Most-read articles are from the articles published in 2021 during the last three month.
Review articles
- Classification of endometriosis
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Soo-Young Lee, Yu-Jin Koo, Dae-Hyung Lee
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Yeungnam Univ J Med. 2021;38(1):10-18. Published online August 7, 2020
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DOI: https://doi.org/10.12701/yujm.2020.00444
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17,970
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33
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Abstract
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- Endometriosis is a chronic disease associated with pelvic pain and infertility. Several classification systems for the severity of endometriosis have been proposed. Of these, the revised American Society for Reproductive Medicine classification is the most well-known. The ENZIAN classification was developed to classify deep infiltrating endometriosis and focused on the retroperitoneal structures. The endometriosis fertility index was developed to predict the fertility outcomes in patients who underwent surgery for endometriosis. Finally, the American Association of Gynecological Laparoscopists classification is currently being developed, for which 30 endometriosis experts are analyzing and researching data by assigning scores to categories considered important; however, it has not yet been fully validated and published. Currently, none of the classification systems are considered the gold standard. In this article, we review the classification systems, identify their pros and cons, and discuss what improvements need to be made to each system in the future.
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Citations
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- Ultrasound Characteristics and Scanning Techniques of Uterosacral Ligaments for the Diagnosis of Endometriosis
Shae Maple, K Jane Chalmers, Eva Bezak, Katelyn Henry, Nayana Parange
Journal of Ultrasound in Medicine.2023; 42(6): 1193. CrossRef - The Influence of Lactoferrin in Plasma and Peritoneal Fluid on Iron Metabolism in Women with Endometriosis
Ewa Skarżyńska, Monika Wróbel, Hanna Zborowska, Mateusz Franciszek Kołek, Grzegorz Mańka, Mariusz Kiecka, Michał Lipa, Damian Warzecha, Robert Spaczyński, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Młodawski,
International Journal of Molecular Sciences.2023; 24(2): 1619. CrossRef - Long Non-Coding RNA SNHG4 Expression in Women with Endometriosis: A Pilot Study
Tomasz Szaflik, Hanna Romanowicz, Krzysztof Szyłło, Beata Smolarz
Genes.2023; 14(1): 152. CrossRef - Epidemiological and Immune Profile Analysis of Italian Subjects with Endometriosis and Multiple Sclerosis
Brunella Zizolfi, Virginia Foreste, Simona Bonavita, Valentina Rubino, Giuseppina Ruggiero, Vincenzo Brescia Morra, Roberta Lanzillo, Antonio Carotenuto, Francesca Boscia, Maurizio Taglialatela, Maurizio Guida
Journal of Clinical Medicine.2023; 12(5): 2043. CrossRef - Rectal endometriosis imaging: A case based pictorial essay
Garvit D. Khatri, Deepashri Basavalingu, Nitin Chaubal, Manjiri Dighe
WFUMB Ultrasound Open.2023; 1(1): 100002. CrossRef -
KRAS
mutations and endometriosis burden of disease
Natasha L Orr, Arianne Albert, Yang Doris Liu, Amy Lum, JooYoon Hong, Catalina L Ionescu, Janine Senz, Tayyebeh M Nazeran, Anna F Lee, Heather Noga, Kate Lawrenson, Catherine Allaire, Christina Williams, Mohamed A Bedaiwy, Michael S Anglesio, Paul J Yong
The Journal of Pathology: Clinical Research.2023;[Epub] CrossRef - The Clinical Presentation of Endometriosis and Its Association to Current Surgical Staging
Matilda Shaked Ashkenazi, Ole Linvåg Huseby, Gard Kroken, Marcela Trocha, Aurora Henriksson, Hanna Jasiak, Karen Cuartas, Alessandra Loschiavo, Isabella Kuhn, Dina Støve, Hanna Grindahl, Emilia Latour, Mathias Melbø, Katrine Holstad, Sebastian Kwiatkowski
Journal of Clinical Medicine.2023; 12(7): 2688. CrossRef - Evaluation and management of endometriosis
T. Yoldemir
Climacteric.2023; 26(3): 248. CrossRef - COX isozymes and non-uniform neoangiogenesis: What is their role in endometriosis?
Andrea Caruana, Charles Savona-Ventura, Jean Calleja-Agius
Prostaglandins & Other Lipid Mediators.2023; 167: 106734. CrossRef - Time to move beyond surgical classification systems for endometriosis
María Isabel Hernández Cardona, Christana Ajewole, Hannah Lewis, Jorge F. Carrillo, Mario E. Castellanos, Stefanie Barish, Juan Diego Villegas Echeverri, Georgine Lamvu
International Journal of Gynecology & Obstetrics.2023;[Epub] CrossRef - Antimüllerian hormone (AMH) and age as predictors of preimplantation genetic testing for aneuploidies (PGT-A) cycle outcomes and blastocyst quality on day 5 in women undergoing in vitro fertilization (IVF)
A. Arnanz, A. Bayram, I. Elkhatib, A. Abdala, A. El-Damen, R. Patel, B. Lawrenz, L. Melado, H. Fatemi, N. De Munck
Journal of Assisted Reproduction and Genetics.2023;[Epub] CrossRef - Association between polymorphisms of cytokine genes and endometriosis: A comprehensive systematic review and meta-analysis
Shulin Zhong, Yuzhen Liang, Zhixi Wu, Li Wei
Journal of Reproductive Immunology.2023; : 103969. CrossRef - Comparison of Clinical and Reproductive Outcomes between Adenomyomectomy and Myomectomy
Kristyna Hlinecka, Michal Mara, Barbora Boudova, Zdenka Lisa, Adela Richtarova, David Kuzel
Journal of Minimally Invasive Gynecology.2022; 29(3): 392. CrossRef - Evaluating Surgical Complexity of Endoscopic Hysterectomy: An Inter-rater and Intra-rater Agreement Study of Novel Scoring Tool
