Journal of Yeungnam Medical Science

Review article

Ophthalmology
Ocular adnexal mucosa-associated lymphoid tissue lymphoma: a narrative review: Hyun Uk Chung, Jun Hyuk Son; J Yeungnam Med Sci. 2022;39(1):3-11. Published online September 15, 2021; DOI: https://doi.org/10.12701/yujm.2021.01263

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Lymphoma is the most common primary tumor of the orbit, accounting for 55% of all orbital malignancies. When divided into histopathological subtypes, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) comprises the largest proportion. Clinical manifestations are unspecific, but in patients with slow-growing painless orbital mass, or red conjunctival lesion suggestive of ‘salmon patch’, ocular adnexa lymphoma (OAL) should be suspected. Although the pathogenetic mechanism of ocular adnexal MALT lymphoma (OAML) is not yet fully understood, the relationship between OAML and Chlamydia psittaci has been hypothesized recently, similar to that between gastric MALT lymphoma and Helicobacter pylori. This suggests a new treatment option for OAML; bacterial eradication therapy with systemic antibiotics. Several other treatment methods for OAML have been introduced, but no treatment guidelines have been established yet. In this article, we summarize the current knowledge on the clinical features, pathogenesis, diagnostic methods, therapeutic strategies, and prognosis of OAML.

Citations

Citations to this article as recorded by

Flow cytometry, cytology and histology in the diagnosis of ocular hematologic neoplasms: a 15-year monocentric experience with a focus on ocular lymphomas
Alessandra Falda, Veronica Davanzo, Dario Marino, Carolina Molin, Paola Fogar, Jasmine Turkman, Jenny Zuin, Silvia Finotto, Marco Pizzi, Giulia Midena, Federica Vianello, Angelo Paolo Dei Tos, Martina Montagnana, Raffaele Parrozzani, Daniela Basso
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Higher incomplete remission rate of ocular extranodal marginal zone B-cell lymphoma in hepatitis B virus infectious patients
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Atypical orbital mucosa-associated lymphoid tissue lymphoma involving the inferior rectus in a young adult: A case report and literature review
Yin-Feng Wang, Hui-Chun Chen, Forn-Chia Lin, Chun-Hsiang Chang, Sheng-Min Hsu, Sheng-Chi Yang
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Application of artificial intelligence in differentiating IgG4-related ophthalmic disease and orbital MALT lymphoma: a review of radiomics and deep learning advances
Wei Weng, Yaomeng Chen, Rouhui Jin, Jinchun Chen, Yuantong Gao, Yongchou Li, Haochen Shao, Shitian Bao, Weikuan Xue
Frontiers in Immunology.2026;[Epub] CrossRef
Single-cell RNA-sequencing reveals cellular heterogeneity and immune microenvironment characteristics between ocular adnexal mucosa-associated lymphoid lymphoma and IgG4−related ophthalmic disease
Yu Yang, Yujiao Wang, Xuelian Jin, Weimin He
Frontiers in Immunology.2025;[Epub] CrossRef
An International Lymphoma Radiation Oncology Group Study of Radiation Therapy for Bilateral Indolent Orbital Adnexal Lymphomas
Krystel Tran, Dongryul Oh, Richard Tsang, Chang-Ok Suh, Hong In Yoon, Hwa Kyung Byun, Senzo Taguchi, Jillian R. Gunther, Bouthaina Dabaja, Chelsea C. Pinnix, John Plastaras, Christopher Wright, Brandon S. Imber, Joachim Yahalom, Khaled Elsayad, Hans T. Ei
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Long Xu, Chi Zhang, Wanwan Shi, Jiaxi Ma, Guiqiang Wang
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Case Report

Pathology and Forensic Medicine
Mesenchymal Chondrosarcoma: 3 Cases Report.: Mi Jin Gu, Young Kyong Bae, Joon Hyuk Choi, Mi Jin Kim, Won Hee Choi, Duk Seop Shin, Jang Soo Suh; Yeungnam Univ J Med. 2000;17(1):87-92. Published online June 30, 2000; DOI: https://doi.org/10.12701/yujm.2000.17.1.87

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Abstract PDF: Mesenchymal chondrosarcoma is a rare malignant tumor of skeletal and extraskeletal origin, and which shows aggressive local behavior as well as a high metastatic potential. We report 3 cases of mesenchymal chondrosarcoma. Two cases were male and one was female. The ages ranged from 25 to 32 years(mean: 28 years). Tissue was obtained by wide excision in two patients, and incisional biopsy in one. The mass locaterd in the rib(case 1), orbital floor(case 2), and abdominal wall(case 3). Roentgenographically, the tumor resembles ordinary chondrosarcoma, showing osteolytic and obstructive appearance with stippled calcification. Grossly, the tumor was lobulating, solid fish-fleshy like mass with calcification and ossification. Histologically, the tumor shows characteristic bimorphic pattern composed of islands of well differentiated hyaline cartilage admixed with a cellular area of undifferentiated small cells. The small cells usually displayed a hemangiopericytoid or an alveolar pattern.

Original Article

Ophthalmology
Clinical Experiences of the Orbital Tumors: Kyung Ha Lee, Wha Sun Chung; Yeungnam Univ J Med. 1996;13(1):78-85. Published online June 30, 1996; DOI: https://doi.org/10.12701/yujm.1996.13.1.78

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Abstract PDF: The authors reviewed 95 cases (46 men and 49 women) of the orbital tumors diagnosed histopathologically at the Department of Ophtalmology, Yeungnam University Hospital from March 1984 through August 1994. Seventy-five cases of benign tumors were found evenly in all decades, but twenty cases of malignant tumors were noticed more frequently in 1st, 6th, and 7th decades. The frequency of benign orbital tumors was in this order; dermolipoma (21%, 20 cases), dermoid cyst (11.6%, 11 cases), mucocele (8.4%, 8 cases), lipoma (7.4%, 7 cases) and pleomorphic adenoma (5.3%, 5 cases). Of malignant orbital tumors, the frequency was in this order; retinoblastoma (3 cases), malignant melanoma (2 cases), sebaceous carcinoma (2 cases), and maxillary sinus carcinoma (2 cases). Malignant orbital tumors of 8 expired patients were revealed as secondary or metastatic tumors.

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