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Funded articles
Resident fellow section: Teaching images
Ultrasound assessment of a supraclavicular lipoma entrapping the brachial plexus: a diagnostic insight
Wei-Ting Wu, Ke-Vin Chang, Kamal Mezian, Vincenzo Ricci, Levent Özçakar
J Yeungnam Med Sci. 2024;41(1):58-60.   Published online December 29, 2023
DOI: https://doi.org/10.12701/jyms.2023.01284
Funded: National Taiwan University Hospital Bei-Hu Branch, Ministry of Science and Technology, Taiwan, National Science and Technology, Taiwan, Taiwan Society of Ultrasound in Medicine
  • 301 View
  • 25 Download
PDF
Communications
The applicability of noncontact sensors in the field of rehabilitation medicine
Yoo Jin Choo, Jun Sung Moon, Gun Woo Lee, Wook-Tae Park, Min Cheol Chang
J Yeungnam Med Sci. 2024;41(1):53-55.   Published online December 26, 2023
DOI: https://doi.org/10.12701/jyms.2023.01144
Funded: National Research Foundation of Korea, Ministry of Science and ICT
  • 428 View
  • 37 Download
AbstractAbstract PDF
A noncontact sensor field is an innovative device that can detect, measure, or monitor physical properties or conditions without direct physical contact with the subject or object under examination. These sensors use a variety of methods, including electromagnetic, optical, and acoustic technique, to collect information about the target without physical interaction. Noncontact sensors find wide-ranging applications in various fields such as manufacturing, robotics, automobiles, security, environmental monitoring, space industry, agriculture, and entertainment. In particular, they are used in the medical field, where they provide continuous monitoring of patient conditions and offer opportunities in rehabilitation medicine. This article introduces the potential of noncontact sensors in the field of rehabilitation medicine.
Original article
Incidence and severity of medication-related osteonecrosis of the jaw in patients with osteoporosis using data from a Korean nationwide sample cohort in 2002 to 2019: a retrospective study
Su-Youn Ko, Tae-Yoon Hwang, Kiwook Baek, Chulyong Park
J Yeungnam Med Sci. 2024;41(1):39-44.   Published online January 3, 2024
DOI: https://doi.org/10.12701/jyms.2023.01116
Funded: Yeungnam University
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  • 42 Download
AbstractAbstract PDF
Background
Medication-related osteonecrosis of the jaw (MRONJ) is a significant concern, particularly among patients taking bisphosphonates (BPs), denosumab, and selective estrogen receptor modulators (SERMs) for osteoporosis. Despite the known risks, large-scale cohort studies examining the incidence and severity of MRONJ are lacking. We aimed to ascertain the incidence and risk of MRONJ among these patients, whom we stratified by age groups, medication types, and duration of use.
Methods
We utilized data from the National Health Insurance Service’s sample cohort database, focusing on patients aged 40 years and above diagnosed with osteoporosis. The patients were divided into three groups: those prescribed BPs only, those prescribed SERMs only, and those prescribed both.
Results
The overall incidence rate of MRONJ was 0.17%. A significantly higher incidence rate was observed among those taking osteoporosis medications, particularly among females with a relative risk of 4.99 (95% confidence interval, 3.21–7.74). The SERM group also had an incidence rate comparable to that of the BP group. Severity was assessed based on the invasiveness of the treatment methods, with 71.3% undergoing invasive treatment in the medication group.
Conclusion
This study provides valuable insights into the incidence and severity of MRONJ among a large cohort of patients with osteoporosis. It underscores the need for comprehensive guidance on MRONJ risks across different medication groups and sets the stage for future research focusing on specific populations and treatment outcomes.
Review article
Octacalcium phosphate, a promising bone substitute material: a narrative review
Jooseong Kim, Sukyoung Kim, Inhwan Song
J Yeungnam Med Sci. 2024;41(1):4-12.   Published online May 9, 2023
DOI: https://doi.org/10.12701/jyms.2023.00010
Funded: National Research Foundation of Korea, Ministry of Education
  • 1,832 View
  • 113 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDF
Biomaterials have been used to supplement and restore function and structure by replacing or restoring parts of damaged tissues and organs. In ancient times, the medical use of biomaterials was limited owing to infection during surgery and poor surgical techniques. However, in modern times, the medical applications of biomaterials are diversifying owing to great developments in material science and medical technology. In this paper, we introduce biomaterials, focusing on calcium phosphate ceramics, including octacalcium phosphate, which has recently attracted attention as a bone graft material.

