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JYMS : Journal of Yeungnam Medical Science

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7 "Inflammation"
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Original article
DA-6034 ameliorates hepatic steatosis and inflammation in high fat diet-induced obese mice
Hong Min Kim, Mi-Hye Kwon, Eun Soo Lee, Kyung Bong Ha, Choon Hee Chung
J Yeungnam Med Sci. 2024;41(2):103-112.   Published online March 15, 2024
DOI: https://doi.org/10.12701/jyms.2023.01389
  • 1,741 View
  • 35 Download
  • 1 Crossref
AbstractAbstract PDF
Background
Nonalcoholic fatty liver disease (NAFLD) is characterized by an increase in hepatic triglyceride content and increased inflammatory macrophage infiltration through the C-C motif chemokine receptor (CCR) 5 pathway in the liver. DA-6034 (7-carboxymethyloxy-3',4',5-trimethoxy flavone), is a synthetic derivative of eupatilin that exhibits anti-inflammatory activity in inflammatory bowel disease. However, the effect of DA-6034 on the inflammatory response in NAFLD is not well elucidated. Therefore, we aimed to determine the effect of DA-6034 on hepatic steatosis and inflammation.
Methods
Forty male C57BL/6J mice were divided into the following four groups: (1) regular diet (RD), (2) RD with DA-6034, (3) high fat diet (HFD), and (4) HFD with DA-6034. All mice were sacrificed 12 weeks after the start of the experiment. The effects of DA-6034 on macrophages were assessed using RAW264.7 cells.
Results
DA-6034 not only reduced hepatic triglyceride levels and lipid accumulation but also macrophage infiltration and proinflammatory cytokines in HFD-fed mice. According to fluorescence-activated cell sorter analysis, DA-6034 reduced the CD8+ T cell fraction in the liver of HFD-fed mice. DA-6034 also reduced CCR5 expression and the migration of liver macrophages in HFD-fed mice and inhibited CCR2 ligand and CCR4 ligand, which stimulated the migration of macrophages.
Conclusion
Overall, DA-6034 attenuates hepatic steatosis and inflammation in obesity by regulating CCR5 expression in macrophages.

Citations

Citations to this article as recorded by  
  • The Role of Pro-Inflammatory Chemokines CCL-1, 2, 4, and 5 in the Etiopathogenesis of Type 2 Diabetes Mellitus in Subjects from the Asir Region of Saudi Arabia: Correlation with Different Degrees of Obesity
    Mohammad Muzaffar Mir, Jaber Alfaifi, Shahzada Khalid Sohail, Syeda Fatima Rizvi, Md Tanwir Akhtar, Mushabab Ayed Abdullah Alghamdi, Rashid Mir, Javed Iqbal Wani, Zia Ul Sabah, Fahad A. Alhumaydhi, Fahad Alremthi, AbdulElah Al Jarallah AlQahtani, Muffarah
    Journal of Personalized Medicine.2024; 14(7): 743.     CrossRef
Case report
Crowned dens syndrome as a rare cause of anterior neck pain after transurethral resection of the prostate: a case report
Myeong Geun Jeong, Bum Soon Park, Eun-Seok Son, Jang Hyuk Cho
J Yeungnam Med Sci. 2023;40(3):289-292.   Published online August 5, 2022
DOI: https://doi.org/10.12701/jyms.2022.00388
  • 1,983 View
  • 83 Download
AbstractAbstract PDF
We describe the case of a 79-year-old man who presented with progressive aggravation of severe axial neck pain and fever 3 days after transurethral resection of the prostate (TURP), despite maintaining neutral neck posture during surgery. Laboratory examination revealed markedly elevated C-reactive protein levels and erythrocyte sedimentation rates. Computed tomography revealed crown-like calcifications surrounding the odontoid process. We diagnosed crowned dens syndrome (CDS) as the cause of acute-onset neck pain after TURP. The patient was treated with nonsteroidal anti-inflammatory drugs for 5 days, and his symptoms resolved completely. CDS is a rare disease characterized by calcific deposits around the odontoid process with acute onset of severe neck pain and restricted motion. Evidence of inflammation on serological testing and fever are typical of CDS. However, the prevalence and pathophysiology of CDS remain unclear. We hypothesized that systemic inflammation after prostate surgery may have induced a local inflammatory response involving calcification around the odontoid process.
Review articles
Hepatic ischemia-reperfusion injury with respect to oxidative stress and inflammatory response: a narrative review
Eun Kyung Choi, Dong Gun Lim
J Yeungnam Med Sci. 2023;40(2):115-122.   Published online March 21, 2022
DOI: https://doi.org/10.12701/jyms.2022.00017
  • 3,357 View
  • 130 Download
  • 6 Web of Science
  • 8 Crossref
AbstractAbstract PDF
Hepatic ischemia-reperfusion injury is a major complication of liver transplantation, trauma, and shock. This pathological condition can lead to graft dysfunction and rejection in the field of liver transplantation and clinical hepatic dysfunction with increased mortality. Although the pathological mechanisms of hepatic ischemia-reperfusion injury are very complex, and several intermediators and cells are involved in this phenomenon, oxidative stress and inflammatory responses are the key processes that aggravate hepatic injury. This review summarizes the current understanding of oxidative stress and inflammatory responses and, in that respect, addresses the therapeutic approaches to attenuate hepatic ischemia-reperfusion injury.