Meenal Misal, Marlene Girardo, Sadikah Behbehani, Vimee Bindra, Mark R. Hoffman, Wei How Lim, Courtney Martin, Sukrant K. Mehta, Alysha Nensi, Thiers Soares, Deborah Taylor, Steve Wagner, Kelly N. Wright, Megan N. Wasson
Journal of Minimally Invasive Gynecology.2022; 29(5): 683. CrossRef - MRI in the Diagnosis of Endometriosis and Related Diseases
Aki Kido, Yuki Himoto, Yusaku Moribata, Yasuhisa Kurata, Yuji Nakamoto
Korean Journal of Radiology.2022; 23(4): 426. CrossRef - Role of Robotic Surgery in Benign Gynecology
Mireille D. Truong, Lauren N. Tholemeier
Obstetrics and Gynecology Clinics of North America.2022; 49(2): 273. CrossRef - NLRP3 activated macrophages promote endometrial stromal cells migration in endometriosis
Feng Zhou, Fanxuan Zhao, Qianmeng Huang, Xiang Lin, Songying Zhang, Yongdong Dai
Journal of Reproductive Immunology.2022; 152: 103649. CrossRef - Endometriosis: A Disease with Few Direct Treatment Options
Patricia Ribeiro de Carvalho França, Anna Carolina Pereira Lontra, Patricia Dias Fernandes
Molecules.2022; 27(13): 4034. CrossRef - The Role of the Immune System in the Development of Endometriosis
Monika Abramiuk, Ewelina Grywalska, Paulina Małkowska, Olga Sierawska, Rafał Hrynkiewicz, Paulina Niedźwiedzka-Rystwej
Cells.2022; 11(13): 2028. CrossRef - Transvaginal Ultrasound vs. Magnetic Resonance Imaging (MRI) Value in Endometriosis Diagnosis
Alexandra Baușic, Ciprian Coroleucă, Cătălin Coroleucă, Diana Comandașu, Roxana Matasariu, Andrei Manu, Francesca Frîncu, Claudia Mehedințu, Elvira Brătilă
Diagnostics.2022; 12(7): 1767. CrossRef - History of Endometriosis Is Independently Associated with an Increased Risk of Ovarian Cancer
Antonio Sarría-Santamera, Zaukiya Khamitova, Arnur Gusmanov, Milan Terzic, Mar Polo-Santos, Miguel A. Ortega, Angel Asúnsolo
Journal of Personalized Medicine.2022; 12(8): 1337. CrossRef - Surgical Classification of Endometriosis
João Nogueira Neto, Mauricio Simões Abrão, Eduardo Schor, Julio Cesar Rosa-e-Silva
Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics.2022; 44(08): 737. CrossRef - Analysis of Long Non-Coding RNA (lncRNA) UCA1, MALAT1, TC0101441, and H19 Expression in Endometriosis
Tomasz Szaflik, Hanna Romanowicz, Krzysztof Szyłło, Radosław Kołaciński, Magdalena M. Michalska, Dariusz Samulak, Beata Smolarz
International Journal of Molecular Sciences.2022; 23(19): 11583. CrossRef - Colorectal infiltrating deep endometriosis: Laparoscopic treatment. A case report
Giuseppe Di Buono, Matilde Micheli, Gaia Russo, Roberta Vella, Giuseppe Amato, Girolamo Geraci, Antonino Agrusa
Frontiers in Surgery.2022;[Epub] CrossRef - Aged garlic extract as a potential prophylactic to reduce the progression of endometriosis and associated pain burden
Emily Redwood, Virginie Lam, Ryusuke Takechi, Deborah Anne Kerr, Connie Jackaman, Arazu Sharif, John Charles Louis Mamo
Frontiers in Pain Research.2022;[Epub] CrossRef - Histotyping and grading of endometriosis and its association with clinico-pathological parameters
Jyothika Litson, Rini Agnes, Gayatri Ravikumar
Journal of Obstetrics and Gynaecology.2022; 42(8): 3628. CrossRef - Plasma and Peritoneal Fluid Fibronectin and Collagen IV Levels as Potential Biomarkers of Endometriosis
Damian Warzecha, Julia Załęcka, Grzegorz Mańka, Mariusz Kiecka, Michał Lipa, Robert Spaczyński, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Młodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Sz
International Journal of Molecular Sciences.2022; 23(24): 15669. CrossRef - Progestins in the symptomatic management of endometriosis: a meta-analysis on their effectiveness and safety
Jon-Benay Mitchell, Sarentha Chetty, Fatima Kathrada
BMC Women's Health.2022;[Epub] CrossRef - Effects of CDKN2B-AS1 on cellular proliferation, invasion and AKT3 expression are attenuated by miR-424-5p in a model of ovarian endometriosis
Sixue Wang, Mingyu Yi, Xinyue Zhang, Tingting Zhang, Li Jiang, Le Cao, Yuxin Zhou, Xiaoling Fang
Reproductive BioMedicine Online.2021; 42(6): 1057. CrossRef - Structured report for dynamic ultrasonography in patients with suspected or known endometriosis: Recommendations of the International Society for Gynecologic Endoscopy (ISGE)
Dusan Djokovic, Patrícia Pinto, Bruno J. van Herendael, Antonio Simone Laganà, Viju Thomas, Jörg Keckstein
European Journal of Obstetrics & Gynecology and Reproductive Biology.2021; 263: 252. CrossRef - Stigma and Endometriosis: A Brief Overview and Recommendations to Improve Psychosocial Well-Being and Diagnostic Delay
Omar T. Sims, Jhumka Gupta, Stacey A. Missmer, Irene O. Aninye
International Journal of Environmental Research and Public Health.2021; 18(15): 8210. CrossRef - AAGL 2021 Endometriosis Classification: An Anatomy-based Surgical Complexity Score
Mauricio S. Abrao, Marina Paula Andres, Charles E. Miller, Julian A. Gingold, Mariona Rius, Joao Siufi Neto, Francisco Carmona
Journal of Minimally Invasive Gynecology.2021; 28(11): 1941. CrossRef - Involvement of bradykinin and bradykinin B1 receptor in patients with endometriosis
Xin Meng, Ying Li, Qingxue Li, Jian Yang, Mingli An, Xinping Fu, Shuancheng Zhang, Jingwei Chen
Experimental and Therapeutic Medicine.2021;[Epub] CrossRef
- Current diagnosis and treatment of vestibular neuritis: a narrative review
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Chang Hoon Bae, Hyung Gyun Na, Yoon Seok Choi
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J Yeungnam Med Sci. 2022;39(2):81-88. Published online August 9, 2021
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DOI: https://doi.org/10.12701/yujm.2021.01228