Citations

Citations to this article as recorded by  
  • Development of Hydroxyapatite Coatings for Orthopaedic Implants from Colloidal Solutions: Part 1—Effect of Solution Concentration and Deposition Kinetics
    Bríd Murphy, Mick A. Morris, Jhonattan Baez
    Nanomaterials.2023; 13(18): 2577.     CrossRef
Original article
Analysis of single nucleotide polymorphisms associated with the vitamin D pathway in the placentas of women with gestational diabetes mellitus: a laboratory study
Mi Ju Kim, Hyun Mi Kim, Hyun-Hwa Cha, Won Joon Seong
J Yeungnam Med Sci. 2023;40(Suppl):S9-S16.   Published online May 8, 2023
DOI: https://doi.org/10.12701/jyms.2023.00150
Funded: Kyungpook National University Research Fund
  • 1,058 View
  • 55 Download
AbstractAbstract PDF
Background
The aim of this study was to analyze the single nucleotide polymorphisms (SNPs) of genes known to be involved in vitamin D metabolism in the placenta using the placental tissue of mothers diagnosed with gestational diabetes mellitus (GDM) to determine whether the SNPs and occurrence of GDM are related.
Methods
We enrolled 80 women of the same gestational age, 40 with and 40 without GDM. The placenta was obtained from each woman after delivery and SNP genotyping was performed on seven SNPs in the CYP27B1 (rs10877012), CYP24A1 (rs2248359, rs6013897, and rs2209314), and GC (rs2282679, rs16847024, and rs3733359) genes. Maternal serum 25-hydroxyvitamin D levels were measured during the first trimester of pregnancy and before delivery.
Results
At the time of delivery, vitamin D levels were lower (21.05±12.05 mg/dL vs. 31.31±20.72 mg/dL, p=0.012) and the frequency of vitamin D deficiency was higher (60.7% vs. 32.5%, p=0.040) in the GDM group. In women with GDM, the G allele of rs10877012 was more common (86.3% vs. 65.0%, p=0.002). The rs10877012 GG genotype was more common in the GDM group (72.5% vs. 42.5%, p=0.007) and the rs10877012 TT genotype was more common in the control group (12.5% vs. 0%, p=0.007).
Conclusion
Mothers with GDM have lower serum concentrations of vitamin D before delivery than healthy controls and vitamin D deficiency is common. A polymorphism in CYP27B1 (rs10877012), is considered to be a cause of GDM pathogenesis.
Case report
Thyroid storm caused by metastatic papillary thyroid carcinoma tissue after total thyroidectomy: a case report
So Hee Kwon, Min-Ji Kim, Sin Yeong Jung, Jae-Han Jeon
J Yeungnam Med Sci. 2023;40(Suppl):S93-S97.   Published online May 17, 2023
DOI: https://doi.org/10.12701/jyms.2023.00199
Funded: National Research Foundation of Korea, Ministry of Science and ICT
  • 1,085 View
  • 66 Download
  • 1 Crossref
AbstractAbstract PDF
Thyroid storm is a life-threatening form of thyrotoxicosis and an endocrinological emergency. We present a case of thyroid storm in a patient with metastatic papillary thyroid cancer. A 67-year-old woman with a history of total thyroidectomy 4 years prior to presentation was admitted with deteriorating mental status, fever, and tachycardia. Laboratory tests revealed severe thyrotoxicosis. Although the patient had no residual thyroid tissue after total thyroidectomy, she had a previously diagnosed metastatic thyroid cancer lesion in the pelvic bone. Despite initial treatment with a standard thyroid storm regimen, the patient died 6 days after hospitalization. The patient had no history of Graves disease; however, a thyroxine receptor antibody was detected postmortem. The patient had a history of exposure to an iodine contrast agent, which is a rare cause of thyrotoxicosis. Thyroxine production from a differentiated thyroid carcinoma is rare but can be a source of clinically significant thyrotoxicosis in patients post-thyroidectomy. Overlapping Graves disease is a common stimulus; however, other causes, such as exogenous iodine, cannot be excluded. This case demonstrates that in the setting of metastatic thyroid carcinoma, thyrotoxicosis cannot be completely ruled out as a cause of suspicious symptoms, even in patients with a history of total thyroidectomy.

