Journal of Yeungnam Medical Science

Case report

Purulent pericarditis: subdiaphragmatic suppurative focus: Kang-Un Choi, Chan-Hee Lee; Yeungnam Univ J Med. 2020;37(1):63-66. Published online September 4, 2019; DOI: https://doi.org/10.12701/yujm.2019.00311

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Purulent pericarditis is defined as a localized pericardial infection with gross pus formation in the pericardial space. Although purulent pericarditis is now rare in the antibiotic era, it may be life-threatening. We describe a rare case of purulent pericarditis that originated from a subdiaphragmatic suppurative focus in an immunocompromised host.

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Sungkyu Lee, Hyeyeon Sung, Chonghee Seo
Journal of Social Science.2021; 32(3): 149. CrossRef

Original article

What are the most important prognostic factors in patients with residual rectal cancer after preoperative chemoradiotherapy?: Sol-Min Kim, Ghilsuk Yoon, An Na Seo; Yeungnam Univ J Med. 2019;36(2):124-135. Published online April 1, 2019; DOI: https://doi.org/10.12701/yujm.2019.00157

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Abstract PDF

Background
We aimed to establish robust histoprognostic predictors on residual rectal cancer after preoperative chemoradiotherapy (CRT).
Methods
Analyzing known histoprognostic factors in 146 patients with residual disease allows associations with patient outcome to be evaluated.
Results
The median follow-up time was 77.8 months, during which 59 patients (40.4%) experienced recurrence and 41 (28.1%) died of rectal cancer. On univariate analysis, residual tumor size, ypT category, ypN category, ypTNM stage, downstage, tumor regression grade, lymphatic invasion, perineural invasion, venous invasion, and circumferential resection margin (CRM) were significantly associated with recurrence free survival (RFS) or/and cancer-specific survival (CSS) (all p<0.005). On multivariate analysis, higher ypTNM stage and CRM positivity were identified as independent prognostic factors for RFS (ypTNM stage, p=0.024; CRM positivity, p<0.001) and CSS (p=0.022, p=0.017, respectively). Furthermore, CRM positivity was an independent predictor of reduced RFS, irrespective of subgrouping according to downstage (non-downstage, p=0.001; downstage, p=0.010) or lymph node metastasis (non-metastasis, p=0.004; metastasis, p=0.007).
Conclusion
CRM status may be as powerful as ypTNM stage as a prognostic indicator for patient outcome in patients with residual rectal cancer after preoperative CRT.

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Poor nutrition and sarcopenia are related to systemic inflammatory response in patients with rectal cancer undergoing preoperative chemoradiotherapy
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International Journal of Colorectal Disease.2022; 37(1): 189. CrossRef
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International Journal of Clinical Oncology.2022; 27(1): 141. CrossRef
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Review Article

Treatment of Rectal Cancer: Sang Hun Jung, Jae Hwang Kim, Min Chul Shim; Yeungnam Univ J Med. 2007;24(2 Suppl):S283-295. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2S.S283

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Abstract PDF: Treatment for rectal cancer continues to develop towards the improved local control and overall survival, maintaining quality of life, and preserving sphincter, genitourinary, and sexual function. Preoperative assessment for tumor depth, lymph node, and distant metastasis has an important role on treatment plan. Preoperative staging is used to determine the indication for neoadjuvant therapy as well as the indication for local excision versus radical cancer resection. Local excision is likely to be curative in patients whose tumor are confined to the submucosa without regional lymph and systemic metastasis. Total mesorectal excision (TME) and autonomic nerve preservation are standard procedure for advanced rectal cancer. In patients with advanced tumor stage (T3/T4 and/or N1) with no distant metastasis, preoperative chemoradiation followed by radical resection has become widely accepted recently.

Review

Target Therapy for Colorectal Cancer.: Kyung Hee Lee; Yeungnam Univ J Med. 2006;23(2):143-151. Published online December 31, 2006; DOI: https://doi.org/10.12701/yujm.2006.23.2.143

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Abstract PDF: In the past decade, the median duration of survival among patients with advanced colorectal cancer has increased from 12 months to about 18 months, primarily as a results of the introduction of irinotecan and oxaliplatin. Advances in the understanding of the molecular mechanisms underlying the development and progression of cancer have resulted in the discovery of new therapeutic interventions that target specific molecular abnormalities. Their specificity, and therefore their potential to bind preferentially and modify tumor-specific targets, sparing normal tissues and causing fewer side-effects compared to conventional cytotoxic agents, makes them an attractive therapeutic option. The future of this approach for the treatment of solid tumors is promising

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