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JYMS : Journal of Yeungnam Medical Science

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Igor Kisil 1 Article
Long-term supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine for pressure ulcer in sedentary older adults: a retrospective matched case-control study
Igor Kisil, Yuri Gimelfarb
J Yeungnam Med Sci. 2023;40(4):364-372.   Published online February 16, 2023
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AbstractAbstract PDF
Growing evidence suggests that beta-hydroxy-beta-methylbutyrate (HMB), arginine (Arg), and glutamine (Gln) positively affect wound recovery. This study investigated the effects of long-term administration of HMB/Arg/Gln on pressure ulcer (PU) healing in sedentary older adults admitted to geriatric and rehabilitation care facilities.
This was a pilot retrospective case (standard of care and HMB/Arg/Gln)-control (standard of care alone) clinical study. Outcome measures were relative healing rates and Pressure Ulcer Scale for Healing (PUSH) scores (calculated after 4, 8, 12, 16, and 20 weeks) and time to healing.
The study subpopulation was comprised of 14 participants (four males, 28.6%) with the median age of 85.5 years (interquartile range [IQR], 82.0–90.2 years). The control subpopulation was comprised of 31 participants (18 males, 58.1%) with the median age of 84.0 years (IQR, 78.0–90.0 years). At the beginning of follow-up, there were no statistically significant demographic (sex and age) and clinical (main diagnosis, baseline area, and PU perimeter) differences between the groups. During the study period, there were no significant differences in the relative healing rates and PUSH scores between the subpopulations. The median time to complete healing in the study and control populations was 170.0 days (95% confidence interval [CI], 85.7–254.3) and 218.0 days (95% CI, 149.2–286.7) (log-rank, chi-square=3.99; p<0.046), respectively.
More than 20 weeks of HMB/Arg/Gln supplementation had a positive effect on difficult PU healing in older adults with multiple comorbidities.


Citations to this article as recorded by  
  • Impact of oral nutritional supplement composition on healing of different chronic wounds: A systematic review
    Allan Carlos Soares do Espírito Santo, Clara Sandra de Araújo Sugizaki, Alcides Corrêa de Morais Junior, Nara Aline Costa, Maria Marcia Bachion, João Felipe Mota
    Nutrition.2024; 124: 112449.     CrossRef

JYMS : Journal of Yeungnam Medical Science