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- Vertigo is the sensation of self-motion of the head or body when no self-motion is occurring or the sensation of distorted self-motion during an otherwise normal head movement. Representative peripheral vertigo disorders include benign paroxysmal positional vertigo, Ménière disease, and vestibular neuritis. Vestibular neuritis, also known as vestibular neuronitis, is the third most common peripheral vestibular disorder after benign paroxysmal positional vertigo and Ménière disease. The cause of vestibular neuritis remains unclear. However, a viral infection of the vestibular nerve or ischemia of the anterior vestibular artery is known to cause vestibular neuritis. In addition, recent studies on immune-mediated mechanisms as the cause of vestibular neuritis have been reported. The characteristic clinical features of vestibular neuritis are abrupt true-whirling vertigo lasting for more than 24 hours, and no presence of cochlear symptoms and other neurological symptoms and signs. To accurately diagnose vestibular neuritis, various diagnostic tests such as the head impulse test, bithermal caloric test, and vestibular-evoked myogenic potential test are conducted. Various treatments for vestibular neuritis have been reported, which are largely divided into symptomatic therapy, specific drug therapy, and vestibular rehabilitation therapy. Symptomatic therapies include generalized supportive care and administration of vestibular suppressants and antiemetics. Specific drug therapies include steroid therapy, antiviral therapy, and vasodilator therapy. Vestibular rehabilitation therapies include generalized vestibular and customized vestibular exercises.
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Citations
Citations to this article as recorded by

- Vertigo in the Setting of COVID-19 Infection: A Case Report
Sanjana Devaragudi, Mohit Gupta
Cureus.2023;[Epub] CrossRef - Hospital Admission Profile Related to Inner Ear Diseases in England and Wales
Esra’ O. Taybeh, Abdallah Y. Naser
Healthcare.2023; 11(10): 1457. CrossRef - Acute vestibular neuritis: A rare complication after the adenoviral vector-based COVID-19 vaccine
Hamze Shahali, Ramin Hamidi Farahani, Parham Hazrati, Ebrahim Hazrati
Journal of NeuroVirology.2022; 28(4-6): 609. CrossRef - A Holistic Approach to a Dizzy Patient: A Practical Update
Ioannis Koukoulithras, Gianna Drousia, Spyridon Kolokotsios, Minas Plexousakis, Alexandra Stamouli, Charis Roussos, Eleana Xanthi
Cureus.2022;[Epub] CrossRef - Identification of hub genes and pathophysiological mechanism related to acute unilateral vestibulopathy by integrated bioinformatics analysis
Yajing Cheng, Jianrong Zheng, Ying Zhan, Cong Liu, Bihua Lu, Jun Hu
Frontiers in Neurology.2022;[Epub] CrossRef
- Beneficial effects of intermittent fasting: a narrative review
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Dae-Kyu Song, Yong-Woon Kim
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J Yeungnam Med Sci. 2023;40(1):4-11. Published online April 4, 2022
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DOI: https://doi.org/10.12701/jyms.2022.00010
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2,714
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164
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- Caloric restriction is a popular approach to treat obesity and its associated chronic illnesses but is difficult to maintain for a long time. Intermittent fasting is an alternative and easily applicable dietary intervention for caloric restriction. Moreover, intermittent fasting has beneficial effects equivalent to those of caloric restriction in terms of body weight control, improvements in glucose homeostasis and lipid profiles, and anti-inflammatory effects. In this review, the beneficial effects of intermittent fasting are discussed.
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Maternal intermittent fasting deteriorates offspring metabolism via suppression of hepatic
mTORC1
signaling
Wenzhen Yin, Lijun Sun, Yuan Liang, Chao Luo, Tiange Feng, Yunhua Zhang, Weizhen Zhang, Yue Yin
The FASEB Journal.2023;[Epub] CrossRef
- Lactate: a multifunctional signaling molecule
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Tae-Yoon Lee
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Yeungnam Univ J Med. 2021;38(3):183-193. Published online February 18, 2021
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DOI: https://doi.org/10.12701/yujm.2020.00892
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15,443
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409
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23
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- Since its discovery in 1780, lactate has long been misunderstood as a waste by-product of anaerobic glycolysis with multiple deleterious effects. Owing to the lactate shuttle concept introduced in the early 1980s, a paradigm shift began to occur. Increasing evidence indicates that lactate is a coordinator of whole-body metabolism. Lactate is not only a readily accessible fuel that is shuttled throughout the body but also a metabolic buffer that bridges glycolysis and oxidative phosphorylation between cells and intracellular compartments. Lactate also acts as a multifunctional signaling molecule through receptors expressed in various cells and tissues, resulting in diverse biological consequences including decreased lipolysis, immune regulation, anti-inflammation, wound healing, and enhanced exercise performance in association with the gut microbiome. Furthermore, lactate contributes to epigenetic gene regulation by lactylating lysine residues of histones, accounting for its key role in immune modulation and maintenance of homeostasis.
