Journal of Yeungnam Medical Science

Volume 20(2); December 2003

Reviews

Surgical Treatment of Gastric Cancer.: Sang Woon Kim; Yeungnam Univ J Med. 2003;20(2):105-116. Published online December 31, 2003; DOI: https://doi.org/10.12701/yujm.2003.20.2.105

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Abstract PDF: No abstract available.

The Role of Thallium-201 Scintigraphy in Bone and Soft Tissue Tumor.: Duk Seop Shin; Yeungnam Univ J Med. 2003;20(2):117-128. Published online December 31, 2003; DOI: https://doi.org/10.12701/yujm.2003.20.2.117

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Abstract PDF: Thallium-201 scintigraphy is used to discriminate the malignant bone tumor from the benign by qualitatively and quantitatively, and to predict the response of preoperative chemotherapy in osteosarcoma, by comparing the changes of thallium uptake ratio after chemotherapy to the tumor necrosis ratio. Thallium-201 scintigraphy scan should be done prior to surgical biopsy. PICKER Prism 2000 gamma camera with high resolution parallel hole collimator is usually used for scanning. The patient is injected with 2-3mCi of Tl-201 and the early phase is checked in 30 minutes and delayed phase in 3 hours. The scan images are visually evaluated by a blinded nuclear medicine physician. We could evaluate true positive, true negative, false positive and false negative by the comparison of results with those of biopsy, and calculate positive and negative predictive value(%), sensitivity(%), specificity(%) and diagnostic accuracy(%). For the quantitative analysis of thallium uptake, we drew the region of interest on the tumor side and contralateral normal side as mirror image, and calculated the uptake ratio with dividing the amount of gamma count in tumor side by normal side. We could calculate the percent changes of thallium uptake ratio in early and delayed phase, and compare them to the ratio of tumor necrosis. Thallium-201 scintigraphy proved as useful imaging study to discriminate malignant bone tumor from benign, but had exception in giant cell tumor and low grade malignant bone tumors. We can use T1-201 scan to differentiate the benign from the malignant tumor, and to evaluate the response of preoperative chemotherapy or radiotherapy, and to determine the residual tumor or local recurrence. For the better result, we need to have a more detail information about false positive cases and a more objective and quantitative reading technique.

Original Articles

Effect of Leptin on the Expression of Chemokine Genes in THP-1 Cells.: Jin Hee Choi, Ho Sun Park, Tae Yoon Lee, Sung Kwang Kim, Hee Sun Kim; Yeungnam Univ J Med. 2003;20(2):129-141. Published online December 31, 2003; DOI: https://doi.org/10.12701/yujm.2003.20.2.129

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Abstract PDF: BACKGROUND
Leptin is a 16-KDa non-glycosylated peptide hormone synthesized almost exclusively by adipocytes. The well-known function of leptin is regulation of food intake and energy expenditure. Leptin also plays a regulatory role in immune and inflammatory process including cytokine production. The purpose of this study was to investigate the effect of leptin on the expression of several chemokine genes(RANTES, IL-8, MCP-1, IP-10, Mig, MIP-1alpha, MIP-1beta, and GRO-alpha) in THP-1 cells. MATERIALS AND METHODS: Total RNA of THP-1 cells were prepared by Trizol method, and then stimulated with the leptin(250 ng/microliter) or LPS(100 ng/microliter). We examined the expression patterns of various chemokine mRNAs in THP-1 cell lines by RT-PCR and Northern blot. RESULTS: Leptin did not induce the expression of chemokine mRNAs in THP-1 cells. The expression patterns of RANTES, IL-8, MCP-1, IP-10, and Mig mRNAs in THP-1 cells stimulated with leptin and LPS simultaneously was almost same to the patterns of LPS alone-induced chemokine mRNAs. RANTES mRNA expression was independent on the concentrations of leptin. Although leptin did not have strong effect on the expression of RANTES, IL-8, MCP-1, IP-10, Mig, MIP-1alpha, MIP-1beta, and GRO-alpha mRNAs in THP-1 cells, leptin could induce the expression of long isoform of leptin receptor(OB-RL) mRNA, and its expression was elevated in simultaneous stimulation of leptin and LPS. CONCLUSION: These data suggest that leptin is able to induce OB-RL in THP-1 cells, however, leptin has little effect on the expression of pro-inflammatory chemokine genes.

