E-Submission
Yeungnam University College of MedicineIndexed in: ESCI, Scopus, PubMed,
PubMed Central, CAS, DOAJ, KCI
PubMed Central, CAS, DOAJ, KCI
FREE article processing charge
Search
- Page Path
- HOME > Search
Focused Review article
- Gastroenterology and Hepatology
- Overview of hepatocarcinogenesis focusing on cellular origins of liver cancer stem cells: a narrative review
- Jong Ryeol Eun
- J Yeungnam Med Sci. 2025;42:3. Published online November 11, 2024
- DOI: https://doi.org/10.12701/jyms.2024.01088
- 1,314 View
- 93 Download
- 1 Web of Science
-
Abstract
PDF - Hepatocellular carcinoma (HCC) accounts for 85% to 90% of primary liver cancers and generally has a poor prognosis. The hierarchical model, which posits that HCC originates from liver cancer stem cells (CSCs), is now widely accepted, as it is for other cancer types. As CSCs typically reside in the G0 phase of the cell cycle, they are resistant to conventional chemotherapy. Therefore, to effectively treat HCC, developing therapeutic strategies that target liver CSCs is essential. Clinically, HCCs exhibit a broad spectrum of pathological and clinical characteristics, ranging from well-differentiated to poorly differentiated forms, and from slow-growing tumors to aggressive ones with significant metastatic potential. Some patients with HCC also show features of cholangiocarcinoma. This HCC heterogeneity may arise from the diverse cellular origins of liver CSCs. This review explores the normal physiology of liver regeneration and provides a comprehensive overview of hepatocarcinogenesis, including cancer initiation, isolation of liver CSCs, molecular signaling pathways, and microRNAs. Additionally, the cellular origins of liver CSCs are reviewed, emphasizing hematopoietic and mesenchymal stem cells, along with the well-known hepatocytes and hepatic progenitor cells.
Review article
- Orthopedics and Sports Medicine
- Current perspectives in stem cell therapies for osteoarthritis of the knee
- Gi Beom Kim, Oog-Jin Shon
- Yeungnam Univ J Med. 2020;37(3):149-158. Published online April 13, 2020
- DOI: https://doi.org/10.12701/yujm.2020.00157
- 11,913 View
- 314 Download
- 12 Crossref
-
Abstract
PDF
- Mesenchymal stem cells (MSCs) are emerging as an attractive option for osteoarthritis (OA) of the knee joint, due to their marked disease-modifying ability and chondrogenic potential. MSCs can be isolated from various organ tissues, such as bone marrow, adipose tissue, synovium, umbilical cord blood, and articular cartilage with similar phenotypic characteristics but different proliferation and differentiation potentials. They can be differentiated into a variety of connective tissues such as bone, adipose tissue, cartilage, intervertebral discs, ligaments, and muscles. Although several studies have reported on the clinical efficacy of MSCs in knee OA, the results lack consistency. Furthermore, there is no consensus regarding the proper cell dosage and application method to achieve the optimal effect of stem cells. Therefore, the purpose of this study is to review the characteristics of various type of stem cells in knee OA, especially MSCs. Moreover, we summarize the clinical issues faced during the application of MSCs.