Citations

Citations to this article as recorded by  
  • Data Analysis and Systematic Scoping Review on the Pathogenesis and Modalities of Treatment of Thyroid Storm Complicated with Myocardial Involvement and Shock
    Eman Elmenyar, Sarah Aoun, Zain Al Saadi, Ahmed Barkumi, Basar Cander, Hassan Al-Thani, Ayman El-Menyar
    Diagnostics.2023; 13(19): 3028.     CrossRef
Resident fellow section: Teaching images
Ultrasound-guided diagnosis/intervention for ischiofemoral impingement syndrome
Wei-Ting Wu, Ke-Vin Chang, Levent Özçakar
J Yeungnam Med Sci. 2023;40(Suppl):S134-S136.   Published online July 12, 2023
DOI: https://doi.org/10.12701/jyms.2023.00500
Funded: National Taiwan University Hospital, Ministry of Science and Technology, Taiwan, Taiwan Society of Ultrasound in Medicine
  • 792 View
  • 65 Download
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Original articles
Classification of dental implant systems using cloud-based deep learning algorithm: an experimental study
Hyun Jun Kong
J Yeungnam Med Sci. 2023;40(Suppl):S29-S36.   Published online July 26, 2023
DOI: https://doi.org/10.12701/jyms.2023.00465
Funded: Wonkwang University
  • 1,363 View
  • 91 Download
  • 1 Crossref
AbstractAbstract PDF
Background
This study aimed to evaluate the accuracy and clinical usability of implant system classification using automated machine learning on a Google Cloud platform.
Methods
Four dental implant systems were selected: Osstem TSIII, Osstem USII, Biomet 3i Os-seotite External, and Dentsply Sirona Xive. A total of 4,800 periapical radiographs (1,200 for each implant system) were collected and labeled based on electronic medical records. Regions of interest were manually cropped to 400×800 pixels, and all images were uploaded to Google Cloud storage. Approximately 80% of the images were used for training, 10% for validation, and 10% for testing. Google automated machine learning (AutoML) Vision automatically executed a neural architecture search technology to apply an appropriate algorithm to the uploaded data. A single-label image classification model was trained using AutoML. The performance of the mod-el was evaluated in terms of accuracy, precision, recall, specificity, and F1 score.
Results
The accuracy, precision, recall, specificity, and F1 score of the AutoML Vision model were 0.981, 0.963, 0.961, 0.985, and 0.962, respectively. Osstem TSIII had an accuracy of 100%. Osstem USII and 3i Osseotite External were most often confused in the confusion matrix.
Conclusion
Deep learning-based AutoML on a cloud platform showed high accuracy in the classification of dental implant systems as a fine-tuned convolutional neural network. Higher-quality images from various implant systems will be required to improve the performance and clinical usability of the model.