Bone Formation by rhBMP-7 Transduced HEK 293 Cells in Nude Mouse.: Su Yon Jeong, Won Tae Chang, Yon Sil Chang, Myun Hwan Ahn, Jae Ryong Kim, In Hwan Song; Yeungnam Univ J Med. 2003;20(2):142-151. Published online December 31, 2003; DOI: https://doi.org/10.12701/yujm.2003.20.2.142

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Abstract PDF: To induce bone formation at ectopic site by tissue engineering and gene therapy, we transplanted collagen sponges containing rhBMP-7 transduced HEK 293 cells in the hypodermis of nude mice. Bone formation was investigated by histological and electron microscopic method at 3, 6, and 9 weeks after transplantation. At 9 weeks after transplantation, eosinophilic bony tissue was observed in the implanted collagen sponge and was confirmed as bone tissue by Von Kossa stain. In the transmission electron microscopic observation, the cells in newly formed bone tissue had eccentrically located nucleus and well developed rough endoplasmic reticulum (rER). Therefore, the cells were evaluated as osteoblasts. Those results suggest that it is possible to form a bone tissue in the ectopic site by transplantation of rhBMP-7 transduced HEK 293 cells. This will be contributed to push more advanced gene therapy for bone formation. However, the HEK 293 cell is unable to apply to the clinical gene therapy. Therefore it is worth to find more compatible cells for clinical application. In addition, collagen sponge is considered as an excellent scaffold and/or carrier for gene therapy and a good biomaterial for tissue engineering.

Evaluation of short-term Hypolipidemic Effect and Safety of Simvastatin(Zocor(R)) in Patients with Hyperlipidemia.: Min Kyoung Kim, Yong Ho Park, Jong sun Park, Dong Gu Shin, Young Jo Kim, Gi Sik Kim; Yeungnam Univ J Med. 2003;20(2):152-159. Published online December 31, 2003; DOI: https://doi.org/10.12701/yujm.2003.20.2.152

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Abstract PDF

BACKGROUND
Hyperlipidemia is the one of the major risk factors causing the atherosclerosis of coronary arteries. Treatment of hyperlipidemia with drugs has been confirmed the effects of therapy showing a decreased incidence of coronary artery disease. Simvastatin is a new drug of HMG-CoA reductase inhibitors and the short-term hypolipidemic effects and safety of simvastatin is evaluated in patients with hyperlipidemia. METHODS: We studied 63 patients (39 males and 24 females, mean age 58) for 12 weeks whose plasma levels of total cholesterol were higher than 240 mg/dL or higher than 220 mg/dL with ischemic heart disease. Simvastatin was administered 20 mg/day and measured lipid profile at 12 week interval. RESULT: 1)Simvastatin significantly reduced the level of the plasma total cholesterol(-29.3%), LDL- cholesterol(-36.9%) and triglyceride(-13%)(p<0.05) but the level of HDL-cholesterol was not changed after 12 weeks simvastatin therapy. 2)the clinical symptoms and laboratory examination before and after simvastatin treatment showed no particular abnormal findings in short term follow up. CONCLUSION: These results suggested that short-term simvastatin therapy in patients with hyperlipidemia seeems to be very effective and safe.

Citations

Citations to this article as recorded by

A Population Pharmacokinetic–Pharmacodynamic Model for Simvastatin that Predicts Low‐Density Lipoprotein‐Cholesterol Reduction in Patients with Primary Hyperlipidaemia
Jimyon Kim, Byung‐Jin Ahn, Hong‐Seok Chae, Seunghoon Han, Kichan Doh, Jeongeun Choi, Yong K. Jun, Yong W. Lee, Dong‐Seok Yim
Basic & Clinical Pharmacology & Toxicology.2011; 109(3): 156. CrossRef

Analysis of Compression Behavior on Intervertebral Disc L4-5 in Pedicle Screw System Instrumented Lumbar Spine under Follower Load.: Myun whan Ahn, Jong chul Ahn, Su ho Lee, Il sub Chung, Choon yeol Lee, Jang woo Lee; Yeungnam Univ J Med. 2003;20(2):160-168. Published online December 31, 2003; DOI: https://doi.org/10.12701/yujm.2003.20.2.160

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Abstract PDF

BACKGROUND
Confirm the stability of intervertebral disc sustaining each fused lumbar spine cases, comparing vertical compression, A-P shear force and rotational moment on intervertebral disc of instrumented lumbar spine with simple vertical compression load and follower load using finite element analysis. MATERIALS AND METHODS: We analyze the stability of intervertebral disc L4-5 supporting fused lumbar spine segments. After performing finite element modelling about L1-L5 lumbar vertebral column and L1-L4 each fusion level pedicle screw system for fused lumbar spine fine element model. Intervertebral discs with complex structure and mechanical properties was modeled using spring element that compensate stiffness and tube-to-tube contact element was employed to give follower load. Performing geometrical non-linear analysis. RESULTS: The differences of intervertebral disc L4-5 behavior under the follower compression load in comparision with vertical compression load are as follows. CONCLUSION: As a result of finite element interpretation of instrumented lumbar spine, the stability of L4-5 sustaining fused lumbar segment, the long level fused lumbar spine observed hing stability under follower load. This research method can be the basis tool of effects prediction for instrumentation, a invention of a more precious finite element interpretation model which consider the role of muscle around the spine is loaded.

