Journal of Yeungnam Medical Science

Original article

Nephrology
Cortical thickness of the rostral anterior cingulate gyrus is associated with frailty in patients with end-stage renal disease undergoing hemodialysis in Korea: a cross-sectional study: Sang Hyun Jung, Jong Soo Oh, So-Young Lee, Hye Yun Jeong; J Yeungnam Med Sci. 2023;40(4):381-387. Published online March 24, 2023; DOI: https://doi.org/10.12701/jyms.2022.00941

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Background
Frailty is defined as a condition of being weak and delicate, and it represents a state of high vulnerability to adverse health outcomes. Recent studies have suggested that the cingulate gyrus is associated with frailty in the elderly population. However, few imaging studies have explored the relationship between frailty and the cingulate gyrus in patients with end-stage renal disease (ESRD) undergoing hemodialysis.
Methods
Eighteen right-handed patients with ESRD undergoing hemodialysis were enrolled in the study. We used the FreeSurfer software package to estimate the cortical thickness of the regions of interest, including the rostral anterior, caudal anterior, isthmus, and posterior cingulate gyri. The Beck Depression Inventory, Beck Anxiety Inventory, and laboratory tests were also conducted.
Results
The cortical thickness of the right rostral anterior cingulate gyrus (ACG) was significantly correlated with the Fried frailty index, age, and creatinine level. Multiple regression analysis indicated that the cortical thickness of the right rostral ACG was associated with frailty after controlling for age and creatinine level.
Conclusion
Our results indicate that the cortical thickness of the rostral ACG may be associated with frailty in patients with ESRD on hemodialysis and that the rostral ACG may play a role in the frailty mechanism of this population.

Citations

Citations to this article as recorded by

The impact of balance exercise on brain age and brain morphometry: insights from MRI analysis
Varima Narula, Denise Taylor, Ruth McLaren, Rachael L. Taylor, Susan Mahon, Paul F. Smith, Shikha Chaudhary, Roger W. Winton, Justin Fernandez, Vickie Shim, Alan Wang
Aging Clinical and Experimental Research.2026;[Epub] CrossRef

Review article

Urology
Frailty and elderly in urology: implications for postoperative complications: Phil Hyun Song; Yeungnam Univ J Med. 2020;37(4):296-301. Published online October 8, 2020; DOI: https://doi.org/10.12701/yujm.2020.00752

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Abstract PDF

The geriatric population is at a greater risk of postoperative complications than young adults. This risk is associated with the physiologic decline seen in this population known as frailty. Unlike fitter patients, frail patients who undergo operative treatment have a greater likelihood of developing postoperative complications and endure prolonged hospital stays. This circumstance is comparable to the urological status. Therefore, tolerable measurement of frailty as a domain of preoperative health status has been suggested to ascertain vulnerability in elderly patients. In this review, we will elaborate on the concept of frailty and examine its importance with respect to surgical complications, focusing on the urological status.

Citations

Citations to this article as recorded by

Frailty and surgical outcomes in genitourinary prosthetic procedures: an ACS-NSQIP comparative analysis of risk indices
Umar Ghaffar, Behzad Abbasi, Nizar Hakam, Adrian Fernandez, Marvin N. Carlisle, Robert Pearce, Hiren V. Patel, Kevin D. Li, Nikit Venishetty, Benjamin N. Breyer
International Urology and Nephrology.2025; 57(9): 2885. CrossRef

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