this condition may be overlooked during esophagogastroduodenoscopy, and it remain undiagnosed. Therefore, this condition needs to be considered when an abnormal mucosa is observed during this procedure. Biopsy performed during endoscopy is the primary diagnostic test, but false negative results are possible; large numbers of samples should be collected from both normal and abnormal mucosae. Endoscopic ultrasonography is useful to assess the depth of invasion and to predict the treatment response. After treatment, follow-up tests are required every 3 months until complete remission is achieved, and annually thereafter. Early diagnosis of gastric MALT lymphoma is difficult, and its diagnosis and follow-up require wide experience and competent endoscopic technique.

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JYMS : Journal of Yeungnam Medical Science