- Comparison of small bowel findings using capsule endoscopy between Crohn’s disease and intestinal tuberculosis in Korea
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Yong Gil Kim, Kyung-Jo Kim, Young-Ki Min
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Yeungnam Univ J Med. 2020;37(2):98-105. Published online November 22, 2019
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DOI: https://doi.org/10.12701/yujm.2019.00374
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Abstract
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- Background
Little is known about capsule endoscopy (CE) findings in patients with intestinal tuberculosis who exhibit small bowel lesions. The aim of the present study was to distinguish between Crohn’s disease (CD) and intestinal tuberculosis based on CE findings.
Methods Findings from 55 patients, who underwent CE using PillCam SB CE (Given Imaging, Yoqneam, Israel) between February 2003 and June 2015, were retrospectively analyzed.
Results CE revealed small bowel lesions in 35 of the 55 patients: 19 with CD and 16 with intestinal tuberculosis. The median age at diagnosis for patients with CD was 26 years and 36 years for those with intestinal tuberculosis. On CE, three parameters, ≥10 ulcers, >3 involved segments and aphthous ulcers, were more common in patients with CD than in those intestinal tuberculosis. Cobblestoning was observed in five patients with CD and in none with intestinal tuberculosis. The authors hypothesized that a diagnosis of small bowel CD could be made when the number of parameters in CD patients was higher than that for intestinal tuberculosis. The authors calculated that the diagnosis of either CD or intestinal tuberculosis would have been made in 34 of the 35 patients (97%).
Conclusion The number of ulcers and involved segments, and the presence of aphthous ulcers, were significantly higher and more common, respectively, in patients with CD than in those with intestinal tuberculosis. Cobblestoning in the small bowel may highly favor a diagnosis of CD on CE.
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Citations
Citations to this article as recorded by
- Deep Learning Radiomics Analysis of CT Imaging for Differentiating Between Crohn’s Disease and Intestinal Tuberculosis
Ming Cheng, Hanyue Zhang, Wenpeng Huang, Fei Li, Jianbo Gao Journal of Imaging Informatics in Medicine.2024; 37(4): 1516. CrossRef - Differentiating gastrointestinal tuberculosis and Crohn's disease- a comprehensive review
Arup Choudhury, Jasdeep Dhillon, Aravind Sekar, Pankaj Gupta, Harjeet Singh, Vishal Sharma BMC Gastroenterology.2023;[Epub] CrossRef - Difficulties in the differential diagnosis of intestinal tuberculosis and Crohn‘s disease
M. N. Reshetnikov, D. V. Plotkin, Yu. R. Zyuzya, A. A. Volkov, O. N. Zuban, E. M. Bogorodskaya Acta Biomedica Scientifica.2021; 6(5): 196. CrossRef - Differentiating intestinal tuberculosis and Crohn disease: Quo Vadis
Vishal Sharma Expert Review of Gastroenterology & Hepatology.2020; 14(8): 647. CrossRef
- A Case of Colchicine-Induced Neutropenia in Liver Cirrhosis Patient.
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Ho Chan Lee, Heon Ju Lee, Yong Gil Kim, Jae Hyun Park, Sung Joon Kim, Jun Seok Park
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Yeungnam Univ J Med. 2009;26(2):125-129. Published online December 31, 2009
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DOI: https://doi.org/10.12701/yujm.2009.26.2.125
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Abstract
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- Colchicine is an alkaloid that has been used for treating acute gouty arthritis, psoriasis, scleroderma and Behcet's syndrome. Colchicine decreased liver fibrosis in rats with carbon tetrachloride induced cirrhosis and in patients with many liver diseases. Therapeutic oral doses of colchicine may cause nausea, vomiting, abdominal pain and diarrhea. The adverse effect of colchicine associated with the dose is bone marrow suppression, and especially neutopenia. Neutropenia has often been reported in patients have taken an overdose of colchicine. We describe a 64-year-old female liver cirrhosis patient with neutropenia that was induced by a therapeutic dose of colchicine.
- A Case of Complete Remission of Hairy Cell Leukemia by 2-Chlorodeoxyadenosine.
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Yong Gil Kim, Sang Jin Lee, Min Kyung Kim, Kyung Hee Lee, Myung Soo Hyun, Hee Sun Cho
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Yeungnam Univ J Med. 2004;21(2):237-241. Published online December 31, 2004
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DOI: https://doi.org/10.12701/yujm.2004.21.2.237
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- Hairy cell leukemia (HCL) is an uncommon chronic B-cell lymphoproliferative disorder that is characterized by cytopenia, splenomegaly, and mononuclear cells displaying cytoplasmic projections. We experienced a case of hairy cell leukemia that developed in a 38-year-old man. He showed marked splenomegaly without palpable lymphoadenopathy. A complete blood cell count revealed leukopenia (3300/microliter with 63% of lymphocyte) and the peripheral blood smear showed abnormal lymphoid cells with cytoplasmic projections. The bone marrow smear revealed abnormal lymphocytes and severe myelofibrosis. Tartrate-resistant acid phosphatase reactivity was strongly positive in the hairy cells. The immunophenotyping results of lymphoid cells were CD5 (-), CD10 (-), CD19 (+), CD25 (+), CD103 (+), CD20 (+), lambda (+). The patient was treated with 2-Chlorodeoxyadenosine at a daily dose of 0.1mg/Kg by a continuous intravenous infusion for 7 days. The patient achieved complete remission.
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