Citations

Citations to this article as recorded by  
  • Thymoquinone-loaded self-nano-emulsifying drug delivery system against ischemia/reperfusion injury
    Badr Bahloul, Roua Chaabani, Yosri Zahra, Nesrine Kalboussi, Jamil Kraiem, Souad Sfar, Nathalie Mignet, Hassen ben Abdennebi
    Drug Delivery and Translational Research.2024; 14(1): 223.     CrossRef
  • Modafinil lightens apoptosis and inflammatory response in hepatic ischemia‐reperfusion injury through inactivation of TLR9/Myd88/p38 signaling
    Tairan Zhang, Xidong Wang
    Drug Development Research.2024;[Epub]     CrossRef
  • Cellular and molecular mechanisms of hepatic ischemia-reperfusion injury: the role of oxidative stress and therapeutic approaches
    Joseph George, Yongke Lu, Mutsumi Tsuchishima, Mikihiro Tsutsumi
    Redox Biology.2024; : 103258.     CrossRef
  • An update on the molecular mechanism and pharmacological interventions for Ischemia-reperfusion injury by regulating AMPK/mTOR signaling pathway in autophagy
    Bin Tang, Zhijian Luo, Rong Zhang, Dongmei Zhang, Guojun Nie, Mingxing Li, Yan Dai
    Cellular Signalling.2023; : 110665.     CrossRef
  • Unveiling the Crucial Roles of O2•–and ATP in Hepatic Ischemia–Reperfusion Injury Using Dual-Color/Reversible Fluorescence Imaging
    Jihong Liu, Wen Zhang, Xin Wang, Qi Ding, Chuanchen Wu, Wei Zhang, Luling Wu, Tony D. James, Ping Li, Bo Tang
    Journal of the American Chemical Society.2023; 145(36): 19662.     CrossRef
  • New insights into ischemia-reperfusion injury signaling pathways in organ transplantation
    Kenneth J. Dery, Jerzy W. Kupiec-Weglinski
    Current Opinion in Organ Transplantation.2022; 27(5): 424.     CrossRef
  • Isolongifolene alleviates liver ischemia/reperfusion injury by regulating AMPK-PGC1α signaling pathway-mediated inflammation, apoptosis, and oxidative stress
    Jinjin Li, Jie Li, Hongbo Fang, Hang Yang, Tianchun Wu, Xiaoyi Shi, Chun Pang
    International Immunopharmacology.2022; 113: 109185.     CrossRef
  • Molecularly Designed Ion-Imprinted Nanoparticles for Real-Time Sensing of Cu(II) Ions Using Quartz Crystal Microbalance
    Nihan Aydoğan, Gülgün Aylaz, Monireh Bakhshpour, Tugba Tugsuz, Müge Andaç
    Biomimetics.2022; 7(4): 191.     CrossRef
Updates on the treatment of adhesive capsulitis with hydraulic distension
Jang Hyuk Cho
Yeungnam Univ J Med. 2021;38(1):19-26.   Published online August 31, 2020
DOI: https://doi.org/10.12701/yujm.2020.00535
  • 9,331 View
  • 236 Download
  • 10 Crossref
AbstractAbstract PDF
Adhesive capsulitis of the shoulder joint is a common disease characterized by pain at the insertional area of the deltoid muscle and decreased range of motion. The pathophysiological process involves fibrous inflammation of the capsule and intraarticular adhesion of synovial folds leading to capsular thickening and contracture. Regarding the multidirectional limitation of motion, a limitation in external rotation is especially prominent, which is related to not only global fibrosis but also to a localized tightness of the anterior capsule. Ultrasound and magnetic resonance imaging studies can be applied to rule out other structural lesions in the diagnosis of adhesive capsulitis. Hydraulic distension of the shoulder joint capsule provides pain relief and an immediate improvement in range of motion by directly expanding the capsule along with the infusion of steroids. However, the optimal technique for hydraulic distension is still a matter of controversy, with regards to the infusion volume and rupture of the capsule. By monitoring the real-time pressure-volume profile during hydraulic distension, the largest possible fluid volume can be infused without rupturing the capsule. The improvement in clinical outcomes is shown to be greater in capsule-preserved hydraulic distension than in capsule-ruptured distension. Moreover, repeated distension is possible, which provides additional clinical improvement. Capsule-preserved hydraulic distension with maximal volume is suggested to be an efficacious treatment option for persistent adhesive capsulitis.

