Introduction

In December 2019, atypical pneumonia of unknown cause was first reported in Wuhan, Hubei Province, China [1-3]. In January 2020, the World Health Organization termed this condition as coronavirus disease 2019 (COVID-19), which began to spread rapidly, and eventually, it was declared a pandemic on March 11, 2020 [4].

In Korea, the first imported case of COVID-19 was confirmed on January 20, 2020 [5]. After the first case in the Daegu-Gyeongbuk area was reported on February 18, 2020, there was a rapid increase in the number of patients, which was the first large outbreak in countries other than China [6,7]. Consequently, difficulties in daily life and hospital care in the Daegu-Gyeongbuk area became prominent.

It has been reported that COVID-19 has led to a high mortality rate among adult patients with diabetes mellitus (DM) [8-10]. However, no severe cases of COVID-19 requiring hospitalization have been reported among children and adolescent patients with type 1 DM (T1DM) [11]. The International Society for Pediatric and Adolescent Diabetes stated that diabetic care should be provided while avoiding hospitalization and emergency room visits to prevent infection [12]. However, we observed an increase in overall blood glucose levels compared to the levels before COVID-19 in patients with T1DM in the Daegu-Gyeongbuk area and also encountered new patients who were hospitalized with more severe diabetic ketoacidosis (DKA). This study aimed to investigate the changes in blood glucose levels and clinical manifestations in pediatric patients with T1DM in the Daegu-Gyengbuk area where there was a large outbreak of COVID-19.

Methods

Ethical statements: This study was approved by the Institutional Review Board (IRB) of Kyungpook National University Chilgok Hospital (IRB No: 2020-09-023) in accordance with the Declaration of Helsinki. Informed consent was waived by the IRB due to the use of anonymized data and the retrospective design.

1. Subjects and methods

The study subjects were children aged <19 years diagnosed with T1DM at Kyungpook National University Children’s Hospital in the Daegu-Gyeongpuk area. A total of 65 patients, including 45 returning patients, 10 newly diagnosed patients during the COVID-19 outbreak, and 10 age-matched patients before the COVID-19 outbreak were included in the control group. A retrospective chart review was conducted. For returning patients undergoing insulin treatment for more than 2 years, patients who had visit records between 3 and 6 months before and after the outbreak were selected. The parameters (age, sex, and changes in hemoglobin A1c [HbA1c] and body mass index [BMI]) before and after COVID-19 were compared. HbA1c levels were analyzed between the similar age and pubertal groups. The age of the patients was divided into 0–4, 5–9, 10–14, 15–18 years old, and was defined as pubertal age from 10 years of age for girls and 11 years of age for boys. For newly diagnosed patients, 10 new patients who were hospitalized after the COVID-19 outbreak were examined for HbA1c levels and severity of symptoms at hospitalization. As a control group of newly diagnosed patients, a total of 10 age-matched patients with T1DM who visited our hospital 4 years prior to the COVID-19 outbreak were selected. Clinical signs reflecting DKA severity at the time of admission, altered mental status, presence of dyspnea, and laboratory parameters such as HbA1c levels, initial serum glucose, venous blood gas analysis (pH, pCO₂, HCO₃^–), hemoglobin, blood urea nitrogen, and creatinine were assessed. The severity criteria were as follows: the biochemical criteria for the diagnosis of DKA were blood glucose level of >200 mg/dL, venous pH of <7.3, serum bicarbonate level of <15 mmol/L, and ketonemia or ketonuria of ≥2+. The severity of DKA was categorized based on the degree of acidosis as follows: (1) mild: venous pH of <7.3 or serum bicarbonate level of <15 mmol/L; (2) moderate: pH of <7.2, serum bicarbonate level of <10 mmol/L; and (3) severe: pH of <7.1, serum bicarbonate level of <5 mmol/L [13].