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Citations
Citations to this article as recorded by

- B cells from old mice induce the generation of inflammatory T cells through metabolic pathways
Kevin Li, Maria Romero, Macarena Cañardo, Denisse Garcia, Alain Diaz, Bonnie B. Blomberg, Daniela Frasca
Mechanisms of Ageing and Development.2023; 209: 111742. CrossRef - Lactate: a pearl dropped in the ocean—an overlooked signal molecule in physiology and pathology
Yue Wu, Wanqi Ma, Wei Liu, Shuping Zhang
Cell Biology International.2023; 47(2): 295. CrossRef - Insights on the role of l-lactate as a signaling molecule in skin aging
Salvatore Chirumbolo, Dario Bertossi, Pierre Magistretti
Biogerontology.2023;[Epub] CrossRef - Role of L-lactate as an energy substrate in primary rat podocytes under physiological and glucose deprivation conditions
Maria Szrejder, Marlena Typiak, Piotr Pikul, Irena Audzeyenka, Patrycja Rachubik, Dorota Rogacka, Magdalena Narajczyk, Agnieszka Piwkowska
European Journal of Cell Biology.2023; 102(2): 151298. CrossRef - Utilization of delactosed whey permeate for the synthesis of ethyl acetate with Kluyveromyces marxianus
Andreas Hoffmann, Alexander Franz, Thomas Walther, Christian Löser
Applied Microbiology and Biotechnology.2023; 107(5-6): 1635. CrossRef - Lactate, histone lactylation and cancer hallmarks
Xinyu Lv, Yingying Lv, Xiaofeng Dai
Expert Reviews in Molecular Medicine.2023;[Epub] CrossRef - Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies
Ariel K. Frame, J. Wesley Robinson, Nader H. Mahmoudzadeh, Jason M. Tennessen, Anne F. Simon, Robert C. Cumming
Aging.2023;[Epub] CrossRef - Human beta defensin-2 loaded PLGA nanoparticles impregnated in collagen-chitosan composite scaffold for the management of diabetic wounds
Bharat Kumar Reddy Sanapalli, Vidyasrilekha Yele, Mantosh Kumar Singh, Shilpa.N. Thumbooru, Madhukiran Parvathaneni, Veera Venkata Satyanarayana Reddy Karri
Biomedicine & Pharmacotherapy.2023; 161: 114540. CrossRef - Immunomodulatory Properties of Probiotics and Their Derived Bioactive Compounds
Christina Thoda, Maria Touraki
Applied Sciences.2023; 13(8): 4726. CrossRef - Lactate‐induced protein lactylation: A bridge between epigenetics and metabolic reprogramming in cancer
Ting Wang, Zeng Ye, Zheng Li, De‐sheng Jing, Gui‐xiong Fan, Meng‐qi Liu, Qi‐feng Zhuo, Shun‐rong Ji, Xian‐jun Yu, Xiao‐wu Xu, Yi Qin
Cell Proliferation.2023;[Epub] CrossRef - Recent Developments in Protein Lactylation in PTSD and CVD: Novel Strategies and Targets
Zisis Kozlakidis, Patricia Shi, Ganna Abarbanel, Carolina Klein, Adonis Sfera
BioTech.2023; 12(2): 38. CrossRef - High-concentrate diet elevates histone lactylation mediated by p300/CBP through the upregulation of lactic acid and induces an inflammatory response in mammary gland of dairy cows
Lairong Wang, Yan Wang, Meijuan Meng, Nana Ma, Guozhen Wei, Ran Huo, Guangjun Chang, Xiangzhen Shen
Microbial Pathogenesis.2023; 180: 106135. CrossRef - ANT2 accelerates cutaneous wound healing in aged skin via regulating energy homeostasis and inflammation
Seung-Hwa Woo, Yun Jeong Mo, Yun-Il Lee, Ji Hwan Park, Daehee Hwang, Tae Jun Park, Hee Young Kang, Sang Chul Park, Young-Sam Lee
Journal of Investigative Dermatology.2023;[Epub] CrossRef - Lactylation driven by lactate metabolism in the disc accelerates intervertebral disc degeneration: A hypothesis
Chuan Cheng, Zhiqiang Xu, Cao Yang, Xinghuo Wu
Medical Hypotheses.2022; 159: 110758. CrossRef - A bioorthogonal chemical reporter for the detection and identification of protein lactylation
Yanan Sun, Yanchi Chen, Tao Peng
Chemical Science.2022; 13(20): 6019. CrossRef - Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells
Lianhong Pan, Fan Feng, Jiaqin Wu, Shibing Fan, Juanjuan Han, Shunxi Wang, Li Yang, Wanqian Liu, Chunli Wang, Kang Xu
Pharmacological Research.2022; 181: 106270. CrossRef - Understanding lactate sensing and signalling
Michelangelo Certo, Alba Llibre, Wheeseong Lee, Claudio Mauro
Trends in Endocrinology & Metabolism.2022; 33(10): 722. CrossRef - Venous Wall of Patients with Chronic Venous Disease Exhibits a Glycolytic Phenotype
Oscar Fraile-Martinez, Cielo García-Montero, Miguel Ángel Alvarez-Mon, Ana M. Gomez-Lahoz, Jorge Monserrat, Maria Llavero-Valero, Fernando Ruiz-Grande, Santiago Coca, Melchor Alvarez-Mon, Julia Buján, Natalio García-Honduvilla, Jose V. Saz, Miguel A. Orte
Journal of Personalized Medicine.2022; 12(10): 1642. CrossRef - Lactate induces metabolic and epigenetic reprogramming of pro‐inflammatory Th17 cells
Aleksandra Lopez Krol, Hannah P Nehring, Felix F Krause, Anne Wempe, Hartmann Raifer, Andrea Nist, Thorsten Stiewe, Wilhelm Bertrams, Bernd Schmeck, Maik Luu, Hanna Leister, Ho‐Ryun Chung, Uta‐Maria Bauer, Till Adhikary, Alexander Visekruna
EMBO reports.2022;[Epub] CrossRef - The function and mechanism of lactate and lactylation in tumor metabolism and microenvironment
Yan Zhang, Qiu Peng, Jinhua Zheng, Yuzhong Yang, Xuemei Zhang, Aiyu Ma, Yuxia Qin, Zailong Qin, Xiang Zheng
Genes & Diseases.2022;[Epub] CrossRef - Crosstalk between glucose metabolism, lactate production and immune response modulation
Lei Ye, Yi Jiang, Mingming Zhang
Cytokine & Growth Factor Reviews.2022; 68: 81. CrossRef - Metabolic orchestration of the wound healing response
Sabine A. Eming, Peter J. Murray, Edward J. Pearce
Cell Metabolism.2021; 33(9): 1726. CrossRef - Epigenetic Regulation of Immunotherapy Response in Triple-Negative Breast Cancer
Pere Llinàs-Arias, Sandra Íñiguez-Muñoz, Kelly McCann, Leonie Voorwerk, Javier I. J. Orozco, Miquel Ensenyat-Mendez, Borja Sesé, Maggie L. DiNome, Diego M. Marzese
Cancers.2021; 13(16): 4139. CrossRef
- Psychiatric understanding and treatment of patients with amputations
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So-Hye Jo, Suk-Hun Kang, Wan-Seok Seo, Bon-Hoon Koo, Hye-Geum Kim, Seok-Ho Yun