Citations

Citations to this article as recorded by  
  • Rotator Interval vs Posterior Approach Ultrasound-guided Corticosteroid Injections in Primary Frozen Shoulder: A Meta-analysis of Randomized Controlled Trials
    Francisco Javier Arrambide-Garza, Juventino Tadeo Guerrero-Zertuche, Neri Alejandro Alvarez-Villalobos, Alejandro Quiroga-Garza, Abraham Espinosa-Uribe, Felix Vilchez-Cavazos, Yolanda Salinas-Alvarez, Juan Antonio Rivera-Perez, Rodrigo Enrique Elizondo-Om
    Archives of Physical Medicine and Rehabilitation.2024; 105(4): 760.     CrossRef
  • A prospective, randomized, blinded study on the efficacy of using corticosteroids in hydrodilatation as a treatment for adhesive capsulitis of the shoulder
    Joan Tomàs Gebellí-Jové, Antonio Buñuel-Viñau, Marta Canela-Capdevila, Jordi Camps, Fàtima Sabench, Petrea Iftimie-Iftimie
    Shoulder & Elbow.2024;[Epub]     CrossRef
  • Frozen Shoulder: Diagnosis and Management
    Sean R. Wise, Paul Seales, Alex P. Houser, Chase B. Weber
    Current Sports Medicine Reports.2023; 22(9): 307.     CrossRef
  • Ultrasound-guided hydrodilatation of glenohumeral joint combined with acupotomy for treatment of frozen shoulder
    Huajun Xu, Yingchun Zhang, Caishan Wang
    Journal of Back and Musculoskeletal Rehabilitation.2022; 35(5): 1153.     CrossRef
  • Impact of capsular preservation on patient-reported outcomes and complication rates in total hip arthroplasty using the direct anterior approach
    Vincent A. Stadelmann, Hannes A. Rüdiger, Selina Nauer, Michael Leunig
    The Bone & Joint Journal.2022; 104-B(7): 826.     CrossRef
  • Management of Patients with Adhesive Capsulitis via Ultrasound-Guided Hydrodilatation without Concomitant Intra-Articular Lidocaine Infusion: A Single-Center Experience
    Yung-Chieh Chen, Shu-Huei Shen, Hong-Jen Chiou, Yung-Liang Wan
    Life.2022; 12(9): 1293.     CrossRef
  • Role of Platelet-Rich Plasma in the Treatment of Adhesive Capsulitis: A Prospective Cohort Study
    Syed Imran Haider, Muhammad Zarak Awais, Muhammad Tahir Iqbal
    Cureus.2022;[Epub]     CrossRef
  • Musculoskeletal complications in patients with diabetes mellitus
    Jong Han Choi, Hae-Rim Kim, Kee-Ho Song
    The Korean Journal of Internal Medicine.2022; 37(6): 1099.     CrossRef
  • Comparison of the spread pattern of medial-to-lateral and lateral-to-medial rotator interval injections: A cadaveric study
    Benjamin J. Kozlowski, John Tran, Philip W.H. Peng, Anne M.R. Agur, Nimish Mittal
    Interventional Pain Medicine.2022; 1(4): 100164.     CrossRef
  • Updates on Intra-articular Corticosteroid Injection for the Treatment of Adhesive Capsulitis
    Ju Heon Oh, In Ho Jung, Eun Woo Park, Jang Hyuk Cho
    Keimyung Medical Journal.2022; 41(2): 51.     CrossRef
Review
Role of the transforming growth factor (TGF)-β1 and TGF-β1 signaling pathway on the pathophysiology of respiratory pneumococcal infections
Maria Jose Andrade, Jae Hyang Lim
Yeungnam Univ J Med. 2017;34(2):149-160.   Published online December 31, 2017
DOI: https://doi.org/10.12701/yujm.2017.34.2.149
  • 2,335 View
  • 20 Download
AbstractAbstract PDF