2. Statistical analysis

Continuous values are presented as the mean±standard deviation. Among the returning patients, the differences in BMI and HbA1c between the two groups were analyzed using the t-test. Due to the small number of newly diagnosed T1DM patients, the distributions of DKA severity, age, sex, HbA1c, glucose, pH, and bicarbonate levels were compared between the groups using Wilcoxon rank-sum tests; the results are reported as medians. All statistical analyses were conducted using IBM SPSS version 20.0 (IBM Corp., Armonk, NY, USA). Statistical significance was set at p<0.05.

Results

1. Changes in body mass index and hemoglobin A1c levels in returning patients with type 1 diabetes mellitus

There were 45 subjects with T1DM, consisting of 22 females and 23 males (1:1 ratio), with a mean age of 15.8±6.13 years. There were one patient aged 0 to 4 years, five patients aged 5 to 9 years, 21 patients aged 10 to 14 years, and 18 patients aged 15 to 18 years. As baseline characteristics, initial random glucose was 413.53±202.62 mg/dL and C-peptide was 0.65±0.56 ng/mL (range, 0.4–2.2 ng/mL). At least one autoantibody was identified in 37 of 45 patients (82.2%). Anti-islet cell antibody (ICA) was identified in two patients (4.4%), glutamic acid decarboxylase antibody (GADA) in 21 patients (46.7%), and insulin autoantibody in 14 patients (31.1%). Six patients (13.3%) were positive for both ICA and GADA. One patient (2.2%) tested positive for all three antibodies.

When the data were compared during a period of 3 to 6 months before and after the COVID-19 outbreak, no significant difference was found in average BMI (21.62±6.17 kg/m² vs. 21.06±4.97 kg/m², p=0.250). The HbA1c levels were significantly increased after the COVID-19 outbreak (before, 7.70%±1.38% vs. after, 8.30%±2.05%; p=0.012) (Table 1). HbA1c levels increased significantly after COVID-19 and tended to be higher in the pubertal group (before, 7.83%±1.56% vs. after, 8.46%±2.40%; p=0.025) than in the prepubertal group (before, 7.03%±0.90% vs. after, 7.23%±1.24%; p=0.565).

2. Comparison of diabetic ketoacidosis severity in patients with newly diagnosed type 1 diabetes mellitus

There were 10 age-matched patients newly diagnosed with T1DM before the onset of the COVID-19 outbreak and 10 patients diagnosed after the outbreak. The frequency of DKA tended to be higher during puberty (Fig. 1). The COVID-19 outbreak period was spring and early summer, and the patients in the age-matched control group before COVID-19 visited the hospital at 2:4:2:2 in spring, summer, autumn, and winter.

The 10 newly diagnosed patients before the outbreak comprised one male and nine female subjects, with a median age of 12.0 years. Four patients were confirmed with DKA at the time of admission, of whom two patients showed severe clinical symptoms such as altered mental status, dyspnea, and tachypnea. Based on DKA severity, patients were classified as follows: two patients had mild disease, and two patients had moderate disease. Two patients required care from the pediatric intensive care unit (PICU). After the outbreak, there were 10 children with newly diagnosed T1DM (six males and four females), with a median age of 11.5 years. Six patients had DKA at the time of admission, of whom four showed severe symptoms. When classified according to DKA severity, three patients had mild disease, two had moderate disease, one patient had severe disease, and three patients required PICU care (Fig. 2).

HbA1c levels of newly diagnosed T1DM patients were significantly higher in patients hospitalized after the COVID-19 outbreak than in those hospitalized before the outbreak (before, 11.15% vs. after, 13.60%; p=0.036) (Table 2). Moreover, random serum glucose levels were higher in patients with T1DM after COVID-19 (before, 300 mg/dL vs. after, 371 mg/dL; p=0.203). The levels of pH and bicarbonate were lower after COVID-19, but not statistically significant (pH: before, 7.40 vs. after, 7.25, p=0.333; bicarbonate: before, 19.50 mmol/L vs. after, 10.50 mmol/L, p=0.221).