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Yeungnam Univ J Med. 2021;38(3):194-201. Published online May 11, 2021
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DOI: https://doi.org/10.12701/yujm.2021.00990
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- Amputation changes the lives of patients and their families. Consequently, the patient must adapt to altered body function and image. During this adaptation process, psychological problems, such as depression, anxiety, and posttraumatic stress disorder, can occur. The psychological difficulties of patients with amputation are often accepted as normal responses that are often poorly recognized by patients, family members, and their primary physicians. Psychological problems can interfere with rehabilitation and cause additional psychosocial problems. Therefore, their early detection and treatment are important. A multidisciplinary team approach, including mental health professionals, is ideal for comprehensive and biopsychosocial management. Mental health professionals could help patients set realistic goals and use adaptive coping styles. Psychiatric approaches should consider the physical, cognitive, psychological, social, and spiritual functions and social support systems before and after amputation. The abilities and limitations of physical, cognitive, psychological, and social functions should also be considered. To improve the patient’s adaptation, psychological interventions such as short-term psychotherapy, cognitive behavioral therapy, mindfulness meditation, biofeedback, and group psychotherapy can be helpful.
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Citations to this article as recorded by

- Effect of Increasing Assistance From a Powered Prosthesis on Weight-Bearing Symmetry, Effort, and Speed During Stand-Up in Individuals With Above-Knee Amputation
Grace R. Hunt, Sarah Hood, Lukas Gabert, Tommaso Lenzi
IEEE Transactions on Neural Systems and Rehabilitation Engineering.2023; 31: 11. CrossRef
Case report
- Cerebral fat embolism syndrome: diagnostic challenges and catastrophic outcomes: a case series
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Hussein A. Algahtani, Bader H. Shirah, Nawal Abdelghaffar, Fawziah Alahmari, Wajd Alhadi, Saeed A. Alqahtani
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J Yeungnam Med Sci. 2023;40(2):207-211. Published online September 7, 2022
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DOI: https://doi.org/10.12701/jyms.2022.00360
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- Fat embolism syndrome is a rare but alarming, life-threatening clinical condition attributed to fat emboli entering the circulation. It usually occurs as a complication of long-bone fractures and joint reconstruction surgery. Neurological manifestations usually occur 12 to 72 hours after the initial insult. These neurological complications include cerebral infarction, spinal cord ischemia, hemorrhagic stroke, seizures, and coma. Other features include an acute confusional state, autonomic dysfunction, and retinal ischemia. In this case series, we describe three patients with fat embolism syndrome who presented with atypical symptoms and signs and with unusual neuroimaging findings. Cerebral fat embolism may occur without any respiratory or dermatological signs. In these cases, diagnosis is established after excluding other differential diagnoses. Neuroimaging using brain magnetic resonance imaging is of paramount importance in establishing a diagnosis. Aggressive hemodynamic and respiratory support from the beginning and consideration of orthopedic surgical intervention within the first 24 hours after trauma are critical to decreased morbidity and mortality.
Review articles
- Hepatic encephalopathy on magnetic resonance imaging and its uncertain differential diagnoses: a narrative review
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Chun Geun Lim, Myong Hun Hahm, Hui Joong Lee
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J Yeungnam Med Sci. 2023;40(2):136-145. Published online January 10, 2023
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DOI: https://doi.org/10.12701/jyms.2022.00689
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- Hepatic encephalopathy (HE) is a severe neuropsychiatric abnormality in patients with either acute or chronic liver failure. Typical brain magnetic resonance imaging findings of HE are bilateral basal ganglia high signal intensities due to manganese deposition in chronic liver disease and hyperintensity in T2, fluid-attenuated inversion recovery, or diffusion-weighted imaging (DWI) with hemispheric white matter changes including the corticospinal tract. Low values on apparent diffusion coefficient mapping of the affected area on DWI, indicating cytotoxic edema, can be observed in acute HE. However, neuropsychological impairment in HE ranges from mild deficits in psychomotor abilities affecting quality of life to stupor or coma with higher grades of hepatic dysfunction. In particular, the long-lasting compensatory mechanisms for the altered metabolism in chronic liver disease make HE imaging results variable. Therefore, the clinical relevance of imaging findings is uncertain and differentiating HE from other metabolic diseases can be difficult. The recent introduction of concepts such as “acute-on-chronic liver failure (ACLF),” a new clinical entity, has led to a change in the clinical view of HE. Accordingly, there is a need to establish a corresponding concept in the field of neuroimaging diagnosis. Herein, we review HE from a historical and etiological perspective to increase understanding of brain imaging and help establish an imaging approach for advanced new concepts such as ACLF. The purpose of this manuscript is to provide an understanding of HE by reviewing neuroimaging findings based on pathological and clinical concepts of HE, thereby assisting in neuroimaging interpretation.
