Journal of Yeungnam Medical Science

Original article

Dentistry
Therapeutic efficacy of mesenchymal stem cells in periodontal regeneration: a systematic review and meta-analysis of clinical trials: Fiki Muhammad Ridho, Anis Irmawati, Raed Labib, Hayyu Norma Almira, Ridwan Alfatah, Bayu Cahyo Bintoro; J Yeungnam Med Sci. 2026;43:42. Published online June 24, 2026; DOI: https://doi.org/10.12701/jyms.2026.43.42

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Abstract PDF Supplementary Material: Background
Periodontitis is a major global health problem that leads to destruction and loss of periodontal tissues. As conventional therapy has a limited capacity to restore the complex architecture of the periodontium, regenerative approaches have been explored. This meta-analysis evaluates the therapeutic efficacy of mesenchymal stem cells (MSCs) for periodontal regeneration in patients with periodontal defects.
Methods
PubMed, Scopus, Web of Science, Dentistry & Oral Sciences Source, and the Cochrane Library were searched for clinical trials. The risk of bias was assessed using Cochrane RoB2. Random- or fixed-effects meta-analyses were used in the pooled analysis and reported as mean differences (MDs) and 95% confidence intervals (CIs). Certainty of evidence was rated using Grading of Recommendations, Assessment, Development, and Evaluation (GRADE).
Results
Ten clinical trials were included in the analysis. MSCs significantly improved probing pocket depth (MD, –0.51; 95% CI, –0.84 to –0.19; p<0.01; I2=62%), clinical attachment level (MD, –0.75; 95% CI, –0.95 to –0.54; p<0.01; I2=40%), cementoenamel junction to the base of defect (MD, –0.49; 95% CI, –0.95 to –0.02; p=0.04; I2=63%), and intrabony defect (MD, –1.09; 95% CI, –1.60 to –0.57; p<0.01; I2=71%). However, no significant improvement in gingival recession was observed (MD, –0.18; 95% CI, –0.38 to 0.01; p=0.07; I2=0%). The GRADE assessment indicated a high-to-moderate certainty.
Conclusion
MSCs represent a promising strategy for periodontal regeneration. Nevertheless, the limited number of studies and the observed heterogeneity warrant cautious interpretation. Larger methodologically rigorous trials are needed to clarify the true contribution of MSCs to periodontal regeneration.

Review article

Dentistry
Role of gene therapy in treatment of cancer with craniofacial regeneration—current molecular strategies, future perspectives, and challenges: a narrative review: Himanshu Singh; J Yeungnam Med Sci. 2024;41(1):13-21. Published online May 23, 2023; DOI: https://doi.org/10.12701/jyms.2023.00073

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Gene therapy involves the introduction of foreign genetic material into host tissue to alter the expression of genetic products. Gene therapy represents an opportunity to alter the course of various diseases. Hence, genetic products utilizing safe and reliable vectors with improved biotechnology will play a critical role in the treatment of various diseases in the future. This review summarizes various important vectors for gene therapy along with modern techniques for potential craniofacial regeneration using gene therapy. This review also explains current molecular approaches for the management and treatment of cancer using gene therapy. The existing literature was searched to find studies related to gene therapy and its role in craniofacial regeneration and cancer treatment. Various databases such as PubMed, Science Direct, Scopus, Web of Science, and Google Scholar were searched for English language articles using the keywords “gene therapy,” “gene therapy in present scenario,” “gene therapy in cancer,” “gene therapy and vector,” “gene therapy in diseases,” and “gene therapy and molecular strategies.”

Citations

Citations to this article as recorded by

Integrated cell membrane encapsulated PQDs-TK quantum dot nanoclusters with ROS-responsive triggering for efficient and visualized DNA delivery
Tiange Wang, Yanlin Sun, Dong Zeng, Mengying Wang, Yajing Zhang, Gang Liu, Xin Chen, Liang Liu
Journal of Colloid and Interface Science.2025; 683: 393. CrossRef

Original article

Dentistry
Regenerative potential of biphasic calcium phosphate and enamel matrix derivatives in the treatment of isolated interproximal intrabony defects: a randomized controlled trial: Pritish Chandra Pal, Ashish Bali, Ramanarayana Boyapati, Sangita Show, Kanikanti Siva Tejaswi, Sourabh Khandelwal; J Yeungnam Med Sci. 2022;39(4):322-331. Published online September 2, 2022; DOI: https://doi.org/10.12701/jyms.2022.00325

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Abstract PDF

Background
The combined use of biomaterials for regeneration may have great biological relevance. This study aimed to compare the regenerative potential of biphasic calcium phosphate (BCP) alone and with growth factor enamel matrix derivatives (EMDs) for the regeneration of intrabony defects at 1 year.
Methods
This randomized controlled trial included 40 sites in 29 patients with stage II/III periodontitis and 2/3 wall intrabony defects that were treated with BCP alone (control group) or a combination of BCP and EMD (test group). BCP alloplastic bone grafts provide better bio-absorbability and accelerate bone formation. EMDs are commercially available amelogenins. Mean values and standard deviations were calculated for the following parameters: plaque index (PI), papillary bleeding index (PBI), vertical probing pocket depth (V-PPD), vertical clinical attachment level (V-CAL), and radiographic defect depth (RDD). Student paired and unpaired t-tests were used to compare the data from baseline to 12 months for each group and between the groups, respectively. The results were considered statistically significant at p<0.05.
Results
At 12 months, the PI and PBI scores of the control and test groups were not significantly different (p>0.05). The mean V-PPD difference, V-CAL gain, and RDD difference were statistically significant in both groups at 12 months (p<0.001 for all parameters). Intergroup comparisons showed that the mean V-PPD reduction (2.13±1.35 mm), V-CAL gain (2.53±1.2 mm), and RDD fill (1.33±1.0 mm) were statistically significant between the groups at 12 months (p<0.001 for all parameters).
Conclusion
BCP and EMDs combination is a promising modality for the regeneration of intrabony defects.

Citations

Citations to this article as recorded by

The role of enamel matrix derivatives in periodontal regeneration following tooth replantation/transplantation: a narrative review of post-reperfusion injury
Junlin Yang, Shouyin Yi, Xin Yang, Lu Yin, Ming Yuan, Kun Tian
Frontiers in Cell and Developmental Biology.2026;[Epub] CrossRef
30 Years of Enamel Matrix Derivative (EMD): Biological Foundations and Systematic Review With Meta‐Analyses Across Multiple Clinical Indications
Richard J. Miron, Nima Farshidfar, Yu‐Kang Tu, Chian‐Heng Su, Paras Ahmad, Nathan E. Estrin, Reinhard Gruber, Yoshinori Shirakata, Dieter D. Bosshardt, Mario Romandini, Anton Sculean
Journal of Periodontal Research.2026;[Epub] CrossRef
Scaffold-Based Biomaterials for Periodontal Regeneration in Periodontitis: A Systematic Review and Meta-Analysis
Felicia Gabriela Beresescu, Simona Mucenic, Adriana Monea, Andrea Bors, Liana Beresescu
Journal of Functional Biomaterials.2026; 17(6): 286. CrossRef
Influence of alloplastic materials, biologics, and their combinations, along with defect characteristics, on short-term intrabony defect surgical treatment outcomes: a systematic review and network meta-analysis
Khanti Rattanpornsompong, Kantapon Rattanaprukskul, Sikharate Prachanukoon, Kanokrat Sriwangyang, Mawika Rinkrathok, Junji Tagami, Thantrira Porntaveetus
BMC Oral Health.2025;[Epub] CrossRef

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