Severe asthma patients comprise about 3% to 13% of all asthma patients, but they have higher hospital utilization rates and higher medical costs than those of nonsevere asthma patients. Treatment methods for severe asthma patients are still lacking; however, the recent development of biologics is expected to have a positive effect. The biological therapies developed so far are mainly aimed at treating asthma patients with type 2 inflammation. These biologics have been found to reduce symptoms of asthma, improve lung function, reduce the use of oral corticosteroids, and improve quality of life of patients. This article reviews the mechanism of action and indications for approved biologics and discusses what should be considered when choosing biologics.
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Advanced bispecific antibody design and inhaled biologics; emerging strategies for asthma Zeina Kassem, Jenny K. W. Lam, Hanieh Khalili RSC Pharmaceutics.2026;[Epub] CrossRef
Allergen Immunotherapy for the Prevention and Treatment of Asthma Thierry Batard, Camille Taillé, Laurent Guilleminault, Andrzej Bozek, Véronique Bordas‐Le Floch, Oliver Pfaar, Walter G. Canonica, Cezmi Akdis, Mohamed H. Shamji, Laurent Mascarell Clinical & Experimental Allergy.2025; 55(2): 111. CrossRef
Determinants of cost-effectiveness results of biological therapies for severe asthma: a systematic methodological assessment Laura de la Torre-Pérez, Marilina Santero, Wendy Nieto-Gutierrez, Christine Giesen, Angela Nardin, Claudia Cosma, Pedro Silva Pires, Andrea Guida, Marcello Simonini, Camila Quirland Lazo, Feng Xie, Pablo Alonso-Coello Journal of Clinical Epidemiology.2025; 178: 111621. CrossRef
Current and Novel Biologic Therapies for Patients with Asthma and Nasal Polyps Hanna K. Mandl, Jessa E. Miller, Daniel M. Beswick Otolaryngologic Clinics of North America.2024; 57(2): 225. CrossRef
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Biologic Therapies across Nasal Polyp Subtypes Kody G. Bolk, Sarah K. Wise Journal of Personalized Medicine.2024; 14(4): 432. CrossRef
Evaluation of multiple-flows exhaled nitric oxide and its clinical significance in severe asthmatic patients treated with biologics: a prospective real-life study Tommaso Pianigiani, Simona Luzzi, Akter Dilroba, Martina Meocci, Elisa Salvadori, Lorenzo Alderighi, Laura Bergantini, Miriana d’Alessandro, Piersante Sestini, Elena Bargagli, Paolo Cameli Journal of Asthma.2024; 61(12): 1619. CrossRef
Long-term Safety and Efficacy of Dupilumab in Patients With Uncontrolled, Moderate-to-Severe Asthma Recruited From Korean Centers: A Subgroup Analysis of the Phase 3 LIBERTY ASTHMA TRAVERSE Trial Chin Kook Rhee, Jung-Won Park, Heung-Woo Park, Hayeon Noh, Jerome Msihid, You Sook Cho Allergy, Asthma & Immunology Research.2024; 16(4): 372. CrossRef
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Tackling the cytokine storm using advanced drug delivery in allergic airway disease Vyoma K. Patel, Sukriti Vishwas, Rajan Kumar, Gabriele De Rubis, Shakti D. Shukla, Keshav Raj Paudel, Bikash Manandhar, Thakur Gurjeet Singh, Dinesh Kumar Chellappan, Monica Gulati, Indu Pal Kaur, Venkata Sita Rama Raju Allam, Philip M. Hansbro, Brian G. Journal of Drug Delivery Science and Technology.2023; 82: 104366. CrossRef
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Effect of Dupilumab in Korean Patients With Uncontrolled Moderate-to-Severe Asthma: A LIBERTY ASTHMA QUEST Sub-analysis Chin Kook Rhee, Jung-Won Park, Heung-Woo Park, You Sook Cho Allergy, Asthma & Immunology Research.2022; 14(2): 182. CrossRef
The role of peripheral eosinophilia in diagnosing lung disorders: experience from a single pneumonological center Justyna Fijołek, Elzbieta Wiatr, Dorota Piotrowska-Kownacka, Kazimierz Roszkowski-Sliz Multidisciplinary Respiratory Medicine.2021;[Epub] CrossRef
Advances in the science and treatment of respiratory diseases Jin Hong Chung Yeungnam University Journal of Medicine.2020; 37(4): 251. CrossRef