Journal of Yeungnam Medical Science

Original Article

Experimental proliferative vitreoretinopathy.: Young Hoon Park, Bong Hwan Lee, Duk Kee Hahn; Yeungnam Univ J Med. 1991;8(1):178-190. Published online June 30, 1991; DOI: https://doi.org/10.12701/yujm.1991.8.1.178

Abstract PDF: The authors performed experimental study to produce proliferative vitreoretinopathy by intravitreal injection of homologous fibroblasts in pigmented rabbits. Twenty four eyes of 12 rabbits were divided into control and experimental groups. In experimental group, the eyes were pretreated with expanding gas, perfluoropropane for the vitrectomy. In control group, no such procedure was preceded. In both groups, 5.0×10⁴, 1.0×10⁵ and 1.5×10⁵ cells of homologous fibroblasts were injected into the vitreous cavity. All the eyes were observed regularly with indirect ophthalmoscope followed by fundus photography. Those eyes were enucleated in 1, 2, 4 weeks for the light and electron microscopic studies. The development and severity of the proliferative vitreoretinopathy were correlated with the numbers of the injected fibroblast. This was more pronounced in the experimental group.

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