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JYMS : Journal of Yeungnam Medical Science

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4 "Neurotoxicity"
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Original article
Impact of calcineurin inhibitors on rat glioma cells viability
Jeong Hun Seong, Woo Yeong Park, Jin Hyuk Paek, Sung Bae Park, Seungyeup Han, Kyo-Cheol Mun, Kyubok Jin
Yeungnam Univ J Med. 2019;36(2):105-108.   Published online January 21, 2019
DOI: https://doi.org/10.12701/yujm.2019.00108
  • 4,357 View
  • 73 Download
  • 1 Crossref
AbstractAbstract PDF
Background
Although kidney transplantation outcomes have improved dramatically after using calcineurin inhibitors (CNIs), CNI toxicity continues to be reported and the mechanism remains uncertain. Here, we investigated the neurotoxicity of CNIs by focusing on the viability of glioma cells.
Methods
Glioma cells were treated with several concentrations of CNIs for 24 hours at 37 ℃ and their cell viability was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.
Results
Exposure to 0, 0.25, 0.5, 2.5, 5.0, and 10.0 mM concentrations respectively showed 100%, 64.3%, 61.3%, 68.1%, 62.4%, and 68.6% cell viability for cyclosporine and 100%, 38.6%, 40.8%, 43.7%, 37.8%, and 43.0% for tacrolimus. The direct toxic effect of tacrolimus on glioma cell viability was stronger than that of cyclosporine at the same concentration.
Conclusion
CNIs can cause neurological side effects by directly exerting cytotoxic effects on brain cells. Therefore, we should carefully monitor the neurologic symptoms and level of CNIs in kidney transplant patients.

Citations

Citations to this article as recorded by  
  • Tacrolimus-Induced Neurotoxicity After Transplant: A Literature Review
    Paige Verona, Jocelyn Edwards, Kassidy Hubert, Federica Avorio, Vincenzina Lo Re, Roberta Di Stefano, Anna Carollo, Heather Johnson, Alessio Provenzani
    Drug Safety.2024;[Epub]     CrossRef
Review Article
Potential health effects of emerging environmental contaminants perfluoroalkyl compounds
Youn Ju Lee
Yeungnam Univ J Med. 2018;35(2):156-164.   Published online December 31, 2018
DOI: https://doi.org/10.12701/yujm.2018.35.2.156
  • 7,689 View
  • 101 Download
  • 7 Crossref
AbstractAbstract PDF
Environmental contaminants are one of the important causal factors for development of various human diseases. In particular, the perinatal period is highly vulnerable to environmental toxicants and resultant dysregulation of fetal development can cause detrimental health outcomes potentially affecting life-long health. Perfluoroalkyl compounds (PFCs), emerging environmental pollutants, are man-made organic molecules, which are widely used in diverse industries and consumer products. PFCs are non-degradable and bioaccumulate in the environment. Importantly, PFCs can be found in cord blood and breast milk as well as in the general population. Due to their physicochemical properties and potential toxicity, many studies have evaluated the health effects of PFCs. This review summarizes the epidemiological and experimental studies addressing the association of PFCs with neurotoxicity and immunotoxicity. While the relationships between PFC levels and changes in neural and immune health are not yet conclusive, accumulative studies provide evidence for positive associations between PFC levels and the incidence of attention deficit hyperactivity disorder and reduced immune response to vaccination both in children and adults. In conclusion, PFCs have the potential to affect human health linked with neurological disorders and immunosuppressive responses. However, our understanding of the molecular mechanism of the effects of PFCs on human health is still in its infancy. Therefore, along with efforts to develop methods to reduce exposure to PFCs, studies on the mode of action of these chemicals are required in the near future.