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- Rule out all differential causes before attributing cerebral bleeding to 5-aminolevulinic acid
Josef Finsterer, Sounira Mehri
Child's Nervous System.2023; 39(4): 847. CrossRef
- Long-term management of Graves disease: a narrative review
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Hyo-Jeong Kim
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J Yeungnam Med Sci. 2023;40(1):12-22. Published online November 4, 2022
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DOI: https://doi.org/10.12701/jyms.2022.00444
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1,461
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103
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- Graves disease (GD) is the most common cause of hyperthyroidism, accounting for more than 90% of cases in Korea. Patients with GD are treated with any of the following: antithyroid drugs (ATDs), radioactive iodine (RAI) therapy, or thyroidectomy. Most patients begin treatment with ATDs, and clinical guidelines suggest that the appropriate treatment period is 12 to 18 months. While RAI treatment and surgery manage thyrotoxicosis by destroying or removing thyroid tissue, ATDs control thyrotoxicosis by inhibiting thyroid hormone synthesis and preserving the thyroid gland. Although ATDs efficiently control thyrotoxicosis symptoms, they do not correct the main etiology of GD; therefore, frequent relapses can follow. Recently, a large amount of data has been collected on long-term ATDs for GD, and low-dose methimazole (MMZ) is expected to be a good option for remission. For the long-term management of recurrent GD, it is important to induce remission by evaluating the patient’s drug response, stopping ATDs at an appropriate time, and actively switching to surgery or RAI therapy, if indicated. Continuing drug treatment for an extended time is now encouraged in patients with a high possibility of remission with low-dose MMZ. It is also important to pay attention to the quality of life of the patients. This review aimed to summarize the appropriate treatment methods and timing of treatment transition in patients who relapsed several times while receiving treatment for GD.
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- Total Thyroidectomy – A Cost-effective Alternative to Anti-Thyroid Drugs in the Management of Grave's Disease
Erivelto Volpi, Leonardo M. Volpi
Clinical Thyroidology.2023; 35(5): 183. CrossRef
- Home mechanical ventilation in children with chronic respiratory failure: a narrative review
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Soyoung Kwak
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J Yeungnam Med Sci. 2023;40(2):123-135. Published online May 27, 2022
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DOI: https://doi.org/10.12701/jyms.2022.00227
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Abstract
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- Advances in perinatal and pediatric intensive care and recent advances in mechanical ventilation during the last two decades have resulted in an exponential increase in the number of children undergoing home mechanical ventilation (HMV) treatment. Although its efficacy in chronic respiratory failure is well established, HMV in children is more complex than that in adults, and there are more considerations. This review outlines clinical considerations for HMV in children. The goal of HMV in children is not only to correct alveolar hypoventilation but also to maximize development as much as possible. The modes of ventilation and ventilator settings, including ventilation masks, tubing, circuits, humidification, and ventilator parameters, should be tailored to the patient’s individual characteristics. To ensure effective HMV, education for the parent and caregiver is important. HMV continues to change the scope of treatment for chronic respiratory failure in children in that it decreases respiratory morbidity and prolongs life spans. Further studies on this topic with larger scale and systemic approach are required to ensure the better outcomes in this population.
Original articles
- Clinical investigation on acute pyelonephritis without pyuria: a retrospective observational study
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Hyung Keun Song, Dong Hyuk Shin, Ji Ung Na, Sang Kuk Han, Pil Cho Choi, Jang Hee Lee
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J Yeungnam Med Sci. 2022;39(1):39-45. Published online August 11, 2021
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DOI: https://doi.org/10.12701/yujm.2021.01207
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Abstract
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- Background
The current guidelines for the diagnosis of acute pyelonephritis (APN) recommend that APN be diagnosed based on the clinical features and the presence of pyuria. However, we observed that some of the patients who are diagnosed with APN do not have characteristic clinical features or pyuria at the initial examination. We performed this study to investigate the characteristics of APN without pyuria.
Methods
A retrospective, cross-sectional study was conducted on 391 patients diagnosed with APN based on clinical and radiologic findings, between 2015 and 2019. The clinical features, laboratory results, and computed tomography (CT) findings were compared between patients with normal white blood cell (WBC) counts and those with abnormal WBC counts (WBC of 0–5/high power field [HPF] vs. >5/HPF) in urine.
Results
More than 50% of patients with APN had no typical urinary tract symptoms and one-third of them had no costovertebral angle (CVA) tenderness. Eighty-eight patients (22.5%) had normal WBC counts (0–5/HPF) on urine microscopy. There was a negative correlation between pyuria (WBC of >5/HPF) and previous antibiotic use (odds ratio, 0.249; 95% confidence interval, 0.140–0.441; p<0.001), and the probability of pyuria was reduced by 75.1% in patients who took antibiotics before visiting the emergency room.
Conclusion
The diagnosis of APN should not be overlooked even if there are no typical clinical features, or urine microscopic examination is normal. If a patient has already taken antibiotics at the time of diagnosis, imaging studies such as CT should be performed more actively, regardless of the urinalysis results.
- Increase in blood glucose level and incidence of diabetic ketoacidosis in children with type 1 diabetes mellitus in the Daegu-Gyeongbuk area during the coronavirus disease 2019 (COVID-19) pandemic: a retrospective cross-sectional study
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Mi Seon Lee, Rosie Lee, Cheol Woo Ko, Jung Eun Moon
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J Yeungnam Med Sci. 2022;39(1):46-52. Published online August 26, 2021
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DOI: https://doi.org/10.12701/yujm.2021.01221
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3,718
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Abstract
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- Background
The coronavirus disease 2019 (COVID-19) outbreak in the Daegu-Gyeongbuk area in 2020 has caused difficulties in the daily life and hospital care of children with type 1 diabetes mellitus (T1DM). We detected an increase in blood sugar levels in these children and the number of patients hospitalized with more severe diabetic ketoacidosis (DKA) compared to those before COVID-19.
