Journal of Yeungnam Medical Science

Original article

Obstetrics, Gynecology, and Reproductive Medicine
Analysis of single nucleotide polymorphisms associated with the vitamin D pathway in the placentas of women with gestational diabetes mellitus: a laboratory study: Mi Ju Kim, Hyun Mi Kim, Hyun-Hwa Cha, Won Joon Seong; J Yeungnam Med Sci. 2023;40(Suppl):S9-S16. Published online May 8, 2023; DOI: https://doi.org/10.12701/jyms.2023.00150

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Background
The aim of this study was to analyze the single nucleotide polymorphisms (SNPs) of genes known to be involved in vitamin D metabolism in the placenta using the placental tissue of mothers diagnosed with gestational diabetes mellitus (GDM) to determine whether the SNPs and occurrence of GDM are related.
Methods
We enrolled 80 women of the same gestational age, 40 with and 40 without GDM. The placenta was obtained from each woman after delivery and SNP genotyping was performed on seven SNPs in the CYP27B1 (rs10877012), CYP24A1 (rs2248359, rs6013897, and rs2209314), and GC (rs2282679, rs16847024, and rs3733359) genes. Maternal serum 25-hydroxyvitamin D levels were measured during the first trimester of pregnancy and before delivery.
Results
At the time of delivery, vitamin D levels were lower (21.05±12.05 mg/dL vs. 31.31±20.72 mg/dL, p=0.012) and the frequency of vitamin D deficiency was higher (60.7% vs. 32.5%, p=0.040) in the GDM group. In women with GDM, the G allele of rs10877012 was more common (86.3% vs. 65.0%, p=0.002). The rs10877012 GG genotype was more common in the GDM group (72.5% vs. 42.5%, p=0.007) and the rs10877012 TT genotype was more common in the control group (12.5% vs. 0%, p=0.007).
Conclusion
Mothers with GDM have lower serum concentrations of vitamin D before delivery than healthy controls and vitamin D deficiency is common. A polymorphism in CYP27B1 (rs10877012), is considered to be a cause of GDM pathogenesis.

Citations

Citations to this article as recorded by

Gestational diabetes mellitus affects the cross-talk among placental, maternal and umbilical cord vitamin D metabolites but fetal transfer is not compromised
Layla G. Ranquine, Deborah Bauer, Nathalia Zuniga, Brenda A. Nagagata, Gabriela D.A. Pinto, Carolina S. Ferreira, Vanessa A. Goes, Daniela B. Mucci, Lívia Belcastro, Fatima Sardinha, Claudio J. Struchiner, Alexandre G. Torres, Sarah R. Meadows, Kerry S. J
Placenta.2025;[Epub] CrossRef

Original Article

Biochemistry
Association Analyses of beta3AR Trp64Arg and UCP-2 -866G/A Polymorphisms with Body Mass Index in Korean.: Hong Soo Jung, Joo Hyun Lee, Jun Sakong, Sung Wook Bae, Jung Hye Kim, Jae Ryong Kim; Yeungnam Univ J Med. 2007;24(2):252-261. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2.252

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Abstract PDF

BACKGROUND
Obesity is the most common nutritional disorder in Western society as well as in Korea. Obesity results from a combination of genetic, environmental, and behavioral factors. MATERIALS AND METHODS: In an attempt to investigate the association of obesity with its candidate genes, beta3 adrenergic receptor (beta3AR) and uncoupling protein 2 (UCP2), we analyzed polymorphisms of beta3AR Trp64Arg and UCP2 -866G/A by PCR-RFLP analysis and the obesity-related phenotypes, including body mass index (BMI), fasting glucose concentration, and plasma lipid profiles in 750 subjects. RESULTS: The Trp64Arg polymorphism in the beta3AR gene was not statistically associated with the BMI. The UCP2 -866G/A polymorphism was significantly higher in obese than in non-obese subjects (P<0.05). However, the UCP2 -866A/A polymorphism was higher in the non-obese subjects. CONCLUSION: These results suggest that the UCP2 -866G/A polymorphism might be more useful for the prediction of obesity and obesity-associated diseases in Korean patients than the beta3AR Trp64Arg polymorphism.

Citations

Citations to this article as recorded by

Clinical Course of Bipolar Disorder in Children and Adolescents
Na-Ri Kang, Young-Sook Kwack
Journal of korean Academy of Child and Adolescent Psychiatry.2012; 23(1): 3. CrossRef

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