Citations

Citations to this article as recorded by  
  • Modifiable contributing factors to COVID-19: A comprehensive review
    Ronald Neil Kostoff, Michael Brandon Briggs, Darja Kanduc, Saikat Dewanjee, Ramesh Kandimalla, Yehuda Shoenfeld, Alan L. Porter, Aristidis Tsatsakis
    Food and Chemical Toxicology.2023; 171: 113511.     CrossRef
  • Effect of prenatal perfluoroheptanoic acid exposure on spermatogenesis in offspring mice
    Yijie Zhou, Weilian Sun, Qiuqin Tang, Yiwen Lu, Mei Li, Jing Wang, Xiumei Han, Di Wu, Wei Wu
    Ecotoxicology and Environmental Safety.2023; 260: 115072.     CrossRef
  • A Systematic Review of Contaminants of Concern in Uganda: Occurrence, Sources, Potential Risks, and Removal Strategies
    Gabson Baguma, Gadson Bamanya, Allan Gonzaga, Wycliffe Ampaire, Patrick Onen
    Pollutants.2023; 3(4): 544.     CrossRef
  • Association between maternal serum concentration of perfluoroalkyl substances (PFASs) at delivery and acute infectious diseases in infancy
    Zixia Wang, Rong Shi, Guodong Ding, Qian Yao, Chengyu Pan, Yu Gao, Ying Tian
    Chemosphere.2022; 289: 133235.     CrossRef
  • The Association between ADHD and Environmental Chemicals—A Scoping Review
    Sonja Moore, Laura Paalanen, Lisa Melymuk, Andromachi Katsonouri, Marike Kolossa-Gehring, Hanna Tolonen
    International Journal of Environmental Research and Public Health.2022; 19(5): 2849.     CrossRef
  • The Occurrence and Distributions of Per- and polyfluoroalkyl substances (PFAS) in groundwater after a PFAS leakage incident in 2018
    Zhi Yuan Yong, Ki Yong Kim, Jeong-Eun Oh
    Environmental Pollution.2020; : 115395.     CrossRef
  • Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults
    Zhanghua Chen, Tingyu Yang, Douglas I. Walker, Duncan C. Thomas, Chenyu Qiu, Leda Chatzi, Tanya L. Alderete, Jeniffer S. Kim, David V. Conti, Carrie V. Breton, Donghai Liang, Elizabeth R. Hauser, Dean P. Jones, Frank D. Gilliland
    Environment International.2020; 145: 106091.     CrossRef
Case Reports
A Case of Neurotoxicity Induced by Valaciclovir in a Continuous Ambulatory Peritoneal Dialysis Patient.
Joon Seok Kim, Jee Eun Yang, Bo Young Lee, Seohyun Lee, Hee Jung Park, Sunpyo Lee, Sang Koo Lee
Yeungnam Univ J Med. 2012;29(2):121-124.   Published online December 31, 2012
DOI: https://doi.org/10.12701/yujm.2012.29.2.121
  • 1,686 View
  • 6 Download
  • 2 Crossref
AbstractAbstract PDF
Valaciclovir is metabolized to acyclovir after ingestion and thereafter exerts its antiviral activity. Because of its superior pharmacokinetic profile, it has quickly replaced acyclovir in the treatment of herpesvirus infection. Neurotoxicity caused by valaciclovir has been reported, however, among patients with pre-existing impaired renal function. This paper reports a case of neurotoxicity of valaciclovir in a patient with end-stage renal disease who was undergoing continuous ambulatory peritoneal dialysis (CAPD). A 67-year-old female on CAPD took 500 mg of valaciclovir twice for herpes zoster. After she took her second dose orally, she developed confusion and disorientation, along with involuntary movements. Her mental confusion progressed to a coma. Discontinuation of valaciclovir showed no rapid improvement. There- fore, hemodialysis was started. After two sessions of hemodialysis, the patient became alert; and after four sessions of hemodialysis, her neurological abnormalities were completely reversed. In conclusion, valaciclovir can induce life-threatening neurotoxicity, especially in CAPD patients, even with appropriate dose reduction, which can be effectively managed by hemodialysis.

Citations

Citations to this article as recorded by  
  • Comparison of Renal Function Indicators According to Hydration Volume in Patients Receiving Intravenous Acyclovir With CNS Infection
    Sanghee Kim, Youngsoon Byun
    Biological Research For Nursing.2015; 17(1): 55.     CrossRef
  • Valacyclovir-Induced Neurotoxicity in a Maintenance Hemodialysis Patient
    June Seong Hwang, Hyo Yoep Song, Hoon Gil Jo, Song I Lee, Byung Hun Lim, Jung Sub Song, Seon Ho Ahn
    Journal of the Korean Geriatrics Society.2014; 18(2): 85.     CrossRef
Intrathecal Methotrexate Induced Neurotoxicity in Children with Acute Lymphoblastic Leukemia
Jae Min Lee, Han Ku Moon, Jeong Ok Hah
Yeungnam Univ J Med. 2007;24(2 Suppl):S761-769.   Published online December 31, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.2S.S761
  • 1,107 View
  • 12 Download
AbstractAbstract PDF
Central nervous system (CNS) prophylaxis is an essential component of the treatment in childhood acute lymphoblastic leukemia (ALL). Methotrexate (MTX) is an dispensable antimetabolite for treatment of ALL. High-dose (HD) MTX and intrathecal (IT) MTX have improved the prognosis and reduced the rate of CNS relapse. However, the drug also has a significant toxic effect on the CNS and can potentially lead to severe neurologic morbidity. The overall incidence of acute MTX induced neurotoxicity has been estimated to be 0.8∼10% of treated children, depending on the amounts of MTX and leucovorin in the treatment protocol. Acute neurotoxicity generally develops within 5∼14 days after IT MTX or HD MTX and may include headache, nausea, emesis, lethargy, altered mental status, blurred vision, aphasia, hemiparesis, and seizure. Diffusion weighted MRI shows restricted diffusion of water in brains of patients with ALL who experienced stroke-like event after IT MTX. We report the cinical and imaging findings of acute neurotoxicity in two patients after intrathecal administration of MTX for CNS prophylaxes of ALL.

JYMS : Journal of Yeungnam Medical Science