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JYMS : Journal of Yeungnam Medical Science

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1 "Skeletal muscle"
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Original Article
Effect of Age on Glucose Metabolism of Skeletal Muscle in Rats.
Eung Chan Jang, Woon Ki Youn, Suck Kang Lee
Yeungnam Univ J Med. 2001;18(1):94-100.   Published online June 30, 2001
DOI: https://doi.org/10.12701/yujm.2001.18.1.94
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AbstractAbstract PDF
BACKGROUND
It is doubtful that aging causes deteriorated glucose metabolism and insulin resistance of skeletal muscle. Some researchers had different results about it. So we have studied the mechanism responsible for the abnormal glucose tolerance associated with aging in rapidly growing and matured rats. MATERIALS AND METHODS: Animals were used S.D. rats. Growing rats were 7 weeks old (BW: 160-190 gm) and matured rats were 28 weeks old (BW: 420-525 gm). RESULTS: Fasting blood glucose and plasma insulin levels were significantly elevated in matured rat compared with growing rats. And during oral glucose tolerance test the glucose level was also significantly elevated in matured rats. These results confirmed an insulin resistant state of aging. Insulin levels at 30 minutes of oral glucose tolerance test was significantly elevated in growing rat. But at 120 minutes it was maintained at higher level in matured rats than in growing rats. It suggested the possibility of increased insulin secretion by initial stimulation of beta-cells in growing rats, and increased secretion and decreased catabolic rate of insulin in matured rats. Glucose uptake rate of soleus muscle in matured rats was lower than that of growing rats, but the difference was not statistically significant. The dose(insulin)- responsive (glucose uptake) curve of soleus muscle was only slightly deviated to the right side. CONCLUSION: Glucose metabolism of rat skeletal muscle was worsened by aging. The data of glucose uptake experiments suggested the possibility of insulin resistance of skeletal muscle in matured rats, but the mechanism of insulin resistance of skeletal muscle need further studies.

Citations

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    The Korea Journal of Herbology.2016; 31(4): 35.     CrossRef
  • The Effect of Jeokbaekhaogwanjung-tang Herbal Acupuncture Solution on the Immune Activity of Spleen Cells of Aged Rats
    Hyun-Suk Lee, Kang-Min Choi, Yun-Kyoung Yim
    Journal of Korean Medicine.2016; 37(1): 90.     CrossRef
  • The Effect of Yongyukjowitang Distillate on the Immune Activity of Spleen Cells of Aged Rats
    Jin-Wook Yi, Moon-Hee Jang, Jae-Song Choi, Taek-Won Ahn
    Journal of Sasang Constitutional Medicine.2013; 25(3): 218.     CrossRef

JYMS : Journal of Yeungnam Medical Science