Citations

Citations to this article as recorded by  
  • Advancements in artificial intelligence algorithms for dental implant identification: A systematic review with meta-analysis
    Ahmed Yaseen Alqutaibi, Radhwan S. Algabri, Dina Elawady, Wafaa Ibrahim Ibrahim
    The Journal of Prosthetic Dentistry.2023;[Epub]     CrossRef
Diagnostic performance of F-18 FDG PET or PET/CT for detection of recurrent gastric cancer: a systematic review and meta-analysis
Chang In Choi, Jae Kyun Park, Tae Yong Jeon, Dae-Hwan Kim
J Yeungnam Med Sci. 2023;40(Suppl):S37-S46.   Published online August 17, 2023
DOI: https://doi.org/10.12701/jyms.2023.00220
Funded: Pusan National University
  • 1,218 View
  • 48 Download
AbstractAbstract PDF
Background
This systematic review and meta-analysis investigated the diagnostic performance of F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) or PET/computed tomography (PET/CT) for the detection of disease recurrence after curative resection of gastric cancer.
Methods
The PubMed and Embase databases, from the earliest available date of indexing through November 30, 2019, were searched for studies evaluating the diagnostic performance of F-18 FDG PET or PET/CT to detect recurrent disease after gastric cancer surgery.
Results
Across 17 studies (1,732 patients), the pooled sensitivity for F-18 FDG PET or PET/CT was 0.82 (95% confidence interval [CI], 0.74–0.88) with heterogeneity of I2=76.5 (p<0.001), and the specificity was 0.86 (95% CI, 0.78–0.91) with heterogeneity of I2=94.2 (p<0.001). Likelihood ratio (LR) tests gave an overall positive LR of 6.0 (95% CI, 3.6–9.7) and negative LR of 0.2 (95% CI, 0.14–0.31). The pooled diagnostic odds ratio was 29 (95% CI, 13–63). The summary receiver operating characteristic curve indicates that the area under the curve was 0.91 (95% CI, 0.88–0.93).
Conclusion
The current meta-analysis showed good sensitivity and specificity of F-18 FDG PET or PET/CT for detecting recurrent disease after curative resection of gastric cancer despite heterogeneity in ethnicity, recurrence rate, histology, and interpretation method.
Incidence and risk factors of deep vein thrombosis and pulmonary thromboembolism after spinal cord disease at a rehabilitation unit: a retrospective study
Yoonhee Kim, Minjae Jeong, Myung Woo Park, Hyun Iee Shin, Byung Chan Lee, Du Hwan Kim
J Yeungnam Med Sci. 2023;40(Suppl):S56-S64.   Published online September 20, 2023
DOI: https://doi.org/10.12701/jyms.2023.00689
Funded: Health Fellowship Foundation
  • 1,044 View
  • 48 Download
  • 1 Crossref
AbstractAbstract PDF
Background
Deep vein thrombosis (DVT) and pulmonary thromboembolism (PTE) are major complications of spinal cord disease. However, studies of their incidence in Korean patients are limited. Thus, this study investigated the incidence and risk factors of DVT and PTE in Korean patients with spinal cord disease.
Methods
We retrospectively analyzed the medical records of 271 patients with spinal cord disease who were admitted to a rehabilitation unit within 3 months of disease onset at a tertiary hospital. The presence of DVT and PTE was mainly determined using Doppler ultrasonography and chest embolism computed tomography. Risk factor analysis included variables such as sex, age, obesity, completeness of motor paralysis, neurological level of injury, cause of injury, lower extremity fracture, active cancer, and functional ambulation category (FAC) score.
Results
The incidences of DVT and PTE in the patients with spinal cord disease were both 6.3%. Risk factor analysis revealed that age of ≥65 years (p=0.031) and FAC score of ≤1 (p=0.023) were significantly associated with DVT development. Traumatic cause of injury (p=0.028) and DVT (p<0.001) were significant risk factors of PTE.
Conclusion
Patients with spinal cord disease developed DVT and PTE within 3 months of disease onset with incidence rates of 6.3% and 6.3%, respectively. Age of ≥65 years and an FAC of score ≤1 were risk factors for DVT. Traumatic cause of injury and DVT were risk factors for PTE. However, given the inconsistent results of previous studies, the risk factors for DVT and PTE remain inconclusive. Therefore, early screening for DVT and PTE should be performed in patients with acute-to-subacute spinal cord disease regardless of the presence or absence of these risk factors.

