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JYMS : Journal of Yeungnam Medical Science

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HOME > J Yeungnam Med Sci > Volume 28(1); 2011 > Article
Review Combined Hepatocellular-Cholangiocarcinoma: Recent Progress in Pathology and Classification.
Joon Hyuk Choi
Journal of Yeungnam Medical Science 2011;28(1):1-12
Published online: June 30, 2011
Department of Pathology, College of Medicine, Yeungnam University, Daegu, Republic of Korea.
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Primary liver carcinomas have been classified into hepatocellular carcinoma, cholangiocarcinoma, and combined hepatocellular-cholangiocarcinoma (CHC). CHC is a tumor containing unequivocal, intimately mixed elements of both hepatocellular carcinoma and cholangiocarcinoma. It forms a small but significant proportion of primary liver carcinomas. The origin and pathogenesis of CHC have not been well established. According to the 2010 WHO classification, CHCs are categorized into 2 groups: the classical type and a subtype with stem cell features. This review describes recent progress in pathology and classification of CHC.

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