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Hepatic ischemia-reperfusion injury with respect to oxidative stress and inflammatory response: a narrative review
Eun Kyung Choi, Dong Gun Lim
J Yeungnam Med Sci. 2023;40(2):115-122.   Published online March 21, 2022
DOI: https://doi.org/10.12701/jyms.2022.00017
  • 4,270 View
  • 149 Download
  • 14 Web of Science
  • 15 Crossref
AbstractAbstract PDF
Hepatic ischemia-reperfusion injury is a major complication of liver transplantation, trauma, and shock. This pathological condition can lead to graft dysfunction and rejection in the field of liver transplantation and clinical hepatic dysfunction with increased mortality. Although the pathological mechanisms of hepatic ischemia-reperfusion injury are very complex, and several intermediators and cells are involved in this phenomenon, oxidative stress and inflammatory responses are the key processes that aggravate hepatic injury. This review summarizes the current understanding of oxidative stress and inflammatory responses and, in that respect, addresses the therapeutic approaches to attenuate hepatic ischemia-reperfusion injury.

Citations

Citations to this article as recorded by  
  • Thymoquinone-loaded self-nano-emulsifying drug delivery system against ischemia/reperfusion injury
    Badr Bahloul, Roua Chaabani, Yosri Zahra, Nesrine Kalboussi, Jamil Kraiem, Souad Sfar, Nathalie Mignet, Hassen ben Abdennebi
    Drug Delivery and Translational Research.2024; 14(1): 223.     CrossRef
  • Modafinil lightens apoptosis and inflammatory response in hepatic ischemia‐reperfusion injury through inactivation of TLR9/Myd88/p38 signaling
    Tairan Zhang, Xidong Wang
    Drug Development Research.2024;[Epub]     CrossRef
  • Cellular and molecular mechanisms of hepatic ischemia-reperfusion injury: The role of oxidative stress and therapeutic approaches
    Joseph George, Yongke Lu, Mutsumi Tsuchishima, Mikihiro Tsutsumi
    Redox Biology.2024; 75: 103258.     CrossRef
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    Chen Zhang, Guanzhao Wu
    Talanta.2024; 279: 126622.     CrossRef
  • Protective effect of irbesartan against hepatic ischemia–reperfusion injury in rats: role of ERK, STAT3, and PPAR-γ inflammatory pathways in rats
    Salma A. El-Marasy, Rasha E. Mostafa, Hoda B. Mabrok, Marwa S. Khattab, Sally A. El Awdan
    Naunyn-Schmiedeberg's Archives of Pharmacology.2024;[Epub]     CrossRef
  • Reversible Fluorescent Probes for Dynamic Imaging of Liver Ischemia-Reperfusion Injury
    Wen Zhang, Jihong Liu, Ping Li, Xin Wang, Bo Tang
    Accounts of Chemical Research.2024; 57(17): 2594.     CrossRef
  • Flavonoids as therapeutics for myocardial ischemia-reperfusion injury: a comprehensive review on preclinical studies
    Vipin Kumar Verma, Priya Bhardwaj, Vaishali Prajapati, Avantika Bhatia, Sayani Purkait, Dharamvir Singh Arya
    Laboratory Animal Research.2024;[Epub]     CrossRef
  • ZLN005, a PGC-1α Activator, Protects the Liver against Ischemia–Reperfusion Injury and the Progression of Hepatic Metastases
    Celine Tohme, Tony Haykal, Ruiqi Yang, Taylor J. Austin, Patricia Loughran, David A. Geller, Richard L. Simmons, Samer Tohme, Hamza O. Yazdani
    Cells.2024; 13(17): 1448.     CrossRef
  • Treatment of Acute and Long-COVID, Diabetes, Myocardial Infarction, and Alzheimer’s Disease: The Potential Role of a Novel Nano-Compound—The Transdermal Glutathione–Cyclodextrin Complex
    Ray Yutani, Vishwanath Venketaraman, Nisar Sheren
    Antioxidants.2024; 13(9): 1106.     CrossRef
  • Fluorescent probes for sensing peroxynitrite: biological applications
    Yan Yang, Jinting Shang, Yiyuan Xia, Yuran Gui
    Redox Report.2024;[Epub]     CrossRef
  • An update on the molecular mechanism and pharmacological interventions for Ischemia-reperfusion injury by regulating AMPK/mTOR signaling pathway in autophagy
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    Cellular Signalling.2023; : 110665.     CrossRef
  • Unveiling the Crucial Roles of O2•–and ATP in Hepatic Ischemia–Reperfusion Injury Using Dual-Color/Reversible Fluorescence Imaging
    Jihong Liu, Wen Zhang, Xin Wang, Qi Ding, Chuanchen Wu, Wei Zhang, Luling Wu, Tony D. James, Ping Li, Bo Tang
    Journal of the American Chemical Society.2023; 145(36): 19662.     CrossRef
  • New insights into ischemia-reperfusion injury signaling pathways in organ transplantation
    Kenneth J. Dery, Jerzy W. Kupiec-Weglinski
    Current Opinion in Organ Transplantation.2022; 27(5): 424.     CrossRef
  • Isolongifolene alleviates liver ischemia/reperfusion injury by regulating AMPK-PGC1α signaling pathway-mediated inflammation, apoptosis, and oxidative stress
    Jinjin Li, Jie Li, Hongbo Fang, Hang Yang, Tianchun Wu, Xiaoyi Shi, Chun Pang
    International Immunopharmacology.2022; 113: 109185.     CrossRef
  • Molecularly Designed Ion-Imprinted Nanoparticles for Real-Time Sensing of Cu(II) Ions Using Quartz Crystal Microbalance
    Nihan Aydoğan, Gülgün Aylaz, Monireh Bakhshpour, Tugba Tugsuz, Müge Andaç
    Biomimetics.2022; 7(4): 191.     CrossRef
Can antioxidants be effective therapeutics for type 2 diabetes?
Soyoung Park, So-Young Park
Yeungnam Univ J Med. 2021;38(2):83-94.   Published online October 8, 2020
DOI: https://doi.org/10.12701/yujm.2020.00563
  • 11,314 View
  • 228 Download
  • 16 Crossref
AbstractAbstract PDF
The global obesity epidemic and the growing elderly population largely contribute to the increasing incidence of type 2 diabetes. Insulin resistance acts as a critical link between the present obesity pandemic and type 2 diabetes. Naturally occurring reactive oxygen species (ROS) regulate intracellular signaling and are kept in balance by the antioxidant system. However, the imbalance between ROS production and antioxidant capacity causes ROS accumulation and induces oxidative stress. Oxidative stress interrupts insulin-mediated intracellular signaling pathways, as supported by studies involving genetic modification of antioxidant enzymes in experimental rodents. In addition, a close association between oxidative stress and insulin resistance has been reported in numerous human studies. However, the controversial results with the use of antioxidants in type 2 diabetes raise the question of whether oxidative stress plays a critical role in insulin resistance. In this review article, we discuss the relevance of oxidative stress to insulin resistance based on genetically modified animal models and human trials.

Citations

Citations to this article as recorded by  
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    Food & Function.2024; 15(16): 8521.     CrossRef
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    Frontiers in Bioscience-Scholar.2024;[Epub]     CrossRef
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    Frontiers in Medicine.2021;[Epub]     CrossRef
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JYMS : Journal of Yeungnam Medical Science
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