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Original article
- Association between gestational age at delivery and lymphocyte-monocyte ratio in the routine second trimester complete blood cell count
- Hyun-Hwa Cha, Jong Mi Kim, Hyun Mi Kim, Mi Ju Kim, Gun Oh Chong, Won Joon Seong
- Yeungnam Univ J Med. 2021;38(1):34-38. Published online June 18, 2020
- DOI: https://doi.org/10.12701/yujm.2020.00234
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- 4 Crossref
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Abstract
PDF - Background
We aimed to determine whether routine second trimester complete blood cell (CBC) count parameters, including neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), and platelet-lymphocyte ratio (PLR), could predict obstetric outcomes.
Methods
We included singleton pregnancies for which the 50-g oral glucose tolerance test and CBC were routinely performed between 24 and 28 weeks of gestation in our outpatient clinic from January 2015 to December 2017. The subjects were divided into three groups according to their pregnancy outcomes as follows: group 1, spontaneous preterm births, including preterm labor and preterm premature rupture of membranes; group 2, indicated preterm birth due to maternal, fetal, or placental causes (hypertensive disorder, fetal growth restriction, or placental abruption); and group 3, term deliveries, regardless of the indication of delivery. We compared the CBC parameters using a bivariate correlation test.
Results
The study included 356 pregnancies. Twenty-eight subjects were in group 1, 20 in group 2, and 308 in group 3. There were no significant differences between the three groups in neutrophil, monocyte, lymphocyte, and platelet counts. Although there was no significant difference in NLR, LMR, and PLR between the three groups, LMR showed a negative correlation with gestational age at delivery (r=−0.126, p=0.016).
Conclusion
We found that a higher LMR in the second trimester was associated with decreased gestational age at delivery. CBC parameters in the second trimester of pregnancy could be used to predict adverse obstetric outcomes. -
Citations
Citations to this article as recorded by
- Relationship between Platelet-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio with Spontaneous Preterm Birth: A Systematic Review and Meta-analysis
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Journal of Immunology Research.2023; 2023: 1. CrossRef - High Apoptotic Index in Amniotic Membrane of Pregnant Women is A Risk Factor for Preterm Labor
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European Journal of Medical and Health Sciences.2023; 5(3): 79. CrossRef - Evaluation of Complete Blood Cell Count Parameters in the Diagnosis of Threatened Preterm Labor and Premature Rupture of Membranes
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Dubai Medical Journal.2022; 5(3): 157. CrossRef - The Association of Inflammatory Biomarker of Neutrophil-to-Lymphocyte Ratio with Spontaneous Preterm Delivery: A Systematic Review and Meta-analysis
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Mediators of Inflammation.2021; 2021: 1. CrossRef
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