Journal of Yeungnam Medical Science

Original Articles

Comparision of Parotid Gland Dose Distribution between 3DCRT and IMRT in Head and Neck Radiation Therapy: Sang Mo Yun, Sung Kyu Kim; Yeungnam Univ J Med. 2007;24(2 Suppl):S443-448. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2S.S443

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Abstract PDF: Purpose：This study compared 3 dimensional conformal radiation therapy (3DCRT) to intensity modulated radiation therapy (IMRT) in parotid glands sparing in head and neck cancers. Materials and Methods：Planning target volume (PTV) was outlined on each CT slice. The dose of 50.4 Gy was prescribed to the PTV with the conventional fraction, 5 fractions per week. We also outlined spinal cord and both parotid glands. With Eclipse 3 dimensional planning system, 3DCRT and IMRT planning were done.
Results
：After plan optimization, PTV dose distribution was evaluated with dose volume histogram. The 90% isodose curve covered almost all of PTV for both techniques. Maximum and median dose for spinal cord were 36.8 Gy and 34.2 Gy in 3DCRT, 39.9 GY and 37.5 Gy in IMRT. For parotid glands, mean and median dose were 33.6 Gy and 37.6 Gy in 3DCRT, 24.9 Gy and 24.5 Gy in IMRT.
Conclusion
：For the non-pharyngeal head and neck cancers, 3DCRT was cost effective radiation modality in prevention radiation therapy induced xerostomia.

Docetaxel and Cisplatin Combination Chemotherapy in Patients with Advanced Head and Neck Cancer.: Sung Won Choi, Young Ho Choi, Chang Hoon Bai, Yong Dae Kim, Si Youn Song; Yeungnam Univ J Med. 2006;23(2):162-170. Published online December 31, 2006; DOI: https://doi.org/10.12701/yujm.2006.23.2.162

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Abstract PDF: BACKGROUND
Head and neck cancer is curable at early stages with local-regional therapy. However, most patients are diagnosed with advanced stage disease that requires combination therapy. The aim of this study was to determine the efficacy of docetaxel and cisplatin combination chemotherapy, in patients with advanced head and neck cancer by evaluating the response, survival and organ preservation rates. MATERIALS AND METHODS: We reviewed retrospectively the medical records of 39 patients with advanced head and neck cancer who received docetaxel and cisplatin combination chemotherapy from March 2000 to July 2004. RESULTS: The average age of the 39 patients was 53.4 (range 30 to 73 years) years and the most common primary site was the hypopharynx (23.0%). There were 36 patients who had stage IV disease and three patients with stage III disease. The overall response rate was 76.9% (30/39), including 12 complete responses (30.8%) and 18 partial responses (46.1%). The response rate based on the primary cancer and neck metastasis was 74.4% and 69.3%; the differences were not significant. Among 16 patients with laryngeal and hypopharyngeal cancer, 13 (81.2%) had their larynx preserved after chemotherapy followed by radiotherapy and a survival rate of 61.5%; three patients (18.8%) received a total laryngectomy and had a survival rate of 66.7%. The overall survival rate from the start of chemotherapy was 56.4% with a median survival of 30 months. The common toxicities observed were alopecia, vomiting, diarrhea, hepatotoxicity and anemia but they were all generally manageable. CONCLUSION: Docetaxel and cisplatin combination chemotherapy is an effective regimen with a relatively high response rate and acceptable toxicity

Radiation Therapy of Head and Neck Cancer with CO-6O HDR Transcatheteric Irradiation.: Sei One Shin, Sung Kyu Kim, Myung Se Kim; Yeungnam Univ J Med. 1990;7(2):109-114. Published online December 31, 1990; DOI: https://doi.org/10.12701/yujm.1990.7.2.109

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Abstract PDF: The basic strategy of irradiation is to deliver a dose to the cancer that is high enough to make cancer cells incapable of reproduction, while keeping the doses to the various healthy tissues below tolerable levels. In order to improve local control and survival, as a boost therapy after external radiotherapy, high dose rate transcatheteric irradiation using remote control after loading system (RALSTRON-20B) was used for twelve patients with head and neck cancers. Present results showed complete remission of cancer in 9 out of 112 patients without treatment related complications. Although this procedure is easy to operate, well trained skillful hand in essential for good results. Furthermore out experience suggested that meticulous treatment planning should be developed for better results.

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