Skip Navigation
Skip to contents

JYMS : Journal of Yeungnam Medical Science

Indexed in: ESCI, Scopus, PubMed,
PubMed Central, CAS, DOAJ, KCI
FREE article processing charge
OPEN ACCESS
SEARCH
Search

Articles

Page Path
HOME > J Yeungnam Med Sci > Volume 34(1); 2017 > Article
Review The relationship between muscle mitochondrial nutritional overloading and insulin resistance
Jae Han Jeon, Jun Sung Moon, Kyu Chang Won, In Kyu Lee
Journal of Yeungnam Medical Science 2017;34(1):19-28
DOI: https://doi.org/10.12701/yujm.2017.34.1.19
Published online: June 30, 2017
1Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. leei@knu.ac.kr
2Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.
prev next
  • 2,044 Views
  • 20 Download
  • 0 Crossref
  • 0 Scopus

The incidence of type 2 diabetes mellitus and insulin resistance is growing rapidly. Multiple organs including the liver, skeletal muscle and adipose tissue control insulin sensitivity coordinately, but the mechanism of skeletal muscle insulin resistance has not yet been fully elucidated. However, there is a growing body of evidence that lipotoxicity induced by mitochondrial dysfunction in skeletal muscle is an important mediator of insulin resistance. However, some recent findings suggest that skeletal mitochondrial dysfunction generated by genetic manipulation is not always correlated with insulin resistance in animal models. A high fat diet can provoke insulin resistance despite a coordinate increase in skeletal muscle mitochondria, which implies that mitochondrial dysfunction is not mandatory in insulin resistance. Furthermore, incomplete fatty acid oxidation by excessive nutrition supply compared to mitochondrial demand can induce insulin resistance without preceding impairment of mitochondrial function. Taken together we suggested that skeletal muscle mitochondrial overloading, not mitochondrial dysfunction, plays a pivotal role in insulin resistance.

Related articles

JYMS : Journal of Yeungnam Medical Science
TOP