Methods
This single-center study was conducted at Kyungpook National University Children’s Hospital. The following patient groups were included; 45 returning patients diagnosed with T1DM and undergoing insulin treatment for more than 2 years and 20 patients newly diagnosed with T1DM before and after COVID-19 were selected by age matching. Returning patients before and after the outbreak were selected, and changes in hemoglobin A1c (HbA1c) levels were retrospectively reviewed. The HbA1c levels and severity of symptoms in newly diagnosed patients during hospitalization were examined.
Results
HbA1c levels in returning patients with T1DM were significantly increased after COVID-19 (before, 7.70%±1.38% vs. after, 8.30%±2.05%; p=0.012). There were 10 and 10 newly diagnosed patients before and after COVID-19, respectively. The proportion of patients with drowsiness and dyspnea at the time of admission was higher after COVID-19 than before (before, 2 of 10 vs. after, 4 of 10). The HbA1c levels were higher in newly diagnosed patients hospitalized after COVID-19 than before (before, 11.15% vs. after, 13.60%; p=0.036).
Conclusion
Due to COVID-19 in the Daegu-Gyeongbuk area, there was an increase in blood glucose levels in children with T1DM and in the incidence of severe DKA in newly diagnosed diabetes mellitus patients.
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- Incidence of diabetic ketoacidosis during COVID-19 pandemic: a meta-analysis of 124,597 children with diabetes
Anas Elgenidy, Ahmed K. Awad, Khaled Saad, Mostafa Atef, Hatem Helmy El-Leithy, Ahmed A. Obiedallah, Emad M. Hammad, Faisal-Alkhateeb Ahmad, Ahmad M. Ali, Hamad Ghaleb Dailah, Amira Elhoufey, Samaher Fathy Taha
Pediatric Research.2023; 93(5): 1149. CrossRef - Comments on Rahmati et al., The global impact of COVID‐19 pandemic on the incidence of pediatric new‐onset type 1 diabetes and ketoacidosis: A systematic review and meta‐analysis. J Med Virol. 2022; 1‐16 (doi: 10.1002/jmv.27996)
Joachim Rosenbauer, Anna Stahl‐Pehe, Sabrina Schlesinger, Oliver Kuß
Journal of Medical Virology.2023;[Epub] CrossRef - Incidence of Diabetic Ketoacidosis Among Pediatrics With Type 1 Diabetes Prior to and During COVID-19 Pandemic: A Meta-Analysis of Observational Studies
Osamah M. Alfayez, Kholood S. Aldmasi, Nada H. Alruwais, Nouf M. Bin Awad, Majed S. Al Yami, Omar A. Almohammed, Abdulaali R. Almutairi
Frontiers in Endocrinology.2022;[Epub] CrossRef - Comparison of Initial Presentation of Pediatric Diabetes Before and During the Coronavirus Disease 2019 Pandemic Era
Yoonha Lee, Minseung Kim, Kyeongeun Oh, Eungu Kang, Young-Jun Rhie, Jieun Lee, Yong Hee Hong, Young-Lim Shin, Jae Hyun Kim
Journal of Korean Medical Science.2022;[Epub] CrossRef - The global impact of COVID‐19 pandemic on the incidence of pediatric new‐onset type 1 diabetes and ketoacidosis: A systematic review and meta‐analysis
Masoud Rahmati, Maryam Keshvari, Shahrzad Mirnasuri, Dong K. Yon, Seung W. Lee, Jae Il Shin, Lee Smith
Journal of Medical Virology.2022; 94(11): 5112. CrossRef - COVID-19 and diabetes: What do we know so far?
Prakash Gangadaran, Himabindu Padinjarathil, Shri Hari Subhashri Rajendran, Manasi P Jogalekar, Chae Moon Hong, Baladhandapani Aruchamy, Uma Maheswari Rajendran, Sridharan Gurunagarajan, Anand Krishnan, Prasanna Ramani, Kavimani Subramanian
Experimental Biology and Medicine.2022; 247(15): 1330. CrossRef - Stress hyperglycemia, Diabetes mellitus and COVID-19 infection: The impact on newly diagnosed type 1 diabetes
Ioanna Farakla, Theano Lagousi, Michael Miligkos, Nicolas C. Nicolaides, Ioannis-Anargyros Vasilakis, Maria Mpinou, Maria Dolianiti, Elina Katechaki, Anilia Taliou, Vasiliki Spoulou, Christina Kanaka-Gantenbein
Frontiers in Clinical Diabetes and Healthcare.2022;[Epub] CrossRef
Case report
- Septic arthritis of the hip joint caused by Klebsiella pneumoniae: a case report
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Jeong-Bo Moon, Jun-Hwan Lee, Byung-Ju Ryu
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J Yeungnam Med Sci. 2023;40(2):193-197. Published online January 13, 2022
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DOI: https://doi.org/10.12701/yujm.2021.01613
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- Klebsiella pneumoniae is an uncommon cause of septic arthritis in adults. However, late detection can cause serious complications, including joint destruction and immobility. The purpose of this study was to report a case of successfully treated septic arthritis of the hip joint (SAHJ) caused by K. pneumoniae. A 49-year-old female patient presented to our hospital with fever and progressive severe pain in the right hip area. Although there was no abnormality on plain radiographs, ultrasonography revealed diffuse swelling of the right hip joint. Under ultrasonography guidance, the hip joint fluid was aspirated, and Gram staining and culturing were performed. The patient’s pain was significantly reduced after the joint aspiration. The Gram staining and culturing revealed gram-negative bacilli, which were subsequently identified as K. pneumoniae. According to the results, systemic intravenous antibiotic (ceftriaxone) was administered without complications, and the patient was discharged on oral antibiotic (ciprofloxacin). Clinical cases of septic arthritis of the knee or sacroiliac joint have been occasionally reported in adults, but cases of SAHJ are rare. Moreover, K. pneumonia-induced SAHJ has not been reported to date. Therefore, we report this very rare case and its successful treatment.