-
Citations
Citations to this article as recorded by
- Stem Cell Therapy for Diseases of Livestock Animals: An In-Depth Review
Raghavendra B. Narasimha, Singireddy Shreya, Vijay Anand Jayabal, Vikas Yadav, Prasana Kumar Rath, Bidyut Prava Mishra, Sudhakar Kancharla, Prachetha Kolli, Gowtham Mandadapu, Sudarshan Kumar, Ashok Kumar Mohanty, Manoj Kumar Jena
Veterinary Sciences.2025; 12(1): 67. CrossRef - Clinical Evaluation of Safety and Efficacy of a Central Current Good Manufacturing Practices Laboratory Produced Autologous Adipose-Derived Stromal Vascular Fraction Cell Therapy Product for the Treatment of Knee Osteoarthritis
Christopher J. Rogers, Robert Harman, Mitchell B. Sheinkop, Peter Hanson, Mary A. Ambach, Tal David, Rahul Desai, Steven Sampson, Danielle Aufierro, Jay Bowen, Gerard Malanga
Stem Cells and Development.2024; 33(7-8): 168. CrossRef - Safety and efficacy of an allogeneic adipose-derived mesenchymal stem cell preparation in the treatment of knee osteoarthritis: A Phase I/IIa randomised controlled trial
Julien Freitag, Matthew Chamberlain, James Wickham, Kiran Shah, Flavia Cicuttini, Yuanyuan Wang, Ann Solterbeck, Lucinda Kenihan, Lesley-Anne Kelly, Renee Castelluccio, Ellee Picken, Melissa Grogan, Michael Kenihan, Abi Tenen, Nirali Shah, Carla Lutz, Tee
Osteoarthritis and Cartilage Open.2024; 6(3): 100500. CrossRef - Innovative Approaches in Knee Osteoarthritis Treatment: A Comprehensive Review of Bone Marrow-Derived Products
José Fábio Lana, Joseph Purita, Madhan Jeyaraman, Bianca Freitas de Souza, Bruno Lima Rodrigues, Stephany Cares Huber, Carolina Caliari, Gabriel Silva Santos, Lucas Furtado da Fonseca, Ignacio Dallo, Annu Navani, Marco Antônio Percope De Andrade, Peter Al
Biomedicines.2024; 12(12): 2812. CrossRef - Human umbilical cord mesenchymal stem cells promoting knee joint chondrogenesis for the treatment of knee osteoarthritis: a systematic review
Pengwei Zhang, Bo Dong, Puwei Yuan, Xun Li
Journal of Orthopaedic Surgery and Research.2023;[Epub] CrossRef - New Horizons in Treatment of Knee Osteoarthritis: A Brief Look-up at Emerging Approaches
Afsaneh Zare, Aida Iraji, Shahrokh Zare, Omid Koohi-Hosseinabadi, Fateme Bagheri, Romina Tanideh, Nader Tanideh
West Kazakhstan Medical Journal.2023; 65(4): 4. CrossRef - Scaffold-Free Cartilage Construct from Infrapatellar Fat Pad Stem Cells for Cartilage Restoration
Orada Sriwatananukulkit, Tulyapruek Tawonsawatruk, Kasem Rattanapinyopituk, Ticomporn Luangwattanawilai, Narongrit Srikaew, Ruedee Hemstapat
Tissue Engineering Part A.2022; 28(5-6): 199. CrossRef - Autologous Protein Solution Effect on Chondrogenic Differentiation of Mesenchymal Stem Cells from Adipose Tissue and Bone Marrow in an Osteoarthritic Environment
Stefania Pagani, Francesca Veronesi, Gianluca Giavaresi, Giuseppe Filardo, Tiziana Papio, Iacopo Romandini, Milena Fini
CARTILAGE.2021; 13(2_suppl): 225S. CrossRef - Mesenchymal Stem Cell-Derived Exosomes and Their Therapeutic Potential for Osteoarthritis
Gi Beom Kim, Oog-Jin Shon, Min-Soo Seo, Young Choi, Wook Tae Park, Gun Woo Lee
Biology.2021; 10(4): 285. CrossRef - Molecular basis for new approaches to therapy of osteoarthritis (part I)
E. V. Chetina, G. A. Markova, A. M. Lila
Modern Rheumatology Journal.2021; 15(4): 7. CrossRef - The therapeutic potential of mesenchymal stem cells in treating osteoporosis
Tianning Chen, Tieyi Yang, Weiwei Zhang, Jin Shao
Biological Research.2021;[Epub] CrossRef - The Role of Chronic Inflammatory Bone and Joint Disorders in the Pathogenesis and Progression of Alzheimer's Disease
Robert A. Culibrk, Mariah S. Hahn
Frontiers in Aging Neuroscience.2020;[Epub] CrossRef
- Stem Cell Therapy for Diseases of Livestock Animals: An In-Depth Review
Review
- Gastroenterology and Hepatology
- Cellular origin of liver cancer stem cells.
- Jong Ryeol Eun
- Yeungnam Univ J Med. 2015;32(1):1-7. Published online June 30, 2015
- DOI: https://doi.org/10.12701/yujm.2015.32.1.1
- 2,448 View
- 29 Download
-
Abstract
PDF
- Over several decades, a hierarchical cancer stem cell (CSC) model has been established in development of solid cancers, including hepatocellular carcinoma(HCC). In terms of this concept, HCCs originate from liver CSCs. Clinically HCCs show a wide range of manifestations from slow growth to very aggressive metastasis. One of the reasons may be that liver CSCs originate from different cells. This review describes the basic concept of CSCs and the cellular origin of liver CSCs.
First
Prev