Citations

Citations to this article as recorded by  
  • Coagulation parameters correlate to venous thromboembolism occurrence during the perioperative period in patients with spinal fractures
    Yong Jiao, Xiaohong Mu
    Journal of Orthopaedic Surgery and Research.2023;[Epub]     CrossRef
Case report
Intravesical bacillus Calmette–Guérin-induced myopathy presenting as rhabdomyolysis: a case report
Chae Hun Lee, Byeong Joo Choi, Jung Hun Kim, Tae Woong Yang, Gi Jeong Kim, Ha Young Shin, Se Hoon Kim, Seung Woo Kim
J Yeungnam Med Sci. 2023;40(4):430-434.   Published online February 13, 2023
DOI: https://doi.org/10.12701/jyms.2022.00850
Funded: National Research Foundation of Korea, Ministry of Science, ICT and Future Planning
  • 905 View
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AbstractAbstract PDF
Intravesical bacillus Calmette–Guérin (BCG) instillation is an adjuvant treatment for non–muscle-invasive urinary bladder cancer. Although most complications associated with BCG immunotherapy are mild and self-limiting, rare albeit serious complications have been reported. Only a few cases of BCG-related rhabdomyolysis have been reported. In this study, we present the case of a 72-year-old woman who developed severe weakness and hyperCKemia following intravesical BCG instillation. A muscle biopsy was performed, and a diagnosis of drug-induced myopathy was made.
Original articles
Association between fatty liver disease and hearing impairment in Korean adults: a retrospective cross-sectional study
Da Jung Jung
J Yeungnam Med Sci. 2023;40(4):402-411.   Published online June 26, 2023
DOI: https://doi.org/10.12701/jyms.2023.00304
Funded: Korea Health Industry Development Institute, Ministry of Health and Welfare
  • 1,588 View
  • 34 Download
AbstractAbstract PDF
Background
We hypothesized that fatty liver disease (FLD) is associated with a high prevalence of hearing loss (HL) owing to metabolic disturbances. This study aimed to evaluate the association between FLD and HL in a large sample of the Korean population.
Methods
We used a dataset of adults who underwent routine voluntary health checkups (n=21,316). Fatty liver index (FLI) was calculated using Bedogni’s equation. The patients were divided into two groups: the non-FLD (NFLD) group (n=18,518, FLI <60) and the FLD group (n=2,798, FLI ≥60). Hearing thresholds were measured using an automatic audiometer. The average hearing threshold (AHT) was calculated as the pure-tone average at four frequencies (0.5, 1, 2, and 3 kHz). HL was defined as an AHT of >40 dB.
Results
HL was observed in 1,370 (7.4%) and 238 patients (8.5%) in the NFLD and FLD groups, respectively (p=0.041). Compared with the NFLD group, the odds ratio for HL in the FLD group was 1.16 (p=0.040) and 1.46 (p<0.001) in univariate and multivariate logistic regression analyses, respectively. Linear regression analyses revealed that FLI was positively associated with AHT in both univariate and multivariate analyses. Analyses using a propensity score-matched cohort showed trends similar to those using the total cohort.
Conclusion
FLD and FLI were associated with poor hearing thresholds and HL. Therefore, active monitoring of hearing impairment in patients with FLD may be helpful for early diagnosis and treatment of HL in the general population.
Cortical thickness of the rostral anterior cingulate gyrus is associated with frailty in patients with end-stage renal disease undergoing hemodialysis in Korea: a cross-sectional study
Sang Hyun Jung, Jong Soo Oh, So-Young Lee, Hye Yun Jeong
J Yeungnam Med Sci. 2023;40(4):381-387.   Published online March 24, 2023
DOI: https://doi.org/10.12701/jyms.2022.00941
Funded: Korea Health Industry Development Institute, Ministry of Health and Welfare
  • 992 View
  • 36 Download
AbstractAbstract PDF
Background
Frailty is defined as a condition of being weak and delicate, and it represents a state of high vulnerability to adverse health outcomes. Recent studies have suggested that the cingulate gyrus is associated with frailty in the elderly population. However, few imaging studies have explored the relationship between frailty and the cingulate gyrus in patients with end-stage renal disease (ESRD) undergoing hemodialysis.
Methods