Citations

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Spinal Stability Evaluation According to the Change in the Spinal Fixation Segment Based on Finite Element Analysis
Cheol-Jeong Kim, Seung Min Son, Jin-Young Heo, Chi-Seung Lee
Journal of the Computational Structural Engineering Institute of Korea.2020; 33(3): 145. CrossRef

Results of Maxillary Sinus Elevation for Endosseous Implant Placement.: Sang Deuk Chun, Bo Yeon Jung, Seung Eun Lee, Hong Sik Yoon, Byung Rho Chin; Yeungnam Univ J Med. 2003;20(2):169-176. Published online December 31, 2003; DOI: https://doi.org/10.12701/yujm.2003.20.2.169

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Abstract PDF: BACKGROUND
Although dental implantation has become widespread and acceptable treatment for dental prosthodontics, maxillary posterior jaw region is often complicated by the pneumatization of the maxillary sinus and physiological resorption of the alveolar bone. When this occurs, the residual bone between the floor of the sinus and the crestal ridge is inadequate for the placement of implants. The sinus elevation procedure provides a way to increase the amount of available bone and to allow the placement of longer implants. MATERIALS & METHODS: We studied 11 patients requiring the implant placements and the maxillary sinus elevation simultaneously from 1996 to 2003 in our clinic. Nine patients were males and two patients were females, aged from 39 to 72(mean=51.6). Four patients had medical compromised states; angina pectoris, diabetes, hypertension, hepatitis. Patients didn't show any pathologic findings clinically or radiographically. We studied the success and survival rate of implants, factors increasing the osseointegrating capacity of implants. RESULTS: The success rate of osseointegration of implants was 93%. At least 6 months after loading on implants, the survival rate of implants was 78.5%. Autogenous bone graft and adequate residual bone height(>6mm) increased survival rate of implants. CONCLUSION: Successful implant placement with maxillary sinus elevation mainly depends on sufficient residual bone height, healthy maxillary sinus, autogenous bone graft.

Treatment of Tibial Condyle Fracture.: Dong Chul Lee, Oog Jin Shon, Sung Hyuk Park; Yeungnam Univ J Med. 2003;20(2):177-186. Published online December 31, 2003; DOI: https://doi.org/10.12701/yujm.2003.20.2.177

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Abstract PDF: BACKGROUND
Clinical and radiological results based on fracture types and associated injuries after the treatment of tibial plateau fracture were evaluated for analyzing prognostic factors. MATERIALS AND METHODS: From June 1997 to June 2002, 50 cases were followed for at least 1 year. Mean age was 47.4 years, and mean follow period was 30.0 months. Fracture classification was performed by the Schatzker method. Clinical and radiological evaluation were performed by the Porter and Rasmussen method. Evaluation was based on degree of reduction and associated injuries, etc. RESULTS: The most common cause of injury was traffic accident (37 cases, 74%), The common fracture types by Schatzker classification were type II (14 cases) and VI (12 cases). Methods of treatment were screw fixation (15 cases), plate and screw (21 cases), external fixator (5 cases), and conservative treatment (9 cases). The most common associated injuries were ipsilateral fibular fracture (18 cases) and MCL (medial collateral ligament) injury (8 cases). CONCLUSION: Acceptable results after treatment of tibial plateau fracture were obtained from the anatomical reduction group, non-associated injury group, the young age group, and the early ROM (range of motion) beginning group.

The Analysis of the Cytokine Expression in Musculoskeletal Tumors.: Joon Han Lee, Eun Seok Kwak, Oog Jin Shon, Hee Sun Kim, Duk Seop Shin; Yeungnam Univ J Med. 2003;20(2):187-196. Published online December 31, 2003; DOI: https://doi.org/10.12701/yujm.2003.20.2.187