Discussion

In this study, we detected a significant increase in HbA1c levels in children with T1DM when social distancing was being implemented due to the COVID-19 outbreak in the Daegu-Gyeongbuk area. Moreover, there were increases in the total number of patients with newly diagnosed T1DM, HbA1c levels, DKA incidence, and DKA severity after the COVID-19 outbreak compared to those before the outbreak. In particular, the number of patients in the pubertal group was higher than that in the prepubertal group, and the HbA1c levels, DKA frequency, and severity were also higher.

It is well known that natural disasters such as hurricanes and earthquakes have a significant impact on DM management [14-17]. In a study examining glucose control in patients with DM in connection with the Great East Japan Earthquake Disaster, HbA1c levels did not increase significantly by actively controlling the drugs through regular outpatient visits [18]. However, the effects of the COVID-19 pandemic on glycemic control in patients with DM and patient management guidelines are not well established. In India, a total lockdown was implemented for 21 days, from March 24, 2020, to prevent the spread of COVID-19; a systematic study revealed that blood sugar levels and DM-related complications were increased during this period [19]. The present study also demonstrated a significant increase in HbA1c levels in children with T1DM after the outbreak. Therefore, we suggest a possible explanation for this phenomenon. Wang et al. [20] reported a decrease in physical activity during the COVID-19 outbreak in students due to limitations in daily life. It has already been reported that students are less physically active, have more screen time, and display irregular sleeping patterns when they are not attending school, such as during weekends and breaks [21,22]. As such, there were restrictions on daily life, including school attendance, as observed in this study, which led to a decrease in physical activity and changes in lifestyle habits. In fact, patients and their guardians at the outpatient clinic cited irregular lifestyle habits as the cause of the increase in blood sugar levels. Moreover, there were no significant changes in BMI, suggesting that the increase in blood sugar level was due to irregular lifestyle changes rather than increased food intake. MacMillan et al. [23] reported that these lifestyle changes have a detrimental impact on blood sugar control. In addition, Nansel et al. [24] reported that dietary control, such as intake of foods with high fiber and low glycemic index and carbohydrate-containing foods improves glycemic control, suggesting that irregular eating habits due to lifestyle changes cause an increase in blood sugar levels. Furthermore, irregular eating habits may interfere with regular insulin injections. Verma et al. [25] reported that COVID-19 lockdown resulted in an increase in blood sugar levels in patients with T1DM because of the difficulty in prescribing blood sugar measuring devices and insulin injections. In this study, there were no cases in which children could not receive insulin treatment due to the unavailability of insulin shots. However, this may be because the insulin dose was not properly controlled by checking blood sugar levels due to irregular lifestyles.

In this study regarding the frequency and severity of DKA in newly diagnosed patients, the HbA1c levels and DKA severity increased after COVID-19. The frequency and severity of DKA increased compared to the previous age-matched patients. In a study conducted by Rabbone et al. [26] in 53 clinics in Italy, it was observed that the proportion of newly diagnosed T1DM patients with severe DKA significantly increased from 44.3% in 2020 to 36.1% in 2019 (p=0.030). A German study conducted by Kamrath et al. [27] also showed that the rates of DKA and severe DKA were higher during the COVID-19 outbreak. In the case of patients with newly diagnosed DM in this study, even when symptoms such as polyurea and polyphagia occurred, because of concerns about infection when visiting a medical institution or when going outside, the patients did not visit the hospital until the disease progressed and the symptoms were severe enough to cause problems in their daily life, such as dyspnea and altered mental status. Moreover, we analyzed the cause of the increased DKA severity before and after the COVID-19 outbreak. In Korea, schools conduct health checkups for all students in the spring, among which, urine analysis is conducted for the 1st and 4th grades of elementary school, the 1st grades of middle school, and the 1st grades of high school [28]. Due to the COVID-19 outbreak in the Daegu-Gyeongbuk area, there were daily life restrictions and delays in school attendance and admissions. During that time, students were unable to attend schools for a considerable period of time to prevent infection during the COVID-19 pandemic; hence, they were unable to undergo health checkups, as this period fell from March to April, which marks the beginning of a new school year in Korea. Furthermore, 1.4% of the students had high blood sugar levels according to the 2019 Student Health Examination Sample Statistics [28]. As such, most of the patients with newly diagnosed DM who have no symptoms or show mild symptoms are identified during school checkups and are asked to visit the hospital. In this study, health checkups in school were not possible during the COVID-19 outbreak. In the control group before the COVID-19 outbreak, two out of 10 patients were referred for hospital treatment due to abnormal findings in the screening test and were diagnosed with T1DM when symptoms were mild. School screening is useful for detecting type 2 DM with relatively mild symptoms and a long latent period of asymptomatic progression. However, it is meaningful because it can be detected through school examinations in the early stage of type 1 DM, when symptoms are not severe. This COVID-19-induced lockdown led to the omission of screening, and the symptoms were recognized only after the onset of severe DKA.