Streptococcus pneumoniae, pneumococcus, is the most common cause of community-acquired pneumonia (CAP). CAP is an important infectious disease with high morbidity and mortality, and it is still one of the leading causes of death worldwide. Many genetic factors of the host and various environmental factors surrounding it have been studied as important determinants of the pathophysiology and outcomes of pneumococcal infections. Various cytokines, including transforming growth factor (TGF)-β1, are involved in different stages of the progression of pneumococcal infection. TGF-β1 is a cytokine that regulates a wide range of cellular and physiological functions, including immune and inflammatory responses. This cytokine has long been known as an anti-inflammatory cytokine that is critical to preventing the progression of an acute infection to a chronic condition. On the other hand, recent studies have unveiled the diverse roles of TGF-β1 on different stages of pneumococcal infections other than mitigating inflammation. This review summarizes the recent findings of the role of TGF-β1 on the pathophysiology of pneumococcal infections, which is fundamental to developing novel therapeutic strategies for such infections in immune-compromised patients.
Case Report
Xanthogranulomatous Inflammation of Transverse Colon
Sang Hun Jung
Yeungnam Univ J Med. 2007;24(2 Suppl):S725-730.   Published online December 31, 2007
DOI: https://doi.org/10.12701/yujm.2007.24.2S.S725
  • 1,191 View
  • 7 Download
AbstractAbstract PDF
Xanthogranulomatous inflammation is an uncommon benign inflammatory disease characterized by aggregation of lipid-laden foamy macrophages (xanthoma cells) that usually presents with tumor-like appearance. The clinical and radiological findings are suggestive of advanced carcinoma of involved organ. A 66-year-man presented fever, upper abdominal mass during 10 days. By computed tomography, barium enema and PET-CT, his case suspected transverse colon malignancy. A laparotomy was performed. On operation, huge mass originated from mid-transverse was identified and transverse colectomy was performed. The pathologic report demonstrated xanthogranulomatous inflammation in transverse colon.
Original Article
The Production Mechanism of TNF-alpha and IL-6 by Group IIA Phospholipase A2.
Jae Hong Ahn, Dae Won Park, Jin Hee Kim, Jei Jun Bae, Yeun Kyoung Bae, Yoon Ki Park
Yeungnam Univ J Med. 2004;21(2):177-190.   Published online December 31, 2004
DOI: https://doi.org/10.12701/yujm.2004.21.2.177
  • 1,485 View
  • 0 Download
AbstractAbstract PDF
BACKGROUND
Secretory phospholipase A2 (sPLA2) are a group of extracellular enzymes that release fatty acids at the sn-2 position of phospholipids. Group IIA sPLA2 (sPLA2-IIA) has been detected in the inflammatory fluids, and its plasma level increases in the inflammatory disease. This study examined the effect of sPLA2-IIA on mouse macropahges in order to investigate the potential mechanism of sPLA2-induced inflammation. MATERIALS AND METHODS: Wild type PLA2 and mutant H48Q PLA2 were purified from HEK293 cells transfected with the corresponding plasmids, and the PLA2 activities were measured using 1-palmitoyl-2-[1- (14) C]linoleoyl-3-phosphatidylethanolamine as substrates. The TNF-alpha and IL-6 released in the supernatants were determined by ELISA. In addition, the TNF-alpha and IL-6 mRNA were analyzed by RT-PCR. RESULTS: sPLA2-IIA stimulated the production of TNF-alpha and IL-6 in a dose- and time-dependent manner. In addition, the effect of sPLA2-IIA on cytokine production from the macrophage was found to be associated with the accumulation of their specific mRNA. The mRNA levels of TNF-alpha and IL-6 peaked at 2 and 6 hours in a time-dependent manner, respectively. CONCLUSION: In conclusion, the production of proinflammatory cytokine might be mediated by the binding of sPLA2-IIA to the receptors.

JYMS : Journal of Yeungnam Medical Science