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Abstract PDF: The cytokines are the hormone-like proteins, which are produced in the mononuclear cells. They have many roles, such as immune mediators, cell differentiations, angiogenesis. The chemokines have chemotactic effects which control the host immune response. There were few reports about the cytokines associated with musculoskeletal tumors. From late 1980s, the cytokine studies of bone tumors such as osteosarcoma were started, but most studies for benign and malignant musculoskeletal tumors were left to be explored. To evaluate the characteristics of the cytokines in variable musculoskeletal tumors, tissues were obtained from the seven patients who visited the Yeungnam University hospital from February to July 2000. They were lipoma (1 case), parosteal osteoma (1 case), enchondroma (2 cases), pigmented villonodular synovitis (1 case), ganglion (1 case), and metastaic squamous cell carcinoma (1 case). The gene experession of the cytokines were analyzed by RNase protection assay (RPA) and reverse transcription-polymerase chain reaction (RT-PCR). The lipoma and parosteal osteoma expressed MIP-1beta, and IP-10 genes. The two enchondromas showed different results, one expressed all of MIP-1alpha, MIP-1beta and IP-10 genes but the other expressed none of above. The pigmented villonodular synovitis strongly expressed MIP-1alpha and IP-10 when compared with the other cases. The ganglion did not express all of the chemokines mentioned above. And the metastatic squamous cell carcinoma expressed all of the chemokines and especially IP-10 was highly expressed. Even though this study has only a few cases, these results provide a basis for the cytokine mediating network study in musculoskeletal tumors.

Multimarker Approach by Troponin T, C-Reactive Protein, and CK-MB to Assessment in AMI in the Emergency Department.: Sam Beom Lee, Jung Ho Kim, Byung Soo Do; Yeungnam Univ J Med. 2003;20(2):197-205. Published online December 31, 2003; DOI: https://doi.org/10.12701/yujm.2003.20.2.197

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Abstract PDF: No abstract available.

Case Reports

Two Cases of Vitamin B12 Deficiency Anemia Combined with Iron Deficiency Anemia.: Eun Hae Kim, Hee Soon Cho, Chae Hoon Lee, Kyung Dong Kim, Myung Soo Hyun; Yeungnam Univ J Med. 2003;20(2):206-211. Published online December 31, 2003; DOI: https://doi.org/10.12701/yujm.2003.20.2.206

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Abstract PDF: Simultaneous deficiency of Vitamin B12 and iron induces that the bone marrow erythroid megaloblastosis and peripheral blood macroovalocytosis are masked because of countervailing the tendency of iron deficiency to produce hypochromic microcytic erythrocytes. We report two cases of Vitamin B12 deficiency anemia with low mean corpuscular volume (MCV) due to combined iron deficiency anemia with review of literature.

A Case of Spontaneous Pneumomediastinum without Direct Cause.: Sam Beom Lee, Jung Ho Kim, Byung Soo Do; Yeungnam Univ J Med. 2003;20(2):212-216. Published online December 31, 2003; DOI: https://doi.org/10.12701/yujm.2003.20.2.212

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Abstract PDF: No abstract available.

A Case of Subcutaneous Emphysema without Associated Injuries at Neck from Motorcycle Accident.: Jung Ho Kim, Sam Beom Lee, Byung Soo Do; Yeungnam Univ J Med. 2003;20(2):217-222. Published online December 31, 2003; DOI: https://doi.org/10.12701/yujm.2003.20.2.217

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Abstract PDF: Subcutaneous emphysema defines collection of air in subcutaneous spaces of body. It is usually originated from air in upper airway and lower respiratory tract such as larynx, trachea, bronchus and lungs. Air in subcutaneous spaces derives from leakage of air due to tearing or ruptures of airway structures, and also accompanies pneumothorax or pneumomediastinum and/or rib or sternal fractures or other major airway injuries. We experienced a case of subcutaneous emphysema caused by laryngeal injury without any associated airway injuries at neck from motorcycle accident, so we would report a case with the review of literatures.

Calcifying Aponeurotic Fibroma: A Case Report.: Joon Hyuk Choi, Jae Sung Seo, Kil Ho Cho; Yeungnam Univ J Med. 2003;20(2):223-228. Published online December 31, 2003; DOI: https://doi.org/10.12701/yujm.2003.20.2.223

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Abstract PDF

Calcifying aponeurotic fibroma is a rare benign soft tissue tumor that usually involves distal extremities in children and adolescents, especially the hands and feet. We report a case of calcifying aponeurotic fibroma arising in a 14-year-old boy who complained of right thumb mass. Surgical excision was performed. The resected specimen showed a 2.0x1.5 cm grayish white, fibrotic tissue. Histologic examination showed proliferation of fibroblastic cells with infiltrative growth pattern. Foci of calcification and chondroid differentiation were present.

Citations

Citations to this article as recorded by

Calcifying Aponeurotic Fibroma of Leg Masquerading as Hemangioma in an Adolescent Male along with Review of Literature
Akriti Jindal, Gargi Kapatia, Manjit Kaur Rana, Rahul Sharma
Indian Journal of Surgical Oncology.2024; 15(1): 136. CrossRef
Calcifying Aponeurotic Fibroma of the Elbow - A Case Report -
Mee-Hye Oh, Eun Ah Jung, Ji Hye Lee, Hyun Deuk Cho, Jong Kyu Han, Yong-Koo Park
The Korean Journal of Pathology.2009; 43(1): 75. CrossRef

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