If symptoms of DM occur in both newly diagnosed patients and previously diagnosed patients, it is important to visit a hospital and check the progress before the symptoms worsen. Regular glucose monitoring and insulin medication are important for glycemic control in pediatric T1DM patients after the acute symptoms have improved. For this, it is important to check the progress of periodic outpatient visits [29]. In an Italian study conducted by Tornese et al. [30], there were cases of good glycemic control in patients with T1DM through continuous glucose monitoring (CGM) and insulin pump along with physical activity and diet control through telemedicine. This study is limited by the lack of statistical data on the reasons for poor blood glucose control. Specifically, there were no studies on the activity, total intake, and insulin dose of the patients. The daily insulin dose, number of daily blood sugar test checks, and rate of CGM application were not investigated. Further research is needed, and more careful patient observation is required while following general DM guidelines during the COVID-19 epidemic. This includes checking the readings of blood sugar and insulin doses through frequent and regular follow-up and monitoring of physical activity and diet.

This retrospective chart review was conducted at a single center. When searching for an age-matched control group for newly diagnosed T1DM patients in the COVID-19 period, patients who visited the hospital in the closest season as possible were selected, but it was difficult to completely match and analyze patients by season by performing a single-center study with small sample size. Further multicenter analysis with a larger number of patients will be needed to identify factors in addition to COVID-19 that may have an influence, such as seasonality. Gender was also considered, but it was difficult to match because of the small number of patients. One more limitation is the lack of data on patients who did not visit the hospital within the study period. However, as the data were collected from a region with a severe COVID-19 outbreak, we believe that this study will be helpful in examining the incidence rate, symptom severity, and changes in the prevalence rate and degree of glycemic control of DM in children and adolescents.

In conclusion, this study reports the incidence of increased blood sugar levels and newly diagnosed cases of T1DM in children with severe DKA due to the COVID-19 situation in the Daegu-Gyeongbuk area. In the future, a large-scale, long-term follow-up study and active blood sugar management in patients with T1DM are required during the COVID-19 pandemic.

Notes

Conflicts of interest

No potential conflict of interest relevant to this article was reported.

Author contributions

Conceptualization: MSL, CWK, JEM; Data curation: MSL, RL, JEM; Formal analysis: MSL; Investigation, Software, Validation: MSL, JEM; Writing-original draft: MSL, RL; Writing-review & editing: CWK, JEM.

Fig. 1.

Distribution by age of newly diagnosed type 1 diabetes mellitus patients before and after the coronavirus disease 2019 (COVID-19) outbreak. Non-diabetic ketoacidosis (DKA) patients were not indicated, and DKA patients were indicated according to severity.

Fig. 2.

Comparison of ratio of diabetic ketoacidosis (DKA) and DKA severity in newly diagnosed type 1 diabetes mellitus patients hospitalized before and after the coronavirus disease 2019 (COVID-19) outbreak.

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Figure & Data

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