Journal of Yeungnam Medical Science

Indexed in: ESCI, Scopus, PubMed,
PubMed Central, CAS, DOAJ, KCI

FREE article processing charge

Search

Review Article

Platelet Activating Factor-Acetylhydrolase: Tae-Yoon Lee; Yeungnam Univ J Med. 2007;24(2 Suppl):S142-151. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2S.S142

Abstract PDF: Platelet activating factor (PAF) is a phospholipid with a strong inflammatory mediator. PAF is synthesized in a variety of cells in response to inflammatory stimuli. PAF is degraded by intracellular and extracellular PAF-acetylhydrolases (PAF-AHs) thus providing proper level of PAF. Plasma PAF-AH deficiency is associated with several diseases such as asthma, systemic lupus erythematosus, juvenile rheumatoid arthritis, acute myocardial infarction, diabetes, and membranous nephropathy. Cloning of plasma PAF-AH gene enabled the use of recombinant PAF-AH as a therapeutic tool for these PAF-mediated diseases.