Eighteen right-handed patients with ESRD undergoing hemodialysis were enrolled in the study. We used the FreeSurfer software package to estimate the cortical thickness of the regions of interest, including the rostral anterior, caudal anterior, isthmus, and posterior cingulate gyri. The Beck Depression Inventory, Beck Anxiety Inventory, and laboratory tests were also conducted.
Results
The cortical thickness of the right rostral anterior cingulate gyrus (ACG) was significantly correlated with the Fried frailty index, age, and creatinine level. Multiple regression analysis indicated that the cortical thickness of the right rostral ACG was associated with frailty after controlling for age and creatinine level.
Conclusion
Our results indicate that the cortical thickness of the rostral ACG may be associated with frailty in patients with ESRD on hemodialysis and that the rostral ACG may play a role in the frailty mechanism of this population.
Review article
Multidisciplinary approach to sarcopenia: a narrative review
Wook Tae Park, Oog-Jin Shon, Gi Beom Kim
J Yeungnam Med Sci. 2023;40(4):352-363.   Published online September 7, 2023
DOI: https://doi.org/10.12701/jyms.2023.00724
Funded: National Research Foundation of Korea, Ministry of Education
  • 1,634 View
  • 132 Download
AbstractAbstract PDF
Sarcopenia is a condition in which muscle mass and strength are decreased and muscle function is impaired. It is an indicator of frailty and loss of independence in older adults. It is also associated with increased physical disability, which increases the risk of falls. As a multifactorial disease, sarcopenia is caused by a combination of factors including aging, hormonal changes, nutritional deficiencies, and physical inactivity. Understanding the underlying pathophysiology of sarcopenia and identifying its different causes is critical to developing effective prevention and treatment strategies. This review summarizes the pathophysiology, consequences, diagnostic methods, and multidisciplinary approaches to sarcopenia.
Focused Review article
Management and rehabilitation of moderate-to-severe diabetic foot infection: a narrative review
Chi Young An, Seung Lim Baek, Dong-Il Chun
J Yeungnam Med Sci. 2023;40(4):343-351.   Published online September 19, 2023
DOI: https://doi.org/10.12701/jyms.2023.00717
Funded: Soonchunhyang Seoul Hospital
  • 1,392 View
  • 101 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDF
Diabetic foot is one of the most devastating consequences of diabetes, resulting in amputation and possibly death. Therefore, early detection and vigorous treatment of infections in patients with diabetic foot are critical. This review seeks to provide guidelines for the therapy and rehabilitation of patients with moderate-to-severe diabetic foot. If a diabetic foot infection is suspected, bacterial cultures should be initially obtained. Numerous imaging studies can be used to identify diabetic foot, and recent research has shown that white blood cell single-photon emission computed tomography/computed tomography has comparable diagnostic specificity and sensitivity to magnetic resonance imaging. Surgery is performed when a diabetic foot ulcer is deep and is accompanied by bone and soft tissue infections. Patients should be taught preoperative rehabilitation before undergoing stressful surgery. During surgical procedures, it is critical to remove all necrotic tissue and drain the inflammatory area. It is critical to treat wounds with suitable dressings after surgery. Wet dressings promote the formation of granulation tissues and new blood vessels. Walking should begin as soon as the patient’s general condition allows it, regardless of the wound status or prior walking capacity. Adequate treatment of comorbidities, including hypertension and dyslipidemia, and smoking cessation are necessary. Additionally, broad-spectrum antibiotics are required to treat diabetic foot infections.

Citations

Citations to this article as recorded by  
  • Unveiling the challenges of diabetic foot infections: diagnosis, pathogenesis, treatment, and rehabilitation
    Chul Hyun Park
    Journal of Yeungnam Medical Science.2023; 40(4): 319.     CrossRef

JYMS : Journal of Yeungnam Medical Science