Journal of Yeungnam Medical Science

Case Reports

Two Cases of Systemic Lupus Erythematosus with Cerebrovascular Involvement.: Bong Jun Kim, Eun Young Lee, Young Hoon Hong, Ki Do Park, Young Doo Song, Choong Ki Lee, Young Ran Shim; Yeungnam Univ J Med. 1998;15(2):371-380. Published online December 31, 1998; DOI: https://doi.org/10.12701/yujm.1998.15.2.371

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Abstract PDF: Systemic lupus erythematosus(SLE) is an autoimmune disease which may affect many different organs and disclose various clinical manifestations. Recently central nervous system(CNS) involvement has been recognized as an increasingly significant contributor to morbidity and mortality of SLE. The clinical manifestations of CNS-lupus are highly variable and range from mild cognitive dysfunction, movement disorder, headache, psychosis to life-threatening stroke and coma. Among the neuropsychiatric disorders encountered in patients with SLE, cerebrovascular disease has been a relatively rare complication. The diagnosis and management of CNS-lupus is difficult because of the lack of useful diagnostic methods. If, cerebrovascular involvement is suspected, then aggressive treatment such as high dose steroid, immunosuppressive therapy, plasma exchange, may be required to reduce high mortality rate. We experienced 2 cases cerebrovascular disease occurring in SLE patients which presented with various neuropsychiatric manifestations. They were diagnosed as CNS-lupus by neuropsychiatric symptoms, brain MRI, and EEG, and showed good response to high dose steroid pulse therapy.

MR imaging of internuclear ophthalmoplegia due to cerebrovascular diseases.: Suk Hee Kim, Young Ki Lee, Jung Sang Hah, Young Ju Byun, Choong Suh Park, Sun Yong Kim; Yeungnam Univ J Med. 1991;8(1):220-230. Published online June 30, 1991; DOI: https://doi.org/10.12701/yujm.1991.8.1.220

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Internuclear ophthalmoplegia is a conjugated gaze disorder characterized by impaired adduction on the side of a lesion involving the medial longitudinal fasciculus with dissociated nystagmus of the other abducting eye. Six patients with INO (who had clinical cerebrovascular diseases) underwent MR imaging and the results were as follows: 1. The MLF lesions were identified by MR imaging in 5 cases 2. The ratio of unilateral INO to bilateral INO was 5:1 3. The nature of lesions was infarction in 4 cases and hemorrhage in 1 case 4. The sites of MLE lesion were in the midbrain in 4 cases and in the pons in 1 case 5. All 5 cases of INO identified by MR imaging had other lesion sites in addition to MLE lesion.

Citations

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A Case Report of Idiopathic Bilateral Internuclear Ophthalmoplegia
Ye-Jin Eom, Chul-Hee Hong
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology.2016; 29(3): 177. CrossRef

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