Review articles
- Pain in amyotrophic lateral sclerosis: a narrative review
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Soyoung Kwak
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J Yeungnam Med Sci. 2022;39(3):181-189. Published online June 8, 2022
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DOI: https://doi.org/10.12701/jyms.2022.00332
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Abstract
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- Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative condition characterized by loss of motor neurons, resulting in motor weakness of the limbs and/or bulbar muscles. Pain is a prevalent but neglected symptom of ALS, and it has a significant negative impact on the quality of life of patients and their caregivers. This review outlines the epidemiology, clinical characteristics, underlying mechanisms, and management strategies of pain in ALS to improve clinical practice and patient outcomes related to pain. Pain is a prevalent symptom among patients with ALS, with a variable reported prevalence. It may occur at any stage of the disease and can involve any part of the body without a specific pattern. Primary pain includes neuropathic pain and pain from spasticity or cramps, while secondary pain is mainly nociceptive, occurring with the progression of muscle weakness and atrophy, prolonged immobility causing degenerative changes in joints and connective tissue, and long-term home mechanical ventilation. Prior to treatment, the exact patterns and causes of pain must first be identified, and the treatment should be tailored to each patient. Treatment options can be classified into pharmacological treatments, including nonsteroidal anti-inflammatory drugs, antiepileptic drugs, drugs for cramps or spasticity, and opioid; and nonpharmacological treatments, including positioning, splints, joint injections, and physical therapy. The development of standardized and specific assessment tools for pain-specific to ALS is required, as are further studies on treatments to reduce pain, diminish suffering, and improve the quality of life of patients with ALS.
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Citations to this article as recorded by

- Likely Pathogenic Variants of Cav1.3 and Nav1.1 Encoding Genes in Amyotrophic Lateral Sclerosis Could Elucidate the Dysregulated Pain Pathways
Zsófia Flóra Nagy, Balázs Sonkodi, Margit Pál, Péter Klivényi, Márta Széll
Biomedicines.2023; 11(3): 933. CrossRef - The blind spot and challenges in pain management
Min Cheol Chang
Journal of Yeungnam Medical Science.2022; 39(3): 179. CrossRef - Synucleinopathy in Amyotrophic Lateral Sclerosis: A Potential Avenue for Antisense Therapeutics?
Bradley Roberts, Frances Theunissen, Francis L. Mastaglia, P. Anthony Akkari, Loren L. Flynn
International Journal of Molecular Sciences.2022; 23(16): 9364. CrossRef - Herbal medicine and acupuncture relieved progressive bulbar palsy for more than 3 years: A case report
Siyang Peng, Weiqian Chang, Yukun Tian, Yajing Yang, Shaohong Li, Jinxia Ni, Wenzeng Zhu
Medicine.2022; 101(45): e31446. CrossRef
- Avulsion injuries: an update on radiologic findings
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Changwon Choi, Sun Joo Lee, Hye Jung Choo, In Sook Lee, Sung Kwan Kim
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Yeungnam Univ J Med. 2021;38(4):289-307. Published online August 13, 2021
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DOI: https://doi.org/10.12701/yujm.2021.01102
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Abstract
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- Avulsion injuries result from the application of a tensile force to a musculoskeletal unit or ligament. Although injuries tend to occur more commonly in skeletally immature populations due to the weakness of their apophysis, adults may also be subject to avulsion fractures, particularly those with osteoporotic bones. The most common sites of avulsion injuries in adolescents and children are apophyses of the pelvis and knee. In adults, avulsion injuries commonly occur within the tendon due to underlying degeneration or tendinosis. However, any location can be involved in avulsion injuries. Radiography is the first imaging modality to diagnose avulsion injury, although advanced imaging modalities are occasionally required to identify subtle lesions or to fully delineate the extent of the injury. Ultrasonography has a high spatial resolution with a dynamic assessment potential and allows the comparison of a bone avulsion with the opposite side. Computed tomography is more sensitive for depicting a tiny osseous fragment located adjacent to the expected attachment site of a ligament, tendon, or capsule. Moreover, magnetic resonance imaging is the best imaging modality for the evaluation of soft tissue abnormalities, especially the affected muscles, tendons, and ligaments. Acute avulsion injuries usually manifest as avulsed bone fragments. In contrast, chronic injuries can easily mimic other disease processes, such as infections or neoplasms. Therefore, recognizing the vulnerable sites and characteristic imaging features of avulsion fractures would be helpful in ensuring accurate diagnosis and appropriate patient management. To this end, familiarity with musculoskeletal anatomy and mechanism of injury is necessary.
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- Isolated fracture of the lesser tuberosity of the humerus – a rare injury that requires surgical treatment
Miodrag Glisic, Vladan Stevanovic, Aleksandar Jevtic, Uros Jovicevic, Ivan Jankovic
Vojnosanitetski pregled.2023; 80(3): 279. CrossRef
Case report
- Palisaded encapsulated neuroma on the lower lip: a case report
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Jung Eun Seol, Seong Min Hong, Sang Woo Ahn, Jong Uk Kim, Woo Jung Jin, So Hee Park, Hyojin Kim
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J Yeungnam Med Sci. 2022;39(2):168-171. Published online July 9, 2021
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DOI: https://doi.org/10.12701/yujm.2021.01088
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- Palisading encapsulated neuroma is a rare, benign, cutaneous nerve sheath tumor. It usually occurs as an asymptomatic solitary skin-colored papule and commonly affects the nose and cheeks. Sometimes, it involves other sites, including the shoulder, upper arm, and trunk, but rarely involves the oral mucosa, including that of the lip. In our case, a 63-year-old female patient complained of a pinkish rubbery nodule on her lower lip. Histopathologic examination demonstrated a well-circumscribed nodule encapsulated by connective tissue stroma in the dermis. The nodule consisted of palisading spindle-shaped tumor cells with wavy and basophilic nuclei. The cells were arranged in streaming fascicles with multiple clefts and were strongly positive for S-100 proteins. To our knowledge, only three cases of palisading encapsulated neuroma on the lower lip have been reported in the Korean literature. Herein, we report a rare case of an oral palisaded encapsulated neuroma.